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List of works by Raymond F. Schinazi

1-Benzyl-2-(1H-indol-3-yl)-5-oxopyrrolidine-2-carbonitrile ⬇️

scientific article published on January 4, 2008

2'-Chloro,2'-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture.

scientific article published on 8 June 2017

2('),3(')-didehydro-2('),3(')-dideoxynucleosides are degraded to furfuryl alcohol under acidic conditions

scientific article published on May 2004

2′-Fluoro-4′-thio-2′,3′-unsaturated Nucleosides: Anti-HIV Activity, Resistance Profile, and Molecular Modeling Studies ⬇️

scientific article published on May 1, 2003

3'-(1,2,3-Triazol-1-yl)-3'-deoxythymidine analogs as substrates for human and Ureaplasma parvum thymidine kinase for structure-activity investigations.

scientific article

5'-O-Aliphatic and amino acid ester prodrugs of (-)-beta-D-(2R,4R)-dioxolane-thymine (DOT): synthesis, anti-HIV activity, cytotoxicity and stability studies

scientific article

5-(Phenylthio)acyclouridine: a powerful enhancer of oral uridine bioavailability: relevance to chemotherapy with 5-fluorouracil and other uridine rescue regimens

scientific article

A CRISPR/Cas9 approach reveals that the polymerase activity of DNA polymerase β is dispensable for HIV-1 infection in dividing and nondividing cells

scientific article

A Complex Network of Interactions between S282 and G283 of Hepatitis C Virus Nonstructural Protein 5B and the Template Strand Affects Susceptibility to Sofosbuvir and Ribavirin

scientific article published on 11 January 2016

A new class of dual-targeted antivirals: monophosphorylated acyclovir prodrug derivatives suppress both human immunodeficiency virus type 1 and herpes simplex virus type 2

scientific article

A new oxygen modification cyclooctaoxygen binds to nucleic acids as sodium crown complex

scientific article published on 26 January 2016

Abundant Non-canonical dUTP Found in Primary Human Macrophages Drives Its Frequent Incorporation by HIV-1 Reverse Transcriptase ⬇️

scientific article published on March 31, 2011

Acute acalculous cholecystitis during Zika virus infection in an immunocompromised patient

scientific article published on 24 November 2017

Acyclovir is activated into a HIV-1 reverse transcriptase inhibitor in herpesvirus-infected human tissues

scientific article

Adenosine Dioxolane Nucleoside Phosphoramidates as Antiviral Agents for Human Immunodeficiency and Hepatitis B Viruses

scientific article published on August 2013

Advances in nucleoside monophosphate prodrugs as anti-HCV agents ⬇️

scientific article published on January 1, 2010

An Efficient Route to β-d-Isoxazolidinyl Nucleosides via Diastereoselective Michael Addition of Hydroxylamine to Unsaturated Esters ⬇️

scientific article published on October 17, 1997

Analysis of multiply spliced transcripts in lymphoid tissue reservoirs of rhesus macaques infected with RT-SHIV during HAART

scientific article

Anti-HIV Host Factor SAMHD1 Regulates Viral Sensitivity to Nucleoside Reverse Transcriptase Inhibitors via Modulation of Cellular Deoxyribonucleoside Triphosphate (dNTP) Levels ⬇️

scientific article published on 05 June 2013

Anti-HIV activity of (-)-(2R,4R)-1- (2-hydroxymethyl-1,3-dioxolan-4-yl)-thymine against drug-resistant HIV-1 mutants and studies of its molecular mechanism

scientific article published in June 2005

Anti-hepatitis C virus activity of novel beta-d-2'-C-methyl-4'-azido pyrimidine nucleoside phosphoramidate prodrugs

scientific article published on 19 October 2009

Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides

scientific article published on 13 July 2009

Anti-infective discorhabdins from a deep-water alaskan sponge of the genus Latrunculia

scientific article published on March 2010

Antiretroviral monocyte efficacy score linked to cognitive impairment in HIV.

scientific article published on 28 September 2012

Antiretroviral therapy in macrophages: implication for HIV eradication

scientific article

Antiviral activities and cellular toxicities of modified 2',3'-dideoxy-2',3'-didehydrocytidine analogues

scientific article

Antiviral activity and pharmacokinetics of 1-(2,3-dideoxy-2-fluoro-beta-L-glyceropent-2-enofuranosyl)cytosine

scientific article

Antiviral activity and tolerability of amdoxovir with zidovudine in a randomized double-blind placebo-controlled study in HIV-1-infected individuals

scientific article

Antiviral activity of nucleoside analogues against norovirus

scientific article published on 14 August 2012

Antiviral agents derived from novel 1-adamantyl singlet nitrenes

scientific article published on 7 December 2012

Antiviral and anticancer optimization studies of the DNA-binding marine natural product aaptamine

scientific article

Antiviral and cellular metabolism interactions between Dexelvucitabine and lamivudine

scientific article published on 2 April 2007

Antiviral effect of orally administered (-)-beta-D-2-aminopurine dioxolane in woodchucks with chronic woodchuck hepatitis virus infection

scientific article

Antiviral efficacy of nine nucleoside reverse transcriptase inhibitors against feline immunodeficiency virus in feline peripheral blood mononuclear cells

