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List of works by C N Johnson

3,4-Dihydro-2H-benzoxazinones are 5-HT(1A) receptor antagonists with potent 5-HT reuptake inhibitory activity.

scientific article published on February 2005

5-Butyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(2,4,6-trimethylphenyl)isoxazole.

scientific article published on 20 February 2002

5-HT6 receptor antagonists: prospects for the treatment of cognitive disorders including dementia.

scientific article published on September 2008

A Fragment-Derived Clinical Candidate for Antagonism of X-Linked and Cellular Inhibitor of Apoptosis Proteins: 1-(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-1 H,2 H,3 H-pyrrolo[3,2- b]pyridin-1-yl)-2-[(2 R,5 R)-5-methyl-2-([(3R)-3-met

scientific article published on 09 August 2018

A regioselective cycloaddition route to isoxazoleboronic esters

scientific article published on 01 September 2001

BACE-1 inhibitors part 3: identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells

scientific article

Bicyclic heteroarylpiperazines as selective brain penetrant 5-HT6 receptor antagonists

scientific article

Design and Synthesis of trans-3-(2-(4-((3-(3-(5-Methyl-1,2,4-oxadiazolyl))- phenyl)carboxamido)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro- 1H-3-benzazepine (SB-414796): A Potent and Selective Dopamine D3 Receptor Antagonist ⬇️

scientific article published on November 6, 2003

Design and synthesis of novel 2,3-dihydro-1H-isoindoles with high affinity and selectivity for the dopamine D3 receptor.

scientific article

Discovery of N-(3-fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040), the first small molecule motilin receptor agonist clinical candidate.

scientific article published in February 2009

Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP).

scientific article

Discovery of potent and stable conformationally constrained analogues of the MCH R1 antagonist SB-568849

scientific article published on 12 July 2006

Discovery process and pharmacological characterization of a novel dual orexin 1 and orexin 2 receptor antagonist useful for treatment of sleep disorders.

scientific article published on 30 June 2011

Enabling synthesis in fragment-based drug discovery by reactivity mapping: photoredox-mediated cross-dehydrogenative heteroarylation of cyclic amines

scientific article published on 21 December 2018

Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP

scientific article

Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase

scientific article published on 23 May 2014

Fragment-to-Lead Medicinal Chemistry Publications in 2015.

scientific article

Fragment-to-Lead Medicinal Chemistry Publications in 2016.

scientific article published on 31 October 2017

Fragment-to-Lead Medicinal Chemistry Publications in 2017

scientific article published on 21 November 2018

Fragment-to-Lead Medicinal Chemistry Publications in 2018

scientific article published on 22 January 2020

Fragment-to-Lead Medicinal Chemistry Publications in 2019

scientific article published on 23 November 2020

Fused aminotetralins: novel antagonists with high selectivity for the dopamine D3 receptor

scientific article published on 01 October 1998

Heterocyclic analogues of 2-aminotetralins with high affinity and selectivity for the dopamine D3 receptor

scientific article published on 01 September 1999

MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells

scientific article

Optimization of sphingosine-1-phosphate-1 receptor agonists: effects of acidic, basic, and zwitterionic chemotypes on pharmacokinetic and pharmacodynamic profiles.

scientific article

PTEN deficiency promotes macrophage infiltration and hypersensitivity of prostate cancer to IAP antagonist/radiation combination therapy.

scientific article published on 20 January 2016

Pharmacological actions of a novel, high-affinity, and selective human dopamine D(3) receptor antagonist, SB-277011-A

scientific article (publication date: September 2000)

Protein Degradation by In-Cell Self-Assembly of Proteolysis Targeting Chimeras.

scientific article published on 5 December 2016

Radiosynthesis and characterization of 11C-GSK215083 as a PET radioligand for the 5-HT6 receptor.

scientific article published on 5 January 2012

SAR of biphenyl carboxamide ligands of the human melanin-concentrating hormone receptor 1 (MCH R1): discovery of antagonist SB-568849.

scientific article published on 12 July 2006

SB-649915, a novel, potent 5-HT1A and 5-HT1B autoreceptor antagonist and 5-HT re-uptake inhibitor in native tissue.

scientific article

Structure-Based Design of Type II Inhibitors Applied to Maternal Embryonic Leucine Zipper Kinase

scientific article published on 23 May 2014

Studies on a series of potent, orally bioavailable, 5-HT(1) receptor ligands

scientific article published on 30 June 2007

Tricyclic azepine derivatives as selective brain penetrant 5-HT6 receptor antagonists

scientific article

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