List of works - Xinmiao Fu

4,4'-Dianilino-1,1'-binaphthyl-5,5'-sulfonate, a novel molecule having chaperone-like activity.

scientific article

5-Methylindole Potentiates Aminoglycoside Against Gram-Positive Bacteria Including Staphylococcus aureus Persisters Under Hypoionic Conditions

scientific article published on 28 February 2020

A Supercomplex Spanning the Inner and Outer Membranes Mediates the Biogenesis of β-Barrel Outer Membrane Proteins in Bacteria.

scientific article

A high-throughput genetically directed protein crosslinking analysis reveals the physiological relevance of the ATP synthase "inserted" state

scientific article published on 31 October 2020

A novel mechanism for small heat shock proteins to function as molecular chaperones.

scientific article

A reciprocating motion-driven rotation mechanism for the ATP synthase.

scientific article published on 30 December 2015

A small heat shock protein enables Escherichia coli to grow at a lethal temperature of 50°C conceivably by maintaining cell envelope integrity.

scientific article

Abiotic regulation: a common way for proteins to modulate their functions.

scientific article

An oxidative fluctuation hypothesis of aging generated by imaging H₂O₂ levels in live Caenorhabditis elegans with altered lifespans.

scientific article published on 18 February 2015

Biogenesis, quality control, and structural dynamics of proteins as explored in living cells via site-directed photocrosslinking

scientific article published on 10 May 2019

Both PDI and PDIp can attack the native disulfide bonds in thermally-unfolded RNase and form stable disulfide-linked complexes ⬇️

scientific article published on January 14, 2011

Chaperone function and mechanism of small heat-shock proteins.

scientific article published on 20 January 2014

Chaperone-dependent mechanisms for acid resistance in enteric bacteria ⬇️

scientific article published on March 27, 2012

Chaperone-like activity of Mycobacterium tuberculosis Hsp16.3 does not require its intact (native) structures

scientific article published on 01 August 2005

Chaperone-like activity of beta-casein.

scientific article

Characterization of the estradiol-binding site structure of human pancreas-specific protein disulfide isomerase: indispensable role of the hydrogen bond between His278 and the estradiol 3-hydroxyl group

scientific article

Characterization of the estradiol-binding site structure of human protein disulfide isomerase (PDI)

scientific article

Chemical synthesis and biochemical characterization of a biotinylated derivative of 17beta-estradiol with a long side chain covalently attached to its C-7alpha position.

scientific article published on 22 June 2008

DegP functions as a critical protease for bacterial acid resistance

scientific article published on 24 August 2018

DegP primarily functions as a protease for the biogenesis of β-barrel outer membrane proteins in the Gram-negative bacterium Escherichia coli.

scientific article

Degp degrades a wide range of substrate proteins in Escherichia coli under stress conditions

scientific article published on 01 December 2019

Development of a general logistic model for disease risk prediction using multiple SNPs

scientific article published on 27 September 2019

Differential degradation for small heat shock proteins IbpA and IbpB is synchronized in Escherichia coli: implications for their functional cooperation in substrate refolding

scientific article

Disulfide bonds convert small heat shock protein Hsp16.3 from a chaperone to a non-chaperone: implications for the evolution of cysteine in molecular chaperones.

scientific article published in August 2003

Forecasting the Cumulative Number of COVID-19 Deaths in China: a Boltzmann Function-based Modeling Study

scientific article published on 02 April 2020

Global COVID-19 fatality analysis reveals Hubei-like countries potentially with severe outbreaks

scientific article published on 29 March 2020

Global analysis of daily new COVID-19 cases reveals many static-phase countries including US and UK potentially with unstoppable epidemics

scientific article published on 12 May 2020

Human pancreas-specific protein disulfide isomerase homolog (PDIp) is redox-regulated through formation of an inter-subunit disulfide bond.

scientific article

Human pancreas-specific protein disulfide-isomerase (PDIp) can function as a chaperone independently of its enzymatic activity by forming stable complexes with denatured substrate proteins.

scientific article published in July 2010

Hypoionic Shock Facilitates Aminoglycoside Killing of Both Nutrient Shift- and Starvation-Induced Bacterial Persister Cells by Rapidly Enhancing Aminoglycoside Uptake

scientific article published on 06 September 2019

Hypoionic shock treatment enables aminoglycosides antibiotics to eradicate bacterial persisters

scientific article

Identification of FkpA as a key quality control factor for the biogenesis of outer membrane proteins under heat shock conditions

scientific article

Identification of bis-ANS binding sites in Mycobacterium tuberculosis small heat shock protein Hsp16.3: evidences for a two-step substrate-binding mechanism.

