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List of works by Ralf Dringen

2-Deoxyribose Deprives Cultured Astrocytes of their Glutathione ⬇️

scientific article published on August 24, 2010

3-bromopyruvate inhibits glycolysis, depletes cellular glutathione, and compromises the viability of cultured primary rat astrocytes.

scientific article published on 4 September 2014

8-Hydroxy-efavirenz, the primary metabolite of the antiretroviral drug Efavirenz, stimulates the glycolytic flux in cultured rat astrocytes.

scientific article published on 4 October 2013

A review of the mechanisms of action of dimethylfumarate in the treatment of psoriasis.

scientific article published on 30 March 2018

Accumulation of iron oxide nanoparticles by cultured brain astrocytes.

scientific article published in June 2009

Accumulation of iron oxide nanoparticles by cultured primary neurons

scientific article published on 12 December 2014

Accumulation of non-transferrin-bound iron by neurons, astrocytes, and microglia.

scientific article published on 30 April 2010

Adsorption and reduction of glutathione disulfide on α-Al2O3 nanoparticles: experiments and modeling

scientific article published on 11 July 2011

Advanced glycation endproducts change glutathione redox status in SH-SY5Y human neuroblastoma cells by a hydrogen peroxide dependent mechanism.

scientific article

Anethole dithiolethione, a putative neuroprotectant, increases intracellular and extracellular glutathione levels during starvation of cultured astroglial cells

scientific article published on 01 December 1998

Antiretroviral protease inhibitors accelerate glutathione export from viable cultured rat neurons

scientific article published on 25 March 2014

Arsenate accumulation and arsenate-induced glutathione export in astrocyte-rich primary cultures.

scientific article published on 29 March 2013

Arsenate stimulates glutathione export from viable cultured rat cerebellar granule neurons

scientific article published on 12 December 2014

Arsenite stimulates glutathione export and glycolytic flux in viable primary rat brain astrocytes.

scientific article published in July 2014

Astrocyte functions in the copper homeostasis of the brain.

scientific article published on 08 September 2012

Astrocytes retain their antioxidant capacity into advanced old age.

scientific article published on September 2010

Bactericidal activity of partially oxidized nanodiamonds.

scientific article published on 5 June 2014

Bifunctional submicron colloidosomes coassembled from fluorescent and superparamagnetic nanoparticles.

scientific article published on 4 November 2014

Catalase in astroglia-rich primary cultures from rat brain: immunocytochemical localization and inactivation during the disposal of hydrogen peroxide.

scientific article

Characterisation and metabolism of astroglia-rich primary cultures from cathepsin K-deficient mice.

scientific article published in September 2012

Comparison of primary and secondary rat astrocyte cultures regarding glucose and glutathione metabolism and the accumulation of iron oxide nanoparticles

scientific article published on 5 November 2013

Consequences of a Chronic Exposure of Cultured Brain Astrocytes to the Anti-Retroviral Drug Efavirenz and its Primary Metabolite 8-Hydroxy Efavirenz.

scientific article

Consequences of a Metabolic Glucose-Depletion on the Survival and the Metabolism of Cultured Rat Astrocytes

scientific article published on 20 February 2019

Copper accelerates glycolytic flux in cultured astrocytes

scientific article published on 13 February 2011

Copper accumulation by cultured astrocytes.

scientific article

Copper export from cultured astrocytes.

scientific article published on 31 December 2011

Copper metabolism of astrocytes.

scientific article published on 12 June 2015

Copper oxide nanoparticles stimulate glycolytic flux and increase the cellular contents of glutathione and metallothioneins in cultured astrocytes.

scientific article published on 26 October 2014

Copper: effects of deficiency and overload.

scientific article published on January 2013

Detoxification of exogenous hydrogen peroxide and organic hydroperoxides by cultured astroglial cells assessed by microtiter plate assay.

scientific article published in March 1998

Dicoumarol Inhibits Multidrug Resistance Protein 1-Mediated Export Processes in Cultured Primary Rat Astrocytes

scientific article published on 15 November 2018

Differential effects of iodoacetamide and iodoacetate on glycolysis and glutathione metabolism of cultured astrocytes.

scientific article published on 24 March 2009

Dual fluorophore doped silica nanoparticles for cellular localization studies in multiple stained cells.

