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List of works by Christopher J Bowman

Altered Gene Expression during Rat Wolffian Duct Development in Response to in Utero Exposure to the Antiandrogen Linuron ⬇️

scientific article published on May 2, 2003

Applying a weight of evidence approach to the evaluation of developmental toxicity of biopharmaceuticals

scientific article published on 24 July 2018

Comparative estrogenicity of estradiol, ethynyl estradiol and diethylstilbestrol in an in vivo, male sheepshead minnow (Cyprinodon variegatus), vitellogenin bioassay

scientific article published on 01 May 2000

Contrasting effects of estrogen on transthyretin and vitellogenin expression in males of the marine fish, Sparus aurata.

scientific article published in September 2000

Decreased maternal and fetal cholesterol following maternal bococizumab (anti-PCSK9 monoclonal antibody) administration does not affect rat embryo-fetal development

scientific article published on 14 September 2015

Developmental toxicity assessment of tanezumab, an anti-nerve growth factor monoclonal antibody, in cynomolgus monkeys (Macaca fascicularis).

scientific article

Developmental toxicity of lersivirine in rabbits when administered throughout organogenesis and when limited to sensitive windows of axial skeletal development.

scientific article published on 11 April 2012

Developmental toxicity study of lersivirine in mice.

scientific article published on 22 March 2012

Effects of in utero exposure to finasteride on androgen-dependent reproductive development in the male rat.

scientific article published on 28 May 2003

Embryo-fetal distribution of a biopharmaceutical IgG2 during rat organogenesis

scientific article published on 20 April 2012

Embryo-fetal transfer of bevacizumab (Avastin) in the rat over the course of gestation and the impact of neonatal Fc receptor (FcRn) binding

scientific article published on 11 September 2012

Estradiol-induced gene expression in largemouth bass (Micropterus salmoides).

scientific article

Estrogen-induced vitellogenin mRNA and protein in sheepshead minnow (Cyprinodon variegatus)

scientific article published on 01 December 2000

Evaluation of a novel delayed-type hypersensitivity assay to Candida albicans in adult and neonatal rats.

scientific article published on 21 November 2014

Goldilocks' Determination of What New In Vivo Data are "Just Right" for Different Common Drug Development Scenarios, Part 1.

scientific article

Immunologic effects of chronic administration of tofacitinib, a Janus kinase inhibitor, in cynomolgus monkeys and rats - Comparison of juvenile and adult responses.

scientific article published on 14 February 2018

Induction of gene expression in sheepshead minnows (Cyprinodon variegatus) treated with 17beta-estradiol, diethylstilbestrol, or ethinylestradiol: the use of mRNA fingerprints as an indicator of gene regulation.

scientific article published in March 2001

Induction of tyrosine hydroxylase by forskolin: modulation with age

scientific article published on 01 April 1997

Juvenile toxicity assessment of anidulafungin in rats: an example of navigating case-by-case study design through scientific and regulatory challenges.

scientific article published on 18 May 2011

Maternal-placental insulin-like growth factor (IGF) signaling and its importance to normal embryo-fetal development.

scientific article published on August 2010

Morphologic, stereologic, and morphometric evaluation of the nervous system in young cynomolgus monkeys (Macaca fascicularis) following maternal administration of tanezumab, a monoclonal antibody to nerve growth factor.

scientific article

Multiple responses in gene expression in fish treated with estrogen.

scientific article published in June 2001

Neonatal Fc Receptor and its Role in the Absorption, Distribution, Metabolism and Excretion of Immunoglobulin G-Based Biotherapeutics ⬇️

scientific article published on September 1, 2013

Non-clinical safety assessment and toxicokinetics of voriconazole and anidulafungin in the juvenile rat: A combination study design in support of a Paediatric Investigation Plan ⬇️

scientific article published on February 16, 2012

Object discrimination reversal as a method to assess cognitive impairment in nonhuman primate enhanced pre- and postnatal developmental (ePPND) studies: statistical power analysis.

scientific article published on 28 August 2012

Placental transfer of (125)Iodinated humanized immunoglobulin G2Δa in the Sprague Dawley rat.

scientific article published on 24 February 2013

Placental transfer of Fc-containing biopharmaceuticals across species, an industry survey analysis

scientific article published in December 2013

Preclinical safety evaluations supporting pediatric drug development with biopharmaceuticals: strategy, challenges, current practices.

scientific article published on 18 July 2011

Reproductive toxicity assessment of sunitinib, a multitargeted receptor tyrosine kinase inhibitor, in male and female rats.

scientific article published on 12 April 2012

Scientific and Regulatory Policy Committee Points to Consider Review: Inclusion of Reproductive and Pathology End Points for Assessment of Reproductive and Developmental Toxicity in Pharmaceutical Drug Development.

scientific article published on 27 May 2016

Sensitive Windows of Skeletal Development in Rabbits Determined by Hydroxyurea Exposure at Different Times throughout Gestation ⬇️

scientific article published on April 11, 2012

Sensitivity of male reproductive endpoints in nonhuman primate toxicity studies: a statistical power analysis.

scientific article published on 19 June 2013

The design of chronic toxicology studies of monoclonal antibodies: implications for the reduction in use of non-human primates.

scientific article

The placenta, transfer of immunoglobulins, and safety assessment of biopharmaceuticals in pregnancy.

scientific article published on March 2012

Tissue distribution of anidulafungin in neonatal rats.

scientific article published on 6 February 2012

Vitellogenin mRNA regulation and plasma clearance in male sheepshead minnows, (Cyprinodon variegatus) after cessation of exposure to 17 beta-estradiol and p-nonylphenol.

scientific article

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