List of works - Wen-Shan Li

A novel sialyltransferase inhibitor AL10 suppresses invasion and metastasis of lung cancer cells by inhibiting integrin-mediated signaling.

scientific article

A novel sialyltransferase inhibitor suppresses FAK/paxillin signaling and cancer angiogenesis and metastasis pathways

scientific article published on 11 January 2011

A synthetic podophyllotoxin derivative exerts anti-cancer effects by inducing mitotic arrest and pro-apoptotic ER stress in lung cancer preclinical models

scientific article

Aggregation induced emission enhancement (AIEE) characteristics of quinoline based compound - A versatile fluorescent probe for pH, Fe(III) ion, BSA binding and optical cell imaging.

scientific article

Aggregation-induced emission enhancement of anthracene-derived Schiff base compounds and their application as a sensor for bovine serum albumin and optical cell imaging

scientific article published on 10 April 2018

Aminopeptidase p mediated detoxification of organophosphonate analogues of sarin: mechanistic and stereochemical study at the phosphorus atom of the substrate

scientific article published in March 2006

Antiangiogenic Effect of Isomalyngamide A Riboside CY01 in Breast Cancer Cells via Inhibition of Migration, Tube Formation and pVEGFR2/pAKT Signals

scientific article published on 19 October 2019

Anticancer efficacy of unique pyridine-based tetraindoles

scientific article published on 28 September 2015

Benzenesulfonamide Derivatives as Calcium/Calmodulin-Dependent Protein Kinase Inhibitors and Antiviral Agents against Dengue and Zika Virus Infections

scientific article published on 03 February 2020

Design of potent inhibitors for Schistosoma japonica glutathione S-transferase

scientific article

Elevation of β-galactoside α2,6-sialyltransferase 1 in a fructoseresponsive manner promotes pancreatic cancer metastasis.

scientific article published on 09 December 2016

Enhanced degradation of chemical warfare agents through molecular engineering of the phosphotriesterase active site

scientific article

Enzymatic and nonenzymatic synthesis of glutathione conjugates: application to the understanding of a parasite's defense system and alternative to the discovery of potent glutathione S-transferase inhibitors

scientific article

Enzymatic synthesis of chiral organophosphothioates from prochiral precursors

scientific article

Evaluation of organophosphorus chemicals-degrading enzymes: a comparison of Escherichia coli and human cytosolic aminopeptidase P.

scientific article published in July 2008

Experimental verification of a predicted, previously unseen separation selectivity pattern in the capillary electrophoretic separation of noncharged enantiomers by octakis(2,3-diacetyl-6-sulfato)-gamma-cyclodextrin

scientific article published on 01 September 2000

Glycosylation enhances the anti-migratory activities of isomalyngamide A analogs

scientific article published on 6 April 2013

Inhibition of chemokine (C-C motif) receptor 7 sialylation suppresses CCL19-stimulated proliferation, invasion and anti-anoikis

scientific article (publication date: 2014)

Inhibition of glutathione S-transferase M1 by new gabosine analogues is essential for overcoming cisplatin resistance in lung cancer cells.

scientific article

Investigation of the proton relay system operative in human cystosolic aminopeptidase P.

scientific article

Isomalyngamide A, A-1 and their analogs suppress cancer cell migration in vitro

scientific article published on 27 May 2011

Liposomal Irinotecan for Treatment of Colorectal Cancer in a Preclinical Model

Liposomal paclitaxel induces fewer hematopoietic and cardiovascular complications than bioequivalent doses of Taxol

scientific article published on 21 June 2018

Lithocholic acid analogues, new and potent alpha-2,3-sialyltransferase inhibitors.

scientific article published on 9 January 2006

Long-range through-bond photoactivated sigma bond cleavage in steroids. Intramolecular sensitized debromination

scientific article published on 01 January 2000

Nano-Diamino-Tetrac (NDAT) Enhances Resveratrol-Induced Antiproliferation by Action on the RRM2 Pathway in Colorectal Cancers

scientific article published on 20 July 2018

Nature-inspired design of tetraindoles: Optimization of the core structure and evaluation of structure-activity relationship

scientific article published on 29 July 2016

Overcoming the drug resistance in breast cancer cells by rational design of efficient glutathione S-transferase inhibitors.

scientific article published in January 2010

Oxidations of N-(3-indoleethyl) cyclic aliphatic amines by horseradish peroxidase: the indole ring binds to the enzyme and mediates electron-transfer amine oxidation.

scientific article published on 29 December 2007

Oxidative trimerization of indoles via water-assisted visible-light photoredox catalysis and the study of their anti-cancer activities

scientific article published on 31 July 2020

Polyfluorinated bipyridine cisplatins manipulate cytotoxicity through the induction of S-G2/M arrest and partial intercalation mechanism

scientific article published on 28 June 2011

Preparation and characterization of amino-linked heterocyclic carbene palladium, gold, and silver complexes and their use as anticancer agents that act by triggering apoptotic cell death.

scientific article published on 28 June 2011

Sialyltransferase Inhibitors Suppress Breast Cancer Metastasis

scientific article published on 28 December 2020

Stereoselective detoxification of chiral sarin and soman analogues by phosphotriesterase.

scientific article

Synthesis and evaluation of the cytotoxicities of tetraindoles: observation that the 5-hydroxy tetraindole (SK228) induces G₂ arrest and apoptosis in human breast cancer cells.

scientific article published on 9 February 2012

Synthesis and structure-activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents

scientific article

Synthesis of B- and C-ring-modified lithocholic acid analogues as potential sialyltransferase inhibitors

scientific article published on 3 May 2016

Tetrac downregulates β-catenin and HMGA2 to promote the effect of resveratrol in colon cancer

scientific article published on 18 December 2017

The novel indole compound SK228 induces apoptosis and FAK/Paxillin disruption in tumor cell lines and inhibits growth of tumor graft in the nude mouse.

scientific article

The tetraindole SK228 reverses the epithelial-to-mesenchymal transition of breast cancer cells by up-regulating members of the miR-200 family.

scientific article

Tyrosine 387 and arginine 404 are critical in the hydrolytic mechanism of Escherichia coli aminopeptidase P.

scientific article published in February 2006

List of works by Wen-Shan Li

A novel sialyltransferase inhibitor AL10 suppresses invasion and metastasis of lung cancer cells by inhibiting integrin-mediated signaling.

