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List of works by Takehiko Sasaki

3' Phosphatase activity toward phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] by voltage-sensing phosphatase (VSP)

scientific article

A Negative Feedback Loop Regulates Integrin Inactivation and Promotes Neutrophil Recruitment to Inflammatory Sites

scientific article published on 19 August 2019

Activation of c-Jun N-Terminal Kinase (JNK) by Lysophosphatidic Acid in Swiss 3T3 Fibroblasts ⬇️

scientific article published on November 1, 1998

CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer.

scientific article published on 15 November 2007

Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity

scientific journal article

Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination.

scientific article published on March 2003

Critical roles of the p110 beta subtype of phosphoinositide 3-kinase in lipopolysaccharide-induced Akt activation and negative regulation of nitrite production in RAW 264.7 cells.

scientific article published on February 2008

DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis

scientific article

Decreased 16:0/20:4-phosphatidylinositol level in the post-mortem prefrontal cortex of elderly patients with schizophrenia.

scientific article published on 23 March 2017

Delivery of endosomes to lysosomes via microautophagy in the visceral endoderm of mouse embryos ⬇️

scientific article published on January 1, 2012

Diet-induced macrophage inhibitory cytokine 1 promotes prostate cancer progression

scientific article published on 16 December 2013

Different properties of SEK1 and MKK7 in dual phosphorylation of stress-induced activated protein kinase SAPK/JNK in embryonic stem cells.

scientific article published on 6 March 2003

Docosahexaenoic acid preserves visual function by maintaining correct disc morphology in retinal photoreceptor cells.

scientific article published on 3 June 2017

Dynamics of human erythroblast enucleation

scientific article published on 02 December 2008

Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice.

scientific article

Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN.

scientific article

Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function.

scientific article

Essential role for phospholipase D2 activation downstream of ERK MAP kinase in nerve growth factor-stimulated neurite outgrowth from PC12 cells.

scientific article published on 29 June 2004

Essential role of class II phosphatidylinositol-3-kinase-C2α in sphingosine 1-phosphate receptor-1-mediated signaling and migration in endothelial cells

scientific article published on 28 November 2012

Fatty acid binding protein 4 enhances prostate cancer progression by upregulating matrix metalloproteinases and stromal cell cytokine production.

scientific article published on 4 December 2017

Hippo pathway controls cell adhesion and context-dependent cell competition to influence skin engraftment efficiency

scientific article published on 14 January 2019

IGF-I secreted by osteoblasts acts as a potent chemotactic factor for osteoblasts.

scientific article published on 31 July 2008

Impaired TCR-mediated apoptosis and Bcl-XL expression in T cells lacking the stress kinase activator SEK1/MKK4 ⬇️

scientific article published on 01 October 1998

Interaction between telencephalin and ERM family proteins mediates dendritic filopodia formation

scientific article published on 01 August 2007

Involvement of proton-sensing TDAG8 in extracellular acidification-induced inhibition of proinflammatory cytokine production in peritoneal macrophages.

scientific article published in March 2009

JNK-interacting protein 1 promotes Akt1 activation.

scientific article published on 3 June 2003

Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation

scientific article published on 01 February 2003

LYCAT, a homologue of C. elegans acl-8,acl-9, and acl-10, determines the fatty acid composition of phosphatidylinositol in mice ⬇️

scientific article published on December 14, 2011

MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence.

scientific article published on 22 February 2004

Metabolic Determinants of Sensitivity to Phosphatidylinositol 3-Kinase Pathway Inhibitor in Small-Cell Lung Carcinoma.

scientific article published on 28 February 2018

PI(3)Kγ has an important context-dependent role in neutrophil chemokinesis

article

Phosphatidylinositol 4-phosphate 5-kinase is essential for ROCK-mediated neurite remodeling.

scientific article published on 27 February 2002

Phosphatidylinositol-3,5-bisphosphate: metabolism and physiological functions.

scientific article published on 15 July 2013

Phosphoinositide 3-Kinaseγ Controls the Intracellular Localization of CpG to Limit DNA-PKcs-Dependent IL-10 Production in Macrophages ⬇️

scientific article published on October 28, 2011

Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure.

scientific article published on 8 September 2003

Phospholipase D2 functions as a downstream signaling molecule of MAP kinase pathway in L1-stimulated neurite outgrowth of cerebellar granule neurons.

scientific article published in April 2004

Plasma membrane phosphatidylinositol (4,5)-bisphosphate is critical for determination of epithelial characteristics

scientific article published on 09 May 2022

Portrait of PTEN: messages from mutant mice.

scientific article published on 15 January 2008

Regulation of Fc R-stimulated phagocytosis by the 72-kDa inositol polyphosphate 5-phosphatase: SHIP1, but not the 72-kDa 5-phosphatase, regulates complement receptor 3 mediated phagocytosis by differential recruitment of these 5-phosphatases to the p

scientific article published on 06 August 2007

Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis.

scientific article

TMEM55a localizes to macrophage phagosomes to down-regulate phagocytosis

scientific article

The ML1Nx2 Phosphatidylinositol 3,5-Bisphosphate Probe Shows Poor Selectivity in Cells

scientific article

The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells.

scientific article published on 14 December 2006

The pathophysiological roles of PI3Ks and therapeutic potential of selective inhibitors in allergic inflammation.

scientific article published on 04 June 2010

[Phosphoinositides in membrane traffic].

scientific article

[Role of PTEN tumor suppressor gene in disease: PTEN-deficient mice]

scientific article published on 01 November 2008

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