scientific article published on March 2014

Application of Molecular Dynamics Simulations to the Design of Nucleotide Inhibitors Binding to Norovirus Polymerase

scientific article published on 01 December 2020

Approaches for the development of antiviral compounds: the case of hepatitis C virus

scientific article

Approaches to hepatitis C treatment and cure using NS5A inhibitors

scientific article published on 05 March 2014

Assessment of the relative potency of emtricitabine and lamivudine

scientific article published in October 2003

Asymmetric binding to NS5A by daclatasvir (BMS-790052) and analogs suggests two novel modes of HCV inhibition

scientific article

Azetidines and spiro azetidines as novel P2 units in hepatitis C virus NS3 protease inhibitors

scientific article published on 30 September 2013

Balancing antiviral potency and host toxicity: identifying a nucleotide inhibitor with an optimal kinetic phenotype for HIV-1 reverse transcriptase

scientific article

Biochemical Characterization of the Active Anti-Hepatitis C Virus Metabolites of 2,6-Diaminopurine Ribonucleoside Prodrug Compared to Sofosbuvir and BMS-986094.

scientific article

Biochemical studies on the mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to 1-(beta-D-dioxolane)thymine triphosphate

scientific article published on 2 April 2007

Cellular Pharmacology and Potency of HIV-1 Nucleoside Analogs in Primary Human Macrophages ⬇️

scientific article published on December 21, 2012

Cellular pharmacology of D-d4FC, a nucleoside analogue active against drug-resistant HIV.

scientific article

Characterization of dengue virus 2 growth in megakaryocyte-erythrocyte progenitor cells

scientific article

Characterization of hepatitis B virus inhibition by novel 2'-fluoro-2',3'-unsaturated beta-D- and L-nucleosides

scientific article published on January 2005

Characterization of β-d-N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus

scientific article

Chemoenzymatic Syntheses and Anti-HIV-1 Activity of Glucose−Nucleoside Conjugates as Prodrugs ⬇️

scientific article published on November 15, 2010

Chronic liver inflammation modifies DNA methylation at the precancerous stage of murine hepatocarcinogenesis

scientific article published on May 2015

Chutes and ladders in hepatitis C nucleoside drug development

scientific article

Cofactor mimics as selective inhibitors of NAD-dependent inosine monophosphate dehydrogenase (IMPDH)--the major therapeutic target

scientific article

Combinations of 2'-C-methylcytidine analogues with interferon-alpha2b and triple combination with ribavirin in the hepatitis C virus replicon system

scientific article

Comparative analysis of in vitro processivity of HIV-1 reverse transcriptases containing mutations 65R, 74V, 184V and 65R+74V.

scientific article published on 23 June 2009

Comparative pharmacokinetics of Racivir, (+/-)-beta-2',3'-dideoxy-5-fluoro-3'-thiacytidine in rats, rabbits, dogs, monkeys and HIV-infected humans

scientific article published in January 2005

Contemporary Approaches to the Discovery and Development of Broad-Spectrum Natural Product Prototypes for the Control of Coronaviruses

scientific article published in 2021

Correction for Mavigner et al., "Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques"

Cost analysis of sofosbuvir/ribavirin versus sofosbuvir/simeprevir for genotype 1 hepatitis C virus in interferon-ineligible/intolerant individuals

scientific article

Cu(I)-catalyzed Huisgen azide-alkyne 1,3-dipolar cycloaddition reaction in nucleoside, nucleotide, and oligonucleotide chemistry

scientific article published on September 2009

D- and L-2',3'-didehydro-2',3'-dideoxy-3'-fluoro-carbocyclic nucleosides: synthesis, anti-HIV activity and mechanism of resistance

scientific article published on 21 March 2007

DPC 817: a cytidine nucleoside analog with activity against zidovudine- and lamivudine-resistant viral variants

scientific article published on May 2002

Delayed chain termination protects the anti-hepatitis B virus drug entecavir from excision by HIV-1 reverse transcriptase

scientific article published on 20 October 2008

Design, synthesis and evaluation of novel anti-HCV molecules that deliver intracellularly three highly potent NS5A inhibitors

scientific article

Design, synthesis, and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication

scientific article

Development of a novel mouse model to evaluate drug candidates against hepatitis B virus

scientific article

Development of a pharmacodynamic model for HIV treatment with nucleoside reverse transcriptase and protease inhibitors

scientific article published in November 2002

Development of a population simulation model for HIV monotherapy virological outcomes using lamivudine

scientific article published in January 2007

Development of an optimized dose for coformulation of zidovudine with drugs that select for the K65R mutation using a population pharmacokinetic and enzyme kinetic simulation model

scientific article published on 06 October 2008

Differential regulatory activities of viral protein X for anti-viral efficacy of nucleos(t)ide reverse transcriptase inhibitors in monocyte-derived macrophages and activated CD4(+) T cells

scientific article

Discovery of a Series of 2'-α-Fluoro,2'-β-bromo-ribonucleosides and Their Phosphoramidate Prodrugs as Potent Pan-Genotypic Inhibitors of Hepatitis C Virus

scientific article published on 07 February 2019

Discovery, characterization, and lead optimization of 7-azaindole non-nucleoside HIV-1 reverse transcriptase inhibitors

scientific article

Dynamics of Subgenomic Hepatitis C Virus Replicon RNA Levels in Huh-7 Cells after Exposure to Nucleoside Antimetabolites

scientific article

ESR as a valuable tool for the investigation of the dynamics of EPC and EPC/cholesterol liposomes containing a carboranyl-nucleoside intended for BNCT.

