List of works - Paul Huang

A comprehensive definition for metabolic syndrome.

scientific article published on May 2009

A novel dual NO-donating oxime and c-Jun N-terminal kinase inhibitor protects against cerebral ischemia-reperfusion injury in mice

scientific article

Accelerated atherosclerosis, aortic aneurysm formation, and ischemic heart disease in apolipoprotein E/endothelial nitric oxide synthase double-knockout mice

scientific article published on 01 July 2001

Acetylcholine-induced relaxation in blood vessels from endothelial nitric oxide synthase knockout mice.

scientific article published in January 1999

Aldosterone regulates vascular gene transcription via oxidative stress-dependent and -independent pathways.

scientific article

Altered respiratory responses to hypoxia in mutant mice deficient in neuronal nitric oxide synthase.

scientific article published in August 1998

An endothelium-derived hyperpolarizing factor distinct from NO and prostacyclin is a major endothelium-dependent vasodilator in resistance vessels of wild-type and endothelial NO synthase knockout mice.

scientific article

Anti-inflammatory effect of targeted delivery of SOD to endothelium: mechanism, synergism with NO donors and protective effects in vitro and in vivo

scientific article

Atorvastatin upregulates type III nitric oxide synthase in thrombocytes, decreases platelet activation, and protects from cerebral ischemia in normocholesterolemic mice

scientific article published on 01 October 2000

C-Reactive Protein Causes Insulin Resistance in Mice Through Fcγ Receptor IIB–Mediated Inhibition of Skeletal Muscle Glucose Delivery ⬇️

scientific article published on October 15, 2012

Cardiovascular roles of nitric oxide: a review of insights from nitric oxide synthase gene disrupted mice

scientific article published on January 2008

Case records of the Massachusetts General Hospital. Case 11-2014. A man with traumatic injuries after a bomb explosion at the Boston Marathon.

scientific article published in April 2014

Contributions of Endothelial and Neuronal Nitric Oxide Synthases to Cerebrovascular Responses to Hyperoxia ⬇️

scientific article published on October 1, 2003

Contributions of nitric oxide synthase isoforms to pulmonary oxygen toxicity, local vs. mediated effects.

scientific article published on 07 March 2008

Decreased arteriolar density in endothelial nitric oxide synthase knockout mice is due to hypertension, not to the constitutive defect in endothelial nitric oxide synthase enzyme

scientific journal article

Deficient eNOS phosphorylation is a mechanism for diabetic vascular dysfunction contributing to increased stroke size.

scientific article published on 29 August 2013

Deficient platelet-derived nitric oxide and enhanced hemostasis in mice lacking the NOSIII gene

scientific article published on 01 June 1999

Delayed paraplegia after spinal cord ischemic injury requires caspase-3 activation in mice.

scientific article

Differential expression of alternatively spliced isoforms of neuronal nitric oxide synthase (nNOS) and N-methyl-D-aspartate receptors (NMDAR) in knockout mice deficient in nNOS alpha (nNOS alpha(Delta/Delta) mice).

scientific article

Disruption of the endothelial nitric oxide synthase gene: effect on vascular response to injury.

scientific article published in November 1998

Effects of neuroglobin overexpression on acute brain injury and long-term outcomes after focal cerebral ischemia.

scientific article published on 10 April 2008

Effects of nitric oxide synthase gene knockout on neurotransmitter release in vivo ⬇️

scientific article published on October 1, 1998

Ejaculatory abnormalities in mice lacking the gene for endothelial nitric oxide synthase (eNOS-/-).

scientific article published in October 1999

Endothelial Fcγ Receptor IIB Activation Blunts Insulin Delivery to Skeletal Muscle to Cause Insulin Resistance in Mice.

scientific article published on 26 April 2016

Endothelial nitric oxide synthase and endothelial dysfunction.

scientific article published on December 2003

Endothelial nitric oxide synthase limits left ventricular remodeling after myocardial infarction in mice.

