List of works - Paul Gregorevic

ACTN3 genotype influences muscle performance through the regulation of calcineurin signaling.

scientific article published on 16 September 2013

Abnormal mitochondrial L-arginine transport contributes to the pathogenesis of heart failure and rexoygenation injury

scientific article

Activin A-Induced Cachectic Wasting Is Attenuated by Systemic Delivery of Its Cognate Propeptide in Male Mice

scientific article published on 01 October 2019

Activin Signaling Regulates Sertoli Cell Differentiation and Function ⬇️

scientific article published on November 1, 2012

Administration of insulin-like growth factor-I improves fatigue resistance of skeletal muscles from dystrophic mdx mice.

scientific article

Beta 2-agonist administration reverses muscle wasting and improves muscle function in aged rats.

scientific article published on 14 November 2003

Bone Geometry Is Altered by Follistatin-Induced Muscle Growth in Young Adult Male Mice

scientific article published on 03 March 2021

Chronic beta-agonist administration affects cardiac function of adult but not old rats, independent of beta-adrenoceptor density.

scientific article

Deficiency in Apoptosis-Inducing Factor Recapitulates Chronic Kidney Disease via Aberrant Mitochondrial Homeostasis

scientific article published on 28 January 2016

Development of novel activin-targeted therapeutics

scientific article

Differential Effects of IL6 and Activin A in the Development of Cancer-Associated Cachexia.

scientific article published on 21 June 2016

Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation

scientific article

Dynamic Changes to the Skeletal Muscle Proteome and Ubiquitinome Induced by the E3 Ligase, ASB2β

scientific article published on 29 January 2021

Dystrophin delivery to muscles of mdx mice using lentiviral vectors leads to myogenic progenitor targeting and stable gene expression.

scientific article

Elevated expression of activins promotes muscle wasting and cachexia.

scientific article published on 30 December 2013

Endurance training adaptations modulate the redox-force relationship of rat isolated slow-twitch skeletal muscles.

scientific article published in January 2003

Erratum to “Efficient Transduction of Skeletal Muscle Using Vectors Based on Adeno-associated Virus Serotype 6”.

scientific article published on 31 July 2009

Evaluation of follistatin as a therapeutic in models of skeletal muscle atrophy associated with denervation and tenotomy.

scientific article

Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise.

scientific article published in January 2018

Follistatin-mediated skeletal muscle hypertrophy is regulated by Smad3 and mTOR independently of myostatin ⬇️

scientific article published on June 18, 2012

Forced expression of muscle specific kinase slows postsynaptic acetylcholine receptor loss in a mouse model of MuSK myasthenia gravis

scientific article published on 22 December 2015

Functional capacity of dystrophins carrying deletions in the N-terminal actin-binding domain

scientific article published on 22 June 2007

Functional deficits in nNOSmu-deficient skeletal muscle: myopathy in nNOS knockout mice

scientific article

Functional enhancement of skeletal muscle by gene transfer.

scientific article

Functional properties of regenerating skeletal muscle following LIF administration

scientific article published on 01 October 2000

Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest.

scientific article

Functional β-adrenoceptors are important for early muscle regeneration in mice through effects on myoblast proliferation and differentiation

scientific article

Gene delivery of medium chain acyl-coenzyme A dehydrogenase (MCAD) induces physiological cardiac hypertrophy and protects against pathological remodelling

scientific article published on 22 January 2018

Gene therapy of mdx mice with large truncated dystrophins generated by recombination using rAAV6.

scientific article

Gene therapy strategies for Duchenne muscular dystrophy utilizing recombinant adeno-associated virus vectors.

scientific article

Generation of MicroRNA-34 Sponges and Tough Decoys for the Heart: Developments and Challenges

scientific article published on 21 September 2018

Generation of a specific activin antagonist by modification of the activin A propeptide.

scientific article published on 12 July 2011

Glucose-6-phosphate dehydrogenase contributes to the regulation of glucose uptake in skeletal muscle.

scientific article published on 09 September 2016

IGF-I treatment improves the functional properties of fast- and slow-twitch skeletal muscles from dystrophic mice

scientific article published on 01 April 2001

In vivo and in vitro correction of the mdx dystrophin gene nonsense mutation by short-fragment homologous replacement

scientific article published on 01 April 2001

Induction of experimental autoimmune orchitis in mice: responses to elevated circulating levels of the activin-binding protein, follistatin

scientific article

Integrated expression analysis of muscle hypertrophy identifies Asb2 as a negative regulator of muscle mass

scientific article published on April 2016

Integrated glycoproteomics identifies a role of N-glycosylation and galectin-1 on myogenesis and muscle development

scientific article published on 16 September 2020

Lentiviral transduction of rat Sertoli cells as a means to modify gene expression.