scientific article published in June 2005

Editorial overview: Antiviral strategies

scholarly article by Erik De Clercq published in June 2016

Efavirenz therapy in rhesus macaques infected with a chimera of simian immunodeficiency virus containing reverse transcriptase from human immunodeficiency virus type 1.

scientific article published on September 2004

Efficacy and safety of 3-week response-guided triple direct-acting antiviral therapy for chronic hepatitis C infection: a phase 2, open-label, proof-of-concept study

scientific article

Efficient synthesis of exo-N-carbamoyl nucleosides: application to the synthesis of phosphoramidate prodrugs ⬇️

scientific article published on May 3, 2012

Efficient synthesis of nucleoside aryloxy phosphoramidate prodrugs utilizing benzyloxycarbonyl protection ⬇️

scientific article published on July 29, 2011

Efficient synthesis of various acycloalkenyl derivatives of pyrimidine using cross-metathesis and Pd(0) methodologies

article published in 2005

Emergence of a novel mutation in the FLLA region of hepatitis B virus during lamivudine therapy

scientific article published on July 2005

Enantioselective synthesis and antiviral activity of purine and pyrimidine cyclopentenyl C-nucleosides

scientific article published on 25 October 2006

Engineering of a chimeric RB69 DNA polymerase sensitive to drugs targeting the cytomegalovirus enzyme

scientific article published on 21 July 2009

Enhanced antiretroviral therapy in rhesus macaques improves RT-SHIV viral decay kinetics

scientific article

Evaluation of Single and Combination Therapies with Tenofovir Disoproxil Fumarate and Emtricitabine In Vitro and in a Robust Mouse Model Supporting High Levels of Hepatitis B Virus Replication ⬇️

scientific article published on September 17, 2012

Exploiting the anti-HIV-1 activity of acyclovir: suppression of primary and drug-resistant HIV isolates and potentiation of the activity by ribavirin

scientific article published on 6 February 2012

Expression, purification, and characterization of a GII.4 norovirus protease.

scientific article

Facile purification of honokiol and its antiviral and cytotoxic properties

scientific article

Food Insufficiency and Medication Adherence Among People Living with HIV/AIDS in Urban and Peri-Urban Settings ⬇️

scientific article published on September 1, 2011

From HCV To HBV Cure

scientific article published on January 2017

HCV direct-acting antiviral agents: the best interferon-free combinations

scientific article published on February 2014

HIV latency reversal research and the potential effects on the central nervous system: is concern warranted?

scientific article published on 9 May 2016

HIV-1 resistance profile of the novel nucleoside reverse transcriptase inhibitor beta-D-2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine (Reverset).

scientific article published on January 2003

Hepatitis B virus resistance to lamivudine and its clinical implications

scientific article

Hepatitis B virus transgenic severe combined immunodeficient mouse model of acute and chronic liver disease

scientific article published in January 2004

Hepatocellular carcinoma in the woodchuck model of hepatitis B virus infection

scientific article published in November 2004

Host SAMHD1 protein restricts endogenous reverse transcription of HIV-1 in nondividing macrophages

article

Impact of protease inhibitors on intracellular concentration of tenofovir-diphosphate among HIV-1 infected patients

scientific article published on June 2015

In silico study supports the efficacy of a reduced dose regimen for stavudine ⬇️

scientific article published on August 22, 2011

In vitro activity of structurally diverse nucleoside analogs against human immunodeficiency virus type 1 with the K65R mutation in reverse transcriptase

scientific article

In vitro selection and analysis of human immunodeficiency virus type 1 resistant to derivatives of beta-2',3'-didehydro-2',3'-dideoxy-5-fluorocytidine

scientific article

In-vitro phenotypic susceptibility of HIV-2 clinical isolates to the integrase inhibitor S/GSK1349572.

scientific article published on November 2010

Inactivation of SARS-CoV-2 and COVID-19 Patient Samples for Contemporary Immunology and Metabolomics Studies

scientific article published on 16 February 2022

Increased activity of unlinked Zika virus NS2B/NS3 protease compared to linked Zika virus protease

scientific article (publication date: March 2017)

Inhibition of hepatitis C replicon RNA synthesis by beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine: a specific inhibitor of hepatitis C virus replication

scientific article published on January 2006

Inhibition of the subgenomic hepatitis C virus replicon in huh-7 cells by 2'-deoxy-2'-fluorocytidine.

scientific article

Insights into the molecular mechanism of inhibition and drug resistance for HIV-1 RT with carbovir triphosphate

scientific article published in April 2002

Interaction of 2'-deoxyguanosine triphosphate analogue inhibitors of HIV reverse transcriptase with human mitochondrial DNA polymerase gamma

scientific article published on January 2007

Interactions of enantiomers of 2',3'-didehydro-2',3'-dideoxy-fluorocytidine with wild type and M184V mutant HIV-1 reverse transcriptase

scientific article published in December 2002

Interplay of ancestral non-primate lentiviruses with the virus-restricting SAMHD1 proteins of their hosts

scientific article published in Journal of Biological Chemistry

Investigating the effects of stereochemistry on incorporation and removal of 5-fluorocytidine analogs by mitochondrial DNA polymerase gamma: comparison of D- and L-D4FC-TP.

scientific article published in April 2004

Jak Inhibitors Modulate Production of Replication-Competent Zika Virus in Human Hofbauer, Trophoblasts, and Neuroblastoma cells

scientific article published on 24 May 2017

Kinetic variations between reverse transcriptases of viral protein X coding and noncoding lentiviruses

scientific article published on 19 December 2014

Lack of pharmacokinetic interaction between amdoxovir and reduced- and standard-dose zidovudine in HIV-1-infected individuals

scientific article

Ligand similarity guided receptor selection enhances docking accuracy and recall for non-nucleoside HIV reverse transcriptase inhibitors

scientific article published on 8 October 2015

Long-term exposure to AZT, but not d4T, increases endothelial cell oxidative stress and mitochondrial dysfunction

scientific article published on 09 December 2008

Magnetic resonance spectroscopy reveals that activated monocytes contribute to neuronal injury in SIV neuroAIDS.

scientific article

Manadomanzamines A and B: a novel alkaloid ring system with potent activity against mycobacteria and HIV-1.

scientific article

Mechanism of Activation of -D-2'-Deoxy-2'-Fluoro-2'-C-Methylcytidine and Inhibition of Hepatitis C Virus NS5B RNA Polymerase

scientific article (publication date: February 2007)

Mechanism of anti-human immunodeficiency virus activity of beta-D-6-cyclopropylamino-2',3'-didehydro-2',3'-dideoxyguanosine

scientific article

Mechanism of antiviral activities of 3'-substituted L-nucleosides against 3TC-resistant HBV polymerase: a molecular modelling approach

scientific article published in November 2003

Mechanisms associated with HIV-1 resistance to acyclovir by the V75I mutation in reverse transcriptase

scientific article published on 09 June 2009

Mechanistic and Kinetic Differences between Reverse Transcriptases of Vpx Coding and Non-coding Lentiviruses

scientific article

Metabolic profiling during HIV-1 and HIV-2 infection of primary human monocyte-derived macrophages.

scientific article

Metabolism of Nucleosides and Nucleotides Prodrugs

scientific article published on 11 October 2017

Metabolism of the anti-hepatitis C virus nucleoside beta-D-N4-hydroxycytidine in different liver cells

scientific article published on December 2004

Metabolism, Biochemical Actions, and Chemical Synthesis of Anticancer Nucleosides, Nucleotides, and Base Analogs

scientific article

Mobile Health Intervention to Reduce HIV Transmission: A Randomized Trial of Behaviorally Enhanced HIV Treatment as Prevention (B-TasP).

scientific article published on 5 February 2018

Modification at the C9 position of the marine natural product isoaaptamine and the impact on HIV-1, mycobacterial, and tumor cell activity ⬇️

scientific article

Modulation of 5-fluorouracil host-toxicity and chemotherapeutic efficacy against human colon tumors by 5-(Phenylthio)acyclouridine, a uridine phosphorylase inhibitor

scientific article published on 10 March 2006

Molecular docking and antiviral activity of N-substituted benzyl/phenyl-2-(3,4-dimethyl-5,5-dioxidopyrazolo[4,3-c][1,2]benzothiazin-2(4H)-yl)acetamides.

scientific article published on 22 January 2015

Molecular mechanism of DApd/DXG against zidovudine- and lamivudine- drug resistant mutants: a molecular modelling approach

scientific article published in March 2002

Molecular mechanism of HIV-1 resistance to 3'-azido-2',3'-dideoxyguanosine

scientific article

Monitoring medication adherence by unannounced pill counts conducted by telephone: reliability and criterion-related validity

scientific article

Monthly Unannounced Pill Counts for Monitoring HIV Treatment Adherence: Tests for Self-Monitoring and Reactivity Effects ⬇️

scientific article published on November 1, 2010

Mutations in the conserved woodchuck hepatitis virus polymerase FLLA and YMDD regions conferring resistance to lamivudine

scientific article

N4-acyl-modified D-2',3'-dideoxy-5-fluorocytidine nucleoside analogues with improved antiviral activity

scientific article

New manzamine alkaloids with activity against infectious and tropical parasitic diseases from an Indonesian sponge. ⬇️

scientific article

Nucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase

scientific article published on January 2004

Nucleotide Substrate Specificity of Anti-Hepatitis C Virus Nucleoside Analogs for Human Mitochondrial RNA Polymerase

scientific article published on 30 May 2017

PAMAM dendrimers and branched polyethyleneglycol (nanoparticles) prodrugs of (-)-beta-D-(2R, 4R)-dioxolane-thymine (DOT) and their anti-HIV activity

scientific article

Pharmacodynamics of (−)-β-2′,3′-Dideoxy-3′-Thiacytidine in Chronically Virus-Infected Woodchucks Compared to Its Pharmacodynamics in Humans.

scientific article published in December 1998

Pharmacokinetics and Placental Transfer of Elvitegravir, Dolutegravir, and Other Antiretrovirals during Pregnancy

scientific article published on 27 March 2017

Pharmacokinetics of the anti-human immunodeficiency virus agent 1-(beta-D-dioxolane)thymine in rhesus monkeys

scientific article published on 7 May 2007

Pharmacokinetics of the antiviral agent beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine in rhesus monkeys

scientific article published on 11 June 2007

Pharmacokinetics of the antiviral agent beta-L-3'-fluoro-2',3'-didehydro-2',3'-dideoxycytidine in rhesus monkeys

scientific article

Pharmacology and pharmacokinetics of the antiviral agent beta-D-2',3'-dideoxy-3'-oxa-5-fluorocytidine in cells and rhesus monkeys

scientific article

Pharmacology of current and promising nucleosides for the treatment of human immunodeficiency viruses

scientific article

Phenolics with antiviral activity from Millettia erythrocalyx and Artocarpus lakoocha

scientific article published in February 2005

Phosphoramidate and phosphate prodrugs of (-)-beta-D-(2R,4R)-dioxolane-thymine: synthesis, anti-HIV activity and stability studies

scientific article published on 28 November 2005

Polyoxometalates in Medicine

scientific article published on 01 February 1998

Potent antiviral effect of reverset in HIV-1-infected adults following a single oral dose.

scientific article published in August 2004

Practical Considerations For Developing Nucleoside Reverse Transcriptase Inhibitors

scientific article published on January 2012

Pre-steady state kinetic analysis of HIV-1 reverse transcriptase for non-canonical ribonucleoside triphosphate incorporation and DNA synthesis from ribonucleoside-containing DNA template

scientific article published on 31 December 2014

Pre-steady state kinetic analysis of cyclobutyl derivatives of 2'-deoxyadenosine 5'-triphosphate as inhibitors of HIV-1 reverse transcriptase

scientific article

Pre-steady-state kinetic studies establish entecavir 5'-triphosphate as a substrate for HIV-1 reverse transcriptase.

scientific article published on 25 October 2007

Preclinical Characterization of GLS4, an Inhibitor of Hepatitis B Virus Core Particle Assembly ⬇️

scientific article published on August 19, 2013

Predicting Zika virus structural biology: Challenges and opportunities for intervention

scientific article

Prevention of rectal SHIV transmission in macaques by daily or intermittent prophylaxis with emtricitabine and tenofovir

scientific article

Probing the mechanistic consequences of 5-fluorine substitution on cytidine nucleotide analogue incorporation by HIV-1 reverse transcriptase

scientific article published on May 2003

Probing the molecular mechanisms of AZT drug resistance mediated by HIV-1 reverse transcriptase using a transient kinetic analysis

scientific article published in July 2003

Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γ

scientific article published on 29 June 2015

Prodrug strategies for improved efficacy of nucleoside antiviral inhibitors

scientific article

Quantifying mixed populations of drug-resistant human immunodeficiency virus type 1.

scientific article

Raltegravir is a potent inhibitor of XMRV, a virus implicated in prostate cancer and chronic fatigue syndrome

scientific article published in 2010

Randomized Clinical Trial of HIV Treatment Adherence Counseling Interventions for People Living With HIV and Limited Health Literacy ⬇️

scientific article published on May 1, 2013

Randomized Factorial Trial of Phone-Delivered Support Counseling and Daily Text Message Reminders for HIV Treatment Adherence

scientific article published on 21 April 2016

Randomized, double-blind, multicenter safety and efficacy study of rifalazil compared with azithromycin for treatment of uncomplicated genital Chlamydia trachomatis infection in women

scientific article

Relationship between antiviral activity and host toxicity: comparison of the incorporation efficiencies of 2',3'-dideoxy-5-fluoro-3'-thiacytidine-triphosphate analogs by human immunodeficiency virus type 1 reverse transcriptase and human mitochondri

scientific article published on April 2004

Replication-dependent 65R-->K reversion in human immunodeficiency virus type 1 reverse transcriptase double mutant K65R + L74V.

scientific article published in April 2004

Residual viremia in an RT-SHIV rhesus macaque HAART model marked by the presence of a predominant plasma clone and a lack of viral evolution

scientific article (publication date: 2014)

Resistance to reverse transcriptase inhibitors used in the treatment and prevention of HIV-1 infection

scientific article published on 30 October 2015

Retinazone inhibits certain blood-borne human viruses including Ebola virus Zaire.

scientific article

Retrovirus reverse transcriptases containing a modified YXDD motif

scientific article

Ribonucleoside Analogue That Blocks Replication of Bovine Viral Diarrhea and Hepatitis C Viruses in Culture

scientific article

Ribonucleoside triphosphates as substrate of human immunodeficiency virus type 1 reverse transcriptase in human macrophages

scientific article

Ribonucleotide incorporation in yeast genomic DNA shows preference for cytosine and guanosine preceded by deoxyadenosine

scientific article published on 15 May 2020

Role of Marine Natural Products in the Genesis of Antiviral Agents

scientific article

Ruxolitinib and tofacitinib are potent and selective inhibitors of HIV-1 replication and virus reactivation in vitro.