scientific article published in September 2001

Estrogen mediates the protective effects of pregnancy and chorionic gonadotropin in a mouse model of vascular injury

scientific article published on 01 September 1999

Expression of neuronal nitric oxide synthase splice variants in atherosclerotic plaques of apoE knockout mice

scientific article published on 14 March 2009

Ezetimibe potently reduces vascular inflammation and arteriosclerosis in eNOS-deficient ApoE ko mice.

scientific article

Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells

scientific article

Genetic Evidence That Carbohydrate-Stimulated Insulin Secretion Leads to Obesity.

scientific article published in January 2018

Genetic deficiency of inducible nitric oxide synthase reduces atherosclerosis and lowers plasma lipid peroxides in apolipoprotein E-knockout mice.

scientific article

HDAC5: going with the flow

scientific article published on 01 April 2010

Hematopoietic stem cell development is dependent on blood flow.

scientific article published on May 2009

Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages

scientific article

Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependent

scientific article

Hyperlipidemia Disrupts Cerebrovascular Reflexes and Worsens Ischemic Perfusion Defect ⬇️

scientific article published on March 13, 2013

Hypertension does not account for the accelerated atherosclerosis and development of aneurysms in male apolipoprotein e/endothelial nitric oxide synthase double knockout mice

scientific article published on 01 November 2001

Immunohistochemical expression of Bcl-2, p53 and caspase-9 in hypothalamus magnocellular centers of nNOS knockout mice following water deprivation.

scientific article

Implantable magnetic relaxation sensors measure cumulative exposure to cardiac biomarkers

scientific article published on 13 February 2011

In vivo imaging of proteolytic activity in atherosclerosis

article

Increased susceptibility to development of triggered activity in myocytes from mice with targeted disruption of endothelial nitric oxide synthase

scientific article published on 01 July 2000

Inducible nitric-oxide synthase is an important contributor to prolonged protective effects of ischemic preconditioning in the mouse kidney.

scientific article published on 7 April 2003

Inhibition of Marfan Syndrome Aortic Root Dilation by Losartan: Role of Angiotensin II Receptor Type 1-Independent Activation of Endothelial Function

scientific article published on 3 February 2018

Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment

scientific article published on 01 July 2005

Interaction of genetic deficiency of endothelial nitric oxide, gender, and pregnancy in vascular response to injury in mice ⬇️

scientific article published on March 15, 1998

Lack of Endothelial Nitric Oxide Synthase Aggravates Murine Pneumococcal Meningitis ⬇️

scientific article published on November 1, 2001

Lack of neuronal NOS has consequences for the expression of POMC and POMC-derived peptides in the mouse pituitary ⬇️

scientific article published on October 1, 2001

Long-term treatment with N(omega)-nitro-L-arginine methyl ester causes arteriosclerotic coronary lesions in endothelial nitric oxide synthase-deficient mice.

scientific article published in September 2002

Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice

scientific article

Loss of nNOS inhibits compensatory muscle hypertrophy and exacerbates inflammation and eccentric contraction-induced damage in mdx mice

scientific article

Macula Densa Nitric Oxide Synthase 1β Protects against Salt-Sensitive Hypertension.

scientific article published on 8 December 2015

Maternal aggression in endothelial nitric oxide synthase-deficient mice

scientific article published on 01 August 2000

Multi-ethnic genome-wide association study for atrial fibrillation

article

Muscarinic cholinergic regulation of cardiac myocyte ICa-L is absent in mice with targeted disruption of endothelial nitric oxide synthase.

scientific article published on May 1998

Myocardial reperfusion injury in neuronal nitric oxide synthase deficient mice.

scientific article published in December 2000

Neuronal and endothelial nitric oxide synthase gene knockout mice.

scientific article

Neuroprotection mediated by changes in the endothelial actin cytoskeleton.

scientific article published in July 2000

Neutrophil killing of Staphylococcus aureus in diabetes, obesity and metabolic syndrome: a prospective cellular surveillance study

scientific article published on 3 October 2017

Nitric Oxide Inhibits α 2 -Adrenoceptor–Mediated Endothelium-Dependent Vasodilation ⬇️

scientific article published on June 29, 1998

Nitric oxide and cerebral ischemic preconditioning.

