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List of works by Alex Domling

1,3,4-Oxadiazoles by Ugi-Tetrazole and Huisgen Reaction

scientific article published on 03 September 2019

1,4,5-Trisubstituted Imidazole-Based p53-MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers.

scientific article

1,4-Thienodiazepine-2,5-diones via MCR (I): synthesis, virtual space and p53-Mdm2 activity.

scientific article published on 18 May 2010

1,4-Thienodiazepine-2,5-diones via MCR (II): scaffold hopping by Gewald and Ugi-deprotection-cyclization strategy

scientific article

2,30-Bis(10H-indole) heterocycles: New p53/MDM2/MDMX antagonists

scientific article

2-Nitrobenzyl Isocyanide as a Universal Convertible Isocyanide.

scientific article published on 31 March 2017

A Systematic Protein Refolding Screen Method using the DGR Approach Reveals that Time and Secondary TSA are Essential Variables

scientific article published on 24 August 2017

A Unique Mdm2-Binding Mode of the 3-Pyrrolin-2-one- and 2-Furanone-Based Antagonists of the p53-Mdm2 Interaction

scientific article

A novel method to highly versatile monomeric PNA building blocks by multi component reactions

scientific article published on 01 October 1999

A novel three-component butenolide synthesis

scientific article published on 01 September 2001

A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018)

scientific article published on 10 September 2018

A universal isocyanide for diverse heterocycle syntheses

scientific article published on 29 October 2014

Ammonia-Promoted One-Pot Tetrazolopiperidinone Synthesis by Ugi Reaction

scientific article

An Efficient Passerini Tetrazole Reaction (PT-3CR).

scientific article

AnchorQuery: Rapid online virtual screening for small-molecule protein-protein interaction inhibitors.

scientific article

Artificial Macrocycles

scientific article published on 07 May 2018

Artificial Macrocycles as IL-17A/IL-17RA Antagonists

scientific article published on 25 October 2017

Artificial Macrocycles as Potent p53-MDM2 Inhibitors.

scientific article published on 20 September 2017

Artificial Macrocycles by Ugi Reaction and Passerini Ring Closure.

scientific article published on 6 September 2016

Automated, Accelerated Nanoscale Synthesis of Iminopyrrolidines

scientific article published on 11 February 2020

Benchmark of Generic Shapes for Macrocycles

scientific article published on 03 December 2020

Benzimidazole-2-one: a novel anchoring principle for antagonizing p53-Mdm2

scientific article published on 20 June 2012

Bioactive Macrocyclic Inhibitors of the PD-1/PD-L1 Immune Checkpoint.

scientific article

Chemistry and biology of multicomponent reactions.

scientific article published on 22 March 2012

Cleavable β-Cyanoethyl Isocyanide in the Ugi Tetrazole Reaction

scientific article published on 09 September 2016

Concise Synthesis of Macrocycles by Multicomponent Reactions

scientific article published on 10 January 2018

Concise Synthesis of Tetrazole Macrocycle

scientific article published on 13 September 2017

Concise Synthesis of Tetrazole-keto-piperazines by Two Consecutive Ugi Reactions.

scientific article published on 17 November 2014

Correction to Pd-Catalyzed de Novo Assembly of Diversely Substituted Indole-Fused Polyheterocycles

scientific article published on 10 June 2020

Crystal structure of truncated human coatomer protein complex subunit ζ1 (Copζ1).

scientific article published in January 2017

Cyanoacetamide MCR (III): three-component Gewald reactions revisited.

scientific article published on January 2010

Cyanoacetamides (IV): versatile one-pot route to 2-quinoline-3-carboxamides.

scientific article published on 18 April 2012

Cysteine Isocyanide in Multicomponent Reaction: Synthesis of Peptido-Mimetic 1,3-Azoles.

scientific article published on 17 August 2017

De Novo Assembly of Highly Substituted Morpholines and Piperazines

scientific article published on 19 January 2017

Design and modular parallel synthesis of a MCR derived alpha-helix mimetic protein-protein interaction inhibitor scaffold.