scientific article published on 15 August 2006

In vivo substrate diversity and preference of small heat shock protein IbpB as revealed by using a genetically incorporated photo-cross-linker.

scientific article published on 17 September 2013

Little Risk of the COVID-19 Resurgence on Students in China (outside Hubei) Caused by School Reopening

scientific article published on 07 April 2020

Multilevel structural characteristics for the natural substrate proteins of bacterial small heat shock proteins.

scientific article published on 16 December 2013

Mycobacterium tuberculosis Hsp16.3 nonamers are assembled and re-assembled via trimer and hexamer intermediates

scientific article published on 01 February 2003

Negligible Risk of the COVID-19 Resurgence Caused by Work Resuming in China (outside Hubei): a Statistical Probability Study

scientific article published on 30 March 2020

Negligible risk of the COVID-19 resurgence caused by work resuming in China (outside Hubei): a statistical probability study

scientific article published on 27 March 2020

PDIp is a major intracellular oestrogen-storage protein that modulates tissue levels of oestrogen in the pancreas.

scientific article

Pancreas-specific protein disulfide isomerase has a cell type-specific expression in various mouse tissues and is absent in human pancreatic adenocarcinoma cells: implications for its functions.

scientific article published on June 2009

Periplasmic proteins of Escherichia coli are highly resistant to aggregation: reappraisal for roles of molecular chaperones in periplasm.

scientific article published in April 2004

Rapid Freezing Enables Aminoglycosides To Eradicate Bacterial Persisters via Enhancing Mechanosensitive Channel MscL-Mediated Antibiotic Uptake

scientific article published on 11 February 2020

Simulating and forecasting the cumulative confirmed cases of SARS-CoV-2 in china by Boltzmann function-based regression analyses

scientific article published on 26 February 2020

Small heat shock protein AgsA forms dynamic fibrils.

scientific article

Small heat shock protein Hsp16.3 modulates its chaperone activity by adjusting the rate of oligomeric dissociation.

scientific article published in October 2003

Small heat shock protein IbpB acts as a robust chaperone in living cells by hierarchically activating its multi-type substrate-binding residues.

scientific article published on 13 March 2013

Stepwise disassembly and apparent nonstepwise reassembly for the oligomeric RbsD protein.

scientific article

Subunit interactions as mediated by "non-interface" residues in living cells for multiple homo-oligomeric proteins

scientific article published on 11 March 2019

Temperature-dependent subunit exchange and chaperone-like activities of Hsp16.3, a small heat shock protein from Mycobacterium tuberculosis.

scientific article published in April 2004

The association of small heat shock protein Hsp16.3 with the plasma membrane of Mycobacterium tuberculosis: dissociation of oligomers is a prerequisite

scientific article published on 01 May 2005

Wuhan and Hubei COVID-19 mortality analysis reveals the critical role of timely supply of medical resources

scientific article (preprint)

Wuhan and Hubei COVID-19 mortality analysis reveals the critical role of timely supply of medical resources

scientific article published on 21 March 2020

List of works by Xinmiao Fu

4,4'-Dianilino-1,1'-binaphthyl-5,5'-sulfonate, a novel molecule having chaperone-like activity.

5-Methylindole Potentiates Aminoglycoside Against Gram-Positive Bacteria Including Staphylococcus aureus Persisters Under Hypoionic Conditions

A Supercomplex Spanning the Inner and Outer Membranes Mediates the Biogenesis of β-Barrel Outer Membrane Proteins in Bacteria.

A high-throughput genetically directed protein crosslinking analysis reveals the physiological relevance of the ATP synthase "inserted" state

A novel mechanism for small heat shock proteins to function as molecular chaperones.

A reciprocating motion-driven rotation mechanism for the ATP synthase.

A small heat shock protein enables Escherichia coli to grow at a lethal temperature of 50°C conceivably by maintaining cell envelope integrity.

Abiotic regulation: a common way for proteins to modulate their functions.

An oxidative fluctuation hypothesis of aging generated by imaging H₂O₂ levels in live Caenorhabditis elegans with altered lifespans.

Biogenesis, quality control, and structural dynamics of proteins as explored in living cells via site-directed photocrosslinking

Both PDI and PDIp can attack the native disulfide bonds in thermally-unfolded RNase and form stable disulfide-linked complexes ⬇️

Chaperone function and mechanism of small heat-shock proteins.

Chaperone-dependent mechanisms for acid resistance in enteric bacteria ⬇️

Chaperone-like activity of Mycobacterium tuberculosis Hsp16.3 does not require its intact (native) structures

Chaperone-like activity of beta-casein.