scientific article published in September 2004

Nitric oxide is involved in ischemia-induced apoptosis in brain: a study in neuronal nitric oxide synthase null mice

scientific article published on 01 January 2001

Nitric oxide is proangiogenic in the retina and choroid.

scientific article

Nitric oxide mediates 17beta-estradiol-stimulated human and rodent osteoblast proliferation and differentiation

scientific article published on 01 November 2000

Nitric oxide protects cardiac sarcolemmal membrane enzyme function and ion active transport against ischemia-induced inactivation.

scientific article published on 6 August 2003

Nitric oxide synthase 3 deficiency limits adverse ventricular remodeling after pressure overload in insulin resistance ⬇️

scientific article published on August 19, 2011

Optical coherence tomography for the quantitative study of cerebrovascular physiology ⬇️

scientific article published on March 2, 2011

Oral nitrite restores age-dependent phenotypes in eNOS-null mice

scientific article published on 23 August 2018

Oxidative stress and compartment of gene expression determine proatherosclerotic effects of inducible nitric oxide synthase.

scientific article

Phosphomimetic modulation of eNOS improves myocardial reperfusion and mimics cardiac postconditioning in mice.

scientific article published on 21 January 2014

Physiological stress increases renal injury in eNOS-knockout mice ⬇️

scientific article published on December 15, 2011

Protective effect of endothelial nitric oxide synthase against induction of chemically-induced diabetes in mice

scientific article published on 20 June 2007

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article published on 01 July 2019

Rapid cerebral ischemic preconditioning in mice deficient in endothelial and neuronal nitric oxide synthases.

scientific article

Refinement of the ipsilateral retinocollicular projection is disrupted in double endothelial and neuronal nitric oxide synthase gene knockout mice.

scientific article published in March 2000

Renal Collecting Duct NOS1 Maintains Fluid–Electrolyte Homeostasis and Blood Pressure ⬇️

scientific article published on April 22, 2013

Resistance of neuronal nitric oxide synthase-deficient mice to cocaine-induced locomotor sensitization.

scientific article published in December 1998

Role of neuronal nitric oxide in the regulation of vasopressin expression and release in response to inhibition of catecholamine synthesis and dehydration.

scientific article published on 11 September 2007

Role of peroxynitrite and neuronal nitric oxide synthase in the activation of poly(ADP-ribose) synthetase in a murine model of cerebral ischemia-reperfusion ⬇️

scientific article published on May 22, 1998

Simvastatin exerts both anti-inflammatory and cardioprotective effects in apolipoprotein E-deficient mice.

scientific article published in May 2001

Soluble guanylate cyclase alpha1beta1 limits stroke size and attenuates neurological injury.

scientific article

Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of nitric oxide synthase 3 ⬇️

scientific article published on June 1, 1998

The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxia.

scientific article

The role of neuronal nitric oxide synthase in cocaine-induced conditioned place preference.

scientific article published in August 1998

Tissue plasminogen activator promotes matrix metalloproteinase-9 upregulation after focal cerebral ischemia.

scientific article published on 28 July 2005

Ultrastructural localization of neuronal nitric oxide synthase in the laterodorsal tegmental nucleus of wild-type and knockout mice.

scientific article published in January 1999

Unraveling the links between diabetes, obesity, and cardiovascular disease.

scientific article published on June 2005

Vascular factors are critical in selective neuronal loss in an animal model of impaired oxidative metabolism.

scientific article published in March 2000

eNOS protects from atherosclerosis despite relevant superoxide production by the enzyme in apoE mice.

scientific article

eNOS, metabolic syndrome and cardiovascular disease.

scientific article published on 31 July 2009

eNOS-derived nitric oxide regulates endothelial barrier function through VE-cadherin and Rho GTPases

scientific article published on 17 September 2013

List of works by Paul Huang

A comprehensive definition for metabolic syndrome.

A novel dual NO-donating oxime and c-Jun N-terminal kinase inhibitor protects against cerebral ischemia-reperfusion injury in mice

Accelerated atherosclerosis, aortic aneurysm formation, and ischemic heart disease in apolipoprotein E/endothelial nitric oxide synthase double-knockout mice

Acetylcholine-induced relaxation in blood vessels from endothelial nitric oxide synthase knockout mice.