scientific article published on 19 January 2006

Design of a novel thiophene inhibitor of 15-lipoxygenase-1 with both anti-inflammatory and neuroprotective properties

scientific article published on 09 July 2016

Desosamine in multicomponent reactions

scientific article published on 27 October 2006

Diastereoselective One Pot Five-Component Reaction toward 4-(Tetrazole)-1,3-Oxazinanes.

scientific article published on 26 October 2017

Discovery of a Potent Allosteric Kinase Modulator by Combining Computational and Synthetic Methods ⬇️

scientific article published on 4 September 2015

Discovery of chromenes as inhibitors of macrophage migration inhibitory factor.

scientific article published on 24 December 2017

Discovery of highly potent p53-MDM2 antagonists and structural basis for anti-acute myeloid leukemia activities.

scientific article published on 17 January 2014

Diverse Isoquinoline Scaffolds by Ugi/Pomeranz-Fritsch and Ugi/Schlittler-Müller Reactions

scientific article published on 29 April 2019

Efficient C2 functionalisation of 2H-2-imidazolines.

scientific article published on 8 November 2007

Efficient and diverse synthesis of indole derivatives.

scientific article published in September 2009

Efficient assembly of iminodicarboxamides by a "truly" four-component reaction.

scientific article published on 11 September 2012

Efficient isocyanide-less isocyanide-based multicomponent reactions

scientific article

Efficient multicomponent reaction synthesis of the schistosomiasis drug praziquantel.

scientific article published on November 2010

Efficient synthesis of arrays of amino acid derived Ugi products with subsequent amidation.

scientific article published in May 2009

Focusing on shared subpockets - new developments in fragment-based drug discovery

scientific article

Fourfold symmetric MCR's via the tetraisocyanide 1,3-diisocyano-2,2-bis(isocyanomethyl)propane

scientific article published on 12 August 2020

Fragment-based library generation for the discovery of a peptidomimetic p53-Mdm4 inhibitor

scientific article

Gd-TEMDO: Design, Synthesis, and MRI Application.

scientific article published on 15 March 2016

Guide for Selection of Relevant Cell Lines During the Evaluation of New Anti-Cancer Compounds.

scientific article

Highly substituted pyrrolidinones and pyridones by 4-CR/2-CR sequence

scientific article published on 01 January 2004

Hot, hotter, hottest

scientific article

How To Design a Successful p53-MDM2/X Interaction Inhibitor: A Thorough Overview Based on Crystal Structures.

scientific article published on 16 December 2015

Identification of Hsp70 modulators through modeling of the substrate binding domain.

scientific article published on 20 April 2009

Identification of a non-competitive inhibitor of Plasmodium falciparum aspartate transcarbamoylase.

scientific article published on 21 February 2018

Immune Checkpoint PD-1/PD-L1: Is There Life Beyond Antibodies?

scientific article published on 27 November 2017

In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of pyrazole-based small molecule inhibitors of Mdm2/4-p53 interaction

scientific article published on 07 June 2015

Inhibitors of programmed cell death 1 (PD-1): a patent review (2010-2015).

scientific article published on July 2016

Isocyanide Multicomponent Reactions on Solid-Phase-Coupled DNA Oligonucleotides for Encoded Library Synthesis

scientific article published on 29 August 2019

Isocyanide based multi component reactions in combinatorial chemistry.

scientific article

Isocyanides as Influenza A Virus Subtype H5N1 Wild-Type M2 Channel Inhibitors

scientific article published on 7 September 2015

Isolation and molecular characterization of novel glucarpidases: Enzymes to improve the antibody directed enzyme pro-drug therapy for cancer treatment.

scientific article published on 26 April 2018

Isosteric exchange of the acylsulfonamide moiety in Abbott's Bcl-XL protein interaction antagonist.

scientific article

Library-to-Library Synthesis of Highly Substituted α-Aminomethyl Tetrazoles via Ugi Reaction.

scientific article

MCR synthesis of a tetracyclic tetrazole scaffold.