scientific article

SAMHD1 controls cell cycle status, apoptosis and HIV-1 infection in monocytic THP-1 cells

scientific article published on 13 May 2016

Scaleable processes for the synthesis of (−)-β-d-2,6-diaminopurine dioxolane (Amdoxovir, DAPD) and (−)-β-d-2-aminopurine dioxolane (APD) ⬇️

scientific article published on May 16, 2012

Selection and Characterization of HIV-1 with a Novel S68 Deletion in Reverse Transcriptase ⬇️

scientific article published on February 28, 2011

Sexual HIV Transmission and Antiretroviral Therapy: A Prospective Cohort Study of Behavioral Risk Factors Among Men and Women Living with HIV/AIDS ⬇️

scientific article published on 01 August 2011

Short communication cellular pharmacology of 9-(beta-D-1,3-dioxolan-4-yl) guanine and its lack of drug interactions with zidovudine in primary human lymphocytes

scientific article published in January 2007

Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques

scholarly article by Maud Mavigner et al published 15 September 2018 in Journal of Virology

Simian immunodeficiency virus macaque models of HIV latency

scientific article published on January 2011

Simultaneous quantification of 9-(beta-D-1,3-dioxolan-4-yl)guanine, Amdoxovir and Zidovudine in human plasma by liquid chromatography-tandem mass spectrometric assay

scientific article published on 27 August 2009

Simultaneous quantification of intracellular natural and antiretroviral nucleosides and nucleotides by liquid chromatography-tandem mass spectrometry

scientific article published on March 2010

Sonication-Assisted Synthesis of(E)-2-Methyl-but-2-enyl Nucleoside Phosphonate Prodrugs

Stereoselective synthesis and antiviral activity of D-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thionucleosides

scientific article published on October 2002

Structural and Antiviral Studies of the Human Norovirus GII.4 Protease

scientific article published on 16 January 2019

Structure-activity relationships of 2'-fluoro-2',3'-unsaturated D-nucleosides as anti-HIV-1 agents

scientific article published in March 2002

Substrate mimicry: HIV-1 reverse transcriptase recognizes 6-modified-3'-azido-2',3'-dideoxyguanosine-5'-triphosphates as adenosine analogs ⬇️

scientific article published on September 13, 2011

Substrates and Inhibitors of SAMHD1.

scientific article

Suppression of hepatitis B virus DNA accumulation in chronically infected cells using a bacterial CRISPR/Cas RNA-guided DNA endonuclease

scientific article published on 29 December 2014

Suppression of virus load by highly active antiretroviral therapy in rhesus macaques infected with a recombinant simian immunodeficiency virus containing reverse transcriptase from human immunodeficiency virus type 1.

scientific article

Synthesis and Anti-HIV Evaluation of 3′-Triazolo Nucleosides ⬇️

scientific article published on April 1, 2011

Synthesis and Anti-Hepatitis B Virus and Anti-Hepatitis C Virus Activities of 7-Deazaneplanocin A Analogues in Vitro

scientific article (publication date: 8 January 2009)

Synthesis and Antiviral Evaluation of 2′,3′-Dideoxy-2′-fluoro-3′-C-hydroxymethyl-β-D-arabinofuranosyl Pyrimidine Nucleosides ⬇️

scientific article published on May 1, 2003

Synthesis and Evaluation of 2,6-Modified Purine 2'-C-Methyl Ribonucleosides as Inhibitors of HCV Replication

scientific article published on 23 November 2015

Synthesis and anti-HCV activity of N9,5'-cyclo-3-(beta-D-ribofuranosyl)-8-azapurin-2-one derivatives

scientific article published in January 2005

Synthesis and anti-HCV activity of a series of β-d-2'-deoxy-2'-dibromo nucleosides and their corresponding phosphoramidate prodrugs

scientific article

Synthesis and anti-HIV activity of (-)-beta-D-(2R,4R)-1,3-dioxolane-2,6-diamino purine (DAPD) (amdoxovir) and (-)-beta-D-(2R,4R)-1,3-dioxolane guanosine (DXG) prodrugs

scientific article

Synthesis and anti-HIV activity of D- and L-thietanose nucleosides

scientific article published on March 2006

Synthesis and anti-HIV activity of beta-D-3'-azido-2',3'-unsaturated nucleosides and beta-D-3'-azido-3'-deoxyribofuranosylnucleosides

scientific article published in January 2005

Synthesis and anti-HIV activity of conformationally restricted bicyclic hexahydroisobenzofuran nucleoside analogs.

scientific article published on 11 February 2009

Synthesis and anti-HIV-1 screening of novel N'-(1-(aryl)ethylidene)-2-(5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-4(1H)-yl)acetohydrazides.

