List of works - Elke Heiss

12/15-lipoxygenase contributes to platelet-derived growth factor-induced activation of signal transducer and activator of transcription 3

scientific article

2-(2,4-dihydroxyphenyl)-5-(E)-propenylbenzofuran promotes endothelial nitric oxide synthase activity in human endothelial cells.

scientific article published on 6 July 2012

6-Dihydroparadol, a Ginger Constituent, Enhances Cholesterol Efflux from THP-1-Derived Macrophages

A Maillard reaction product enhances eNOS activity in human endothelial cells.

scientific article

Activated AMPK boosts the Nrf2/HO-1 signaling axis--A role for the unfolded protein response

scientific article

Activation of Nrf2 signaling by natural products-can it alleviate diabetes?

scientific article published on 28 December 2017

Activation of the Nrf2-ARE pathway by the Alternaria alternata mycotoxins altertoxin I and II.

scientific article

Active NF-E2-related factor (Nrf2) contributes to keep endothelial NO synthase (eNOS) in the coupled state: role of reactive oxygen species (ROS), eNOS, and heme oxygenase (HO-1) levels.

scientific article published on 21 September 2009

Activity-guided isolation of NF-κB inhibitors and PPARγ agonists from the root bark of Lycium chinense Miller

scientific article

An increased autophagic flux contributes to the anti-inflammatory potential of urolithin A in macrophages.

scientific article published on 11 October 2017

Ascorbate stimulates endothelial nitric oxide synthase enzyme activity by rapid modulation of its phosphorylation status.

scientific article published on 17 April 2012

Assessment of anti-inflammatory properties of extracts from Honeysuckle (Lonicera sp. L., Caprifoliaceae) by ATR-FTIR spectroscopy

scientific article

Bilirubin Decreases Macrophage Cholesterol Efflux and ATP-Binding Cassette Transporter A1 Protein Expression.

scientific article published on 28 April 2017

Bioactivity-guided isolation of 1,2,3,4,6-Penta-O-galloyl-D-glucopyranose from Paeonia lactiflora roots as a PTP1B inhibitor.

scientific article published on September 2010

Bioguided Isolation of (9Z)-Octadec-9-enoic Acid from Phellodendron amurense Rupr. and Identification of Fatty Acids as PTP1B Inhibitors

scientific article published on 28 November 2011

Bupleurum chinense Roots: a Bioactivity-Guided Approach toward Saponin-Type NF-κB Inhibitors.

scientific article published on 8 September 2017

Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop.

scientific article

Capsaicin and nonivamide similarly modulate outcome measures of mitochondrial energy metabolism in HepG2 and 3T3-L1 cells

scientific article published on 24 January 2018

Capsaicin from chili ( Capsicum spp.) inhibits vascular smooth muscle cell proliferation

scientific article

Chronic treatment with resveratrol induces redox stress- and ataxia telangiectasia-mutated (ATM)-dependent senescence in p53-positive cancer cells.

scientific article

Computer-aided discovery, validation, and mechanistic characterization of novel neolignan activators of peroxisome proliferator-activated receptor gamma

scientific article

Constituents of Mediterranean Spices Counteracting Vascular Smooth Muscle Cell Proliferation: Identification and Characterization of Rosmarinic Acid Methyl Ester as a Novel Inhibitor

scientific article published on 5 February 2018

Direct binding of Cbl to Tyr568 and Tyr936 of the stem cell factor receptor/c-Kit is required for ligand-induced ubiquitination, internalization and degradation.

scientific article published on October 2006

Discovery and resupply of pharmacologically active plant-derived natural products: A review ⬇️

scientific article

Discovery of a novel IKK-β inhibitor by ligand-based virtual screening techniques

scientific article

Drugs from nature targeting inflammation (DNTI): a successful Austrian interdisciplinary network project

scientific article

Erythrodiol, an Olive Oil Constituent, Increases the Half-Life of ABCA1 and Enhances Cholesterol Efflux from THP-1-Derived Macrophages.