scientific article

Leukemia inhibitory factor ameliorates muscle fiber degeneration in the mdx mouse

scientific article published on 01 November 2000

Loss of the long non-coding RNA OIP5-AS1 exacerbates heart failure in a sex-specific manner

scientific article published on 13 May 2021

Mechanisms involved in follistatin-induced hypertrophy and increased insulin action in skeletal muscle

scientific article published on 11 August 2019

Modulating myosin restores muscle function in a mouse model of nemaline myopathy

scientific article published on 17 February 2016

Molecular characterization of latent GDF8 reveals mechanisms of activation.

scientific article published on 18 January 2018

Muscle specific kinase protects dystrophic mdx mouse muscles from eccentric contraction-induced loss of force-producing capacity

scientific article published on 18 August 2019

Onset of experimental severe cardiac fibrosis is mediated by overexpression of Angiotensin-converting enzyme 2.

scientific article published on 16 February 2009

Phenotypic improvement of dystrophic muscles by rAAV/microdystrophin vectors is augmented by Igf1 codelivery.

scientific article published on September 2005

Phosphoinositide 3-kinase (p110α) gene delivery limits diabetes-induced cardiac NADPH oxidase and cardiomyopathy in a mouse model with established diastolic dysfunction.

scientific article published on 9 May 2017

Phosphorylation within the cysteine-rich region of dystrophin enhances its association with β-dystroglycan and identifies a potential novel therapeutic target for skeletal muscle wasting

scientific article

Preclinical studies for gene therapy of Duchenne muscular dystrophy.

scientific article published on 24 May 2010

Regulation of Tissue Growth by the Mammalian Hippo Signaling Pathway.

scientific article published on 24 November 2017

Sex-Specific Control of Human Heart Maturation by the Progesterone Receptor

scientific article published on 08 March 2021

Silencing of miR-34a attenuates cardiac dysfunction in a setting of moderate, but not severe, hypertrophic cardiomyopathy.

scientific article

Site-Specific Glycation and Chemo-enzymatic Antibody Sortagging for the Retargeting of rAAV6 to Inflamed Endothelium

scientific article published on 23 July 2019

Skeletal Muscle-Specific Overexpression of Heat Shock Protein 72 Improves Skeletal Muscle Insulin-Stimulated Glucose Uptake But Does Not Alter Whole Body Metabolism.

scientific article published on 13 April 2018

Skeletal muscle-specific overexpression of IGFBP-2 promotes a slower muscle phenotype in healthy but not dystrophic mdx mice and does not affect the dystrophic pathology.

scientific article

Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice.

scientific article published on July 2016

Specific targeting of TGF-β family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease

scientific article

Suppression of microRNA-29 Expression by TGF-β1 Promotes Collagen Expression and Renal Fibrosis ⬇️

scientific article published on November 17, 2011

Sustained AAV-mediated dystrophin expression in a canine model of Duchenne muscular dystrophy with a brief course of immunosuppression

scientific article published on 10 April 2007

Systemic administration of micro-dystrophin restores cardiac geometry and prevents dobutamine-induced cardiac pump failure

scientific article published on 17 April 2007

Systemic delivery of genes to striated muscles using adeno-associated viral vectors.

scientific article

Systemic microdystrophin gene delivery improves skeletal muscle structure and function in old dystrophic mdx mice.

scientific article published on 04 March 2008

TGF-β Regulates miR-206 and miR-29 to Control Myogenic Differentiation through Regulation of HDAC4 ⬇️

scientific article published on February 15, 2011

TGFβ and BMP signaling in skeletal muscle: potential significance for muscle-related disease.

scientific article

Targeting of Fn14 Prevents Cancer-Induced Cachexia and Prolongs Survival.

scientific article published on September 2015

The Effect of ACTN3 Gene Doping on Skeletal Muscle Performance

scientific article published on 26 April 2018

The Hippo Signaling Pathway in the Regulation of Skeletal Muscle Mass and Function

scientific article published on 15 January 2018

The Hippo pathway effector YAP is a critical regulator of skeletal muscle fibre size

scientific article published on 12 January 2015

The TGF-β Signalling Network in Muscle Development, Adaptation and Disease.

scientific article published on January 2016

The atypical 'b' splice variant of phospholipase Cβ1 promotes cardiac contractile dysfunction.

