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List of works by Jeffrey Keller

4-hydroxynonenal increases neuronal susceptibility to oxidative stress

scientific article published on 01 December 1999

4-hydroxynonenal, a lipid peroxidation product, impairs glutamate transport in cortical astrocytes.

scientific article published in February 1998

A Combination of Essential Fatty Acids, Panax Ginseng Extract, and Green Tea Catechins Modifies Brain fMRI Signals in Healthy Older Adults

scientific article published on 01 January 2018

A ketogenic diet improves motor performance but does not affect β-amyloid levels in a mouse model of Alzheimer's disease.

scientific article published on 12 February 2013

A longitudinal study on dual-tasking effects on gait: cognitive change predicts gait variance in the elderly

scientific article

Adipose-specific ablation of Nrf2 transiently delayed high-fat diet-induced obesity by altering glucose, lipid and energy metabolism of male mice

scientific article published on 15 December 2016

Aging and dietary restriction effects on ubiquitination, sumoylation, and the proteasome in the heart.

scientific article published on 30 April 2008

Aging is associated with hypoxia and oxidative stress in adipose tissue: implications for adipose function.

scientific article published on 17 May 2011

Alpha-synuclein alters proteasome function, protein synthesis, and stationary phase viability.

scientific article

Amino acid analog toxicity in primary rat neuronal and astrocyte cultures: implications for protein misfolding and TDP-43 regulation

scientific journal article

Amyloid beta-peptide effects on synaptosomes from apolipoprotein E-deficient mice.

scientific article published on April 2000

Analysis of Werner's expression within the brain and primary neuronal culture

scientific journal article

Analysis of gene expression in neural cells subject to chronic proteasome inhibition.

scientific article published on February 2004

Antiinflammatory effects of estrogen on microglial activation

scientific article published on 01 October 2000

Antioxidants and antioxidant treatment in disease

scientific article published on 01 May 2012

Apolipoprotein E Genotype Linked to Spatial Gait Characteristics: Predictors of Cognitive Dual Task Gait Change.

scientific article

Assessment of cognition, physical performance, and gait in the context of mild cognitive impairment and dementia

scientific article published on 01 January 2012

Astrocytes: regulation of brain homeostasis via apolipoprotein E.

scientific article

Autophagy, proteasomes, lipofuscin, and oxidative stress in the aging brain.

scientific article published in December 2004

Beta-amyloid mediated nitration of manganese superoxide dismutase: implication for oxidative stress in a APPNLH/NLH X PS-1P264L/P264L double knock-in mouse model of Alzheimer's disease.

scientific article

Brain injury caused by HIV protease inhibitors: role of lipodystrophy and insulin resistance.

scientific article

Cell-specific actions of HIV-Tat and morphine on opioid receptor expression in glia.

scientific article published on July 2008

Characterization of chronic low-level proteasome inhibition on neural homeostasis.

scientific article published in July 2003

Chronic exercise modulates RAS components and improves balance between pro- and anti-inflammatory cytokines in the brain of SHR

scientific article published on 29 November 2011

Cognitive impairment following high fat diet consumption is associated with brain inflammation.

scientific article

Cognitive impairment in humanized APP×PS1 mice is linked to Aβ(1-42) and NOX activation.

scientific article published on 28 July 2011

Comparison of Male and Female Patients in Louisiana Medical Marijuana Dispensaries

scientific article published on 15 June 2020

Comparison of older adults' steps per day using NL-1000 pedometer and two GT3X+ accelerometer filters.

scientific article

Comparison of rat liver and brain proteasomes for oxidative stress-induced inactivation: Influence of ageing and dietary restriction

scientific article published on January 2009

Cryopreservation of rat cortical synaptosomes and analysis of glucose and glutamate transporter activities, and mitochondrial function ⬇️

scientific article published on September 1, 1998

Cyclic nucleotides attenuate lipid peroxidation-mediated neuron toxicity

scientific article published on 01 November 1998

Cytochrome c release and caspase activation after traumatic brain injury.