A novel sialyltransferase inhibitor suppresses FAK/paxillin signaling and cancer angiogenesis and metastasis pathways

A synthetic podophyllotoxin derivative exerts anti-cancer effects by inducing mitotic arrest and pro-apoptotic ER stress in lung cancer preclinical models

Aggregation induced emission enhancement (AIEE) characteristics of quinoline based compound - A versatile fluorescent probe for pH, Fe(III) ion, BSA binding and optical cell imaging.

Aggregation-induced emission enhancement of anthracene-derived Schiff base compounds and their application as a sensor for bovine serum albumin and optical cell imaging

Aminopeptidase p mediated detoxification of organophosphonate analogues of sarin: mechanistic and stereochemical study at the phosphorus atom of the substrate

Antiangiogenic Effect of Isomalyngamide A Riboside CY01 in Breast Cancer Cells via Inhibition of Migration, Tube Formation and pVEGFR2/pAKT Signals

Anticancer efficacy of unique pyridine-based tetraindoles

Benzenesulfonamide Derivatives as Calcium/Calmodulin-Dependent Protein Kinase Inhibitors and Antiviral Agents against Dengue and Zika Virus Infections

Design of potent inhibitors for Schistosoma japonica glutathione S-transferase

Elevation of β-galactoside α2,6-sialyltransferase 1 in a fructoseresponsive manner promotes pancreatic cancer metastasis.

Enhanced degradation of chemical warfare agents through molecular engineering of the phosphotriesterase active site

Enzymatic and nonenzymatic synthesis of glutathione conjugates: application to the understanding of a parasite's defense system and alternative to the discovery of potent glutathione S-transferase inhibitors

Enzymatic synthesis of chiral organophosphothioates from prochiral precursors

Evaluation of organophosphorus chemicals-degrading enzymes: a comparison of Escherichia coli and human cytosolic aminopeptidase P.

Experimental verification of a predicted, previously unseen separation selectivity pattern in the capillary electrophoretic separation of noncharged enantiomers by octakis(2,3-diacetyl-6-sulfato)-gamma-cyclodextrin

Glycosylation enhances the anti-migratory activities of isomalyngamide A analogs

Inhibition of chemokine (C-C motif) receptor 7 sialylation suppresses CCL19-stimulated proliferation, invasion and anti-anoikis

Inhibition of glutathione S-transferase M1 by new gabosine analogues is essential for overcoming cisplatin resistance in lung cancer cells.

Investigation of the proton relay system operative in human cystosolic aminopeptidase P.

Isomalyngamide A, A-1 and their analogs suppress cancer cell migration in vitro

Liposomal Irinotecan for Treatment of Colorectal Cancer in a Preclinical Model

Liposomal paclitaxel induces fewer hematopoietic and cardiovascular complications than bioequivalent doses of Taxol

Lithocholic acid analogues, new and potent alpha-2,3-sialyltransferase inhibitors.

Long-range through-bond photoactivated sigma bond cleavage in steroids. Intramolecular sensitized debromination

Nano-Diamino-Tetrac (NDAT) Enhances Resveratrol-Induced Antiproliferation by Action on the RRM2 Pathway in Colorectal Cancers

Nature-inspired design of tetraindoles: Optimization of the core structure and evaluation of structure-activity relationship

Overcoming the drug resistance in breast cancer cells by rational design of efficient glutathione S-transferase inhibitors.

Oxidations of N-(3-indoleethyl) cyclic aliphatic amines by horseradish peroxidase: the indole ring binds to the enzyme and mediates electron-transfer amine oxidation.

Oxidative trimerization of indoles via water-assisted visible-light photoredox catalysis and the study of their anti-cancer activities

Polyfluorinated bipyridine cisplatins manipulate cytotoxicity through the induction of S-G2/M arrest and partial intercalation mechanism

Preparation and characterization of amino-linked heterocyclic carbene palladium, gold, and silver complexes and their use as anticancer agents that act by triggering apoptotic cell death.

Sialyltransferase Inhibitors Suppress Breast Cancer Metastasis

Stereoselective detoxification of chiral sarin and soman analogues by phosphotriesterase.

Synthesis and evaluation of the cytotoxicities of tetraindoles: observation that the 5-hydroxy tetraindole (SK228) induces G₂ arrest and apoptosis in human breast cancer cells.

Synthesis and structure-activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents

Synthesis of B- and C-ring-modified lithocholic acid analogues as potential sialyltransferase inhibitors

Tetrac downregulates β-catenin and HMGA2 to promote the effect of resveratrol in colon cancer

The novel indole compound SK228 induces apoptosis and FAK/Paxillin disruption in tumor cell lines and inhibits growth of tumor graft in the nude mouse.

The tetraindole SK228 reverses the epithelial-to-mesenchymal transition of breast cancer cells by up-regulating members of the miR-200 family.

Tyrosine 387 and arginine 404 are critical in the hydrolytic mechanism of Escherichia coli aminopeptidase P.