scientific article published on 25 April 2015

The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass.

scientific article published on 21 October 2013

The calcineurin signal transduction pathway is essential for successful muscle regeneration in mdx dystrophic mice.

scientific article published on 16 January 2004

Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function

scientific article

Therapeutic silencing of miR-652 restores heart function and attenuates adverse remodeling in a setting of established pathological hypertrophy

scientific article published on 21 August 2014

Transduction of skeletal muscles with common reporter genes can promote muscle fiber degeneration and inflammation

scientific article

Using AAV vectors expressing the β2-adrenoceptor or associated Gα proteins to modulate skeletal muscle mass and muscle fibre size.

scientific article published on 14 March 2016

Viral-mediated gene therapy for the muscular dystrophies: successes, limitations and recent advances

scientific article published on 26 September 2006

Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease

scientific article published on 17 May 2021

miR-206 represses hypertrophy of myogenic cells but not muscle fibers via inhibition of HDAC4

scientific article

miR-21 promotes renal fibrosis in diabetic nephropathy by targeting PTEN and SMAD7.

scientific article published on 28 September 2015

rAAV6-microdystrophin preserves muscle function and extends lifespan in severely dystrophic mice.

scientific article

rAAV6-microdystrophin rescues aberrant Golgi complex organization in mdx skeletal muscles.

scientific article published on 20 August 2007

List of works by Paul Gregorevic

ACTN3 genotype influences muscle performance through the regulation of calcineurin signaling.

Abnormal mitochondrial L-arginine transport contributes to the pathogenesis of heart failure and rexoygenation injury

Activin A-Induced Cachectic Wasting Is Attenuated by Systemic Delivery of Its Cognate Propeptide in Male Mice

Activin Signaling Regulates Sertoli Cell Differentiation and Function ⬇️

Administration of insulin-like growth factor-I improves fatigue resistance of skeletal muscles from dystrophic mdx mice.

Beta 2-agonist administration reverses muscle wasting and improves muscle function in aged rats.

Bone Geometry Is Altered by Follistatin-Induced Muscle Growth in Young Adult Male Mice

Chronic beta-agonist administration affects cardiac function of adult but not old rats, independent of beta-adrenoceptor density.

Deficiency in Apoptosis-Inducing Factor Recapitulates Chronic Kidney Disease via Aberrant Mitochondrial Homeostasis

Development of novel activin-targeted therapeutics

Differential Effects of IL6 and Activin A in the Development of Cancer-Associated Cachexia.

Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation

Dynamic Changes to the Skeletal Muscle Proteome and Ubiquitinome Induced by the E3 Ligase, ASB2β

Dystrophin delivery to muscles of mdx mice using lentiviral vectors leads to myogenic progenitor targeting and stable gene expression.

Elevated expression of activins promotes muscle wasting and cachexia.

Endurance training adaptations modulate the redox-force relationship of rat isolated slow-twitch skeletal muscles.

Erratum to “Efficient Transduction of Skeletal Muscle Using Vectors Based on Adeno-associated Virus Serotype 6”.

Evaluation of follistatin as a therapeutic in models of skeletal muscle atrophy associated with denervation and tenotomy.

Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise.

Follistatin-mediated skeletal muscle hypertrophy is regulated by Smad3 and mTOR independently of myostatin ⬇️

Forced expression of muscle specific kinase slows postsynaptic acetylcholine receptor loss in a mouse model of MuSK myasthenia gravis

Functional capacity of dystrophins carrying deletions in the N-terminal actin-binding domain

Functional deficits in nNOSmu-deficient skeletal muscle: myopathy in nNOS knockout mice

Functional enhancement of skeletal muscle by gene transfer.

Functional properties of regenerating skeletal muscle following LIF administration

Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest.

Functional β-adrenoceptors are important for early muscle regeneration in mice through effects on myoblast proliferation and differentiation

Gene delivery of medium chain acyl-coenzyme A dehydrogenase (MCAD) induces physiological cardiac hypertrophy and protects against pathological remodelling

Gene therapy of mdx mice with large truncated dystrophins generated by recombination using rAAV6.

Gene therapy strategies for Duchenne muscular dystrophy utilizing recombinant adeno-associated virus vectors.

Generation of MicroRNA-34 Sponges and Tough Decoys for the Heart: Developments and Challenges

Generation of a specific activin antagonist by modification of the activin A propeptide.

Glucose-6-phosphate dehydrogenase contributes to the regulation of glucose uptake in skeletal muscle.

