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List of works by Raymond L. Woosley

"Conventional" antihistamines slow cardiac repolarization in isolated perfused (Langendorff) feline hearts

scientific article published on 01 July 1998

A prescription for better prescriptions

scientific article published on 01 January 1994

Acetylator phenotype and lupus erythematosus

scientific article published on March 1981

Acute electrophysiologic effects of sodium administration in dogs treated with O-desmethyl encainide

scientific article published on 01 October 1989

Acute treatment of recent-onset atrial fibrillation and flutter with a tailored dosing regimen of intravenous amiodarone. A randomized, digoxin-controlled study

scientific article published on 01 April 1995

Adenosine A1-receptor occupancy predicts A1-receptor antagonist effects of N-0861

scientific article published on 01 November 1998

Administration of prostacyclin prevents ventricular fibrillation following coronary occlusion in conscious dogs

scientific article published on 01 September 1982

Adverse Drug Event Causality Analysis (ADECA): A Process for Evaluating Evidence and Assigning Drugs to Risk Categories for Sudden Death

scientific article

Agranulocytosis during combined procainamide and phenytoin therapy

scientific article published on December 1979

Altered distribution of debrisoquine oxidation phenotypes in patients with systemic lupus erythematosus

scientific article published on 01 July 1986

Amiodarone dosing: a proposal based on its pharmacokinetics

scientific article published on 01 October 1983

Amiodarone-induced lymphocyte toxicity and mitochondrial function

scientific article published on 01 July 1996

An Integrative Data Science Pipeline to Identify Novel Drug Interactions that Prolong the QT Interval

scientific article

An accelerated pathway for targeted cancer therapies.

scientific article

An audience with Ray Woosley

scientific article published on 17 October 2008

An interview with Raymond L. Woosley

scientific article published on 6 June 2014

Analysis of potential adverse drug reactions--a case of mistaken identity

scientific article published on 01 July 1994

Antiarrhythmic activity of the O-demethyl metabolite of encainide

scientific article published on 01 June 1982

Antiarrhythmic activity, electrocardiographic effects and pharmacokinetics of the encainide metabolites O-desmethyl encainide and 3-methoxy-O-desmethyl encainide in man

scientific article published on 01 February 1988

Antiarrhythmic drugs

scientific article published on January 1991

Antiarrhythmic effects of a lidocaine congener, tocainide, 2-amino-2',6'-propionoxylidide, in man.

scientific article

Antiarrhythmic effects of the quaternary propranolol analog that does not induce beta-adrenergic blockade

scientific article published on July 1982

Antiarrhythmic efficacy, clinical electrophysiology, and pharmacokinetics of 3-methoxy-O-desmethyl encainide (MODE) in patients with inducible ventricular tachycardia or fibrillation

scientific article published in November 1989

Antiarrhythmic efficacy, pharmacokinetics and safety of N-acetylprocainamide in human subjects: Comparison with procainamide

article

Antiarrhythmic therapy: clinical pharmacology update

scientific article published on July 1984

Assessing cardiovascular drug safety for clinical decision-making

scientific article published on 16 April 2013

Biological sex analysis in clinical research

scientific article published on 01 November 2000

Biomedical research funding: view of the National Caucus of Basic Biomedical Science Chairs

scientific article published on 01 October 1992

Block and enhancement of cardiac ion channel currents by des-oxo-amiodarone.

scientific article published in January 1988

Bretylium: relations between plasma concentrations and pharmacologic actions in high-frequency ventricular arrhythmias

scientific article published on 01 February 1985

CAST: implications for drug development

scientific article published in May 1990

Cardiac actions of erythromycin: influence of female sex.

scientific article published in November 1998

Centers for education and research in therapeutics

scientific article published on 01 March 1994

Centers for education and research on therapeutics report: survey of medication errors education during undergraduate and graduate medical education in the United States.

scientific article published in January 2002

Changes in the pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine with concomitant administration of erythromycin

scientific article published on 01 September 1992

Chlorpheniramine plasma concentration and histamine H1-receptor occupancy.

