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List of works by Alex Domling

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Multicomponent Reactions with Isocyanides.

scientific article
Chemistry and biology of multicomponent reactions.

scientific article published on 22 March 2012
Structure of the Complex of Human Programmed Death 1, PD-1, and Its Ligand PD-L1.

scientific article published on 22 October 2015
Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery.

scientific article published on 15 March 2010
Survivin is a therapeutic target in Merkel cell carcinoma.

scientific article
Small molecular weight protein-protein interaction antagonists: an insurmountable challenge?

scientific article
The Structure‐Based Design of Mdm2/Mdmx–p53 Inhibitors Gets Serious

scientific article published on February 21, 2011
Recent advances in isocyanide-based multicomponent chemistry.

scientific article
Robust generation of lead compounds for protein-protein interactions by computational and MCR chemistry: p53/Hdm2 antagonists.

scientific article published on July 2010
Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1)

scientific article (publication date: 24 May 2016)
Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1.

scientific article published on 14 June 2017
Programmed Death‐1: Therapeutic Success after More than 100 Years of Cancer Immunotherapy

scientific article published on January 28, 2014
Transient Protein States in Designing Inhibitors of the MDM2-p53 Interaction

scientific article
1,4-Thienodiazepine-2,5-diones via MCR (I): synthesis, virtual space and p53-Mdm2 activity.

scientific article published on 18 May 2010
Structural Biology of the Immune Checkpoint Receptor PD-1 and Its Ligands PD-L1/PD-L2.

scientific article published in August 2017
Multicomponent Reactions, Union of MCRs and Beyond.

scientific article published on 11 September 2015
The p53-MDM2/MDMX axis – A chemotype perspective

scientific article published on January 1, 2011
Mdm2 and MdmX inhibitors for the treatment of cancer: a patent review (2011-present).

scientific article published on 04 February 2013
Efficient multicomponent reaction synthesis of the schistosomiasis drug praziquantel.

scientific article published on November 2010
Praziquantel and schistosomiasis.

scientific article published on September 2010
MCR synthesis of praziquantel derivatives

scientific article published on 30 January 2012
Efficient and diverse synthesis of indole derivatives.

scientific article published in September 2009
Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells.

scientific article published on 7 August 2017
Short and diverse route toward complex natural product-like macrocycles

scientific article published on 01 April 2003
Artificial Macrocycles by Ugi Reaction and Passerini Ring Closure.

scientific article published on 6 September 2016
Efficient assembly of iminodicarboxamides by a "truly" four-component reaction.

scientific article published on 11 September 2012
The Gewald multicomponent reaction

scientific article published on February 27, 2010
Bioactive Macrocyclic Inhibitors of the PD-1/PD-L1 Immune Checkpoint.

scientific article
Versatile Multicomponent Reaction Macrocycle Synthesis Using α-Isocyano-ω-carboxylic Acids

scientific article published on 6 October 2015
Rational Development of a Potent 15-Lipoxygenase-1 Inhibitor with in Vitro and ex Vivo Anti-inflammatory Properties

scientific article published on 2 September 2015
Discovery of Highly Potent p53-MDM2 Antagonists and Structural Basis for Anti-Acute Myeloid Leukemia Activities

scientific article published on January 17, 2014
Design and modular parallel synthesis of a MCR derived alpha-helix mimetic protein-protein interaction inhibitor scaffold.

scientific article published on 19 January 2006
Inhibitors of programmed cell death 1 (PD-1): a patent review (2010-2015).

scientific article published on July 2016
How To Design a Successful p53-MDM2/X Interaction Inhibitor: A Thorough Overview Based on Crystal Structures.

scientific article published on 16 December 2015
Polycyclic compounds by Ugi-Pictet-Spengler sequence.

scientific article published on 29 December 2010
Cyanoacetamide MCR (III): three-component Gewald reactions revisited.

scientific article published on January 2010
Tritylamine as an ammonia surrogate in the Ugi tetrazole synthesis.

scientific article
Rational design and synthesis of 1,5-disubstituted tetrazoles as potent inhibitors of the MDM2-p53 interaction.

scientific article published on 16 November 2016
Concise Synthesis of Tetrazole-keto-piperazines by Two Consecutive Ugi Reactions.

scientific article published on 17 November 2014
Total synthesis of tubulysin U and V

scientific article published on 01 November 2006
Modern multicomponent reactions for better drug syntheses

scientific article published on September 1, 2014
Robust NMR screening for lead compounds using tryptophan-containing proteins.

scientific article published in June 2009
Efficient isocyanide-less isocyanide-based multicomponent reactions

scientific article
Immune Checkpoint PD-1/PD-L1: Is There Life Beyond Antibodies?

scientific article published on 27 November 2017
Various cyclization scaffolds by a truly Ugi 4-CR.

scientific article published on 13 June 2013
Two-Step Synthesis of Complex Artificial Macrocyclic Compounds

scientific article
MCR synthesis of a tetracyclic tetrazole scaffold.

scientific article published on 20 December 2014
Efficient synthesis of arrays of amino acid derived Ugi products with subsequent amidation.

scientific article published in May 2009
Multicomponent synthesis of diverse 1,4-benzodiazepine scaffolds.

scientific article published on 16 November 2012
AnchorQuery: Rapid online virtual screening for small-molecule protein-protein interaction inhibitors.

scientific article

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