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List of works by Jan A Ehses

Characterization of the carboxyl-terminal domain of the rat glucose-dependent insulinotropic polypeptide (GIP) receptor. A role for serines 426 and 427 in regulating the rate of internalization

scientific article published on 01 August 1999

Cytokine production by islets in health and diabetes: cellular origin, regulation and function.

scientific article published on 22 January 2010

Differential Activation of Innate Immune Pathways by Distinct Islet Amyloid Polypeptide (IAPP) Aggregates

scientific article published on 19 January 2016

Dipeptidyl peptidase IV inhibition in animal models of diabetes.

scientific article published in January 2003

Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats.

scientific article published on March 2003

Early reduction of circulating homocysteine levels in Goto–Kakizaki rat, a spontaneous nonobese model of type 2 diabetes

scientific article published on 05 April 2011

Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I.

scientific article published on 9 October 2009

Glucose-dependent insulinotropic polypeptide (GIP): development of DP IV-resistant analogues with therapeutic potential.

scientific article published in January 2003

Glucose-dependent insulinotropic polypeptide activates the Raf-Mek1/2-ERK1/2 module via a cyclic AMP/cAMP-dependent protein kinase/Rap1-mediated pathway.

scientific article published on 22 July 2002

Glucose-dependent insulinotropic polypeptide promotes beta-(INS-1) cell survival via cyclic adenosine monophosphate-mediated caspase-3 inhibition and regulation of p38 mitogen-activated protein kinase.

scientific article published on 19 June 2003

Glucose-dependent insulinotropic polypeptide receptor null mice exhibit compensatory changes in the enteroinsular axis.

scientific article published on 21 January 2003

Glycoprotein 130 receptor signaling mediates α-cell dysfunction in a rodent model of type 2 diabetes.

scientific article published on 8 May 2014

Hypercholesterolaemia, signs of islet microangiopathy and altered angiogenesis precede onset of type 2 diabetes in the Goto–Kakizaki (GK) rat

scientific article published on 10 July 2011

IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction.

scientific article

IL-1 mediates amyloid-associated islet dysfunction and inflammation in human islet amyloid polypeptide transgenic mice

scientific article published on 10 December 2014

Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation.

scientific article published on 29 July 2008

Increased number of islet-associated macrophages in type 2 diabetes.

scientific article

Induction of CXCL1 by extracellular matrix and autocrine enhancement by interleukin-1 in rat pancreatic beta-cells.

scientific article published on 16 August 2007

Insulin inhibits IL-10-mediated regulatory T cell function: implications for obesity.

scientific article

Insulitis in type 2 diabetes

scientific article published on 01 November 2008

Interleukin-1-receptor antagonist in type 2 diabetes mellitus

scientific article (publication date: 12 April 2007)

Interleukin-6 Delays Gastric Emptying in Humans with Direct Effects on Glycemic Control

scientific article published on 03 May 2018

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells.

scientific article

Interleukin-6 regulates pancreatic alpha-cell mass expansion

scientific article

Is there a role for the adaptive immune system in pancreatic beta cell failure in type 2 diabetes?

scientific article published on 21 December 2013

Islet endothelial activation and oxidative stress gene expression is reduced by IL-1Ra treatment in the type 2 diabetic GK rat

scientific article

Islet inflammation impairs the pancreatic beta-cell in type 2 diabetes.

scientific article published on December 2009

Islet inflammation in type 2 diabetes: from metabolic stress to therapy.

scientific article published on February 2008

Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets

scientific article

Mechanisms of beta-cell death in type 2 diabetes.

scientific article

Pancreatic islet inflammation in type 2 diabetes: from alpha and beta cell compensation to dysfunction.

scientific article published on October 2009

Regenerating 1 and 3b gene expression in the pancreas of type 2 diabetic Goto-Kakizaki (GK) rats

scientific article (publication date: 2014)

Resident macrophages mediate islet amyloid polypeptide-induced islet IL-1β production and β-cell dysfunction.

scientific article

Role of glucose in chronic desensitization of isolated rat islets and mouse insulinoma (betaTC-3) cells to glucose-dependent insulinotropic polypeptide.

scientific article published on May 2000

Susceptibility to Fatty Acid-Induced β-Cell Dysfunction Is Enhanced in Prediabetic Diabetes-Prone BioBreeding Rats: A Potential Link Between β-Cell Lipotoxicity and Islet Inflammation ⬇️

scientific article published on November 13, 2012

Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes.

scientific article published on 19 June 2009

TLR2/6 and TLR4-activated macrophages contribute to islet inflammation and impair beta cell insulin gene expression via IL-1 and IL-6

scientific article published on 12 May 2014

Targeting 12-lipoxygenase as a novel strategy to combat the effects of inflammation on beta cells in diabetes.

scientific article published on 24 December 2014

Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet.

scientific article published on 21 April 2010

Toll-like receptors and NLRP3 as central regulators of pancreatic islet inflammation in type 2 diabetes

scientific article published on 04 February 2014

[Interleukin-1 receptor antagonist-treatment of patients with type 2 diabetes]

scientific article published on 01 November 2007

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