List of works - Hans-Günther Schmalz

3β-Acet-oxy-19-hy-droxy-Δ(5)-pregnen-20-one.

scientific article published on 31 January 2013

A catalytic-enantioselective entry to planar chiral pi-complexes: enantioselective methoxycarbonylation of 1,2-dichlorobenzene-Cr(CO)(3)

scientific article published on 01 May 2001

A fast and simple LC-MS-based characterization of the flavonoid biosynthesis pathway for few seed(ling)s.

scientific article

A modular toolkit to inhibit proline-rich motif-mediated protein-protein interactions.

scientific article published on 6 April 2015

A novel conjugate of a cell-penetrating peptide and a ferrocenyl amino acid: a potential electrochemical sensor for living cells?

scientific article published on 14 March 2012

A practical synthesis of trans-3-substituted proline derivatives through 1,4-addition

scientific article published on 15 December 2010

Acyloxybutadiene Iron Tricarbonyl Complexes as Enzyme-Triggered CO-Releasing Molecules (ET-CORMs)

scientific article published on 14 February 2011

Acyloxybutadiene tricarbonyl iron complexes as enzyme-triggered CO-releasing molecules (ET-CORMs): a structure-activity relationship study

scientific article published on 07 June 2012

An approach to serrulatane diterpenes via endo-selective conjugate nucleophilic addition to arene-Cr(CO)3 complexes

scientific article published on 01 October 2002

An efficient organometallic approach to new carbocyclic nucleoside analogues

scientific article published on 01 February 2002

An enantioselective total synthesis of helioporins C and E.

scientific article published on 13 November 2012

Anti-inflammatory AreneChromium Complexes Acting as Specific Inhibitors of NOD2 Signalling

scientific article published on 25 October 2010

Aryl-Phenyl Scrambling in Intermediate Organopalladium Complexes: A Gas-Phase Study of the Mizoroki-Heck Reaction

scientific article published on 13 March 2014

Azides derived from colchicine and their use in library synthesis: A practical entry to new bioactive derivatives of an old natural drug.

scientific article

B-nor-methylene Colchicinoid PT-100 Selectively Induces Apoptosis in Multidrug-Resistant Human Cancer Cells via an Intrinsic Pathway in a Caspase-Independent Manner

scientific article published on 11 January 2022

Benzylic endo-alkylation of phthalan-Cr(CO)3 complexes via temporary silylation: an entry to trans-1,3-disubstituted dihydroisobenzofurans

scientific article published on 01 July 2002

Chemistry. A molecular shuttle for hydrogen cyanide

scientific article published on 01 February 2016

Chiral Phosphine-Phosphite Ligands in Asymmetric Gold Catalysis: Highly Enantioselective Synthesis of Furo[3,4-d]-Tetrahydropyridazine Derivatives through [3+3]-Cycloaddition.

scientific article published on 4 January 2018

Cobalt catalysis in the gas phase: experimental characterization of cobalt(I) complexes as intermediates in regioselective Diels-Alder reactions

scientific article published on 26 September 2013

Cobalt-catalyzed 1,4-hydrobutadienylation of 1-aryl-1,3-dienes with 2,3-dimethyl-1,3-butadiene

scientific article published on 31 August 2011

Design and Stereoselective Synthesis of ProM-2: A Spirocyclic Diproline Mimetic with Polyproline Type II (PPII) Helix Conformation.

scientific article published on 23 April 2015

Design, synthesis, and functional evaluation of CO-releasing molecules triggered by Penicillin G amidase as a model protease.

scientific article published on 2 June 2015

Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells

scientific article published on 12 November 2020

Different design of enzyme-triggered CO-releasing molecules (ET-CORMs) reveals quantitative differences in biological activities in terms of toxicity and inflammation.

scientific article published on 5 June 2014

Electrophilic activation of benzaldehydes through ortho palladation: one-pot synthesis of 3-methylene-indan-1-ols through a domino allylstannylation/Heck reaction under neutral conditions

scientific article published on 01 January 2009

Enantioselective Cu-catalyzed 1,4-addition of Grignard reagents to cyclohexenone using taddol-derived phosphine-phosphite ligands and 2-methyl-THF as a solvent.