scientific article published in August 1995

Clarification to the www.qtdrugs.org updated lists

scientific article published on 01 May 2009

Class I antiarrhythmic agents: quinidine, procainamide and N-acetylprocainamide, disopyramide

scientific article

Clinical implications of variable antiarrhythmic drug metabolism

scientific article published on February 1, 1992

Clinical importance of metabolites of antiarrhythmic drugs

scientific article published on 01 January 1984

Clinical pharmacokinetics of disopyramide

scientific article

Clinical pharmacokinetics of encainide

scientific article published on March 1988

Clinical pharmacokinetics of moricizine

scientific article published on February 1990

Clinical pharmacology of old and new antiarrhythmic drugs.

scientific article

Clinical pharmacology of propafenone: pharmacokinetics, metabolism and concentration-response relations

scientific article published on 01 November 1984

Co-inheritance of the polymorphic metabolism of encainide and debrisoquin

scientific article published on 01 March 1986

Community pharmacy and pharmacist staff call center: assessment of medication safety and effectiveness

scientific article

Community pharmacy managers' perception of computerized drug-drug interaction alerts

scientific article published on 01 March 2006

Comparative evaluation of HERG currents and QT intervals following challenge with suspected torsadogenic and nontorsadogenic drugs.

scientific article

Comparison of tegaserod (HTF 919) and its main human metabolite with cisapride and erythromycin on cardiac repolarization in the isolated rabbit heart

scientific article published on 01 July 1999

Comparison of the effects of placebo and encainide on programmed electrical stimulation and ventricular arrhythmia frequency

scientific article published on 01 August 1982

Competition between lidocaine and one of its metabolites, glycylxylidide, for cardiac sodium channels

scientific article

Concentration-dependent pharmacologic properties of sotalol

scientific article published on 01 May 1986

Concentration/response relations for the multiple antiarrhythmic actions of sotalol

scientific article published on 01 January 1990

Control of ventricular preexcitation and associated arrhythmias by encainide

scientific article published in October 1981

Correction to “Geographic Variation in the Prescription of Schedule II Opioid Analgesics among Outpatients in the United States”.

scientific article published in June 2006

Correlation between N-acetyltransferase activity and NAT2 genotype in Chinese males

article

Coupling Data Mining and Laboratory Experiments to Discover Drug Interactions Causing QT Prolongation

scientific article

Covalent binding of procainamide in vitro and in vivo to hepatic protein in mice

scientific article published on 01 May 1981

Cumulation of N-acetylprocainamide, an active metabolite of procainamide, in patients with impaired renal function

scientific article published on July 1, 1977

Determination of clemastine in human plasma by gas chromatography with nitrogen-phosphorus detection

scientific article published on 01 July 2000

Determination of dextromethorphan metabolic phenotype by salivary analysis with a reference to genotype in Chinese patients receiving renal hemodialysis

scientific article published on 01 April 1996

Diagramming patients' views of root causes of adverse drug events in ambulatory care: an online tool for planning education and research

scientific article published on 31 July 2006

Differential effects of D-sotalol, quinidine, and amiodarone on dispersion of ventricular repolarization in the isolated rabbit heart

scientific article published on 01 November 1997

Differential effects of O-demethyl encainide on induced and spontaneous arrhythmias in the conscious dog

scientific article published on 01 September 1984

Discovering adverse reactions: why does it take so long?

scientific article published on 01 October 2004

Disposition kinetics of encainide and metabolites

scientific article published on August 1986

Drug Development and the FDA's Critical Path Initiative

article

Drug labeling revisions-guaranteed to fail?

scientific article published on 01 December 2000

Drug therapy. Encainide

scientific article published on April 1988

Drug therapy. Flecainide

scientific article

Drug therapy. Tocainide

scientific article published on July 1986

Drug-induced QT prolongation in women during the menstrual cycle

scientific article published in March 2001

Effect of acetylator phenotype on the rate at which procainamide induces antinuclear antibodies and the lupus syndrome

scientific article published on May 1978

Effect of low dose quinidine on encainide pharmacokinetics and pharmacodynamics. Influence of genetic polymorphism.

scientific article published on April 1989

Effects of concentration and steric configuration of propranolol on AV conduction and ventricular repolarization in the dog

scientific article published on 01 July 1981

Effects of congestive heart failure on the pharmacokinetics and pharmacodynamics of antiarrhythmic agents

scientific article published on January 1986

Efficacy and safety of ACC-9358, a new antiarrhythmic agent

scientific article published on 01 April 1990

Electropharmacologic synergism with mexiletine and quinidine.