scientific article

Effects of Long-Term Rice Bran Extract Supplementation on Survival, Cognition and Brain Mitochondrial Function in Aged NMRI Mice.

scientific article published on 27 June 2016

Effects of iron chelators, iron salts, and iron oxide nanoparticles on the proliferation and the iron content of oligodendroglial OLN-93 cells.

scientific article

Endocytotic uptake of iron oxide nanoparticles by cultured brain microglial cells.

scientific article published on 31 May 2013

Endogenous glutathione and catalase protect cultured rat astrocytes from the iron-mediated toxicity of hydrogen peroxide.

scientific article

Enhancing Cellular Uptake and Doxorubicin Delivery of Mesoporous Silica Nanoparticles via Surface Functionalization: Effects of Serum.

scientific article published on 12 November 2015

Exposure of Cultured Astrocytes to Menadione Triggers Rapid Radical Formation, Glutathione Oxidation and Mrp1-Mediated Export of Glutathione Disulfide

scientific article published on 26 February 2019

Expression of hepatoma-derived growth factor family members in the adult central nervous system.

scientific article

Expression of mRNAs of multidrug resistance proteins (Mrps) in cultured rat astrocytes, oligodendrocytes, microglial cells and neurones.

scientific article published in August 2002

Expression of multidrug resistance proteins (Mrps) in astrocytes of the mouse brain: a single cell RT-PCR study.

scientific article

Ferritin up-regulation and transient ROS production in cultured brain astrocytes after loading with iron oxide nanoparticles.

scientific article published on 28 June 2012

Formaldehyde in brain: an overlooked player in neurodegeneration?

scientific article

Formaldehyde metabolism and formaldehyde-induced stimulation of lactate production and glutathione export in cultured neurons.

scientific article published on 24 February 2013

Formaldehyde stimulates Mrp1-mediated glutathione deprivation of cultured astrocytes

scientific article published on 19 January 2011

Formate generated by cellular oxidation of formaldehyde accelerates the glycolytic flux in cultured astrocytes.

scientific article published on 18 January 2012

Formation and rapid export of the monochlorobimane-glutathione conjugate in cultured rat astrocytes

scientific article published on 07 November 2006

Fumaric acid diesters deprive cultured primary astrocytes rapidly of glutathione.

scientific article published on 22 January 2010

Glucose-6-phosphate dehydrogenase and NADPH-consuming enzymes in the rat olfactory bulb.

scientific article published in May 2005

Glutamate induces release of glutathione from cultured rat astrocytes--a possible neuroprotective mechanism?

scientific article published on 7 January 2008

Glutathione metabolism and oxidative stress in neurodegeneration

scientific article published on 01 August 2000

Glutathione pathways in the brain.

scientific article

Glutathione peroxidase 1 and a high cellular glutathione concentration are essential for effective organic hydroperoxide detoxification in astrocytes.

scientific article published in December 2006

Glutathione restoration as indicator for cellular metabolism of astroglial cells

scientific article published on 01 January 1998

Glutathione-Dependent Detoxification Processes in Astrocytes

scientific article

Glycogen is mobilized during the disposal of peroxides by cultured astroglial cells from rat brain

scientific article published on 01 September 2000

Handling of Copper and Copper Oxide Nanoparticles by Astrocytes.

scientific article published on 13 August 2015

Hemin toxicity: a preventable source of brain damage following hemorrhagic stroke.

scientific article published on January 2009

How to Study the Uptake and Toxicity of Nanoparticles in Cultured Brain Cells: The Dos and Don't Forgets

scientific article published on 07 August 2018

Identification of Nepsilon-(carboxymethyl)lysine-positive cells in astroglia-rich primary cultures.

scientific article published in October 2003

Inactivation of astrocytic glutamine synthetase by hydrogen peroxide requires iron.

scientific article

Inhibition of Astrocytic Glutamine Synthetase by Lead is Associated with a Slowed Clearance of Hydrogen Peroxide by the Glutathione System.

scientific article

Involvement of glutathione peroxidase and catalase in the disposal of exogenous hydrogen peroxide by cultured astroglial cells ⬇️

scientific article published on June 6, 1997

Iron accumulation, iron-mediated toxicity and altered levels of ferritin and transferrin receptor in cultured astrocytes during incubation with ferric ammonium citrate.

