List of works - Tony Lai

7 A Novel Protein for Ca2+ Signaling at Fertilization

scientific article published on January 1, 1998

A mechanism of ryanodine receptor modulation by FKBP12/12.6, protein kinase A, and K201.

scientific article published in January 2010

A ryanodine fluorescent derivative reveals the presence of high-affinity ryanodine binding sites in the Golgi complex of rat sympathetic neurons, with possible functional roles in intracellular Ca(2+) signaling.

scientific article published in May 2001

Altered RyR2 regulation by the calmodulin F90L mutation associated with idiopathic ventricular fibrillation and early sudden cardiac death

scientific article published on 15 July 2014

Analysis of type 1 ryanodine receptor-12 kDa FK506-binding protein interaction.

scientific article published in July 2001

Antigen unmasking enhances visualization efficacy of the oocyte activation factor, phospholipase C zeta, in mammalian sperm.

scientific article published on 08 December 2016

Arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia: insights from a RyR2 R4496C knock-in mouse model

scientific article published on 06 July 2006

Arrhythmogenic calmodulin E105A mutation alters cardiac RyR2 regulation leading to cardiac dysfunction in zebrafish

scientific article published on 02 April 2019

Association of cardiac myosin-binding protein-C with the ryanodine receptor channel - putative retrograde regulation?

scientific article published on 03 August 2018

Binding of phosphoinositide-specific phospholipase C-zeta (PLC-zeta) to phospholipid membranes: potential role of an unstructured cluster of basic residues

scientific article published on 12 April 2007

CMV promoter is inadequate for expression of mutant human RyR2 in transgenic rabbits ⬇️

scientific article published on September 29, 2010

Ca(2+) dynamics in oocytes from naturally-aged mice

scientific article published on 20 January 2016

Ca2+ syntillas, miniature Ca2+ release events in terminals of hypothalamic neurons, are increased in frequency by depolarization in the absence of Ca2+ influx.

scientific article published in February 2004

Calcium oscillations, sperm factors and egg activation at fertilisation.

scientific article published in July 1998

Calsequestrin interacts directly with the cardiac ryanodine receptor luminal domain.

scientific article published on 08 September 2016

Cell cycle-dependent Ca2+ oscillations in mouse embryos are regulated by nuclear targeting of PLCzeta.

scientific article

Central domain of the human cardiac muscle ryanodine receptor does not mediate interaction with FKBP12.6.

scientific article published in January 2005

Characterization of a novel PKA phosphorylation site, serine-2030, reveals no PKA hyperphosphorylation of the cardiac ryanodine receptor in canine heart failure.

scientific article published on 24 March 2005

Chimeras of sperm PLCζ reveal disparate protein domain functions in the generation of intracellular Ca2+ oscillations in mammalian eggs at fertilization

scientific article published on 23 October 2013

Dantrolene rescues aberrant N-terminus intersubunit interactions in mutant pro-arrhythmic cardiac ryanodine receptors.

scientific article published on 19 November 2014

Differential Ca2+ sensitivity of RyR2 mutations reveals distinct mechanisms of channel dysfunction in sudden cardiac death.

scientific article

Differential expression and regulation of ryanodine receptor and myo-inositol 1,4,5-trisphosphate receptor Ca2+ release channels in mammalian tissues and cell lines ⬇️

scientific article published on October 1, 1997

Dihydropyridine receptors and type 1 ryanodine receptors constitute the molecular machinery for voltage-induced Ca2+ release in nerve terminals.

scientific article published in July 2006

Disparities in the association of the ryanodine receptor and the FK506-binding proteins in mammalian heart.

scientific article

Distinctive malfunctions of calmodulin mutations associated with heart RyR2-mediated arrhythmic disease

scientific journal article

Divergent effect of mammalian PLCζ in generating Ca²⁺ oscillations in somatic cells compared with eggs

scientific article

Dysregulated ryanodine receptors mediate cellular toxicity: restoration of normal phenotype by FKBP12.6

scientific article (publication date: August 2003)

