List of works - Isabelle Krimm

1D NMR WaterLOGSY as an efficient method for fragment-based lead discovery

scientific article published on 01 December 2019

1H, 13C and 15N backbone resonance assignments of the dimeric yeast peroxiredoxin YLR109w.

scientific article

1H, 13C and 15N resonance assignments of the C-terminal domain of human lamin A/C

scientific article published on 01 April 2002

2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 1. Identification of an Allosteric Binding Site

scientific article published on 18 February 2019

A coil-helix instead of a helix-coil motif can be induced in a chloroplast transit peptide from Chlamydomonas reinhardtii

scientific article published on 01 October 1999

Binding evaluation of fragment-based scaffolds for probing allosteric enzymes.

scientific article published on 24 January 2012

Biochemical characterization and nuclear magnetic resonance structure of novel alpha-conotoxins isolated from the venom of Conus consors

scientific article

Crystal structure and solution NMR dynamics of a D (type II) peroxiredoxin glutaredoxin and thioredoxin dependent: a new insight into the peroxiredoxin oligomerism.

scientific article published in February 2005

Discovery of fragment molecules that bind the human peroxiredoxin 5 active site

scientific article

Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors

scientific article published on 04 November 2019

Enabling STD-NMR fragment screening using stabilized native GPCR: A case study of adenosine receptor.

scientific article

F-ara-AMP is a substrate of cytoplasmic 5'-nucleotidase II (cN-II): HPLC and NMR studies of enzymatic dephosphorylation

scientific article published on 01 March 2006

Fragment-based deconstruction of Bcl-xL inhibitors

scientific article published on 01 March 2010

Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities

scientific article

Glutathionylation Induces the Dissociation of 1-Cys D-peroxiredoxin Non-covalent Homodimer

scientific article published in Journal of Biological Chemistry

Identification of Noncompetitive Inhibitors of Cytosolic 5'-Nucleotidase II Using a Fragment-Based Approach

scientific article

Identifying Protein Allosteric Transitions for Drug Discovery with 1D NMR.

scientific article published on 6 March 2017

Letter to the Editor:1H,13C and15N resonance assignments of poplar phloem glutaredoxin

scientific article published on 01 October 2004

Ligand Specificity in Fragment-Based Drug Design

scientific article published on 01 July 2010

Ligand specificity, privileged substructures and protein druggability from fragment-based screening.

scientific article

Ligand-Orientation Based Fragment Selection in STD NMR Screening

scientific article published on 22 October 2015

Modification and Biological Evaluation of a Series of 1,5-Diaryl-1,2,4-triazole Compounds as Novel Agents against Pancreatic Cancer Metastasis through Targeting Myoferlin

scientific article published on 08 May 2019

NMR investigation of protein-ligand interactions for G-protein coupled receptors

scientific article published on 09 July 2019

NMR screening applied to the fragment-based generation of inhibitors of creatine kinase exploiting a new interaction proximate to the ATP binding site.

scientific article

NMR structures and activity of a novel alpha-like toxin from the scorpion Leiurus quinquestriatus hebraeus

scientific article

NMR-based analysis of protein–ligand interactions ⬇️

scientific article published on April 18, 2013

Overview of Probing Protein-Ligand Interactions Using NMR.

scientific article

Performance of protein-ligand docking with simulated chemical shift perturbations

scientific article

Protein-ligand structure guided by backbone and side-chain proton chemical shift perturbations

scientific article

Protein-protein interactions within peroxiredoxin systems.

scientific article published on September 2006

The carboxyl-terminal region common to lamins A and C contains a DNA binding domain.

scientific article published in May 2003

The single mutation Trp35-->Ala in the 35-40 redox site of Chlamydomonas reinhardtii thioredoxin h affects its biochemical activity and the pH dependence of C36-C39 1H-13C NMR.

scientific article published in July 1998

[Fragment-based screening: a promising avenue for drug design]

scientific article published on 01 February 2015

List of works by Isabelle Krimm

1D NMR WaterLOGSY as an efficient method for fragment-based lead discovery

1H, 13C and 15N backbone resonance assignments of the dimeric yeast peroxiredoxin YLR109w.

1H, 13C and 15N resonance assignments of the C-terminal domain of human lamin A/C

2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 1. Identification of an Allosteric Binding Site

A coil-helix instead of a helix-coil motif can be induced in a chloroplast transit peptide from Chlamydomonas reinhardtii

Binding evaluation of fragment-based scaffolds for probing allosteric enzymes.

Biochemical characterization and nuclear magnetic resonance structure of novel alpha-conotoxins isolated from the venom of Conus consors

Crystal structure and solution NMR dynamics of a D (type II) peroxiredoxin glutaredoxin and thioredoxin dependent: a new insight into the peroxiredoxin oligomerism.

Discovery of fragment molecules that bind the human peroxiredoxin 5 active site

Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors

Enabling STD-NMR fragment screening using stabilized native GPCR: A case study of adenosine receptor.

F-ara-AMP is a substrate of cytoplasmic 5'-nucleotidase II (cN-II): HPLC and NMR studies of enzymatic dephosphorylation

Fragment-based deconstruction of Bcl-xL inhibitors

Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities

Glutathionylation Induces the Dissociation of 1-Cys D-peroxiredoxin Non-covalent Homodimer

Identification of Noncompetitive Inhibitors of Cytosolic 5'-Nucleotidase II Using a Fragment-Based Approach

Identifying Protein Allosteric Transitions for Drug Discovery with 1D NMR.

Letter to the Editor:1H,13C and15N resonance assignments of poplar phloem glutaredoxin

Ligand Specificity in Fragment-Based Drug Design

Ligand specificity, privileged substructures and protein druggability from fragment-based screening.

Ligand-Orientation Based Fragment Selection in STD NMR Screening

Modification and Biological Evaluation of a Series of 1,5-Diaryl-1,2,4-triazole Compounds as Novel Agents against Pancreatic Cancer Metastasis through Targeting Myoferlin

NMR investigation of protein-ligand interactions for G-protein coupled receptors

NMR screening applied to the fragment-based generation of inhibitors of creatine kinase exploiting a new interaction proximate to the ATP binding site.

NMR structures and activity of a novel alpha-like toxin from the scorpion Leiurus quinquestriatus hebraeus

NMR-based analysis of protein–ligand interactions ⬇️

Overview of Probing Protein-Ligand Interactions Using NMR.

Performance of protein-ligand docking with simulated chemical shift perturbations

Protein-ligand structure guided by backbone and side-chain proton chemical shift perturbations

Protein-protein interactions within peroxiredoxin systems.

The carboxyl-terminal region common to lamins A and C contains a DNA binding domain.

The single mutation Trp35-->Ala in the 35-40 redox site of Chlamydomonas reinhardtii thioredoxin h affects its biochemical activity and the pH dependence of C36-C39 1H-13C NMR.

[Fragment-based screening: a promising avenue for drug design]