scientific article

Enantioselective nickel-catalyzed hydrocyanation of vinylarenes using chiral phosphine-phosphite ligands and TMS-CN as a source of HCN

scientific article published on 20 December 2012

Enantioselective synthesis of a trans-7,8-dimethoxycalamenene

scientific article published on 04 August 2007

Enantioselective synthesis of ferrocenyl nucleoside analogues with apoptosis-inducing activity

scientific article published on 01 June 2006

Enzyme-triggered CO-releasing molecules (ET-CORMs): Evaluation of biological activity in relation to their structure ⬇️

scientific article published on June 14, 2013

Exercises in pyrrolidine chemistry: gram scale synthesis of a Pro-Pro dipeptide mimetic with a polyproline type II helix conformation

scientific article published on 07 September 2011

Gaining absolute control of the regiochemistry in the cobalt-catalyzed 1,4-hydrovinylation reaction

scientific article published on 31 October 2011

Gold(I)-catalyzed reaction of 1-(1-alkynyl)-cyclopropyl ketones with nucleophiles: a modular entry to highly substituted furans

scientific article published on 01 October 2006

Gram-scale synthesis of pinusolide and evaluation of its antileukemic potential.

scientific article published on 14 June 2006

Gram-scale synthesis of suspension-polymerized styrene-divinylbenzene-based resins using an oscillatory baffled reactor

scientific article published on 01 October 2002

Hydrogen Peroxide Sensors Based on Fluorescence Quenching of the 2-AminobenzimidazoleFluorophore

scientific article published on 05 December 2019

Individual steps of the Mizoroki-Heck reaction and intrinsic reactivity of intermediate organopalladium complexes studied in the gas phase

scientific article published in January 2015

Iron containing anti-tumoral agents: unexpected apoptosis-inducing activity of a ferrocene amino acid derivative.

scientific article published on 11 June 2010

Iron-containing nucleoside analogues with pronounced apoptosis-inducing activity.

scientific article published on March 2004

Lipophilic prodrugs of a triazole-containing colchicine analogue in liposomes: biological effects on human tumor cells

scientific article published on September 2013

Low-Pressure Cobalt-Catalyzed Enantioselective Hydrovinylation of Vinylarenes

scientific article published on 25 April 2016

Methyl Fumarate-Derived Iron Carbonyl Complexes (FumET-CORMs) as Powerful Anti-inflammatory Agents

scientific article published on 2 November 2017

Microwave-assisted amination of a chloropurine derivative in the synthesis of acyclic nucleoside analogues.

scientific article published on 28 February 2005

Molecular Oxygen as a Redox Catalyst in Intramolecular Photocycloadditions of Coumarins

scientific article published on 03 May 2012

N-Capping of primary amines with 2-acyl-benzaldehydes to give isoindolinones

scientific article published on 08 September 2011

New Colchicine-Derived Triazoles and Their Influence on Cytotoxicity and Microtubule Morphology.

scientific article published on 29 December 2015

New caspase-independent but ROS-dependent apoptosis pathways are targeted in melanoma cells by an iron-containing cytosine analogue.

scientific article published on February 2010

New modular manganese(I) tricarbonyl complexes as PhotoCORMs: in vitro detection of photoinduced carbon monoxide release using COP-1 as a fluorogenic switch-on probe

scientific article published on 01 June 2014

Nucleophile- or light-induced synthesis of 3-substituted phthalides from 2-formylarylketones

scientific article published on 22 April 2012

Nucleoside analogues with a 1,3-diene-Fe(CO)3 substructure: stereoselective synthesis, configurational assignment, and apoptosis-inducing activity.

scientific article published on 9 August 2013

On the Antibiotic and Antifungal Activity of Pestalone, Pestalachloride A, and Structurally Related Compounds

scientific article published on 01 August 2013

Organometallic nucleosides induce non-classical leukemic cell death that is mitochondrial-ROS dependent and facilitated by TCL1-oncogene burden

scientific article published on 4 June 2015

Palladium-catalyzed cyanomethylation of aryl halides through domino Suzuki coupling-isoxazole fragmentation

scientific article published on 19 April 2011

Paraoxonase-1 is a major determinant of clopidogrel efficacy

scientific article published on 19 December 2010

Pd-Catalyzed Asymmetric N-Allylation of Amino Acid Esters with Exceptional Levels of Catalyst Control: Stereo-Divergent Synthesis of ProM-15 and Related Bicyclic Dipeptide Mimetics

scientific article published on 18 February 2020

Pd-catalyzed enantioselective allylic substitution: new strategic options for the total synthesis of natural products

scientific article published on 01 June 2003

Potassium (1-methoxy-carbonyl-2-methyl-prop-2-en-2-yl-idene)azinate.