Effects of regional ischemia on the ryanodine-sensitive Ca2+ release channel of canine cardiac sarcoplasmic reticulum

scientific article published on October 1, 1992

Egg Activation at Fertilization by a Soluble Sperm Protein.

scientific article

Essential Role of the EF-hand Domain in Targeting Sperm Phospholipase Cζ to Membrane Phosphatidylinositol 4,5-Bisphosphate (PIP2).

scientific article

Expression of a cardiac Ca(2+)-release channel isoform in mammalian brain ⬇️

scientific article published on December 1, 1992

Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization.

scientific article published in November 1998

Expression of sperm PLCζ and clinical outcomes of ICSI-AOA in men affected by globozoospermia due to DPY19L2 deletion.

scientific article published on 29 December 2017

FKBP12.6 binding of ryanodine receptors carrying mutations associated with arrhythmogenic cardiac disease

scientific article

Functional disparity between human PAWP and PLCζ in the generation of Ca2+ oscillations for oocyte activation

scientific article

Functional heterogeneity of ryanodine receptor mutations associated with sudden cardiac death.

scientific article

Genetic and Biochemical Approaches for In Vivo and In Vitro Assessment of Protein Oligomerization: The Ryanodine Receptor Case Study

scientific article (publication date: 27 July 2016)

Hax-1 identified as a two-pore channel (TPC)-binding protein

scientific article

Human PLCζ exhibits superior fertilization potency over mouse PLCζ in triggering the Ca(2+) oscillations required for mammalian oocyte activation

scientific article

Hypertrophic cardiomyopathy-linked variants of cardiac myosin-binding protein C3 display altered molecular properties and actin interaction

scientific article published on 14 December 2018

Intrinsic lattice formation by the ryanodine receptor calcium-release channel

scientific article published on 01 September 2000

Is PAWP the "real" sperm factor?

scientific article published on May 2015

Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).

scientific article

Male infertility-linked point mutation reveals a vital binding role for the C2 domain of sperm PLCζ.

scientific article published on 7 March 2017

Mineralocorticoid modulation of cardiac ryanodine receptor activity is associated with downregulation of FK506-binding proteins.

scientific article

Modification of smooth muscle Ca2+-sparks by tetracaine: evidence for sequential RyR activation.

scientific article published on 14 June 2007

Multiple isoforms of the ryanodine receptor are expressed in rat pancreatic acinar cells.

scientific article

Mutations in PLCδ1 associated with hereditary leukonychia display divergent PIP2 hydrolytic function.

scientific article

N-terminus oligomerization is conserved in intracellular calcium release channels

scientific article published on April 2014

Na+-dependent SR Ca2+ overload induces arrhythmogenic events in mouse cardiomyocytes with a human CPVT mutation.

scientific article published on 15 January 2010

PLC? and the initiation of Ca2+ oscillations in fertilizing mammalian eggs ⬇️

scientific article published on 05 December 2012

PLCzeta(zeta): a sperm protein that triggers Ca2+ oscillations and egg activation in mammals.

scientific article

PLCζ causes Ca(2+) oscillations in mouse eggs by targeting intracellular and not plasma membrane PI(4,5)P(2).

scientific article

PLCζ or PAWP: revisiting the putative mammalian sperm factor that triggers egg activation and embryogenesis

scientific article

Phospholipase C zeta and calcium oscillations at fertilisation: The evidence, applications, and further questions

scientific article

Phospholipase C-ζ-induced Ca2+ oscillations cause coincident cytoplasmic movements in human oocytes that failed to fertilize after intracytoplasmic sperm injection

scientific article

Phospholipase Czeta causes Ca2+ oscillations and parthenogenetic activation of human oocytes.

scientific article published in December 2004

Phospholipase Cζ binding to PtdIns(4,5)P2 requires the XY-linker region

scientific article

Physical coupling between ryanodine receptor-calcium release channels.

scientific article published on 25 April 2005

Presence and localization of oscillin in human spermatozoa in relation to the integrity of the sperm membrane ⬇️

scientific article published on February 27, 1998

Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.

scientific article published on 05 August 2013

Presynaptic calcium stores underlie large-amplitude miniature IPSCs and spontaneous calcium transients.