scientific article published on 20 December 2014

MCR synthesis of praziquantel derivatives

scientific article published on 30 January 2012

Macrocycles: MCR synthesis and applications in drug discovery

scientific article published on 12 July 2018

Massive parallel catalyst screening: toward asymmetric MCRs

scientific article published on 01 October 2003

Mdm2 and MdmX inhibitors for the treatment of cancer: a patent review (2011-present).

scientific article published on 04 February 2013

Modern Multicomponent Reactions for better Drug Syntheses**

scientific article

Molecular Target Validation of Aspartate Transcarbamoylase from Plasmodium falciparum by Torin 2

scientific article published on 12 March 2020

Multicomponent Peptide Stapling as a Diversity-Driven Tool for the Development of Inhibitors of Protein-Protein Interactions

scientific article published on 06 February 2020

Multicomponent Reaction Based Synthesis of 1-Tetrazolylimidazo[1,5- a]pyridines

scientific article published on 26 June 2018

Multicomponent Reactions with Isocyanides.

scientific article

Multicomponent Reactions, Union of MCRs and Beyond.

scientific article published on 11 September 2015

Multicomponent synthesis of diverse 1,4-benzodiazepine scaffolds.

scientific article published on 16 November 2012

N-Hydroxyimide Ugi Reaction toward α-Hydrazino Amides.

scientific article published on 21 February 2017

New MCRs: the first 4-component reaction leading to 2,4-disubstituted thiazoles

scientific article published on 01 January 2003

Novel anti-tuberculosis agents from MCR libraries.

scientific article

Novel nonpeptidic inhibitors of HIV-1 protease obtained via a new multicomponent chemistry strategy.

scientific article

Oligomeric protein interference validates druggability of aspartate interconversion in Plasmodium falciparum

scientific article published on 28 February 2019

One-pot synthesis of 2-amino-indole-3-carboxamide and analogous.

scientific article published on 17 December 2010

One-pot synthesis of highly functionalized seleno amino acid derivatives

scientific article published on 01 September 2009

Optimized Inhibitors of MDM2 via an Attempted Protein-Templated Reductive Amination

scientific article published on 12 December 2019

Parallel synthesis of arrays of amino-acid-derived isocyanoamides useful as starting materials in IMCR

scientific article published on 01 November 2006

Pd-Catalyzed de Novo Assembly of Diversely Substituted Indole-Fused Polyheterocycles

scientific article published on 03 September 2019

Photoactivation provides a mechanistic explanation for pan-assay interference behaviour of 2-aminopyrroles in lipoxygenase inhibition

scientific article published on 24 July 2017

Polycyclic compounds by Ugi-Pictet-Spengler sequence.

scientific article published on 29 December 2010

Praziquantel and schistosomiasis.

scientific article published on September 2010

Programmed death-1: therapeutic success after more than 100 years of cancer immunotherapy.

scientific article

Rapid Discovery of Aspartyl Protease Inhibitors Using an Anchoring Approach

scientific article published on 18 March 2020

Rapid approach to complex boronic acids

scientific article published on 05 July 2019

Rational Development of a Potent 15-Lipoxygenase-1 Inhibitor with in Vitro and ex Vivo Anti-inflammatory Properties

scientific article published on 2 September 2015

Rational design and synthesis of 1,5-disubstituted tetrazoles as potent inhibitors of the MDM2-p53 interaction.

scientific article published on 16 November 2016

Recent advances in isocyanide-based multicomponent chemistry.

scientific article

Robust NMR screening for lead compounds using tryptophan-containing proteins.

scientific article published in June 2009

Robust generation of lead compounds for protein-protein interactions by computational and MCR chemistry: p53/Hdm2 antagonists.

scientific article published on July 2010

Scaffold hopping via ANCHOR.QUERY: β-lactams as potent p53-MDM2 antagonists†.

scientific article published on 15 March 2017

Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder.

scientific article published on 11 January 2011

Short and diverse route toward complex natural product-like macrocycles

scientific article published on 01 April 2003

Small molecular weight protein-protein interaction antagonists: an insurmountable challenge?