scientific article published on 27 March 2010

Prevention of colitis by controlled oral drug delivery of carbon monoxide

scientific article published on 27 August 2016

Stereoselective syntheses of the 2-Isopropenyl-2,3-dihydrobenzofuran nucleus: potential chiral building blocks for the syntheses of tremetone, hydroxytremetone, and rotenone.

scientific article published on 22 March 2007

Studies toward the total synthesis of mumbaistatin, a highly potent glucose-6-phosphate translocase inhibitor. Synthesis of a mumbaistatin analogue.

scientific article

Synthesis and biological evaluation of furanoallocolchicinoids.

scientific article

Synthesis of B-ring-modified steroids through BF3-promoted rearrangement/substitution of 6β-hydroxy-5,19-cyclosteroids

scientific article published on 05 July 2012

Synthesis of the 8,19-Epoxysteroid Eurysterol A

scientific article published on 09 March 2020

Synthetic Indolactam V Analogues as Inhibitors of PAR2-Induced Calcium Mobilization in Triple-Negative Breast Cancer Cells

scientific article published in December 2017

Tandem Hydroalumination/Cu-Catalyzed Asymmetric Vinyl Metalation as a New Access to Enantioenriched Vinylcyclopropane Derivatives.

scientific article published on 25 July 2017

Total Synthesis of Indole‐Derived Allocolchicine Analogues Exhibiting Strong Apoptosis‐Inducing Activity ⬇️

scientific article published on August 27, 2012

Total Synthesis of the Antiviral Natural Product Houttuynoid B

scientific article published on 27 January 2016

Total Synthesis of α-Tocopherol through Enantioselective Iridium-Catalyzed Fragmentation of a Spiro-Cyclobutanol Intermediate

scientific article published on 15 March 2019

Total syntheses of colchicine in comparison: a journey through 50 years of synthetic organic chemistry.

scientific article published in June 2004

Total synthesis of (R,R,R)-α-tocopherol through asymmetric Cu-catalyzed 1,4-addition

scientific article published on 01 August 2014

Total synthesis of cyclo-mumbaistatin analogues through anionic homo-Fries rearrangement.

scientific article published on 27 January 2011

Total synthesis of the marine antibiotic pestalone and its surprisingly facile conversion into pestalalactone and pestalachloride A

scientific article published on 01 October 2010

Triple-Helix-Stabilizing Effects in Collagen Model Peptides Containing PPII-Helix-Preorganized Diproline Modules

scientific article published on 03 February 2020

Unexpected endo selectivity of conjugate nucleophilic addition to an arene-Cr(CO)3 complex: enantioselective synthesis of the diterpene 11-epi-helioporin B

scientific article published on 01 November 2001

trans-1,2-Bis(3,5-dimethoxy-phen-yl)ethene.

scientific article published on 15 August 2009

trans-Ethylenedi-p-phenylene diacetate ⬇️

scientific article published on August 26, 2009

List of works by Hans-Günther Schmalz

3β-Acet-oxy-19-hy-droxy-Δ(5)-pregnen-20-one.

A catalytic-enantioselective entry to planar chiral pi-complexes: enantioselective methoxycarbonylation of 1,2-dichlorobenzene-Cr(CO)(3)

A fast and simple LC-MS-based characterization of the flavonoid biosynthesis pathway for few seed(ling)s.

A modular toolkit to inhibit proline-rich motif-mediated protein-protein interactions.

A novel conjugate of a cell-penetrating peptide and a ferrocenyl amino acid: a potential electrochemical sensor for living cells?

A practical synthesis of trans-3-substituted proline derivatives through 1,4-addition

Acyloxybutadiene Iron Tricarbonyl Complexes as Enzyme-Triggered CO-Releasing Molecules (ET-CORMs)

Acyloxybutadiene tricarbonyl iron complexes as enzyme-triggered CO-releasing molecules (ET-CORMs): a structure-activity relationship study

An approach to serrulatane diterpenes via endo-selective conjugate nucleophilic addition to arene-Cr(CO)3 complexes

An efficient organometallic approach to new carbocyclic nucleoside analogues

An enantioselective total synthesis of helioporins C and E.

Anti-inflammatory AreneChromium Complexes Acting as Specific Inhibitors of NOD2 Signalling

Aryl-Phenyl Scrambling in Intermediate Organopalladium Complexes: A Gas-Phase Study of the Mizoroki-Heck Reaction

Azides derived from colchicine and their use in library synthesis: A practical entry to new bioactive derivatives of an old natural drug.

B-nor-methylene Colchicinoid PT-100 Selectively Induces Apoptosis in Multidrug-Resistant Human Cancer Cells via an Intrinsic Pathway in a Caspase-Independent Manner

Benzylic endo-alkylation of phthalan-Cr(CO)3 complexes via temporary silylation: an entry to trans-1,3-disubstituted dihydroisobenzofurans

Chemistry. A molecular shuttle for hydrogen cyanide

Chiral Phosphine-Phosphite Ligands in Asymmetric Gold Catalysis: Highly Enantioselective Synthesis of Furo[3,4-d]-Tetrahydropyridazine Derivatives through [3+3]-Cycloaddition.

Cobalt catalysis in the gas phase: experimental characterization of cobalt(I) complexes as intermediates in regioselective Diels-Alder reactions

Cobalt-catalyzed 1,4-hydrobutadienylation of 1-aryl-1,3-dienes with 2,3-dimethyl-1,3-butadiene

Design and Stereoselective Synthesis of ProM-2: A Spirocyclic Diproline Mimetic with Polyproline Type II (PPII) Helix Conformation.

Design, synthesis, and functional evaluation of CO-releasing molecules triggered by Penicillin G amidase as a model protease.

Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells

Different design of enzyme-triggered CO-releasing molecules (ET-CORMs) reveals quantitative differences in biological activities in terms of toxicity and inflammation.

Electrophilic activation of benzaldehydes through ortho palladation: one-pot synthesis of 3-methylene-indan-1-ols through a domino allylstannylation/Heck reaction under neutral conditions

Enantioselective Cu-catalyzed 1,4-addition of Grignard reagents to cyclohexenone using taddol-derived phosphine-phosphite ligands and 2-methyl-THF as a solvent.

Enantioselective nickel-catalyzed hydrocyanation of vinylarenes using chiral phosphine-phosphite ligands and TMS-CN as a source of HCN

Enantioselective synthesis of a trans-7,8-dimethoxycalamenene

Enantioselective synthesis of ferrocenyl nucleoside analogues with apoptosis-inducing activity

Enzyme-triggered CO-releasing molecules (ET-CORMs): Evaluation of biological activity in relation to their structure ⬇️

Exercises in pyrrolidine chemistry: gram scale synthesis of a Pro-Pro dipeptide mimetic with a polyproline type II helix conformation

Gaining absolute control of the regiochemistry in the cobalt-catalyzed 1,4-hydrovinylation reaction

Gold(I)-catalyzed reaction of 1-(1-alkynyl)-cyclopropyl ketones with nucleophiles: a modular entry to highly substituted furans

Gram-scale synthesis of pinusolide and evaluation of its antileukemic potential.

Gram-scale synthesis of suspension-polymerized styrene-divinylbenzene-based resins using an oscillatory baffled reactor

Hydrogen Peroxide Sensors Based on Fluorescence Quenching of the 2-AminobenzimidazoleFluorophore

Individual steps of the Mizoroki-Heck reaction and intrinsic reactivity of intermediate organopalladium complexes studied in the gas phase

Iron containing anti-tumoral agents: unexpected apoptosis-inducing activity of a ferrocene amino acid derivative.

Iron-containing nucleoside analogues with pronounced apoptosis-inducing activity.