scientific article published in December 2000

Recognition force microscopy/spectroscopy of ion channels: applications to the skeletal muscle Ca2+ release channel (RYR1).

scientific article

Redistribution of mitochondria leads to bursts of ATP production during spontaneous mouse oocyte maturation.

scientific article

Redox regulation of the ryanodine receptor/calcium release channel

scientific article published on 01 November 2006

Redox sensitivity of the ryanodine receptor interaction with FK506-binding protein.

scientific article published on 2 January 2007

Rescue of failed oocyte activation after ICSI in a mouse model of male factor infertility by recombinant phospholipase Cζ

scientific article

Role of FKBP12.6 in hypoxia- and norepinephrine-induced Ca2+ release and contraction in pulmonary artery myocytes.

scientific article published in April 2004

Role of ryanodine receptor mutations in cardiac pathology: more questions than answers?

scientific article published on 01 November 2006

Ryanodine receptor arrays: not just a pretty pattern?

scientific article published on 10 March 2008

Ryanodine receptor binding to FKBP12 is modulated by channel activation state.

scientific article published on 21 September 2005

Ryanodine receptor mutations in arrhythmias: advances in understanding the mechanisms of channel dysfunction.

scientific article

Ryanodine receptor oligomeric interaction: identification of a putative binding region.

scientific article

Ryanodine receptor regulation by intramolecular interaction between cytoplasmic and transmembrane domains.

scientific article

Ryanodine receptor type I and nicotinic acid adenine dinucleotide phosphate receptors mediate Ca2+ release from insulin-containing vesicles in living pancreatic beta-cells (MIN6).

scientific article published on 21 January 2003

Ryanodine receptor-mediated arrhythmias and sudden cardiac death.

scientific article published on April 2009

Ryanodine receptors are part of the myospryn complex in cardiac muscle.

scientific article

Ryanodine stores and calcium regulation in the inner segments of salamander rods and cones.

scientific article published on 24 January 2003

Sizes of opioid receptor types in rat brain membranes ⬇️

scientific article published on August 17, 1984

Spatial organization of RYRs and BK channels underlying the activation of STOCs by Ca(2+) sparks in airway myocytes

scientific article

Sperm PLCζ: from structure to Ca2+ oscillations, egg activation and therapeutic potential.

scientific article published on 21 October 2013

Sperm-induced Ca2+ release during egg activation in mammals.

scientific article published on 21 April 2014

Sperm-specific post-acrosomal WW-domain binding protein (PAWP) does not cause Ca2+ release in mouse oocytes.

scientific article

Starting a new life: sperm PLC-zeta mobilizes the Ca2+ signal that induces egg activation and embryo development: an essential phospholipase C with implications for male infertility.

scientific article

Structural and functional interactions within ryanodine receptor.

scientific article published on June 2015

Structural insights into the human RyR2 N-terminal region involved in cardiac arrhythmias

scientific article

The cytosolic sperm factor that triggers Ca2+ oscillations and egg activation in mammals is a novel phospholipase C: PLCzeta.

scientific article published on April 2004

The dynamics of MAPK inactivation at fertilization in mouse eggs.

scientific article

The dynamics of PKC-induced phosphorylation triggered by Ca2+ oscillations in mouse eggs

scientific article published on January 2013

The human glucosamine-6-phosphate deaminase gene: cDNA cloning and expression, genomic organization and chromosomal localization ⬇️

scientific article published on August 17, 1998

The role and mechanism of action of sperm PLC-zeta in mammalian fertilisation.

scientific article

The soluble mammalian sperm factor protein that triggers Ca2+ oscillations in eggs: evidence for expression of mRNA(s) coding for sperm factor protein(s) in spermatogenic cells.

scientific article published in July 2000

The sperm phospholipase C-ζ and Ca2+ signalling at fertilization in mammals.

scientific article published on February 2016

Toward a molecular understanding of the structure-function of ryanodine receptor Ca2+ release channels: perspectives from recombinant expression systems.

scientific article

Upregulation of functional ryanodine receptors during in vitro aging of human diploid fibroblasts

scientific article published on 01 April 1998

List of works by Tony Lai

7 A Novel Protein for Ca2+ Signaling at Fertilization

A mechanism of ryanodine receptor modulation by FKBP12/12.6, protein kinase A, and K201.