scientific article published in March 2004

Iron-Doping of Copper Oxide Nanoparticles Lowers Their Toxic Potential on C6 Glioma Cells

scientific article published on 29 January 2020

Lysosomal iron liberation is responsible for the vulnerability of brain microglial cells to iron oxide nanoparticles: comparison with neurons and astrocytes.

scientific article published on 19 August 2015

Magnetic field-induced acceleration of the accumulation of magnetic iron oxide nanoparticles by cultured brain astrocytes

scientific article published on 07 November 2011

Menadione-mediated WST1 reduction assay for the determination of metabolic activity of cultured neural cells

scientific article

Metabolic pathways for glucose in astrocytes.

scientific article published on September 1997

Metabolism and functions of copper in brain.

scientific article published on 17 January 2014

Metabolism and functions of glutathione in brain.

scientific article published in December 2000

Metabolism of Mannose in Cultured Primary Rat Neurons

scientific article published on 27 March 2017

Metabolism of glycine in primary astroglial cells: synthesis of creatine, serine, and glutathione.

scientific article

Metformin Accelerates Glycolytic Lactate Production in Cultured Primary Cerebellar Granule Neurons

scientific article

Microglial cells in culture express a prominent glutathione system for the defense against reactive oxygen species.

scientific article published in September 2000

Modulation of Silica Nanoparticle Uptake into Human Osteoblast Cells by Variation of the Ratio of Amino and Sulfonate Surface Groups: Effects of Serum.

scientific article published on 21 June 2015

Modulation of copper accumulation and copper-induced toxicity by antioxidants and copper chelators in cultured primary brain astrocytes

scientific article published on 11 July 2015

Monitoring of the Cytoskeleton-Dependent Intracellular Trafficking of Fluorescent Iron Oxide Nanoparticles by Nanoparticle Pulse-Chase Experiments in C6 Glioma Cells

scientific article published on 08 September 2018

Multiassay analysis of the toxic potential of hydrogen peroxide on cultured neurons.

scientific article published on 30 October 2014

Multidrug resistance protein 1-mediated export of glutathione and glutathione disulfide from brain astrocytes.

scientific article published in January 2005

Neurones express glutamine synthetase when deprived of glutamine or interaction with astrocytes.

scientific article published on 16 June 2010

Neurotoxicity of Copper.

scientific article published in January 2017

Oligodendroglial cells in culture effectively dispose of exogenous hydrogen peroxide: comparison with cultured neurones, astroglial and microglial cells.

scientific article published in August 2002

Oxidative and antioxidative potential of brain microglial cells.

scientific article

PVP-coated, negatively charged silver nanoparticles: A multi-center study of their physicochemical characteristics, cell culture and in vivo experiments

scientific article

Pathways of neuron-astrocyte interactions and their possible role in neuroprotection.

scientific article

Peroxide detoxification by brain cells.

scientific article

Physisorption of enzymatically active chymotrypsin on titania colloidal particles

scientific article published on 19 May 2015

Physisorption of α-chymotrypsin on SiO2 and TiO2: A comparative study via experiments and molecular dynamics simulations.

scientific article

Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway.

scientific article published on July 2005

Prostacyclin synthase is localized in rat, bovine and human neuronal brain cells.

scientific article

Rapid clearance of tertiary butyl hydroperoxide by cultured astroglial cells via oxidation of glutathione

scientific article published on 01 June 1998

Reporter dyes demonstrate functional expression of multidrug resistance proteins in the marine flatworm Macrostomum lignano: the sponge-derived dye Ageladine A is not a substrate of these transporters

scientific article published on 16 October 2013

Short time exposure to hydrogen peroxide induces sustained glutathione export from cultured neurons

scientific article published on 11 February 2014

Structure-activity relationships for the impact of selected isothiazol-3-one biocides on glutathione metabolism and glutathione reductase of the human liver cell line Hep G2.

scientific article

Sustained hydrogen peroxide stress decreases lactate production by cultured astrocytes.

scientific article published in September 2009

Synergistic accumulation of iron and zinc by cultured astrocytes.

scientific article published on 12 June 2010

TNF alpha increases activity of gamma-glutamyl transpeptidase in cultured rat astroglial cells.

scientific article published in February 2004

The Antidiabetic Drug Metformin Stimulates Glycolytic Lactate Production in Cultured Primary Rat Astrocytes.

