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List of works by Yasushi Sasaki

A case of mucoepidermoid carcinoma of the intrahepatic bile duct

scientific article published on 01 April 1991

A novel approach to cancer treatment using structural hybrids of the p53 gene family.

scientific article published on 7 September 2012

A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth

scientific article published on 23 June 2009

A single recombinant adenovirus expressing p53 and p21-targeting artificial microRNAs efficiently induces apoptosis in human cancer cells.

scientific article

A subset of diffuse-type gastric cancer is susceptible to mTOR inhibitors and checkpoint inhibitors

scientific article published on 12 March 2019

AKR1B10, a transcriptional target of p53, is downregulated in colorectal cancers associated with poor prognosis.

scientific article published on 18 October 2013

Aberrant DNA methylation associated with silencing BNIP3 gene expression in haematopoietic tumours.

scientific article

Aberrant methylation and histone deacetylation associated with silencing of SLC5A8 in gastric cancer

scientific article published on May 2004

Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer.

scientific article published on February 2005

Abnormal beta-catenin expression in oral cancer with no gene mutation: correlation with expression of cyclin D1 and epidermal growth factor receptor, Ki-67 labeling index, and clinicopathological features.

scientific article published in March 2005

Activation of the ribosomal protein L13 gene in human gastrointestinal cancer.

scientific article

Aggressive variant of splenic marginal zone lymphoma characterized using a cancer panel test and treated with rituximab-containing chemotherapy: A case report

scientific article published on 01 August 2020

Analysis of lung tumorigenesis in chimeric mice indicates the Pulmonary adenoma resistance 2 (Par2) locus to operate in the tumor-initiation stage in a cell-autonomous manner: detection of polymorphisms in the Poli gene as a candidate for Par2.

scientific article published in April 2003

Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines.

scientific article

Array-based genome-wide RNAi screening to identify shRNAs that enhance p53-related apoptosis in human cancer cells

scientific article

Assessment of the quality of DNA from various formalin-fixed paraffin-embedded (FFPE) tissues and the use of this DNA for next-generation sequencing (NGS) with no artifactual mutation.

scientific article

CHFR protein regulates mitotic checkpoint by targeting PARP-1 protein for ubiquitination and degradation

scientific article published on 15 February 2012

CHFR, a potential tumor suppressor, downregulates interleukin-8 through the inhibition of NF-kappaB.

scientific article

CLCA2, a target of the p53 family, negatively regulates cancer cell migration and invasion

scientific article published on 18 September 2012

CRKL oncogene is downregulated by p53 through miR-200s

scientific article published on 16 June 2015

Chemotherapy after progression on nivolumab is essential for responders with genetic alterations of driver gene: Review of two recurrent/metastatic oral squamous cell carcinoma patients

scientific article published on 12 December 2019

Combination of KRAS and SMAD4 mutations in formalin-fixed paraffin-embedded tissues as a biomarker for pancreatic cancer

scientific article published on 21 April 2020

Comparative genome analysis identifies the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation.

scientific article published on May 2006

Corrigendum to "Prognostic Effect of Long Noncoding RNA NEAT1 Expression Depends on p53 Mutation Status in Cancer"

scientific article published on 07 August 2019

Cytoplasmic RASSF2A is a proapoptotic mediator whose expression is epigenetically silenced in gastric cancer

scientific article published on 29 February 2008

DLEU1 promotes oral squamous cell carcinoma progression by activating interferon-stimulated genes

scientific article published on 14 October 2021

DNA methylation and histone deacetylation associated with silencing DAP kinase gene expression in colorectal and gastric cancers

scientific article

DNA methylation of interferon regulatory factors in gastric cancer and noncancerous gastric mucosae

scientific article

DOT1L inhibition blocks multiple myeloma cell proliferation by suppressing IRF4-MYC signaling

scholarly article by Kazuya Ishiguro et al published January 2019 in Haematologica

Dysregulation of miRNA in chronic hepatitis B is associated with hepatocellular carcinoma risk after nucleos(t)ide analogue treatment

scientific article published on 17 July 2018

Enhancing epithelial engraftment of rat mesenchymal stem cells restores epithelial barrier integrity.

scientific article published in July 2009

Epigenetic alteration of DNA in mucosal wash fluid predicts invasiveness of colorectal tumors.

scientific article published in May 2011

Epigenetic inactivation of CHFR and sensitivity to microtubule inhibitors in gastric cancer

scientific article (publication date: 15 December 2003)

Epigenetic inactivation of CHFR in human tumors

scientific article

Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma.

scientific article

Epigenetic inactivation of SFRP genes in oral squamous cell carcinoma.