A ryanodine fluorescent derivative reveals the presence of high-affinity ryanodine binding sites in the Golgi complex of rat sympathetic neurons, with possible functional roles in intracellular Ca(2+) signaling.

Altered RyR2 regulation by the calmodulin F90L mutation associated with idiopathic ventricular fibrillation and early sudden cardiac death

Analysis of type 1 ryanodine receptor-12 kDa FK506-binding protein interaction.

Antigen unmasking enhances visualization efficacy of the oocyte activation factor, phospholipase C zeta, in mammalian sperm.

Arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia: insights from a RyR2 R4496C knock-in mouse model

Arrhythmogenic calmodulin E105A mutation alters cardiac RyR2 regulation leading to cardiac dysfunction in zebrafish

Association of cardiac myosin-binding protein-C with the ryanodine receptor channel - putative retrograde regulation?

Binding of phosphoinositide-specific phospholipase C-zeta (PLC-zeta) to phospholipid membranes: potential role of an unstructured cluster of basic residues

CMV promoter is inadequate for expression of mutant human RyR2 in transgenic rabbits ⬇️

Ca(2+) dynamics in oocytes from naturally-aged mice

Ca2+ syntillas, miniature Ca2+ release events in terminals of hypothalamic neurons, are increased in frequency by depolarization in the absence of Ca2+ influx.

Calcium oscillations, sperm factors and egg activation at fertilisation.

Calsequestrin interacts directly with the cardiac ryanodine receptor luminal domain.

Cell cycle-dependent Ca2+ oscillations in mouse embryos are regulated by nuclear targeting of PLCzeta.

Central domain of the human cardiac muscle ryanodine receptor does not mediate interaction with FKBP12.6.

Characterization of a novel PKA phosphorylation site, serine-2030, reveals no PKA hyperphosphorylation of the cardiac ryanodine receptor in canine heart failure.

Chimeras of sperm PLCζ reveal disparate protein domain functions in the generation of intracellular Ca2+ oscillations in mammalian eggs at fertilization

Dantrolene rescues aberrant N-terminus intersubunit interactions in mutant pro-arrhythmic cardiac ryanodine receptors.

Differential Ca2+ sensitivity of RyR2 mutations reveals distinct mechanisms of channel dysfunction in sudden cardiac death.

Differential expression and regulation of ryanodine receptor and myo-inositol 1,4,5-trisphosphate receptor Ca2+ release channels in mammalian tissues and cell lines ⬇️

Dihydropyridine receptors and type 1 ryanodine receptors constitute the molecular machinery for voltage-induced Ca2+ release in nerve terminals.

Disparities in the association of the ryanodine receptor and the FK506-binding proteins in mammalian heart.

Distinctive malfunctions of calmodulin mutations associated with heart RyR2-mediated arrhythmic disease

Divergent effect of mammalian PLCζ in generating Ca²⁺ oscillations in somatic cells compared with eggs

Dysregulated ryanodine receptors mediate cellular toxicity: restoration of normal phenotype by FKBP12.6

Effects of regional ischemia on the ryanodine-sensitive Ca2+ release channel of canine cardiac sarcoplasmic reticulum

Egg Activation at Fertilization by a Soluble Sperm Protein.

Essential Role of the EF-hand Domain in Targeting Sperm Phospholipase Cζ to Membrane Phosphatidylinositol 4,5-Bisphosphate (PIP2).

Expression of a cardiac Ca(2+)-release channel isoform in mammalian brain ⬇️

Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization.

Expression of sperm PLCζ and clinical outcomes of ICSI-AOA in men affected by globozoospermia due to DPY19L2 deletion.

FKBP12.6 binding of ryanodine receptors carrying mutations associated with arrhythmogenic cardiac disease

Functional disparity between human PAWP and PLCζ in the generation of Ca2+ oscillations for oocyte activation

Functional heterogeneity of ryanodine receptor mutations associated with sudden cardiac death.