scientific article published on 10 July 2013

Synthesis and anti-hepatitis C virus activity of nucleoside derivatives of N3, 5'-anhydro-4-(beta-D-ribofuranosyl)-8-aza-purin-2-ones

scientific article published on January 2005

Synthesis and anti-viral activity of a series of d- and l-2'-deoxy-2'-fluororibonucleosides in the subgenomic HCV replicon system

scientific article published on March 2005

Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl purine nucleosides as inhibitors of hepatitis C virus RNA replication

scientific article published on 20 December 2005

Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl-7-deazapurine nucleosides, their phosphoramidate prodrugs and 5'-triphosphates ⬇️

scientific article published on September 29, 2011

Synthesis and antiviral activity of novel acyclic nucleosides in the 5-alkynyl- and 6-alkylfuro[2,3-d]pyrimidine series.

scientific article published on February 2005

Synthesis and antiviral activity of purine 2',3'-dideoxy-2',3'-difluoro-D-arabinofuranosyl nucleosides

scientific article

Synthesis and antiviral evaluation of 2-amino-6-carbamoylpurine dioxolane nucleoside derivatives and their phosphoramidates prodrugs

scientific article published on 13 October 2014

Synthesis and antiviral evaluation of 2′,2′,3′,3′-tetrafluoro nucleoside analogs

scientific article

Synthesis and antiviral evaluation of fluorinated acyclo-nucleosides and their phosphoramidates

scientific article published on 19 October 2016

Synthesis and antiviral evaluation of novel heteroarylpyrimidines analogs as HBV capsid effectors

scientific article published on 6 January 2017

Synthesis and biological activity of 5',9-anhydro-3-purine-isonucleosides as potential anti-hepatitis C virus agents

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Synthesis and biological evaluation of new potent and selective HCV NS5A inhibitors ⬇️

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Synthesis and biological evaluation of novel 5(H)-phenanthridin-6-ones, 5(H)-phenanthridin-6-one diketo acid, and polycyclic aromatic diketo acid analogs as new HIV-1 integrase inhibitors

scientific article published on 16 November 2006

Synthesis and broad spectrum antiviral evaluation of bis(POM) prodrugs of novel acyclic nucleosides

scientific article published on 4 July 2013

Synthesis and evaluation of 2'-substituted cyclobutyl nucleosides and nucleotides as potential anti-HIV agents

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Synthesis and evaluation of 3'-azido-2',3'-dideoxypurine nucleosides as inhibitors of human immunodeficiency virus

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Synthesis and evaluation of Janus type nucleosides as potential HCV NS5B polymerase inhibitors ⬇️

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Synthesis and evaluation of non-dimeric HCV NS5A inhibitors ⬇️

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Synthesis and evaluation of novel potent HCV NS5A inhibitors ⬇️

scientific article published on May 24, 2012

Synthesis and in vitro anti-HCV activity of beta-D- and 1-2'-deoxy-2'-fluororibonucleosides

scientific article published on January 2005

Synthesis and potent anti-HIV activity of L-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thiocytidine

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Synthesis and structure-activity relationships of novel anti-hepatitis C agents: N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one derivatives

scientific article published on October 2005

Synthesis of (2S)-2-Chloro-2-fluororibolactone via Stereoselective Electrophilic Fluorination

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Synthesis of 1,2,3-triazolo-carbanucleoside analogues of ribavirin targeting an HCV in replicon.

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Synthesis of 5-haloethynyl- and 5-(1,2-dihalo)vinyluracil nucleosides: antiviral activity and cellular toxicity.

scientific article published on November 2005

Synthesis of 5′-Methylene-Phosphonate Furanonucleoside Prodrugs: Application to D-2′-Deoxy-2′-α-fluoro-2′-β-C-methyl Nucleosides ⬇️

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Synthesis of Cyclopentanyl Carbocyclic 5-Fluorocytosine ((−)-5-Fluorocarbodine) Using a Facially Selective Hydrogenation Approach ⬇️

scientific article published on December 26, 2012

Synthesis of Dihydroisoxazole Nucleoside and Nucleotide Analogs ⬇️

scientific article published on January 10, 1997

Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one and its 3'-deoxysugar analogue as potential anti-hepatitis C virus agents

scientific article published in January 2005

Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one, a novel compound with anti-hepatitis C virus activity

scientific article published on November 2004

Synthesis of beta-enantiomers of N4-hydroxy-3'-deoxypyrimidine nucleosides and their evaluation against bovine viral diarrhoea virus and hepatitis C virus in cell culture

scientific article published on January 2004

Synthesis of carbocyclic nucleoside analogs with five-membered heterocyclic nucleobases

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Synthesis of dihydropyrimidine α,γ-diketobutanoic acid derivatives targeting HIV integrase

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Synthesis of enantiomerically pure D-FDOC, an anti-HIV agent

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Synthesis of neplanocin F analogues as potential antiviral agents

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Synthesis of novel spiro[2.3]hexane carbocyclic nucleosides via enzymatic resolution

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Synthesis of nucleoside phosphate and phosphonate prodrugs

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Synthesis of oxathiolane imidazole nucleosides

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Synthesis of purine modified 2′-C-methyl nucleosides as potential anti-HCV agents ⬇️

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Synthesis of sulfamoylbenzamide derivatives as HBV capsid assembly effector

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Synthesis, anti-HIV activity, and molecular mechanism of drug resistance of L-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thionucleosides

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Synthesis, antiviral activity, and mechanism of drug resistance of D- and L-2',3'-didehydro-2',3'-dideoxy-2'-fluorocarbocyclic nucleosides

