List of works - Jens Erik Nielsen

Analysing the pH-dependent properties of proteins using pKa calculations

scientific article published on 19 May 2006

Analysis of an industrial production suspension of Bacillus lentus subtilisin crystals by powder diffraction: a powerful quality-control tool

scientific article

Analyzing enzymatic pH activity profiles and protein titration curves using structure-based pKa calculations and titration curve fitting.

scientific article published in January 2009

Calculating pKa values in the cAMP‐dependent protein kinase: The effect of conformational change and ligand binding ⬇️

scientific article published on December 1, 2010

Capturing, sharing and analysing biophysical data from protein engineering and protein characterization studies ⬇️

scientific article published on August 19, 2010

Designed human serum hyaluronidase 1 variant, HYAL1DeltaL, exhibits activity up to pH 5.9

scientific article

Determination of electrostatic interaction energies and protonation state populations in enzyme active sites.

scientific article published on 29 September 2007

Electrostatics in the active site of an alpha-amylase

scientific article published on 01 September 1999

Evolution of the isoelectric point of mammalian proteins as a consequence of indels and adaptive evolution

scientific article published on 08 March 2011

First implication of STRA6 mutations in isolated anophthalmia, microphthalmia, and coloboma: a new dimension to the STRA6 phenotype

scientific article (publication date: December 2011)

Heparin enhances serpin inhibition of the cysteine protease cathepsin L.

scientific article published on 3 December 2009

Highly perturbed pKa values in the unfolded state of hen egg white lysozyme.

scientific article published on 3 April 2012

Improving the analysis of NMR spectra tracking pH-induced conformational changes: removing artefacts of the electric field on the NMR chemical shift.

scientific article

Integrated prediction of the effect of mutations on multiple protein characteristics.

scientific article published in January 2011

On the development of protein pKa calculation algorithms.

scientific article

Optimizing the hydrogen-bond network in Poisson-Boltzmann equation-based pK(a) calculations.

scientific article published in June 2001

Predicting the open conformations of protein kinases using molecular dynamics simulations.

scientific article published on 19 August 2011

Protein dielectric constants determined from NMR chemical shift perturbations

scientific article

Protein engineering of bacterial alpha-amylases.

scientific article

Redesigning protein pKa values.

scientific article published on 22 December 2006

Structural artifacts in protein-ligand X-ray structures: implications for the development of docking scoring functions

scientific article published on 01 September 2009

Structure of a GH51 α-L-arabinofuranosidase from Meripilus giganteus: conserved substrate recognition from bacteria to fungi

scientific article published on 16 October 2020

pKD: re-designing protein pKa values.

scientific article published on July 2006

List of works by Jens Erik Nielsen

Analysing the pH-dependent properties of proteins using pKa calculations

Analysis of an industrial production suspension of Bacillus lentus subtilisin crystals by powder diffraction: a powerful quality-control tool

Analyzing enzymatic pH activity profiles and protein titration curves using structure-based pKa calculations and titration curve fitting.

Calculating pKa values in the cAMP‐dependent protein kinase: The effect of conformational change and ligand binding ⬇️

Capturing, sharing and analysing biophysical data from protein engineering and protein characterization studies ⬇️

Designed human serum hyaluronidase 1 variant, HYAL1DeltaL, exhibits activity up to pH 5.9

Determination of electrostatic interaction energies and protonation state populations in enzyme active sites.

Electrostatics in the active site of an alpha-amylase

Evolution of the isoelectric point of mammalian proteins as a consequence of indels and adaptive evolution

First implication of STRA6 mutations in isolated anophthalmia, microphthalmia, and coloboma: a new dimension to the STRA6 phenotype

Heparin enhances serpin inhibition of the cysteine protease cathepsin L.

Highly perturbed pKa values in the unfolded state of hen egg white lysozyme.

Improving the analysis of NMR spectra tracking pH-induced conformational changes: removing artefacts of the electric field on the NMR chemical shift.

Integrated prediction of the effect of mutations on multiple protein characteristics.

On the development of protein pKa calculation algorithms.

Optimizing the hydrogen-bond network in Poisson-Boltzmann equation-based pK(a) calculations.

Predicting the open conformations of protein kinases using molecular dynamics simulations.

Protein dielectric constants determined from NMR chemical shift perturbations

Protein engineering of bacterial alpha-amylases.

Redesigning protein pKa values.

Structural artifacts in protein-ligand X-ray structures: implications for the development of docking scoring functions

Structure of a GH51 α-L-arabinofuranosidase from Meripilus giganteus: conserved substrate recognition from bacteria to fungi

pKD: re-designing protein pKa values.