IGF-I treatment improves the functional properties of fast- and slow-twitch skeletal muscles from dystrophic mice

In vivo and in vitro correction of the mdx dystrophin gene nonsense mutation by short-fragment homologous replacement

Induction of experimental autoimmune orchitis in mice: responses to elevated circulating levels of the activin-binding protein, follistatin

Integrated expression analysis of muscle hypertrophy identifies Asb2 as a negative regulator of muscle mass

Integrated glycoproteomics identifies a role of N-glycosylation and galectin-1 on myogenesis and muscle development

Lentiviral transduction of rat Sertoli cells as a means to modify gene expression.

Leukemia inhibitory factor ameliorates muscle fiber degeneration in the mdx mouse

Loss of the long non-coding RNA OIP5-AS1 exacerbates heart failure in a sex-specific manner

Mechanisms involved in follistatin-induced hypertrophy and increased insulin action in skeletal muscle

Modulating myosin restores muscle function in a mouse model of nemaline myopathy

Molecular characterization of latent GDF8 reveals mechanisms of activation.

Muscle specific kinase protects dystrophic mdx mouse muscles from eccentric contraction-induced loss of force-producing capacity

Onset of experimental severe cardiac fibrosis is mediated by overexpression of Angiotensin-converting enzyme 2.

Phenotypic improvement of dystrophic muscles by rAAV/microdystrophin vectors is augmented by Igf1 codelivery.

Phosphoinositide 3-kinase (p110α) gene delivery limits diabetes-induced cardiac NADPH oxidase and cardiomyopathy in a mouse model with established diastolic dysfunction.

Phosphorylation within the cysteine-rich region of dystrophin enhances its association with β-dystroglycan and identifies a potential novel therapeutic target for skeletal muscle wasting

Preclinical studies for gene therapy of Duchenne muscular dystrophy.

Regulation of Tissue Growth by the Mammalian Hippo Signaling Pathway.

Sex-Specific Control of Human Heart Maturation by the Progesterone Receptor

Silencing of miR-34a attenuates cardiac dysfunction in a setting of moderate, but not severe, hypertrophic cardiomyopathy.

Site-Specific Glycation and Chemo-enzymatic Antibody Sortagging for the Retargeting of rAAV6 to Inflamed Endothelium

Skeletal Muscle-Specific Overexpression of Heat Shock Protein 72 Improves Skeletal Muscle Insulin-Stimulated Glucose Uptake But Does Not Alter Whole Body Metabolism.

Skeletal muscle-specific overexpression of IGFBP-2 promotes a slower muscle phenotype in healthy but not dystrophic mdx mice and does not affect the dystrophic pathology.

Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice.

Specific targeting of TGF-β family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease

Suppression of microRNA-29 Expression by TGF-β1 Promotes Collagen Expression and Renal Fibrosis ⬇️

Sustained AAV-mediated dystrophin expression in a canine model of Duchenne muscular dystrophy with a brief course of immunosuppression

Systemic administration of micro-dystrophin restores cardiac geometry and prevents dobutamine-induced cardiac pump failure

Systemic delivery of genes to striated muscles using adeno-associated viral vectors.

Systemic microdystrophin gene delivery improves skeletal muscle structure and function in old dystrophic mdx mice.

TGF-β Regulates miR-206 and miR-29 to Control Myogenic Differentiation through Regulation of HDAC4 ⬇️

TGFβ and BMP signaling in skeletal muscle: potential significance for muscle-related disease.

Targeting of Fn14 Prevents Cancer-Induced Cachexia and Prolongs Survival.

The Effect of ACTN3 Gene Doping on Skeletal Muscle Performance

The Hippo Signaling Pathway in the Regulation of Skeletal Muscle Mass and Function

The Hippo pathway effector YAP is a critical regulator of skeletal muscle fibre size

The TGF-β Signalling Network in Muscle Development, Adaptation and Disease.

The atypical 'b' splice variant of phospholipase Cβ1 promotes cardiac contractile dysfunction.

The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass.

The calcineurin signal transduction pathway is essential for successful muscle regeneration in mdx dystrophic mice.

Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function

Therapeutic silencing of miR-652 restores heart function and attenuates adverse remodeling in a setting of established pathological hypertrophy

Transduction of skeletal muscles with common reporter genes can promote muscle fiber degeneration and inflammation

Using AAV vectors expressing the β2-adrenoceptor or associated Gα proteins to modulate skeletal muscle mass and muscle fibre size.

Viral-mediated gene therapy for the muscular dystrophies: successes, limitations and recent advances

Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease