List of works - V Bellotti

A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis

scientific article

A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo.

scientific article

Affinity capillary electrophoresis is a powerful tool to identify transthyretin binding drugs for potential therapeutic use in amyloidosis

scientific article published on 01 September 2000

Amyloid fibrils derived from the apolipoprotein A1 Leu174Ser variant contain elements of ordered helical structure

scientific article

Amyloid persistence in decellularized liver: biochemical and histopathological characterization.

scientific article published on 8 December 2015

Amyloidogenic and associated proteins in systemic amyloidosis proteome of adipose tissue.

scientific article

An Asp to Asn mutation is a toxic trigger in beta-2 microglobulin: structure and biophysics.

scientific article published in March 2017

Antiamyloidogenic and proamyloidogenic chaperone effects of C-reactive protein and serum amyloid P component.

scientific article published in March 2017

Assessment of cellular responses after short- and long-term exposure to silver nanoparticles in human neuroblastoma (SH-SY5Y) and astrocytoma (D384) cells.

scientific article published on 13 February 2014

Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic 2-microglobulin variant

scientific article

Benefit of doxycycline treatment on articular disability caused by dialysis related amyloidosis.

scientific article published on 4 June 2013

Bifunctional crosslinking ligands for transthyretin

scientific article

Binding of Monovalent and Bivalent Ligands by Transthyretin Causes Different Short- and Long-Distance Conformational Changes

scientific article published on 22 August 2019

Biochemical and Electrophysiological Modification of Amyloid Transthyretin on Cardiomyocytes

scientific article published on November 2016

C. elegans expressing D76N β2-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis

scientific article published on 27 December 2019

C. elegans expressing human β2-microglobulin: a novel model for studying the relationship between the molecular assembly and the toxic phenotype

scientific article

Citrate stabilized gold nanoparticles interfere with amyloid fibril formation: D76N and ΔN6 β2-microglobulin variants

scientific article published on 01 March 2018

Citrate-stabilized gold nanoparticles hinder fibrillogenesis of a pathological variant of β2-microglobulin.

scientific article published on 7 March 2017

Class I Major Histocompatibility Complex, the Trojan Horse for Secretion of Amyloidogenic β 2 -Microglobulin

scientific article

Co-fibrillogenesis of Wild-type and D76N β2-Microglobulin: THE CRUCIAL ROLE OF FIBRILLAR SEEDS.

scientific article published on 26 February 2016

Collagen plays an active role in the aggregation of beta2-microglobulin under physiopathological conditions of dialysis-related amyloidosis

scientific article published in Journal of Biological Chemistry

Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity.

scientific article

Conformational dynamics of the beta2-microglobulin C terminal in the cell-membrane-anchored major histocompatibility complex type I

scientific article published on 01 April 2000

Conformational switching and fibrillogenesis in the amyloidogenic fragment of apolipoprotein a-I.

scientific article published on 5 November 2002

D-strand perturbation and amyloid propensity in beta-2 microglobulin

scientific article

DE loop mutations affect beta2-microglobulin stability and amyloid aggregation

scientific article

Detection of fragments of beta2-microglobulin in amyloid fibrils

scientific article published on 01 January 2000

Determining the energy landscape of proteins by a fast isotope exchange NMR approach.

scientific article published on 5 March 2012

Effect of tetracyclines on the dynamics of formation and destructuration of beta2-microglobulin amyloid fibrils

scientific article

Effects of the Known Pathogenic Mutations on the Aggregation Pathway of the Amyloidogenic Peptide of Apolipoprotein A-I

article

Enhanced molecular chaperone activity of the small heat-shock protein alphaB-cystallin following covalent immobilization onto a solid-phase support

scientific article published on 01 June 2011

Enhanced toxicity of silver nanoparticles in transgenic Caenorhabditis elegans expressing amyloidogenic proteins.

scientific article published on 14 October 2015

Equilibrium unfolding thermodynamics of beta2-microglobulin analyzed through native-state H/D exchange

scientific article

Fibrillogenesis of humanβ2-microglobulin in three-dimensional silicon microstructures

scientific article published on 23 January 2012

Folding and fibrillogenesis: clues from beta2-microglobulin.

scientific article published on 15 June 2010

Hepatitis C virus-associated cryoglobulinaemicglomerulonephritis with delayed appearance ofmonoclonal cryoglobulinaemia.

scientific article published in February 2001

Hereditary systemic amyloidosis due to Asp76Asn variant β2-microglobulin

scientific article

Historical and Current Concepts of Fibrillogenesis and In vivo Amyloidogenesis: Implications of Amyloid Tissue Targeting

scientific article

Human beta-2 microglobulin W60V mutant structure: Implications for stability and amyloid aggregation

scientific article

Identification and characterization of a new ligand-binding site in FnbB, a fibronectin-binding adhesin from Streptococcus dysgalactiae.

scientific article published on March 2003

Increasing the accuracy of proteomic typing by decellularisation of amyloid tissue biopsies.

scientific article published on 21 June 2017

Inhibition of the mechano-enzymatic amyloidogenesis of transthyretin: role of ligand affinity, binding cooperativity and occupancy of the inner channel.

scientific article

Interference of citrate-stabilized gold nanoparticles with β2-microglobulin oligomeric association

scientific article published on 01 May 2018

Lysine 58-cleaved beta2-microglobulin is not detectable by 2D electrophoresis in ex vivo amyloid fibrils of two patients affected by dialysis-related amyloidosis.

scientific article

Lysozyme: a paradigmatic molecule for the investigation of protein structure, function and misfolding.

scientific article

Micro-heterogeneity and aggregation in beta2-microglobulin solutions: effects of temperature, pH, and conformational variant addition.

scientific article published on 7 March 2006

Misidentification of transthyretin and immunoglobulin variants by proteomics due to methyl lysine formation in formalin-fixed paraffin-embedded amyloid tissue

scientific article

Molecular dynamics simulation of β2-microglobulin in denaturing and stabilizing conditions

scientific article published on 22 December 2010

Molecular dynamics simulation suggests possible interaction patterns at early steps of beta2-microglobulin aggregation.

scientific article published on 8 December 2006

Molecular insights into cell toxicity of a novel familial amyloidogenic variant of β2-microglobulin

scientific article published on 18 March 2016

Monitoring the interaction between β2-microglobulin and the molecular chaperone αB-crystallin by NMR and mass spectrometry: αB-crystallin dissociates β2-microglobulin oligomers.

scientific article published on 03 May 2013

Multifaceted anti-amyloidogenic and pro-amyloidogenic effects of C-reactive protein and serum amyloid P component in vitro.

scientific article published on 06 July 2016

Native-unlike long-lived intermediates along the folding pathway of the amyloidogenic protein beta2-microglobulin revealed by real-time two-dimensional NMR.

scientific article published on 22 December 2009

Neurodegenerative diseases caused by protein aggregation: a phenomenon at the borderline between molecular evolution and ageing.

scientific article published in October 2004

Occurrence of monoclonal components in general practice: clinical implications

scientific article published on 01 April 1992

Oleuropein aglycone: A polyphenol with different targets against amyloid toxicity.

scientific article published on 20 March 2018

Pharmaceutical strategies against amyloidosis: old and new drugs in targeting a "protein misfolding disease".

scientific article published on April 2004

Plasminogen activation triggers transthyretin amyloidogenesis

scientific article published in Journal of Biological Chemistry

Preliminary crystallographic characterization of the human β2 microglobulin His31Tyr mutant in a tetrameric assembly

scientific article published on 27 June 2003

Probing the influence of citrate-capped gold nanoparticles on an amyloidogenic protein

scientific article published on 4 March 2015

Properties of Some Variants of Human β2-Microglobulin and Amyloidogenesis

scientific article published in Journal of Biological Chemistry

Protein Aggregation

scientific article published on 01 November 2001

Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis

scientific article

Proteomics in protein misfolding diseases.

scientific article published in January 2009

Proteomics of beta2-microglobulin amyloid fibrils.

scientific article

Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability

scientific article published on 6 May 2016

Recombinant amyloidogenic domain of ApoA-I: Analysis of its fibrillogenic potential

article

Reduction of conformational mobility and aggregation in W60G β2-microglobulin: assessment by 15N NMR relaxation.

scientific article published on 18 October 2013

Review: immunoglobulin light chain amyloidosis--the archetype of structural and pathogenic variability.

scientific article

Single-shot NMR measurement of protein unfolding landscapes.

scientific article published on 13 April 2012

Solution structure of beta(2)-microglobulin and insights into fibrillogenesis.

scientific article

Structural and folding dynamic properties of the T70N variant of human lysozyme.

scientific article published on 22 April 2003

Structure of an early native-like intermediate of β2-microglobulin amyloidogenesis

scientific article

Structure, folding dynamics, and amyloidogenesis of D76N β2-microglobulin: roles of shear flow, hydrophobic surfaces, and α-crystallin.