scientific article

Epigenetic inactivation of class II transactivator (CIITA) is associated with the absence of interferon-gamma-induced HLA-DR expression in colorectal and gastric cancer cells.

scientific article

Epigenetic silencing of NTSR1 is associated with lateral and noninvasive growth of colorectal tumors.

scientific article published on 17 August 2015

Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer.

scientific article

FGFR Signaling as a Candidate Therapeutic Target for Cancers Resistant to Carbon Ion Radiotherapy

scientific article published on 14 September 2019

Fledglings in p53 signaling network.

scientific article published on 14 July 2017

Forkhead transcription factor FOXF1 is a novel target gene of the p53 family and regulates cancer cell migration and invasiveness.

scientific article published on 4 November 2013

Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors.

scientific article published on 3 August 2007

Frequent tumor burden monitoring of esophageal squamous cell carcinoma with circulating tumor DNA using individually designed digital PCR

scientific article published on 01 October 2020

Gene amplification and overexpression of PRDM14 in breast cancers.

scientific article

Generation of functional liver organoids on combining hepatocytes and cholangiocytes with hepatobiliary connections ex vivo

scientific article published on 07 June 2021

Genetic analyses of mosaic neurofibromatosis type 1 with giant café-au-lait macule, plexiform neurofibroma and multiple melanocytic nevi

scientific article published on 04 April 2020

Genome-wide profiling of chromatin signatures reveals epigenetic regulation of MicroRNA genes in colorectal cancer.

scientific article

Genomic characterization for familial cases with urothelial carcinoma

scientific article published on 27 June 2019

Genomic characterization of esophageal squamous cell carcinoma: Insights from next-generation sequencing

scientific article

Genomic screening for genes silenced by DNA methylation revealed an association between RASD1 inactivation and dexamethasone resistance in multiple myeloma.

scientific article

Genomic screening for genes upregulated by demethylation revealed novel targets of epigenetic silencing in breast cancer.

scientific article published on 27 October 2009

Heat shock enhances the expression of cytotoxic granule proteins and augments the activities of tumor-associated antigen-specific cytotoxic T lymphocytes

scientific article

Histone deacetylase inhibitor FK228 enhances adenovirus-mediated p53 family gene therapy in cancer models

scientific article

IGFBP7 is a p53-responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype

scientific article

Identification and analysis of large intergenic non-coding RNAs regulated by p53 family members through a genome-wide analysis of p53-binding sites.

scientific article published on 8 January 2014

Identification and characterization of a metastatic suppressor BRMS1L as a target gene of p53.

scientific article published on 13 October 2017

Identification and characterization of early growth response 2, a zinc-finger transcription factor, as a p53-regulated proapoptotic gene

scientific article published on 01 December 2010

Identification and characterization of the intercellular adhesion molecule-2 gene as a novel p53 target

scientific article published on 18 August 2016

Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer

scientific article published on January 2007

Identification of HRK as a target of epigenetic inactivation in colorectal and gastric cancer.

scientific article

Identification of SCN3B as a novel p53-inducible proapoptotic gene.

scientific article

Identification of flotillin-2, a major protein on lipid rafts, as a novel target of p53 family members

scientific article

Identification of genes highly expressed in G2-arrested Chinese hamster ovary cells by differential display analysis

scientific article published on 01 January 2000

Identification of pigment epithelium-derived factor as a direct target of the p53 family member genes.

scientific article

Identification of the interleukin 4 receptor alpha gene as a direct target for p73.

scientific article published on December 2003

Identification of the osteopontin gene as a direct target of TP53.

scientific article published on March 2002

Impaired diversity of the lung microbiome predicts progression of idiopathic pulmonary fibrosis

scientific article published on 27 February 2018

In vitro transformation of adult rat hepatic progenitor cells into pancreatic endocrine hormone-producing cells

scientific journal article

Increased expression of T-fimbrin gene after DNA damage in CHO cells and inactivation of T-fimbrin by CpG methylation in human colorectal cancer cells

scientific article

Induction of tenascin-C by tumor-specific EWS-ETS fusion genes

scientific article

Integrated genetic and epigenetic analysis of cancer-related genes in non-ampullary duodenal adenomas and intramucosal adenocarcinomas

scientific article published on 08 August 2020

LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobacter pylori-related enlarged-fold gastritis.

scientific article

Long non-coding RNA NEAT1 is a transcriptional target of p53 and modulates p53-induced transactivation and tumor-suppressor function.

scientific article published on 14 March 2017

Malignant paraganglioma of the posterior mediastinum: A case report with genetic analysis

scientific article published on 08 November 2018

MicroRNA-31 expression in relation to BRAF mutation, CpG island methylation and colorectal continuum in serrated lesions.

scientific article published on 30 April 2014

Molecular diagnostics of a single drug-resistant multiple myeloma case using targeted next-generation sequencing.