scientific article published in July 1986

Electrophysiologic actions of O-demethyl encainide: an active metabolite

scientific article published on 01 August 1983

Electrophysiologic actions of high plasma concentrations of propranolol in human subjects

scientific article published in December 1983

Electrophysiologic effects of intravenous and oral sotalol for sustained ventricular tachycardia secondary to coronary artery disease

scientific article published on 01 May 1988

Electrophysiologic features of torsades de pointes: insights from a new isolated rabbit heart model

scientific article published on 01 October 1997

Electrophysiological effects of high-dose propranolol in dogs: evidence in vivo for effects not mediated by the beta adrenoceptor

scientific article published on 01 April 1984

Electrophysiology of O-demethyl encainide in a canine model of sustained ventricular tachycardia

scientific article published on 01 July 1984

Encainide disposition in patients with chronic cirrhosis

scientific article published on August 1986

Encainide disposition in patients with renal failure

scientific article published on 01 July 1986

Evaluating drugs after their approval for clinical use

scientific article published on 01 May 1994

Evaluation of warfarin drug interaction listings in US product information for warfarin and interacting drugs

scientific article

Evidence for the biotransformation of procainamide to a reactive metabolite

scientific article

Familial dilated cardiomyopathy

scientific article published on 01 June 1992

Farewell to our Good Friend and Outstanding Colleague David Flockhart (1952-2015).

scientific article

Female gender as a risk factor for drug-induced cardiac arrhythmias: evaluation of clinical and experimental evidence

scientific article published in June 1998

Female gender is a risk factor for torsades de pointes in an in vitro animal model

scientific article published on 01 August 1999

Flecainide dose-response relations in stable ventricular arrhythmias

scientific article published on 01 February 1984

Formal education about medication errors in internal medicine clerkships

scientific article published on 01 September 2001

Frequency-dependent interactions of mexiletine and quinidine on depolarization and repolarization in canine Purkinje fibers

scientific article published on 01 December 1987

From Bench to Bedside: Role of Gender-Based Therapeutics in the Clinical Care of Women ⬇️

scientific article published on February 1, 1998

Further evidence for the lack of association between acetylator phenotype and systemic lupus erythematosus

scientific article published on 01 April 1986

Gadolinium decreases stretch-induced vulnerability to atrial fibrillation

scientific article published on 01 May 2000

Gender and age differences in medications dispensed from a national chain drugstore

scientific article published in June 2008

Gender difference in the cycle length-dependent QT and potassium currents in rabbits

scientific article published in May 1998

Geographic variation in the prescription of schedule II opioid analgesics among outpatients in the United States

scientific article

Grapefruit juice alters terfenadine pharmacokinetics, resulting in prolongation of repolarization on the electrocardiogram

scientific article published on 01 April 1996

Greater quinidine-induced QTc interval prolongation in women

scientific article published on 01 April 2000

Guanethidine

scientific article published on 01 January 1977

Guanethidine

scientific article published on 01 November 1976

Immediate- versus controlled-release disopyramide: importance of saturable binding

scientific article published on 01 July 1993

Importance of metabolites in antiarrhythmic therapy

scientific article published on 01 September 1983

In vivo androgen treatment shortens the QT interval and increases the densities of inward and delayed rectifier potassium currents in orchiectomized male rabbits

scientific article

Incidence and clinical features of the quinidine-associated long QT syndrome: implications for patient care

scientific article published on June 1986

Indications for different modes of surgical therapy in medically refractory ventricular arrhythmias

scientific article published on 01 June 1986

Influence of genetic polymorphism on the metabolism and disposition of encainide in man

scientific article published on 01 March 1984

Influence of opioid agonists on cardiac human ether-a-go-go-related gene K(+) currents

scientific article

Influence of theobromine magnesium oleate on formation of experimental atheroma

scientific article published on 01 September 1973

Interactions between cocaine and dopamine agonists on cardiovascular function in squirrel monkeys

scientific article published in January 2002

Intravenous amiodarone for recurrent sustained hypotensive ventricular tachyarrhythmias. Intravenous Amiodarone Multicenter Trial Group

scientific article published on January 1996

Investigation of potential mechanisms of sex differences in quinidine-induced torsade de pointes risk.