scientific article

Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1.

scientific article published on 14 June 2017

Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells.

scientific article published on 7 August 2017

Special issue on Mini-MCR issue and SCS-09--Second International Symposium on Combinatorial Sciences in Biology, Chemistry, Catalysts and Materials. Editorial

scientific article published on 01 February 2011

Structural Biology of the Immune Checkpoint Receptor PD-1 and Its Ligands PD-L1/PD-L2.

scientific article published in August 2017

Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1)

scientific article (publication date: 24 May 2016)

Structure of the Complex of Human Programmed Death 1, PD-1, and Its Ligand PD-L1.

scientific article published on 22 October 2015

Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery.

scientific article published on 15 March 2010

Sulfur-Switch Ugi Reaction for Macrocyclic Disulfide-Bridged Peptidomimetics.

scientific article published on 5 June 2017

Survivin is a therapeutic target in Merkel cell carcinoma.

scientific article

Synthesis and Enantiomeric Separation of a Novel Spiroketal Derivative: A Potent Human Telomerase Inhibitor with High in Vitro Anticancer Activity.

scientific article published on 3 September 2016

Synthesis of highly substituted imidazole Uracil containing molecules via Ugi-4CR and Passerini-3CR.

scientific article published on 19 February 2018

Tetrazoles via Multicomponent Reactions

scientific article published on 01 February 2019

The Catalytic Enantioselective Ugi Four-Component Reactions

scientific article published on 15 November 2018

The Gewald multicomponent reaction.

scientific article published on 27 February 2010

The Structure‐Based Design of Mdm2/Mdmx–p53 Inhibitors Gets Serious ⬇️

scientific article published on February 21, 2011

The p53-MDM2/MDMX axis - A chemotype perspective

scientific article published on January 2011

The relevance of Ki calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor.

scientific article published on 5 May 2017

Total synthesis of tubulysin U and V

scientific article published on 01 November 2006

Towards a facile and convenient synthesis of highly functionalized indole derivatives based on multi-component reactions.

scientific article published on March 2014

Towards erythropoietin mimicking small molecules.

scientific article

Transient Protein States in Designing Inhibitors of the MDM2-p53 Interaction

scientific article

Tricycles by a new Ugi variation and Pictet-Spengler reaction in one pot.

scientific article published on 6 May 2013

Triglyceride profiling in adipose tissues from obese insulin sensitive, insulin resistant and type 2 diabetes mellitus individuals.

scientific article

Tritylamine as an ammonia surrogate in the Ugi tetrazole synthesis.

scientific article

Tubulysin Synthesis Featuring Stereoselective Catalysis and Highly Convergent Multicomponent Assembly

scientific article published on 25 June 2020

Two Cycles with One Catch: Hydrazine in Ugi 4-CR and Its Postcyclizations.

scientific article

Two-Step Macrocycle Synthesis by Classical Ugi Reaction.

scientific article published on 12 January 2018

Two-Step Synthesis of Complex Artificial Macrocyclic Compounds

scientific article

Ugi 4-CR Synthesis of γ- and δ-Lactams providing new access to diverse enzyme interactions, a PDB analysis

scientific article published on July 2014

Ugi Multicomponent Reaction Based Synthesis of Medium-Sized Rings

scientific article published on 30 October 2017

Unconventional Passerini Reaction toward α-Aminoxy-amides

scientific article published in December 2016

Various cyclization scaffolds by a truly Ugi 4-CR.

scientific article published on 13 June 2013

Versatile Multicomponent Reaction Macrocycle Synthesis Using α-Isocyano-ω-carboxylic Acids

scientific article published on 6 October 2015

Versatile Protecting-Group Free Tetrazolomethane Amine Synthesis by Ugi Reaction

scientific article published on 22 February 2016

With unprotected amino acids to tetrazolo peptidomimetics.

scientific article published on 14 July 2017

α-Amino Acid-Isosteric α-Amino Tetrazoles.

scientific article published on 28 January 2016

β-Carbolinone Analogues from the Ugi Silver Mine

scientific article published on 17 April 2018

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