scientific article published on 5 October 2015

Molecular dissection of premalignant colorectal lesions reveals early onset of the CpG island methylator phenotype.

scientific article published on 17 September 2012

Mutation profiling of uterine cervical cancer patients treated with definitive radiotherapy

scientific article published on 17 September 2020

Mutational analysis of the beta-catenin gene in gastric carcinomas

scientific article published on 01 March 2001

Mutational analysis of uterine cervical cancer that survived multiple rounds of radiotherapy

scientific article published on 24 August 2018

Myogenic lineage differentiated mesenchymal stem cells enhance recovery from dextran sulfate sodium-induced colitis in the rat.

scientific article

N-propionyl-cysteaminylphenol-magnetite conjugate (NPrCAP/M) is a nanoparticle for the targeted growth suppression of melanoma cells

scientific article published on 19 March 2009

PRDM5 identified as a target of epigenetic silencing in colorectal and gastric cancer.

scientific article published on August 2007

Pathogenesis of multiple pancreatic cancers involves multicentric carcinogenesis and intrapancreatic metastasis

scientific article published on 15 January 2020

Plasticity of lung cancer stem-like cells is regulated by the transcription factor HOXA5 that is induced by oxidative stress.

scientific article published on 13 July 2016

Profiling cancer-related gene mutations in oral squamous cell carcinoma from Japanese patients by targeted amplicon sequencing.

scientific article published on 15 July 2017

Prognostic Effect of Long Noncoding RNA NEAT1 Expression Depends on p53 Mutation Status in Cancer

scientific article published on 02 May 2019

Prognostic nutritional index and early mortality with percutaneous endoscopic gastrostomy

scientific article published on 01 September 2018

Renal angiomyolipoma (AML) harboring a missense mutation of TSC2 with copy-neutral loss of heterozygosity (CN-LOH)

scientific article published on 17 December 2019

Screening for long noncoding RNAs associated with oral squamous cell carcinoma reveals the potentially oncogenic actions of DLEU1

scientific article published on 01 August 2018

Significance of gene mutations in the Wnt signaling pathway in traditional serrated adenomas of the colon and rectum

scientific article published on 24 February 2020

Small interfering RNA-induced CHFR silencing sensitizes oral squamous cell cancer cells to microtubule inhibitors.

scientific article published on 6 July 2005

Subcapsular hematoma of the liver and pylethrombosis in the setting of cholestatic liver injury

scientific article published on 01 December 1996

Surface microstructures are associated with mutational intratumoral heterogeneity in colorectal tumors

scientific article published on 11 June 2018

Systemic Prophylactic Antibiotics for the Modified Introducer Method for Percutaneous Endoscopic Gastrostomy: A Prospective, Randomized, Double-Blind Study

scientific article

TET1 Depletion Induces Aberrant CpG Methylation in Colorectal Cancer Cells

scientific article

Target amplicon exome-sequencing identifies promising diagnosis and prognostic markers involved in RTK-RAS and PI3K-AKT signaling as central oncopathways in primary central nervous system lymphoma.

scientific article published on 8 June 2018

Targeted next-generation sequencing of 50 cancer-related genes in Japanese patients with oral squamous cell carcinoma

scientific article published on 01 September 2018

Targeted sequencing reveals genetic variants associated with sensitivity of 79 human cancer xenografts to anticancer drugs

scientific article published on 21 November 2017

The Id2 gene is a novel target of transcriptional activation by EWS-ETS fusion proteins in Ewing family tumors.

scientific article

The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer

scientific article

The effect of IGF-I receptor blockade for human esophageal squamous cell carcinoma and adenocarcinoma.

scientific article published on 13 September 2013

The effect of forced expression of mutated K-RAS gene on gastrointestinal cancer cell lines and the IGF-1R targeting therapy.

scientific article published on 17 June 2016

The p53 family member genes are involved in the Notch signal pathway

scientific article

The role of T-fimbrin in the response to DNA damage: silencing of T-fimbrin by small interfering RNA sensitizes human liver cancer cells to DNA-damaging agents

scientific article

Whole-exome sequencing of 79 xenografts as a potential approach for the identification of genetic variants associated with sensitivity to cytotoxic anticancer drugs

scientific article published on 28 September 2020

p53 family members regulate the expression of the apolipoprotein D gene.

scientific article

p53 mediates the suppression of cancer cell invasion by inducing LIMA1/EPLIN.

scientific article published on 13 January 2017

p53 negatively regulates the hepatoma growth factor HDGF.

scientific article published on 17 October 2011

p53-induced ARVCF modulates the splicing landscape and supports the tumor suppressive function of p53

scientific article published on 11 December 2019

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