scientific article published on 12 March 2015

Is It Possible for FDA Regulatory Scientists and Industry Scientists to Work Together?

scientific article published on 01 March 2012

Is dispersion of ventricular repolarization rate dependent?

scientific article published on 01 October 1997

It Is Important Research, but Why Is It Necessary?

scientific article published on April 1, 2013

Lack of triggered automaticity despite repolarization abnormalities due to bepridil and lidoflazine

scientific article published on 01 January 1990

Making medicines safer--the need for an independent drug safety board.

scientific article published in December 1998

Mechanism of cardiotoxicity of halofantrine

scientific article (publication date: May 2000)

Mechanism of the cardiotoxic actions of terfenadine

scientific article published on 01 March 1993

Medical decision support systems and therapeutics: The role of autopilots

scientific article published on 9 September 2015

Metabolism of L-methionine- 35 S in zinc-deficient rats

scientific article published on 01 September 1972

Metabolism of procainamide in the perfused rat liver.

scientific article published on May 1981

Metabolism of procainamide to a hydroxylamine by rat and human hepatic microsomes

scientific article published on 01 January 1984

Mexiletine and tocainide: a comparison of antiarrhythmic efficacy, adverse effects, and predictive value of lidocaine testing

scientific article published in May 1989

Mexiletine and tocainide: a profile of two lidocaine analogs

scientific article published in March 1987

Mexiletine in the treatment of resistant ventricular arrhythmias: enhancement of efficacy and reduction of dose-related side effects by combination with quinidine

scientific article published on 01 May 1983

Molecular basis for the antigenicity of lidocaine analogs: tocainide and mexiletine

scientific article published in March 1984

Multicenter trial of sotalol compared with procainamide in the suppression of inducible ventricular tachycardia: a double-blind, randomized parallel evaluation. Sotalol Multicenter Study Group

scientific article published on January 1995

N-Desethyacecainide is a metabolite of procainamide in man; convenient method for the preparation of an N-dealkylated drug metabolite

scientific article published on September 1979

N-acetylation phenotype and genotype and risk of bladder cancer in benzidine-exposed workers

scientific article published in April 1993

New concepts affecting the use of antiarrhythmic agents

scientific article published on June 1990

New initiative speeds tuberculosis drug development: novel drug regimens become possible in years, not decades

scientific article published on 01 June 2010

New insights into the definition and meaning of proarrhythmia during initiation of antiarrhythmic drug therapy from the Cardiac Arrhythmia Suppression Trial and its pilot study. The CAST and CAPS Investigators.

scientific article

Normal distribution of acetylation phenotypes in systemic lupus erythematosus

scientific article published on 01 March 1978

Olanzapine-induced rhabdomyolysis

scientific article published in September 2001

One Hundred Years of Drug Regulation: Where Do We Go from Here? ⬇️

scientific article published on October 16, 2012

Opportunities in phase IV to improve drug development

scientific article published on 01 January 1997

Overview of the clinical pharmacology of antiarrhythmic drugs

scientific article published on January 1988

Oxidative metabolism of encainide: polymorphism, pharmacokinetics and clinical considerations

scientific article published in May 1986

P-Glycoprotein in clinical cardiology.

scientific article

Pentamidine-induced torsades de pointes: safe completion of therapy with inhaled pentamidine

scientific article published on 01 June 1991

Pharmacies and prevention of potentially fatal drug interactions

scientific article published on 01 April 1996

Pharmacogenetic characteristics of the eosinophilia-myalgia syndrome

scientific article published on 01 October 1994

Pharmacokinetic and pharmacodynamic interaction of N-acetyl procainamide and procainamide in humans

scientific article (publication date: September 1989)

Pharmacokinetic, pharmacodynamic, and safety evaluation of an accelerated dose titration regimen of sotalol in healthy middle-aged subjects

scientific article published on 01 July 1999

Pharmacokinetics and nondialyzability of mexiletine in renal failure

Pharmacokinetics and pharmacodynamics of antiarrhythmic agents in patients with congestive heart failure

scientific article published on November 1987

Pharmacokinetics of antiarrhythmic drugs

scientific article published on 01 May 1978

Pharmacokinetics of moricizine HCl.