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Synthesis, antiviral activity, and stability of nucleoside analogs containing tricyclic bases

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Synthesis, antiviral activity, cytotoxicity and cellular pharmacology of l-3′-azido-2′,3′-dideoxypurine nucleosides ⬇️

scientific article published on May 30, 2011

Synthesis, biological evaluation and 3D-QSAR studies of 3-keto salicylic acid chalcones and related amides as novel HIV-1 integrase inhibitors

scientific article published on March 2011

Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol

scientific article published on 10 June 2007

Synthesis, docking, and biological studies of phenanthrene β-diketo acids as novel HIV-1 integrase inhibitors

scientific article published on 11 September 2013

Synthesis, evaluation of anti-HIV-1 and anti-HCV activity of novel 2′,3′-dideoxy-2′,2′-difluoro-4′-azanucleosides ⬇️

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Synthesis, structure-activity relationships, and drug resistance of beta-d-3'-fluoro-2',3'-unsaturated nucleosides as anti-HIV Agents

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Synthesis, structure-activity relationships, and mechanism of drug resistance of D- and L-beta-3'-fluoro-2',3'-unsaturated-4'-thionucleosides as anti-HIV agents

scientific article published in March 2004

Telbivudine exerts no antiviral activity against HIV-1 in vitro and in humans.

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Template-assisted synthesis of adenine-mutagenized cDNA by a retroelement protein complex

The 3'-azido group is not the primary determinant of 3'-azido-3'-deoxythymidine (AZT) responsible for the excision phenotype of AZT-resistant HIV-1.

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The Base Component of 3′-Azido-2′,3′-Dideoxynucleosides Influences Resistance Mutations Selected in HIV-1 Reverse Transcriptase ⬇️

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The Impact of Macrophage Nucleotide Pools on HIV-1 Reverse Transcription, Viral Replication, and the Development of Novel Antiviral Agents ⬇️

scientific article published on January 1, 2012

The Janus kinase inhibitor ruxolitinib reduces HIV replication in human macrophages and ameliorates HIV encephalitis in a murine model

scientific article published on 3 February 2016

The Synthesis and Biological Evaluation of Novel Bridging Nucleoside Analogues ⬇️

scientific article published on February 1, 2002

The boron-neutron capture agent beta-D-5-o-carboranyl-2'-deoxyuridine accumulates preferentially in dividing brain tumor cells

scientific article published on September 2005

Three new manzamine alkaloids from a common Indonesian sponge and their activity against infectious and tropical parasitic diseases

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Tissue disposition of 5-o-carboranyluracil--a novel agent for the boron neutron capture therapy of prostate cancer

scientific article published in January 2004

Toward Elimination of Hepatitis B Virus Using Novel Drugs, Approaches, and Combined Modalities

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Towards HBV curative therapies

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Towards an HBV cure: state-of-the-art and unresolved questions--report of the ANRS workshop on HBV cure.

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Towards new boron carriers for boron neutron capture therapy: metallacarboranes and their nucleoside conjugates

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Treatment as prevention and cure towards global eradication of hepatitis C virus

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Treatment of hepatitis C virus infection with direct-acting antiviral agents: 100% cure?

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Universal Profiling of HIV-1 Pol for Genotypic Study and Resistance Analysis Across Subtypes ⬇️

scientific article published on January 1, 2011

Use of dietary supplements among people living with HIV/AIDS is associated with vulnerability to medical misinformation on the internet ⬇️

scientific article published on January 10, 2012

Valacyclovir Decreases Plasma HIV-1 RNA in HSV-2 Seronegative Individuals: A Randomized Placebo-Controlled Crossover Trial

scientific article published on 3 March 2015

Variation of human immunodeficiency virus type-1 reverse transcriptase within the simian immunodeficiency virus genome of RT-SHIV.

scientific article published on 31 January 2014

Viral Decay Kinetics in the Highly Active Antiretroviral Therapy-Treated Rhesus Macaque Model of AIDS ⬇️

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Viral pharmacodynamic model for (-)-beta-2',3'-dideoxy-5-fluoro-3'-thiacytidine (emtricitabine) in chronically infected woodchucks

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Viral sanctuaries during highly active antiretroviral therapy in a nonhuman primate model for AIDS

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Virulence and reduced fitness of simian immunodeficiency virus with the M184V mutation in reverse transcriptase

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William H Prusoff Dies at 90 – A Renaissance Man that Revolutionized the Treatment of Herpesviruses and HIV ⬇️

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Zika in the Americas, year 2: What have we learned? What gaps remain? A report from the Global Virus Network

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dNTP pool modulation dynamics by SAMHD1 protein in monocyte-derived macrophages.

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l-2',3'-Didehydro-2',3'-dideoxy-3'-fluoronucleosides: synthesis, anti-HIV activity, chemical and enzymatic stability, and mechanism of resistance

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β-D-2'-C-Methyl-2,6-diaminopurine Ribonucleoside Phosphoramidates are Potent and Selective Inhibitors of Hepatitis C Virus (HCV) and Are Bioconverted Intracellularly to Bioactive 2,6-Diaminopurine and Guanosine 5'-Triphosphate Forms

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