scientific article published on 06 September 2013

Structure, stability, and aggregation of β-2 microglobulin mutants: insights from a Fourier transform infrared study in solution and in the crystalline state

scientific article published on 3 April 2012

Systemic Exosomal Delivery of shRNA Minicircles Prevents Parkinsonian Pathology

scientific article published on 27 August 2019

Systemic amyloidosis: lessons from β2-microglobulin.

scientific article

Targeting C-reactive protein for the treatment of cardiovascular disease.

scientific article

The complementary role of histology and proteomics for diagnosis and typing of systemic amyloidosis

scientific article published on 02 April 2019

The controlling roles of Trp60 and Trp95 in beta2-microglobulin function, folding and amyloid aggregation properties

scientific article

The effects of an ideal beta-turn on beta-2 microglobulin fold stability.

scientific article

The intracellular quality control system down-regulates the secretion of amyloidogenic apolipoprotein A-I variants: A possible impact on the natural history of the disease

scientific article published on 15 July 2010

The polyphenol Oleuropein aglycone hinders the growth of toxic transthyretin amyloid assemblies.

scientific article published on 12 January 2016

Topological investigation of amyloid fibrils obtained from beta2-microglobulin.

scientific article

Use of anti-(beta2 microglobulin) mAb to study formation of amyloid fibrils

scientific article published on 01 October 1997

beta 2-microglobulin can be refolded into a native state from ex vivo amyloid fibrils

scientific article published on 01 November 1998

beta2-microglobulin H31Y variant 3D structure highlights the protein natural propensity towards intermolecular aggregation

scientific article

α-Synuclein structural features inhibit harmful polyunsaturated fatty acid oxidation, suggesting roles in neuroprotection

scientific article

List of works by V Bellotti

A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis

A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo.

Affinity capillary electrophoresis is a powerful tool to identify transthyretin binding drugs for potential therapeutic use in amyloidosis

Amyloid fibrils derived from the apolipoprotein A1 Leu174Ser variant contain elements of ordered helical structure

Amyloid persistence in decellularized liver: biochemical and histopathological characterization.

Amyloidogenic and associated proteins in systemic amyloidosis proteome of adipose tissue.

An Asp to Asn mutation is a toxic trigger in beta-2 microglobulin: structure and biophysics.

Antiamyloidogenic and proamyloidogenic chaperone effects of C-reactive protein and serum amyloid P component.

Assessment of cellular responses after short- and long-term exposure to silver nanoparticles in human neuroblastoma (SH-SY5Y) and astrocytoma (D384) cells.

Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic 2-microglobulin variant

Benefit of doxycycline treatment on articular disability caused by dialysis related amyloidosis.

Bifunctional crosslinking ligands for transthyretin

Binding of Monovalent and Bivalent Ligands by Transthyretin Causes Different Short- and Long-Distance Conformational Changes

Biochemical and Electrophysiological Modification of Amyloid Transthyretin on Cardiomyocytes

C. elegans expressing D76N β2-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis

C. elegans expressing human β2-microglobulin: a novel model for studying the relationship between the molecular assembly and the toxic phenotype

Citrate stabilized gold nanoparticles interfere with amyloid fibril formation: D76N and ΔN6 β2-microglobulin variants

Citrate-stabilized gold nanoparticles hinder fibrillogenesis of a pathological variant of β2-microglobulin.

Class I Major Histocompatibility Complex, the Trojan Horse for Secretion of Amyloidogenic β 2 -Microglobulin

Co-fibrillogenesis of Wild-type and D76N β2-Microglobulin: THE CRUCIAL ROLE OF FIBRILLAR SEEDS.

Collagen plays an active role in the aggregation of beta2-microglobulin under physiopathological conditions of dialysis-related amyloidosis

Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity.

Conformational dynamics of the beta2-microglobulin C terminal in the cell-membrane-anchored major histocompatibility complex type I

Conformational switching and fibrillogenesis in the amyloidogenic fragment of apolipoprotein a-I.

D-strand perturbation and amyloid propensity in beta-2 microglobulin

DE loop mutations affect beta2-microglobulin stability and amyloid aggregation

Detection of fragments of beta2-microglobulin in amyloid fibrils

Determining the energy landscape of proteins by a fast isotope exchange NMR approach.

Effect of tetracyclines on the dynamics of formation and destructuration of beta2-microglobulin amyloid fibrils

Effects of the Known Pathogenic Mutations on the Aggregation Pathway of the Amyloidogenic Peptide of Apolipoprotein A-I

Enhanced molecular chaperone activity of the small heat-shock protein alphaB-cystallin following covalent immobilization onto a solid-phase support

Enhanced toxicity of silver nanoparticles in transgenic Caenorhabditis elegans expressing amyloidogenic proteins.

