List of works - Michael F. Koehler

A new synthetic approach to the C ring of known as well as novel bryostatin analogues

scientific article published on 01 November 2003

Albumin affinity tags increase peptide half-life in vivo.

scientific article

An integrated suite of modeling tools that empower scientists in structure- and property-based drug design.

scientific article

Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres

scientific article

Design and Development of a Series of Potent and Selective Type II Inhibitors of CDK8.

scientific article published on 5 April 2016

Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells

scientific article published on 06 January 2016

Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349.

scientific article

Optimized arylomycins are a new class of Gram-negative antibiotics

scientific article published in Nature

Phosphate ester serum albumin affinity tags greatly improve peptide half-life in vivo

scientific article published on 01 May 2003

Potent, selective, and orally bioavailable inhibitors of mammalian target of rapamycin (mTOR) kinase based on a quaternary substituted dihydrofuropyrimidine.

scientific article published on 15 April 2011

Potent, selective, and orally bioavailable inhibitors of the mammalian target of rapamycin kinase domain exhibiting single agent antiproliferative activity.

scientific article published on 12 December 2012

Pyrimidoaminotropanes as potent, selective, and efficacious small molecule kinase inhibitors of the mammalian target of rapamycin (mTOR).

scientific article

Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity

scientific article

Structural basis for dual-mode inhibition of the ABC transporter MsbA

scientific article published in Nature

Structure-Guided Rescaffolding of Selective Antagonists of BCL-X L

scientific article

The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1 ⬇️

scientific article published on June 9, 1998

The rational design of potential chemotherapeutic agents: synthesis of bryostatin analogues.

scientific article

List of works by Michael F. Koehler

A new synthetic approach to the C ring of known as well as novel bryostatin analogues

Albumin affinity tags increase peptide half-life in vivo.

An integrated suite of modeling tools that empower scientists in structure- and property-based drug design.

Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres

Design and Development of a Series of Potent and Selective Type II Inhibitors of CDK8.

Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells

Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349.

Optimized arylomycins are a new class of Gram-negative antibiotics

Phosphate ester serum albumin affinity tags greatly improve peptide half-life in vivo

Potent, selective, and orally bioavailable inhibitors of mammalian target of rapamycin (mTOR) kinase based on a quaternary substituted dihydrofuropyrimidine.

Potent, selective, and orally bioavailable inhibitors of the mammalian target of rapamycin kinase domain exhibiting single agent antiproliferative activity.

Pyrimidoaminotropanes as potent, selective, and efficacious small molecule kinase inhibitors of the mammalian target of rapamycin (mTOR).

Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity

Structural basis for dual-mode inhibition of the ABC transporter MsbA

Structure-Guided Rescaffolding of Selective Antagonists of BCL-X L

The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1 ⬇️

The rational design of potential chemotherapeutic agents: synthesis of bryostatin analogues.