Aldosterone regulates vascular gene transcription via oxidative stress-dependent and -independent pathways.

Altered respiratory responses to hypoxia in mutant mice deficient in neuronal nitric oxide synthase.

An endothelium-derived hyperpolarizing factor distinct from NO and prostacyclin is a major endothelium-dependent vasodilator in resistance vessels of wild-type and endothelial NO synthase knockout mice.

Anti-inflammatory effect of targeted delivery of SOD to endothelium: mechanism, synergism with NO donors and protective effects in vitro and in vivo

Atorvastatin upregulates type III nitric oxide synthase in thrombocytes, decreases platelet activation, and protects from cerebral ischemia in normocholesterolemic mice

C-Reactive Protein Causes Insulin Resistance in Mice Through Fcγ Receptor IIB–Mediated Inhibition of Skeletal Muscle Glucose Delivery ⬇️

Cardiovascular roles of nitric oxide: a review of insights from nitric oxide synthase gene disrupted mice

Case records of the Massachusetts General Hospital. Case 11-2014. A man with traumatic injuries after a bomb explosion at the Boston Marathon.

Contributions of Endothelial and Neuronal Nitric Oxide Synthases to Cerebrovascular Responses to Hyperoxia ⬇️

Contributions of nitric oxide synthase isoforms to pulmonary oxygen toxicity, local vs. mediated effects.

Decreased arteriolar density in endothelial nitric oxide synthase knockout mice is due to hypertension, not to the constitutive defect in endothelial nitric oxide synthase enzyme

Deficient eNOS phosphorylation is a mechanism for diabetic vascular dysfunction contributing to increased stroke size.

Deficient platelet-derived nitric oxide and enhanced hemostasis in mice lacking the NOSIII gene

Delayed paraplegia after spinal cord ischemic injury requires caspase-3 activation in mice.

Differential expression of alternatively spliced isoforms of neuronal nitric oxide synthase (nNOS) and N-methyl-D-aspartate receptors (NMDAR) in knockout mice deficient in nNOS alpha (nNOS alpha(Delta/Delta) mice).

Disruption of the endothelial nitric oxide synthase gene: effect on vascular response to injury.

Effects of neuroglobin overexpression on acute brain injury and long-term outcomes after focal cerebral ischemia.

Effects of nitric oxide synthase gene knockout on neurotransmitter release in vivo ⬇️

Ejaculatory abnormalities in mice lacking the gene for endothelial nitric oxide synthase (eNOS-/-).

Endothelial Fcγ Receptor IIB Activation Blunts Insulin Delivery to Skeletal Muscle to Cause Insulin Resistance in Mice.

Endothelial nitric oxide synthase and endothelial dysfunction.

Endothelial nitric oxide synthase limits left ventricular remodeling after myocardial infarction in mice.

Estrogen mediates the protective effects of pregnancy and chorionic gonadotropin in a mouse model of vascular injury

Expression of neuronal nitric oxide synthase splice variants in atherosclerotic plaques of apoE knockout mice

Ezetimibe potently reduces vascular inflammation and arteriosclerosis in eNOS-deficient ApoE ko mice.

Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells

Genetic Evidence That Carbohydrate-Stimulated Insulin Secretion Leads to Obesity.

Genetic deficiency of inducible nitric oxide synthase reduces atherosclerosis and lowers plasma lipid peroxides in apolipoprotein E-knockout mice.

HDAC5: going with the flow

Hematopoietic stem cell development is dependent on blood flow.

Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages

Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependent

Hyperlipidemia Disrupts Cerebrovascular Reflexes and Worsens Ischemic Perfusion Defect ⬇️

Hypertension does not account for the accelerated atherosclerosis and development of aneurysms in male apolipoprotein e/endothelial nitric oxide synthase double knockout mice

Immunohistochemical expression of Bcl-2, p53 and caspase-9 in hypothalamus magnocellular centers of nNOS knockout mice following water deprivation.