scientific article

Ethnopharmacological in vitro studies on Austria's folk medicine--an unexplored lore in vitro anti-inflammatory activities of 71 Austrian traditional herbal drugs

scientific article

Eurycomalactone Inhibits Expression of Endothelial Adhesion Molecules at a Post-Transcriptional Level

scientific article published on 17 November 2017

Glucose availability is a decisive factor for Nrf2-mediated gene expression

scientific journal article

Glycolytic switch in response to betulinic acid in non-cancer cells

scientific article published on 22 December 2014

Honokiol: a non-adipogenic PPARγ agonist from nature

scientific article

Identification and characterization of [6]-shogaol from ginger as inhibitor of vascular smooth muscle cell proliferation

scientific article

Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2

scientific article published on 09 May 2006

Identification of chromomoric acid C-I as an Nrf2 activator in Chromolaena odorata

scientific article

Identification of isosilybin a from milk thistle seeds as an agonist of peroxisome proliferator-activated receptor gamma

scientific article

Identification of ostruthin from Peucedanum ostruthium rhizomes as an inhibitor of vascular smooth muscle cell proliferation ⬇️

scientific article

Identification of plumericin as a potent new inhibitor of the NF-κB pathway with anti-inflammatory activity in vitro and in vivo

scientific article

Ikarugamycin induces DNA damage, intracellular calcium increase, p38 MAP kinase activation and apoptosis in HL-60 human promyelocytic leukemia cells.

scientific article published on 12 March 2011

Imbricaric acid and perlatolic acid: multi-targeting anti-inflammatory depsides from Cetrelia monachorum ⬇️

scientific article published in 2013

Impact of glutathione modulation on the toxicity of the Fusarium mycotoxins deoxynivalenol (DON), NX-3 and butenolide in human liver cells

article

Impact of phase I metabolism on uptake, oxidative stress and genotoxicity of the emerging mycotoxin alternariol and its monomethyl ether in esophageal cells

scientific article published on 15 July 2016

Impact of trans-resveratrol-sulfates and -glucuronides on endothelial nitric oxide synthase activity, nitric oxide release and intracellular reactive oxygen species

scientific article

Increased aerobic glycolysis is important for the motility of activated VSMC and inhibited by indirubin-3'-monoxime

scientific article published on 14 May 2016

Indirubin and Indirubin Derivatives for Counteracting Proliferative Diseases

scientific article

Indirubin-3'-monoxime blocks vascular smooth muscle cell proliferation by inhibition of signal transducer and activator of transcription 3 signaling and reduces neointima formation in vivo

scientific article published on 16 September 2010

Indirubin-3'-monoxime exerts a dual mode of inhibition towards leukotriene-mediated vascular smooth muscle cell migration

scientific article

Inhibition of growth factor mediated Akt phosphorylation in vascular smooth muscle cells by resveratrol: the contribution of SH2 domain containing phosphatase 2 and reactive oxygen species

Interference with platelet-derived growth factor-induced signalling in vascular smooth muscle cells by roscovitine.

scientific article published on 5 November 2008

Leoligin, the Major Lignan from Edelweiss (Leontopodium nivale subsp. alpinum), Promotes Cholesterol Efflux from THP-1 Macrophages.

scientific article published on 24 May 2016

Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro ⬇️

scientific article

Linked magnolol dimer as a selective PPARγ agonist - Structure-based rational design, synthesis, and bioactivity evaluation

scientific article

Mechanism-based in vitro screening of potential cancer chemopreventive agents

scientific article

NADPH oxidases 1 and 4 mediate cellular senescence induced by resveratrol in human endothelial cells.

scientific article

NF-κB inhibitors from Eurycoma longifolia ⬇️

scientific article published on 27 January 2014

Narciclasine inhibits angiogenic processes by activation of Rho kinase and by downregulation of the VEGF receptor 2

scientific article published on 02 August 2019

Natural Products to Counteract the Epidemic of Cardiovascular and Metabolic Disorders

scientific article

Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review

scientific article

No evidence for modulation of endothelial nitric oxide synthase by the olive oil polyphenol hydroxytyrosol in human endothelial cells.

scientific article published on 30 March 2007

Nonprenylated Xanthones from Gentiana lutea, Frasera caroliniensis, and Centaurium erythraea as Novel Inhibitors of Vascular Smooth Muscle Cell Proliferation.

scientific article published on 13 November 2015

Norfuraneol dephosphorylates eNOS at threonine 495 and enhances eNOS activity in human endothelial cells.