scientific article published in September 2002

Decreased RNA, and increased RNA oxidation, in ribosomes from early Alzheimer's disease.

scientific article

Designer adiponectin receptor agonist stabilizes metabolic function and prevents brain injury caused by HIV protease inhibitors

scientific article

Development of diet-induced insulin resistance in adult Drosophila melanogaster.

scientific article published on 20 April 2012

Dietary Plant Lectins Appear to Be Transported from the Gut to Gain Access to and Alter Dopaminergic Neurons of Caenorhabditis elegans, a Potential Etiology of Parkinson's Disease.

scientific article published on 7 March 2016

Dietary and donepezil modulation of mTOR signaling and neuroinflammation in the brain.

scientific article

Dietary resistant starch improves selected brain and behavioral functions in adult and aged rodents ⬇️

scientific article published on July 1, 2013

Differences in amyloid-β clearance across mouse and human blood-brain barrier models: kinetic analysis and mechanistic modeling.

scientific article published on 24 January 2014

Dopamine induces proteasome inhibition in neural PC12 cell line.

scientific article

Effects of Ghrelin on the Proteolytic Pathways of Alzheimer's Disease Neuronal Cells.

scientific article

Effects of aging and dietary restriction on ubiquitination, sumoylation, and the proteasome in the spleen

scientific article

Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: contributions of maternal diet

scientific journal article

Effects of short-term Western diet on cerebral oxidative stress and diabetes related factors in APP x PS1 knock-in mice.

scientific article

Elevated adiponectin prevents HIV protease inhibitor toxicity and preserves cerebrovascular homeostasis in mice.

scientific article

Elevated levels of 3-nitrotyrosine in brain from subjects with amnestic mild cognitive impairment: implications for the role of nitration in the progression of Alzheimer's disease.

scientific article published on 7 March 2007

Estrogen and brain inflammation: effects on microglial expression of MHC, costimulatory molecules and cytokines.

scientific article published on April 2005

Evaluation of rage isoforms, ligands, and signaling in the brain.

scientific article

Evidence for Synaptic Apoptosis ⬇️

scientific article published on September 1, 1998

Evidence of increased oxidative damage in subjects with mild cognitive impairment.

scientific article

Examining Relationships between Multiple Self-Reported Sleep Measures and Gait Domains in Cognitively Healthy Older Adults

scientific article published on 09 May 2019

Extra-virgin olive oil attenuates amyloid-β and tau pathologies in the brains of TgSwDI mice

scientific article

Feasibility, reliability, and validity of a smartphone based application for the assessment of cognitive function in the elderly.

scientific article

HIV-Tat elicits microglial glutamate release: role of NAPDH oxidase and the cystine-glutamate antiporter.

scientific article published on 19 September 2010

High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling

scientific article

High-Throughput Screening for Identification of Blood-Brain Barrier Integrity Enhancers: A Drug Repurposing Opportunity to Rectify Vascular Amyloid Toxicity.

scientific article

Human cerebral neuropathology of Type 2 diabetes mellitus

scientific article

I'd Do Anything for Research, But I Won't Do That: Interest in Pharmacological Interventions in Older Adults Enrolled in a Longitudinal Aging Study.

scientific article

Impaired proteasome function in Alzheimer's disease

scientific article published on 01 July 2000

Increased sensitivity to mitochondrial toxin-induced apoptosis in neural cells expressing mutant presenilin-1 is linked to perturbed calcium homeostasis and enhanced oxyradical production.

scientific article published in June 1998

Intersection between metabolic dysfunction, high fat diet consumption, and brain aging.

scientific article

Intrinsic differences in brain and spinal cord mitochondria: Implication for therapeutic interventions.

scientific article

LMP2 knock-out mice have reduced proteasome activities and increased levels of oxidatively damaged proteins.

scientific article published in January 2006

Launch of BBA Clinical: Translating molecular insights to clinical research.