Characterization of the estradiol-binding site structure of human pancreas-specific protein disulfide isomerase: indispensable role of the hydrogen bond between His278 and the estradiol 3-hydroxyl group

Characterization of the estradiol-binding site structure of human protein disulfide isomerase (PDI)

Chemical synthesis and biochemical characterization of a biotinylated derivative of 17beta-estradiol with a long side chain covalently attached to its C-7alpha position.

DegP functions as a critical protease for bacterial acid resistance

DegP primarily functions as a protease for the biogenesis of β-barrel outer membrane proteins in the Gram-negative bacterium Escherichia coli.

Degp degrades a wide range of substrate proteins in Escherichia coli under stress conditions

Development of a general logistic model for disease risk prediction using multiple SNPs

Differential degradation for small heat shock proteins IbpA and IbpB is synchronized in Escherichia coli: implications for their functional cooperation in substrate refolding

Disulfide bonds convert small heat shock protein Hsp16.3 from a chaperone to a non-chaperone: implications for the evolution of cysteine in molecular chaperones.

Forecasting the Cumulative Number of COVID-19 Deaths in China: a Boltzmann Function-based Modeling Study

Global COVID-19 fatality analysis reveals Hubei-like countries potentially with severe outbreaks

Global analysis of daily new COVID-19 cases reveals many static-phase countries including US and UK potentially with unstoppable epidemics

Human pancreas-specific protein disulfide isomerase homolog (PDIp) is redox-regulated through formation of an inter-subunit disulfide bond.

Human pancreas-specific protein disulfide-isomerase (PDIp) can function as a chaperone independently of its enzymatic activity by forming stable complexes with denatured substrate proteins.

Hypoionic Shock Facilitates Aminoglycoside Killing of Both Nutrient Shift- and Starvation-Induced Bacterial Persister Cells by Rapidly Enhancing Aminoglycoside Uptake

Hypoionic shock treatment enables aminoglycosides antibiotics to eradicate bacterial persisters

Identification of FkpA as a key quality control factor for the biogenesis of outer membrane proteins under heat shock conditions

Identification of bis-ANS binding sites in Mycobacterium tuberculosis small heat shock protein Hsp16.3: evidences for a two-step substrate-binding mechanism.

In vivo substrate diversity and preference of small heat shock protein IbpB as revealed by using a genetically incorporated photo-cross-linker.

Little Risk of the COVID-19 Resurgence on Students in China (outside Hubei) Caused by School Reopening

Multilevel structural characteristics for the natural substrate proteins of bacterial small heat shock proteins.

Mycobacterium tuberculosis Hsp16.3 nonamers are assembled and re-assembled via trimer and hexamer intermediates

Negligible Risk of the COVID-19 Resurgence Caused by Work Resuming in China (outside Hubei): a Statistical Probability Study

Negligible risk of the COVID-19 resurgence caused by work resuming in China (outside Hubei): a statistical probability study

PDIp is a major intracellular oestrogen-storage protein that modulates tissue levels of oestrogen in the pancreas.

Pancreas-specific protein disulfide isomerase has a cell type-specific expression in various mouse tissues and is absent in human pancreatic adenocarcinoma cells: implications for its functions.

Periplasmic proteins of Escherichia coli are highly resistant to aggregation: reappraisal for roles of molecular chaperones in periplasm.

Rapid Freezing Enables Aminoglycosides To Eradicate Bacterial Persisters via Enhancing Mechanosensitive Channel MscL-Mediated Antibiotic Uptake

Simulating and forecasting the cumulative confirmed cases of SARS-CoV-2 in china by Boltzmann function-based regression analyses

Small heat shock protein AgsA forms dynamic fibrils.

Small heat shock protein Hsp16.3 modulates its chaperone activity by adjusting the rate of oligomeric dissociation.

Small heat shock protein IbpB acts as a robust chaperone in living cells by hierarchically activating its multi-type substrate-binding residues.

Stepwise disassembly and apparent nonstepwise reassembly for the oligomeric RbsD protein.

Subunit interactions as mediated by "non-interface" residues in living cells for multiple homo-oligomeric proteins

Temperature-dependent subunit exchange and chaperone-like activities of Hsp16.3, a small heat shock protein from Mycobacterium tuberculosis.

The association of small heat shock protein Hsp16.3 with the plasma membrane of Mycobacterium tuberculosis: dissociation of oligomers is a prerequisite

Wuhan and Hubei COVID-19 mortality analysis reveals the critical role of timely supply of medical resources

Wuhan and Hubei COVID-19 mortality analysis reveals the critical role of timely supply of medical resources