scientific article published on 26 November 2008

Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms.

scientific article published on 15 June 2001

Optimization and application of a fluorimetric assay for the identification of histone deacetylase inhibitors from plant origin ⬇️

scientific article published on June 1, 2011

Piperine Congeners as Inhibitors of Vascular Smooth Muscle Cell Proliferation

scientific article published on 01 July 2015

Piperine inhibits ABCA1 degradation and promotes cholesterol efflux from THP-1-derived macrophages

scientific article

Plumericin inhibits proliferation of vascular smooth muscle cells by blocking STAT3 signaling via S-glutathionylation

scientific article published on 09 February 2016

Polyacetylenes from Notopterygium incisum--new selective partial agonists of peroxisome proliferator-activated receptor-gamma ⬇️

scientific article published on 22 April 2013

Polyyne hybrid compounds from Notopterygium incisum with peroxisome proliferator-activated receptor gamma agonistic effects

scientific article published on 21 October 2014

Quantitation of phenylpropanoids and iridoids in insulin-sensitising extracts of Leonurus sibiricus L. (Lamiaceae).

scientific article published on 2 September 2015

Ratanhiaphenol III from Ratanhiae radix is a PTP1B inhibitor.

scientific article published on 3 February 2012

Regulation of Nrf2 and NF-κB activities may contribute to the anti-inflammatory mechanism of xylopic acid

scientific article published on 8 March 2022

Regulation of eNOS enzyme activity by posttranslational modification.

scientific article published on January 2014

Resveratrol blocks Akt activation in angiotensin II- or EGF-stimulated vascular smooth muscle cells in a redox-independent manner.

scientific article published on 10 November 2010

Resveratrol inhibits migration and Rac1 activation in EGF‐ but not PDGF‐activated vascular smooth muscle cells ⬇️

scientific article published on July 5, 2011

Screening of Vietnamese medicinal plants for NF-κB signaling inhibitors: assessing the activity of flavonoids from the stem bark of Oroxylum indicum.

scientific article

Selected Extracts of Chinese Herbal Medicines: Their Effect on NF-κB, PPARα and PPARγ and the Respective Bioactive Compounds

scientific article

Silymarin Constituents Enhance ABCA1 Expression in THP-1 Macrophages.

scientific article

Synergy study of the inhibitory potential of red wine polyphenols on vascular smooth muscle cell proliferation.

scientific article

The Dietary Constituent Falcarindiol Promotes Cholesterol Efflux from THP-1 Macrophages by Increasing ABCA1 Gene Transcription and Protein Stability

scientific article

The Herbal DrugMelampyrum pratenseL. (Koch): Isolation and Identification of Its Bioactive Compounds Targeting Mediators of Inflammation ⬇️

scientific article published on February 26, 2013

The yeast SEC20 gene is required for N- and O-glycosylation in the Golgi. Evidence that impaired glycosylation does not correlate with the secretory defect.

scientific article published on 24 May 2001

Time-dependent modulation of thioredoxin reductase activity might contribute to sulforaphane-mediated inhibition of NF-kappaB binding to DNA.

scientific article published on November 2005

Tylophorine reduces protein biosynthesis and rapidly decreases cyclin D1, inhibiting vascular smooth muscle cell proliferation in vitro and in organ culture

scientific article published on 23 April 2019

Walnut leaf extract inhibits PTP1B and enhances glucose-uptake in vitro.

scientific article

Xanthohumol Blocks Proliferation and Migration of Vascular Smooth Muscle Cells in Vitro and Reduces Neointima Formation in Vivo

scientific article

List of works by Elke Heiss

12/15-lipoxygenase contributes to platelet-derived growth factor-induced activation of signal transducer and activator of transcription 3

2-(2,4-dihydroxyphenyl)-5-(E)-propenylbenzofuran promotes endothelial nitric oxide synthase activity in human endothelial cells.

6-Dihydroparadol, a Ginger Constituent, Enhances Cholesterol Efflux from THP-1-Derived Macrophages

A Maillard reaction product enhances eNOS activity in human endothelial cells.

Activated AMPK boosts the Nrf2/HO-1 signaling axis--A role for the unfolded protein response

Activation of Nrf2 signaling by natural products-can it alleviate diabetes?