scientific article published on 7 December 2013

Leptin regulates amyloid β production via the γ-secretase complex ⬇️

scientific article published on December 26, 2012

Lessons in the study of Alzheimer's disease: a tribute to Dr. William R. Markesbery.

scientific article published on 17 July 2010

Longitudinal assessment of neuropsychological and temporal/spatial gait characteristics of elderly fallers: taking it all in stride

scientific article

Lysophosphatidic acid and apoptosis of nerve growth factor-differentiated PC12 cells

scientific article published on 01 September 1998

Lysophosphatidic acid induction of neuronal apoptosis and necrosis

scientific article published on 01 April 2000

Memory for names test provides a useful confrontational naming task for aging and continuum of dementia.

scientific article published on January 2011

Metabolic and neurologic consequences of chronic lopinavir/ritonavir administration to C57BL/6 mice ⬇️

scientific article published on October 21, 2010

Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction.

scientific article published in January 1998

Mixed oligomers and monomeric amyloid-β disrupts endothelial cells integrity and reduces monomeric amyloid-β transport across hCMEC/D3 cell line as an in vitro blood-brain barrier model.

scientific article

Modulation of apolipoprotein E and interleukin-1beta in the aging liver.

scientific article

Morphine and HIV-Tat increase microglial-free radical production and oxidative stress: possible role in cytokine regulation.

scientific article published on 19 November 2008

Multiple Self-Reported Sleep Measures Are Differentially Associated With Cognitive Performance in Community-Dwelling Nondemented Elderly.

scientific article

Mutant Amyloid Precursor Protein Differentially Alters Adipose Biology under Obesogenic and Non-Obesogenic Conditions ⬇️

scientific article published on August 17, 2012

NADPH oxidase drives cytokine and neurotoxin release from microglia and macrophages in response to HIV-Tat.

scientific article published on February 2009

NOX activity in brain aging: exacerbation by high fat diet.

scientific article

NOX2 deficiency attenuates markers of adiposopathy and brain injury induced by high-fat diet ⬇️

scientific article published on December 11, 2012

Natural polyphenols as proteasome modulators and their role as anti-cancer compounds.

scientific article

Neuron Specific Toxicity of Oligomeric Amyloid-β: Role for JUN-Kinase and Oxidative Stress ⬇️

scientific article published on January 1, 2010

Obesity and vulnerability of the CNS.

scientific article published on 17 October 2008

Obesity increases cerebrocortical reactive oxygen species and impairs brainfunction ⬇️

scientific article published on October 29, 2012

Oleocanthal enhances amyloid-β clearance from the brains of TgSwDI mice and in vitro across a human blood-brain barrier model

scientific article

Opposing actions of native and oxidized lipoprotein on motor neuron-like cells.

scientific article published on May 1999

Oxidative inactivation of the proteasome in Alzheimer's disease.

scientific article

Oxidative stress alters neuronal RNA- and protein-synthesis: Implications for neural viability.

scientific article published in August 2007

Oxidative stress and cerebral endothelial cells: Regulation of the blood–brain-barrier and antioxidant based interventions ⬇️

scientific article published on December 20, 2011

Oxidative stress, neurodegeneration, and the balance of protein degradation and protein synthesis ⬇️

scientific article published on September 19, 2012

Oxidative stress-associated impairment of proteasome activity during ischemia-reperfusion injury

scientific article published on 01 October 2000

Oxidized high-density lipoprotein induces neuron death

scientific article published on 01 February 2000

Pedometer-assessed steps per day as a predictor of cognitive performance in older adults

scientific article published on 06 August 2018

Pilot feasibility and safety study examining the effect of medium chain triglyceride supplementation in subjects with mild cognitive impairment: A randomized controlled trial

scientific article

Pittsburgh compound B and the postmortem diagnosis of Alzheimer disease.

scientific article

Polyglutamine expansion, protein aggregation, proteasome activity, and neural survival.

scientific article published on 8 January 2002

Possible involvement of proteasome inhibition in aging: implications for oxidative stress.