scientific article published on October 1987

Pharmacokinetics of sertraline across pregnancy and postpartum

scientific article

Pharmacologic causes of arrhythmogenic actions of antiarrhythmic drugs

scientific article

Pharmacologic evaluation of standard and controlled-release disopyramide

scientific article published on February 1987

Pharmacologic reversal of hypotensive effect complicating antiarrhythmic therapy with bretylium

scientific article published on September 1982

Pharmacology, electrophysiology, and pharmacokinetics of mexiletine

scientific article published on May 1984

Plasma concentrations of quinidine, its major metabolites, and dihydroquinidine in patients with torsades de pointes

scientific article published on June 1988

Polymorphism of propafenone metabolism and disposition in man: clinical and pharmacokinetic consequences

scientific article published on 01 April 1987

Potent electrophysiologic effects of the major metabolites of propafenone in canine Purkinje fibers

scientific article published on 01 March 1988

Potential applications of free drug level monitoring in cardiovascular therapy

scientific article published on 01 January 1984

Potential determinants of prescribers' drug-drug interaction knowledge

scientific article published on 08 August 2008

Potential drug-drug interactions within Veterans Affairs medical centers

scientific article published in July 2007

Predicting the Unpredictable: Drug-Induced QT Prolongation and Torsades de Pointes

scientific article published on April 2016

Prescribers' knowledge of and sources of information for potential drug-drug interactions: a postal survey of US prescribers

scientific article

Prescription of QT-prolonging drugs in a cohort of about 5 million outpatients

scientific article published in February 2003

Proarrhythmia, arrhythmogenesis or aggravation of arrhythmia--a status report, 1987

scientific article published on 01 April 1987

Prolongation of QT interval in isolated feline hearts by antipsychotic drugs

scientific article published on 01 December 1998

Propranolol and depression

scientific article published on January 1982

Prospective pharmacokinetically based development of effective infusion regimens for ACC–9358, a new antiarrhythmic drug

article

QT interval: a measure of drug action

scientific article

QT prolongation and arrhythmia suppression

scientific article published on 01 February 1985

QTc interval prolongation associated with intravenous methadone.

scientific article

Recainam dose titration and pharmacokinetics in patients with resistant arrhythmias.

scientific article

Reducing inappropriate prescribing of sublingual nifedipine.

scientific article

Registry for torsades de pointes with drug treatment exists

scientific article published on March 2001

Regulating manufacturer-affiliated communication in the information age

scientific article published on 01 June 1999

Regulatory and reimbursement innovation

scientific article published on March 2013

Relation between ventricular function and antiarrhythmic responses to sotalol

scientific article published on 01 October 1989

Relationship of CYP2D6 (debrisoquine hydroxylase) genotype to breast cancer susceptibility

scientific article published on 01 December 1993

Relationships between psychotropic drug dosage, plasma drug concentration, and prolactin levels in nursing home residents

scientific article published in December 2000

Renal excretion of 3-O-methyl-D-glucose

scientific article published on 01 June 1968

Renal excretion of some isomeric hexoses in the dog

scientific article published on 01 January 1967

Renal tubular secretion of L-glucose

scientific article published on 01 February 1968

Renal tubular transport of 2-deoxy-D-glucose in dogs and rats

scientific article published on 01 May 1970

Research at the interface of industry, academia and regulatory science

scientific article published on 01 May 2010

Risk/benefit considerations in antiarrhythmic therapy

scientific article published on 01 July 1986

Role of plasma concentration monitoring in the evaluation of response to antiarrhythmic drugs

scientific article published on October 1988

S-mephenytoin hydroxylation phenotypes in a Jordanian population

scientific article published on 01 November 1995

Safe drug use in long QT syndrome and Brugada syndrome: comparison of website statistics

scientific article published on 26 March 2013

Salivary analysis for determination of dextromethorphan metabolic phenotype

scientific article published on 01 April 1991

Selection of an antiarrhythmic drug for a sudden-death-prevention trial

scientific article published in April 1982

Sex hormones prolong the QT interval and downregulate potassium channel expression in the rabbit heart

scientific article published in September 1996

Simultaneous analysis of dapsone and monoacetyldapsone employing high performance liquid chromatography: a rapid method for determination of acetylator phenotype

scientific article published on November 1978

Simultaneous quantification of procainamide and N-acetylprocainamide with high-performance liquid chromatography

scientific article published on December 22, 1976

Sotalol

scientific article

Spectrum of antiarrhythmic response to encainide.