Equilibrium unfolding thermodynamics of beta2-microglobulin analyzed through native-state H/D exchange

Fibrillogenesis of humanβ2-microglobulin in three-dimensional silicon microstructures

Folding and fibrillogenesis: clues from beta2-microglobulin.

Hepatitis C virus-associated cryoglobulinaemicglomerulonephritis with delayed appearance ofmonoclonal cryoglobulinaemia.

Hereditary systemic amyloidosis due to Asp76Asn variant β2-microglobulin

Historical and Current Concepts of Fibrillogenesis and In vivo Amyloidogenesis: Implications of Amyloid Tissue Targeting

Human beta-2 microglobulin W60V mutant structure: Implications for stability and amyloid aggregation

Identification and characterization of a new ligand-binding site in FnbB, a fibronectin-binding adhesin from Streptococcus dysgalactiae.

Increasing the accuracy of proteomic typing by decellularisation of amyloid tissue biopsies.

Inhibition of the mechano-enzymatic amyloidogenesis of transthyretin: role of ligand affinity, binding cooperativity and occupancy of the inner channel.

Interference of citrate-stabilized gold nanoparticles with β2-microglobulin oligomeric association

Lysine 58-cleaved beta2-microglobulin is not detectable by 2D electrophoresis in ex vivo amyloid fibrils of two patients affected by dialysis-related amyloidosis.

Lysozyme: a paradigmatic molecule for the investigation of protein structure, function and misfolding.

Micro-heterogeneity and aggregation in beta2-microglobulin solutions: effects of temperature, pH, and conformational variant addition.

Misidentification of transthyretin and immunoglobulin variants by proteomics due to methyl lysine formation in formalin-fixed paraffin-embedded amyloid tissue

Molecular dynamics simulation of β2-microglobulin in denaturing and stabilizing conditions

Molecular dynamics simulation suggests possible interaction patterns at early steps of beta2-microglobulin aggregation.

Molecular insights into cell toxicity of a novel familial amyloidogenic variant of β2-microglobulin

Monitoring the interaction between β2-microglobulin and the molecular chaperone αB-crystallin by NMR and mass spectrometry: αB-crystallin dissociates β2-microglobulin oligomers.

Multifaceted anti-amyloidogenic and pro-amyloidogenic effects of C-reactive protein and serum amyloid P component in vitro.

Native-unlike long-lived intermediates along the folding pathway of the amyloidogenic protein beta2-microglobulin revealed by real-time two-dimensional NMR.

Neurodegenerative diseases caused by protein aggregation: a phenomenon at the borderline between molecular evolution and ageing.

Occurrence of monoclonal components in general practice: clinical implications

Oleuropein aglycone: A polyphenol with different targets against amyloid toxicity.

Pharmaceutical strategies against amyloidosis: old and new drugs in targeting a "protein misfolding disease".

Plasminogen activation triggers transthyretin amyloidogenesis

Preliminary crystallographic characterization of the human β2 microglobulin His31Tyr mutant in a tetrameric assembly

Probing the influence of citrate-capped gold nanoparticles on an amyloidogenic protein

Properties of Some Variants of Human β2-Microglobulin and Amyloidogenesis

Protein Aggregation

Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis

Proteomics in protein misfolding diseases.

Proteomics of beta2-microglobulin amyloid fibrils.

Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability

Recombinant amyloidogenic domain of ApoA-I: Analysis of its fibrillogenic potential

Reduction of conformational mobility and aggregation in W60G β2-microglobulin: assessment by 15N NMR relaxation.

Review: immunoglobulin light chain amyloidosis--the archetype of structural and pathogenic variability.

Single-shot NMR measurement of protein unfolding landscapes.

Solution structure of beta(2)-microglobulin and insights into fibrillogenesis.

Structural and folding dynamic properties of the T70N variant of human lysozyme.

Structure of an early native-like intermediate of β2-microglobulin amyloidogenesis

Structure, folding dynamics, and amyloidogenesis of D76N β2-microglobulin: roles of shear flow, hydrophobic surfaces, and α-crystallin.

Structure, stability, and aggregation of β-2 microglobulin mutants: insights from a Fourier transform infrared study in solution and in the crystalline state

Systemic Exosomal Delivery of shRNA Minicircles Prevents Parkinsonian Pathology

Systemic amyloidosis: lessons from β2-microglobulin.

Targeting C-reactive protein for the treatment of cardiovascular disease.

The complementary role of histology and proteomics for diagnosis and typing of systemic amyloidosis