scientific article

Postmortem Pittsburgh Compound B (PiB) binding increases with Alzheimer's disease progression.

scientific article published on January 2012

Preface for the special issue of imaging brain aging and neurodegenerative disease.

scientific article published on 9 January 2012

Preliminary comparison of clinical and free-living measures of stepping cadence in older adults

scientific article published on 03 December 2012

Prolonged diet induced obesity has minimal effects towards brain pathology in mouse model of cerebral amyloid angiopathy: implications for studying obesity-brain interactions in mice.

scientific article

Proteasome alterations during adipose differentiation and aging: links to impaired adipocyte differentiation and development of oxidative stress ⬇️

scientific article published on August 10, 2011

Proteasome inhibition in oxidative stress neurotoxicity: implications for heat shock proteins.

scientific article published on May 2001

Proteasome inhibition increases DNA and RNA oxidation in astrocyte and neuron cultures.

scientific article published in December 2004

Proteasome inhibition induces reversible impairments in protein synthesis.

scientific article published in June 2006

Proteasome or calpain inhibition does not alter cellular tau levels in neuroblastoma cells or primary neurons.

scientific article

Proteasome synthesis and assembly are required for survival during stationary phase.

scientific article

Protective effect of Pycnogenol in human neuroblastoma SH-SY5Y cells following acrolein-induced cytotoxicity

scientific article

Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients

scientific article published on 01 November 1998

Protein oxidation and cellular homeostasis: Emphasis on metabolism.

scientific article published on 30 August 2006

RNA in brain disease: no longer just "the messenger in the middle".

scientific article published on June 2007

Rationale and methods for a multicenter clinical trial assessing exercise and intensive vascular risk reduction in preventing dementia (rrAD Study)

scientific article published on 01 March 2019

Relationship Between Cognitive Domains, Physical Performance, and Gait in Elderly and Demented Subjects ⬇️

scientific article published on January 1, 2012

Reliability and Validity of a Novel Internet-Based Battery to Assess Mood and Cognitive Function in the Elderly.

scientific article published on 31 August 2016

Ribosome dysfunction is an early event in Alzheimer's disease.

scientific article

Role of P-glycoprotein in mediating rivastigmine effect on amyloid-β brain load and related pathology in Alzheimer's disease mouse model

scientific article published on 15 January 2016

Role of physiological levels of 4-hydroxynonenal on adipocyte biology: implications for obesity and metabolic syndrome ⬇️

scientific article published on October 16, 2012

Selective vulnerability of neurons to acute toxicity after proteasome inhibitor treatment: Implications for oxidative stress and insolubility of newly synthesized proteins ⬇️

scientific article published on November 1, 2010

Steps per day, peak cadence, body mass index, and age in community-dwelling older adults

scientific article published on 01 May 2013

Synaptic transport of human immunodeficiency virus-Tat protein causes neurotoxicity and gliosis in rat brain.

scientific article published in September 2003

The Complex Interactions Between Obesity, Metabolism and the Brain

scientific article published on 24 May 2019

The db mutation improves memory in younger mice in a model of Alzheimer's disease

scientific article published on 26 April 2019

The fine-tuning of proteolytic pathways in Alzheimer's disease

scientific article published on 27 April 2016

The many nuances of oxidative stress and proteolysis

scientific article published on 01 January 2006

The stationary phase model of aging in yeast for the study of oxidative stress and age-related neurodegeneration.

scientific article

Truncated apolipoprotein E (ApoE) causes increased intracellular calcium and may mediate ApoE neurotoxicity.

scientific article

Understanding heterogeneity in older adults: Latent growth curve modeling of cognitive functioning.

scientific article

Vulnerability of synaptosomes from apoE knock-out mice to structural and oxidative modifications induced by A beta(1-40): implications for Alzheimer's disease.

scientific article published in February 2001

Wild type and mutant amyloid precursor proteins influence downstream effects of proteasome and autophagy inhibition.

scientific article published on 8 November 2013

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