scientific article published in November 1985

Stereoselective disposition and pharmacologic activity of propafenone enantiomers

scientific article published on 01 May 1989

Suppression of chronic ventricular arrhythmias with propranolol

scientific article published on 01 October 1979

Suppression of resistant ventricular arrhythmias by twice daily dosing with flecainide.

scientific article published in December 1981

Suppression of ventricular arrhythmias in man by d-propranolol independent of beta-adrenergic receptor blockade

scientific article published on March 1990

Suppression of ventricular ectopic depolarizations by tocainide

scientific article published on 01 December 1977

Survey of clinical pharmacology training in the United States and Canada

scientific article published on 01 July 1996

Teaching objectives for fellowship programs in clinical electrophysiology

scientific article published in July 1988

Teaching objectives for fellowship programs in clinical electrophysiology

scientific article published on 01 July 1988

Terfenadine increases the QT interval in isolated guinea pig heart

scientific article published on 01 January 1995

Testosterone-mediated modulation of HERG blockade by proarrhythmic agents

scientific article

The Cardiac Arrhythmia Suppression Trial: first CAST ... then CAST-II.

scientific article published on April 1992

The Critical Path Institute's approach to precompetitive sharing and advancing regulatory science

scientific article published on May 2010

The FDA critical path initiative and its influence on new drug development.

scientific article

The antiarrhythmic activity of meobentine sulfate in man

scientific article published on 01 July 1984

The antiestrogen tamoxifen blocks the delayed rectifier potassium current, IKr, in rabbit ventricular myocytes

scientific article published on 01 December 1998

The clinical value of FDA class C drugs approved from 1981 to 1988

scientific article published on 01 December 1992

The development and testing of intravenous dosing regimens: application to flecainide for the suppression of ventricular arrhythmias

scientific article published on 01 May 1988

The documented role of pharmacogenetic: in the identification and administration of new medications for treating drug abuse

scientific article published on 01 January 1996

The electrocardiographic effects of cetirizine in normal subjects

scientific article published on 01 September 1994

The essential role of integrative biomedical sciences in protecting and contributing to the health and well-being of our nation

scientific article published on 01 June 1994

The hydroxylation of omeprazole correlates with S-mephenytoin metabolism: a population study

scientific article published on 01 June 1995

The implications of procainamide metabolism to its induction of lupus

scientific article published on August 1981

The role of genetically determined polymorphic drug metabolism in the beta-blockade produced by propafenone

scientific article published on June 1990

The translational path includes the FDA's critical path

scientific article published on 11 August 2008

They are from the government and they really are here to help you

scientific article published on 01 February 2008

Time to replace Bazett's QT-correction.

scientific article

Tocainide plus quinidine for treatment of ventricular arrhythmias

scientific article published in March 1988

Tolerance to the humoral and hemodynamic effects of caffeine in man.

scientific article

Total suppression of ventricular arrhythmias by encainide. Pharmacokinetic and electrocardiographic characteristics

scientific article published on 01 April 1980

Treatment of tobacco dependence: innovative regulatory approaches to reduce death and disease: preface

scientific article published on 01 January 1998

Treatment of ventricular arrhythmias in the failing heart: pharmacologic and clinical considerations

Urinary excretion of radiosulfur following taurine- 35 S injection in zinc deficient rats.

scientific article

Warfarin interactions with substances listed in drug information compendia and in the FDA-approved label for warfarin sodium.

scientific article published on 8 July 2009

Withdrawal of haloperidol, thioridazine, and lorazepam in the nursing home: a controlled, double-blind study

scientific article published in August 1999

Workload and availability of technology in metropolitan community pharmacies

scientific article published on 01 March 2006

d-sotalol reduces heart rate in vivo through a beta-adrenergic receptor-independent mechanism

scientific article published on April 1993

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