Implantable magnetic relaxation sensors measure cumulative exposure to cardiac biomarkers

In vivo imaging of proteolytic activity in atherosclerosis

Increased susceptibility to development of triggered activity in myocytes from mice with targeted disruption of endothelial nitric oxide synthase

Inducible nitric-oxide synthase is an important contributor to prolonged protective effects of ischemic preconditioning in the mouse kidney.

Inhibition of Marfan Syndrome Aortic Root Dilation by Losartan: Role of Angiotensin II Receptor Type 1-Independent Activation of Endothelial Function

Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment

Interaction of genetic deficiency of endothelial nitric oxide, gender, and pregnancy in vascular response to injury in mice ⬇️

Lack of Endothelial Nitric Oxide Synthase Aggravates Murine Pneumococcal Meningitis ⬇️

Lack of neuronal NOS has consequences for the expression of POMC and POMC-derived peptides in the mouse pituitary ⬇️

Long-term treatment with N(omega)-nitro-L-arginine methyl ester causes arteriosclerotic coronary lesions in endothelial nitric oxide synthase-deficient mice.

Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice

Loss of nNOS inhibits compensatory muscle hypertrophy and exacerbates inflammation and eccentric contraction-induced damage in mdx mice

Macula Densa Nitric Oxide Synthase 1β Protects against Salt-Sensitive Hypertension.

Maternal aggression in endothelial nitric oxide synthase-deficient mice

Multi-ethnic genome-wide association study for atrial fibrillation

Muscarinic cholinergic regulation of cardiac myocyte ICa-L is absent in mice with targeted disruption of endothelial nitric oxide synthase.

Myocardial reperfusion injury in neuronal nitric oxide synthase deficient mice.

Neuronal and endothelial nitric oxide synthase gene knockout mice.

Neuroprotection mediated by changes in the endothelial actin cytoskeleton.

Neutrophil killing of Staphylococcus aureus in diabetes, obesity and metabolic syndrome: a prospective cellular surveillance study

Nitric Oxide Inhibits α 2 -Adrenoceptor–Mediated Endothelium-Dependent Vasodilation ⬇️

Nitric oxide and cerebral ischemic preconditioning.

Nitric oxide is involved in ischemia-induced apoptosis in brain: a study in neuronal nitric oxide synthase null mice

Nitric oxide is proangiogenic in the retina and choroid.

Nitric oxide mediates 17beta-estradiol-stimulated human and rodent osteoblast proliferation and differentiation

Nitric oxide protects cardiac sarcolemmal membrane enzyme function and ion active transport against ischemia-induced inactivation.

Nitric oxide synthase 3 deficiency limits adverse ventricular remodeling after pressure overload in insulin resistance ⬇️

Optical coherence tomography for the quantitative study of cerebrovascular physiology ⬇️

Oral nitrite restores age-dependent phenotypes in eNOS-null mice

Oxidative stress and compartment of gene expression determine proatherosclerotic effects of inducible nitric oxide synthase.

Phosphomimetic modulation of eNOS improves myocardial reperfusion and mimics cardiac postconditioning in mice.

Physiological stress increases renal injury in eNOS-knockout mice ⬇️

Protective effect of endothelial nitric oxide synthase against induction of chemically-induced diabetes in mice

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Rapid cerebral ischemic preconditioning in mice deficient in endothelial and neuronal nitric oxide synthases.

Refinement of the ipsilateral retinocollicular projection is disrupted in double endothelial and neuronal nitric oxide synthase gene knockout mice.

Renal Collecting Duct NOS1 Maintains Fluid–Electrolyte Homeostasis and Blood Pressure ⬇️

Resistance of neuronal nitric oxide synthase-deficient mice to cocaine-induced locomotor sensitization.

Role of neuronal nitric oxide in the regulation of vasopressin expression and release in response to inhibition of catecholamine synthesis and dehydration.

Role of peroxynitrite and neuronal nitric oxide synthase in the activation of poly(ADP-ribose) synthetase in a murine model of cerebral ischemia-reperfusion ⬇️