List of works - Elisabeth P Carpenter

A comparative study of uracil-DNA glycosylases from human and herpes simplex virus type 1.

scientific article

A lower X-gate in TASK channels traps inhibitors within the vestibule

scientific article published on 29 April 2020

A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels ⬇️

scientific article published on 01 February 2019

ATP Binding and Hydrolysis Properties of ABCB10 and Their Regulation by Glutathione

scientific article published on 8 June 2015

An overview of heavy-atom derivatization of protein crystals

scientific article

Asymmetric mechanosensitivity in a eukaryotic ion channel.

scientific article published on 18 September 2017

Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel.

scientific article published on 24 March 2017

Crystal structure of a prokaryotic homologue of the mammalian oligopeptide-proton symporters, PepT1 and PepT2

scientific article

Crystal structure of the acid-induced arginine decarboxylase from Escherichia coli: reversible decamer assembly controls enzyme activity

scientific article

Four distinct structural domains in Clostridium difficile toxin B visualized using SAXS.

scientific article

High-level bacterial expression and purification of apicomplexan micronemal proteins for structural studies.

scientific article

Insights into How Nucleotide-Binding Domains Power ABC Transport

scientific article

Insights into outer membrane protein crystallization.

scientific article

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

scientific article published in March 2015

Mammalian Glucose Transporter Activity Is Dependent upon Anionic and Conical Phospholipids

scientific article

Mass spectrometry captures off-target drug binding and provides mechanistic insights into the human metalloprotease ZMPSTE24.

scientific article published on 15 August 2016

MemProtMD: Automated Insertion of Membrane Protein Structures into Explicit Lipid Membranes.

scientific article

Molecular insights into lipid-assisted Ca(2+) regulation of the TRP channel Polycystin-2

scientific journal article

Overcoming the challenges of membrane protein crystallography.

scientific article

PCR-based gene synthesis as an efficient approach for expression of the A+T-rich malaria genome.

scientific article published in December 1999

Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states

scientific article

Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics.

scientific article

Purification and interaction analyses of two human lysosomal vitamin B12 transporters: LMBD1 and ABCD4.

scientific article published in November 2014

Structure and Molecular Mechanism of a Nucleobase-Cation-Symport-1 Family Transporter

scientific article

Structure of a central stalk subunit F of prokaryotic V-type ATPase/synthase from Thermus thermophilus

scientific article

Structure of dehydroquinate synthase reveals an active site capable of multistep catalysis

scientific article

Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2).

scientific article published on 19 December 2016

Structures and functions of mitochondrial ABC transporters.

scientific article

Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design

scientific article published on 01 November 2018

The SGC beyond structural genomics: redefining the role of 3D structures by coupling genomic stratification with fragment-based discovery.

scientific article published on 8 November 2017

The structural basis of ZMPSTE24-dependent laminopathies

scientific article

The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K

scientific article published on 02 September 2019

Thioredoxin A Active-Site Mutants Form Mixed Disulfide Dimers That Resemble Enzyme–Substrate Reaction Intermediates

scientific article

ZMPSTE24 missense mutations that cause progeroid diseases decrease prelamin A cleavage activity and/or protein stability

scientific article published on 13 July 2018

List of works by Elisabeth P Carpenter

A comparative study of uracil-DNA glycosylases from human and herpes simplex virus type 1.

A lower X-gate in TASK channels traps inhibitors within the vestibule

A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels ⬇️

ATP Binding and Hydrolysis Properties of ABCB10 and Their Regulation by Glutathione

An overview of heavy-atom derivatization of protein crystals

Asymmetric mechanosensitivity in a eukaryotic ion channel.

Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel.

Crystal structure of a prokaryotic homologue of the mammalian oligopeptide-proton symporters, PepT1 and PepT2

Crystal structure of the acid-induced arginine decarboxylase from Escherichia coli: reversible decamer assembly controls enzyme activity

Four distinct structural domains in Clostridium difficile toxin B visualized using SAXS.

High-level bacterial expression and purification of apicomplexan micronemal proteins for structural studies.

Insights into How Nucleotide-Binding Domains Power ABC Transport

Insights into outer membrane protein crystallization.

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

Mammalian Glucose Transporter Activity Is Dependent upon Anionic and Conical Phospholipids

Mass spectrometry captures off-target drug binding and provides mechanistic insights into the human metalloprotease ZMPSTE24.

MemProtMD: Automated Insertion of Membrane Protein Structures into Explicit Lipid Membranes.

Molecular insights into lipid-assisted Ca(2+) regulation of the TRP channel Polycystin-2

Overcoming the challenges of membrane protein crystallography.

PCR-based gene synthesis as an efficient approach for expression of the A+T-rich malaria genome.

Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states

Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics.

Purification and interaction analyses of two human lysosomal vitamin B12 transporters: LMBD1 and ABCD4.

Structure and Molecular Mechanism of a Nucleobase-Cation-Symport-1 Family Transporter

Structure of a central stalk subunit F of prokaryotic V-type ATPase/synthase from Thermus thermophilus

Structure of dehydroquinate synthase reveals an active site capable of multistep catalysis

Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2).

Structures and functions of mitochondrial ABC transporters.

Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design

The SGC beyond structural genomics: redefining the role of 3D structures by coupling genomic stratification with fragment-based discovery.

The structural basis of ZMPSTE24-dependent laminopathies

The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K

Thioredoxin A Active-Site Mutants Form Mixed Disulfide Dimers That Resemble Enzyme–Substrate Reaction Intermediates

ZMPSTE24 missense mutations that cause progeroid diseases decrease prelamin A cleavage activity and/or protein stability