Genetic and Biochemical Approaches for In Vivo and In Vitro Assessment of Protein Oligomerization: The Ryanodine Receptor Case Study

Hax-1 identified as a two-pore channel (TPC)-binding protein

Human PLCζ exhibits superior fertilization potency over mouse PLCζ in triggering the Ca(2+) oscillations required for mammalian oocyte activation

Hypertrophic cardiomyopathy-linked variants of cardiac myosin-binding protein C3 display altered molecular properties and actin interaction

Intrinsic lattice formation by the ryanodine receptor calcium-release channel

Is PAWP the "real" sperm factor?

Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).

Male infertility-linked point mutation reveals a vital binding role for the C2 domain of sperm PLCζ.

Mineralocorticoid modulation of cardiac ryanodine receptor activity is associated with downregulation of FK506-binding proteins.

Modification of smooth muscle Ca2+-sparks by tetracaine: evidence for sequential RyR activation.

Multiple isoforms of the ryanodine receptor are expressed in rat pancreatic acinar cells.

Mutations in PLCδ1 associated with hereditary leukonychia display divergent PIP2 hydrolytic function.

N-terminus oligomerization is conserved in intracellular calcium release channels

Na+-dependent SR Ca2+ overload induces arrhythmogenic events in mouse cardiomyocytes with a human CPVT mutation.

PLC? and the initiation of Ca2+ oscillations in fertilizing mammalian eggs ⬇️

PLCzeta(zeta): a sperm protein that triggers Ca2+ oscillations and egg activation in mammals.

PLCζ causes Ca(2+) oscillations in mouse eggs by targeting intracellular and not plasma membrane PI(4,5)P(2).

PLCζ or PAWP: revisiting the putative mammalian sperm factor that triggers egg activation and embryogenesis

Phospholipase C zeta and calcium oscillations at fertilisation: The evidence, applications, and further questions

Phospholipase C-ζ-induced Ca2+ oscillations cause coincident cytoplasmic movements in human oocytes that failed to fertilize after intracytoplasmic sperm injection

Phospholipase Czeta causes Ca2+ oscillations and parthenogenetic activation of human oocytes.

Phospholipase Cζ binding to PtdIns(4,5)P2 requires the XY-linker region

Physical coupling between ryanodine receptor-calcium release channels.

Presence and localization of oscillin in human spermatozoa in relation to the integrity of the sperm membrane ⬇️

Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.

Presynaptic calcium stores underlie large-amplitude miniature IPSCs and spontaneous calcium transients.

Recognition force microscopy/spectroscopy of ion channels: applications to the skeletal muscle Ca2+ release channel (RYR1).

Redistribution of mitochondria leads to bursts of ATP production during spontaneous mouse oocyte maturation.

Redox regulation of the ryanodine receptor/calcium release channel

Redox sensitivity of the ryanodine receptor interaction with FK506-binding protein.

Rescue of failed oocyte activation after ICSI in a mouse model of male factor infertility by recombinant phospholipase Cζ

Role of FKBP12.6 in hypoxia- and norepinephrine-induced Ca2+ release and contraction in pulmonary artery myocytes.

Role of ryanodine receptor mutations in cardiac pathology: more questions than answers?

Ryanodine receptor arrays: not just a pretty pattern?

Ryanodine receptor binding to FKBP12 is modulated by channel activation state.

Ryanodine receptor mutations in arrhythmias: advances in understanding the mechanisms of channel dysfunction.

Ryanodine receptor oligomeric interaction: identification of a putative binding region.

Ryanodine receptor regulation by intramolecular interaction between cytoplasmic and transmembrane domains.

Ryanodine receptor type I and nicotinic acid adenine dinucleotide phosphate receptors mediate Ca2+ release from insulin-containing vesicles in living pancreatic beta-cells (MIN6).

Ryanodine receptor-mediated arrhythmias and sudden cardiac death.

Ryanodine receptors are part of the myospryn complex in cardiac muscle.

Ryanodine stores and calcium regulation in the inner segments of salamander rods and cones.

Sizes of opioid receptor types in rat brain membranes ⬇️