Activation of the Nrf2-ARE pathway by the Alternaria alternata mycotoxins altertoxin I and II.

Active NF-E2-related factor (Nrf2) contributes to keep endothelial NO synthase (eNOS) in the coupled state: role of reactive oxygen species (ROS), eNOS, and heme oxygenase (HO-1) levels.

Activity-guided isolation of NF-κB inhibitors and PPARγ agonists from the root bark of Lycium chinense Miller

An increased autophagic flux contributes to the anti-inflammatory potential of urolithin A in macrophages.

Ascorbate stimulates endothelial nitric oxide synthase enzyme activity by rapid modulation of its phosphorylation status.

Assessment of anti-inflammatory properties of extracts from Honeysuckle (Lonicera sp. L., Caprifoliaceae) by ATR-FTIR spectroscopy

Bilirubin Decreases Macrophage Cholesterol Efflux and ATP-Binding Cassette Transporter A1 Protein Expression.

Bioactivity-guided isolation of 1,2,3,4,6-Penta-O-galloyl-D-glucopyranose from Paeonia lactiflora roots as a PTP1B inhibitor.

Bioguided Isolation of (9Z)-Octadec-9-enoic Acid from Phellodendron amurense Rupr. and Identification of Fatty Acids as PTP1B Inhibitors

Bupleurum chinense Roots: a Bioactivity-Guided Approach toward Saponin-Type NF-κB Inhibitors.

Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop.

Capsaicin and nonivamide similarly modulate outcome measures of mitochondrial energy metabolism in HepG2 and 3T3-L1 cells

Capsaicin from chili ( Capsicum spp.) inhibits vascular smooth muscle cell proliferation

Chronic treatment with resveratrol induces redox stress- and ataxia telangiectasia-mutated (ATM)-dependent senescence in p53-positive cancer cells.

Computer-aided discovery, validation, and mechanistic characterization of novel neolignan activators of peroxisome proliferator-activated receptor gamma

Constituents of Mediterranean Spices Counteracting Vascular Smooth Muscle Cell Proliferation: Identification and Characterization of Rosmarinic Acid Methyl Ester as a Novel Inhibitor

Direct binding of Cbl to Tyr568 and Tyr936 of the stem cell factor receptor/c-Kit is required for ligand-induced ubiquitination, internalization and degradation.

Discovery and resupply of pharmacologically active plant-derived natural products: A review ⬇️

Discovery of a novel IKK-β inhibitor by ligand-based virtual screening techniques

Drugs from nature targeting inflammation (DNTI): a successful Austrian interdisciplinary network project

Erythrodiol, an Olive Oil Constituent, Increases the Half-Life of ABCA1 and Enhances Cholesterol Efflux from THP-1-Derived Macrophages.

Ethnopharmacological in vitro studies on Austria's folk medicine--an unexplored lore in vitro anti-inflammatory activities of 71 Austrian traditional herbal drugs

Eurycomalactone Inhibits Expression of Endothelial Adhesion Molecules at a Post-Transcriptional Level

Glucose availability is a decisive factor for Nrf2-mediated gene expression

Glycolytic switch in response to betulinic acid in non-cancer cells

Honokiol: a non-adipogenic PPARγ agonist from nature

Identification and characterization of [6]-shogaol from ginger as inhibitor of vascular smooth muscle cell proliferation

Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2

Identification of chromomoric acid C-I as an Nrf2 activator in Chromolaena odorata

Identification of isosilybin a from milk thistle seeds as an agonist of peroxisome proliferator-activated receptor gamma

Identification of ostruthin from Peucedanum ostruthium rhizomes as an inhibitor of vascular smooth muscle cell proliferation ⬇️

Identification of plumericin as a potent new inhibitor of the NF-κB pathway with anti-inflammatory activity in vitro and in vivo

Ikarugamycin induces DNA damage, intracellular calcium increase, p38 MAP kinase activation and apoptosis in HL-60 human promyelocytic leukemia cells.