Lipophilic prodrugs of a triazole-containing colchicine analogue in liposomes: biological effects on human tumor cells

Low-Pressure Cobalt-Catalyzed Enantioselective Hydrovinylation of Vinylarenes

Methyl Fumarate-Derived Iron Carbonyl Complexes (FumET-CORMs) as Powerful Anti-inflammatory Agents

Microwave-assisted amination of a chloropurine derivative in the synthesis of acyclic nucleoside analogues.

Molecular Oxygen as a Redox Catalyst in Intramolecular Photocycloadditions of Coumarins

N-Capping of primary amines with 2-acyl-benzaldehydes to give isoindolinones

New Colchicine-Derived Triazoles and Their Influence on Cytotoxicity and Microtubule Morphology.

New caspase-independent but ROS-dependent apoptosis pathways are targeted in melanoma cells by an iron-containing cytosine analogue.

New modular manganese(I) tricarbonyl complexes as PhotoCORMs: in vitro detection of photoinduced carbon monoxide release using COP-1 as a fluorogenic switch-on probe

Nucleophile- or light-induced synthesis of 3-substituted phthalides from 2-formylarylketones

Nucleoside analogues with a 1,3-diene-Fe(CO)3 substructure: stereoselective synthesis, configurational assignment, and apoptosis-inducing activity.

On the Antibiotic and Antifungal Activity of Pestalone, Pestalachloride A, and Structurally Related Compounds

Organometallic nucleosides induce non-classical leukemic cell death that is mitochondrial-ROS dependent and facilitated by TCL1-oncogene burden

Palladium-catalyzed cyanomethylation of aryl halides through domino Suzuki coupling-isoxazole fragmentation

Paraoxonase-1 is a major determinant of clopidogrel efficacy

Pd-Catalyzed Asymmetric N-Allylation of Amino Acid Esters with Exceptional Levels of Catalyst Control: Stereo-Divergent Synthesis of ProM-15 and Related Bicyclic Dipeptide Mimetics

Pd-catalyzed enantioselective allylic substitution: new strategic options for the total synthesis of natural products

Potassium (1-methoxy-carbonyl-2-methyl-prop-2-en-2-yl-idene)azinate.

Prevention of colitis by controlled oral drug delivery of carbon monoxide

Stereoselective syntheses of the 2-Isopropenyl-2,3-dihydrobenzofuran nucleus: potential chiral building blocks for the syntheses of tremetone, hydroxytremetone, and rotenone.

Studies toward the total synthesis of mumbaistatin, a highly potent glucose-6-phosphate translocase inhibitor. Synthesis of a mumbaistatin analogue.

Synthesis and biological evaluation of furanoallocolchicinoids.

Synthesis of B-ring-modified steroids through BF3-promoted rearrangement/substitution of 6β-hydroxy-5,19-cyclosteroids

Synthesis of the 8,19-Epoxysteroid Eurysterol A

Synthetic Indolactam V Analogues as Inhibitors of PAR2-Induced Calcium Mobilization in Triple-Negative Breast Cancer Cells

Tandem Hydroalumination/Cu-Catalyzed Asymmetric Vinyl Metalation as a New Access to Enantioenriched Vinylcyclopropane Derivatives.

Total Synthesis of Indole‐Derived Allocolchicine Analogues Exhibiting Strong Apoptosis‐Inducing Activity ⬇️

Total Synthesis of the Antiviral Natural Product Houttuynoid B

Total Synthesis of α-Tocopherol through Enantioselective Iridium-Catalyzed Fragmentation of a Spiro-Cyclobutanol Intermediate

Total syntheses of colchicine in comparison: a journey through 50 years of synthetic organic chemistry.

Total synthesis of (R,R,R)-α-tocopherol through asymmetric Cu-catalyzed 1,4-addition

Total synthesis of cyclo-mumbaistatin analogues through anionic homo-Fries rearrangement.

Total synthesis of the marine antibiotic pestalone and its surprisingly facile conversion into pestalalactone and pestalachloride A

Triple-Helix-Stabilizing Effects in Collagen Model Peptides Containing PPII-Helix-Preorganized Diproline Modules

Unexpected endo selectivity of conjugate nucleophilic addition to an arene-Cr(CO)3 complex: enantioselective synthesis of the diterpene 11-epi-helioporin B

trans-1,2-Bis(3,5-dimethoxy-phen-yl)ethene.

trans-Ethylenedi-p-phenylene diacetate ⬇️