scientific article

The Menadione-Mediated WST1 Reduction by Cultured Astrocytes Depends on NQO1 Activity and Cytosolic Glucose Metabolism

scientific article published on 04 January 2020

The Protein Tyrosine Kinase Inhibitor Tyrphostin 23 Strongly Accelerates Glycolytic Lactate Production in Cultured Primary Astrocytes.

scientific article

The antidiabetic drug metformin decreases mitochondrial respiration and tricarboxylic acid cycle activity in cultured primary rat astrocytes

scientific article

The chemically synthesized ageladine A-derivative LysoGlow84 stains lysosomes in viable mammalian brain cells and specific structures in the marine flatworm Macrostomum lignano

scientific article

The cytosolic redox state of astrocytes: Maintenance, regulation and functional implications for metabolite trafficking.

scientific article published on 31 October 2009

The detoxification of cumene hydroperoxide by the glutathione system of cultured astroglial cells hinges on hexose availability for the regeneration of NADPH

scientific article published on 01 September 1999

The gamma-glutamyl transpeptidase inhibitor acivicin preserves glutathione released by astroglial cells in culture

scientific article published on 01 June 1997

The multidrug resistance protein 1 (Mrp1), but not Mrp5, mediates export of glutathione and glutathione disulfide from brain astrocytes.

scientific article published on 15 March 2006

The multidrug resistance protein MRP1 mediates the release of glutathione disulfide from rat astrocytes during oxidative stress

scientific journal article

The pivotal role of astrocytes in the metabolism of iron in the brain.

scientific article published on 6 June 2007

The putative heme transporter HCP1 is expressed in cultured astrocytes and contributes to the uptake of hemin.

scientific article

The regeneration of reduced glutathione in rat forebrain mitochondria identifies metabolic pathways providing the NADPH required

scientific article published on 01 November 1999

The tricarboxylic acid cycle activity in cultured primary astrocytes is strongly accelerated by the protein tyrosine kinase inhibitor tyrphostin 23.

scientific article published on 25 November 2016

Treatment with iron oxide nanoparticles induces ferritin synthesis but not oxidative stress in oligodendroglial cells.

scientific article published on 2 July 2011

Uptake and Toxicity of Copper Oxide Nanoparticles in C6 Glioma Cells.

scientific article published on 03 August 2016

Uptake and metabolism of iron and iron oxide nanoparticles in brain astrocytes.

scientific article published on December 2013

Uptake and metabolism of iron oxide nanoparticles in brain cells.

scientific article

Uptake and toxicity of arsenite and arsenate in cultured brain astrocytes.

scientific article published on 4 May 2014

Uptake and toxicity of copper oxide nanoparticles in cultured primary brain astrocytes

scientific article published on 22 August 2013

Uptake of Intact Copper Oxide Nanoparticles Causes Acute Toxicity in Cultured Glial Cells

scientific article published on 14 August 2019

Uptake of dimercaptosuccinate-coated magnetic iron oxide nanoparticles by cultured brain astrocytes

scientific article published on 24 February 2011

Uptake of ferrous iron by cultured rat astrocytes.

scientific article published in February 2010

Uptake of fluorescent iron oxide nanoparticles by oligodendroglial OLN-93 cells.

scientific article published on 25 December 2013

Uptake, Metabolic Effects and Toxicity of Arsenate and Arsenite in Astrocytes.

scientific article published on 11 April 2015

Uptake, metabolism and toxicity of iron oxide nanoparticles in cultured microglia, astrocytes and neurons

scientific article published on 12 June 2015

Use of Dipeptides for the Synthesis of Glutathione by Astroglia‐Rich Primary Cultures ⬇️

scientific article published on August 1, 1997

Utilizing the protein corona around silica nanoparticles for dual drug loading and release

scientific article published on 17 September 2015

Zinc prevents the copper-induced damage of cultured astrocytes.

scientific article published on 25 June 2010

Zinc stimulates the production of toxic reactive oxygen species (ROS) and inhibits glutathione reductase in astrocytes.

scientific article published on 17 January 2007

β-Lapachone Induces Acute Oxidative Stress in Rat Primary Astrocyte Cultures that is Terminated by the NQO1-Inhibitor Dicoumarol

scientific article published on 13 August 2020

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