Imbricaric acid and perlatolic acid: multi-targeting anti-inflammatory depsides from Cetrelia monachorum ⬇️

Impact of glutathione modulation on the toxicity of the Fusarium mycotoxins deoxynivalenol (DON), NX-3 and butenolide in human liver cells

Impact of phase I metabolism on uptake, oxidative stress and genotoxicity of the emerging mycotoxin alternariol and its monomethyl ether in esophageal cells

Impact of trans-resveratrol-sulfates and -glucuronides on endothelial nitric oxide synthase activity, nitric oxide release and intracellular reactive oxygen species

Increased aerobic glycolysis is important for the motility of activated VSMC and inhibited by indirubin-3'-monoxime

Indirubin and Indirubin Derivatives for Counteracting Proliferative Diseases

Indirubin-3'-monoxime blocks vascular smooth muscle cell proliferation by inhibition of signal transducer and activator of transcription 3 signaling and reduces neointima formation in vivo

Indirubin-3'-monoxime exerts a dual mode of inhibition towards leukotriene-mediated vascular smooth muscle cell migration

Inhibition of growth factor mediated Akt phosphorylation in vascular smooth muscle cells by resveratrol: the contribution of SH2 domain containing phosphatase 2 and reactive oxygen species

Interference with platelet-derived growth factor-induced signalling in vascular smooth muscle cells by roscovitine.

Leoligin, the Major Lignan from Edelweiss (Leontopodium nivale subsp. alpinum), Promotes Cholesterol Efflux from THP-1 Macrophages.

Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro ⬇️

Linked magnolol dimer as a selective PPARγ agonist - Structure-based rational design, synthesis, and bioactivity evaluation

Mechanism-based in vitro screening of potential cancer chemopreventive agents

NADPH oxidases 1 and 4 mediate cellular senescence induced by resveratrol in human endothelial cells.

NF-κB inhibitors from Eurycoma longifolia ⬇️

Narciclasine inhibits angiogenic processes by activation of Rho kinase and by downregulation of the VEGF receptor 2

Natural Products to Counteract the Epidemic of Cardiovascular and Metabolic Disorders

Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review

No evidence for modulation of endothelial nitric oxide synthase by the olive oil polyphenol hydroxytyrosol in human endothelial cells.

Nonprenylated Xanthones from Gentiana lutea, Frasera caroliniensis, and Centaurium erythraea as Novel Inhibitors of Vascular Smooth Muscle Cell Proliferation.

Norfuraneol dephosphorylates eNOS at threonine 495 and enhances eNOS activity in human endothelial cells.

Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms.

Optimization and application of a fluorimetric assay for the identification of histone deacetylase inhibitors from plant origin ⬇️

Piperine Congeners as Inhibitors of Vascular Smooth Muscle Cell Proliferation

Piperine inhibits ABCA1 degradation and promotes cholesterol efflux from THP-1-derived macrophages

Plumericin inhibits proliferation of vascular smooth muscle cells by blocking STAT3 signaling via S-glutathionylation

Polyacetylenes from Notopterygium incisum--new selective partial agonists of peroxisome proliferator-activated receptor-gamma ⬇️

Polyyne hybrid compounds from Notopterygium incisum with peroxisome proliferator-activated receptor gamma agonistic effects

Quantitation of phenylpropanoids and iridoids in insulin-sensitising extracts of Leonurus sibiricus L. (Lamiaceae).

Ratanhiaphenol III from Ratanhiae radix is a PTP1B inhibitor.

Regulation of Nrf2 and NF-κB activities may contribute to the anti-inflammatory mechanism of xylopic acid

Regulation of Nrf2 and NF-κB activities may contribute to the anti-inflammatory mechanism of xylopic acid

Regulation of eNOS enzyme activity by posttranslational modification.

Resveratrol blocks Akt activation in angiotensin II- or EGF-stimulated vascular smooth muscle cells in a redox-independent manner.

Resveratrol inhibits migration and Rac1 activation in EGF‐ but not PDGF‐activated vascular smooth muscle cells ⬇️

Screening of Vietnamese medicinal plants for NF-κB signaling inhibitors: assessing the activity of flavonoids from the stem bark of Oroxylum indicum.

Selected Extracts of Chinese Herbal Medicines: Their Effect on NF-κB, PPARα and PPARγ and the Respective Bioactive Compounds

Silymarin Constituents Enhance ABCA1 Expression in THP-1 Macrophages.

Synergy study of the inhibitory potential of red wine polyphenols on vascular smooth muscle cell proliferation.