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List of works by Raymond C. Stevens

5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.

scientific article published on 19 January 2018

A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor

scientific article

A mass spectrometry plate reader: monitoring enzyme activity and inhibition with a Desorption/Ionization on Silicon (DIOS) platform

scientific article published in July 2004

A novel approach to quantify G-protein-coupled receptor dimerization equilibrium using bioluminescence resonance energy transfer

scientific article

A structurally guided dissection-then-evolution strategy for ligand optimization of smoothened receptor

scientific article published on 28 April 2017

Advances in GPCR modeling evaluated by the GPCR Dock 2013 assessment: meeting new challenges

scientific article published on 24 July 2014

Agonist-bound structure of the human P2Y12 receptor

scientific article

Agonists for 13 trace amine-associated receptors provide insight into the molecular basis of odor selectivity

scientific article

Allosteric Coupling of Drug Binding and Intracellular Signaling in the A2A Adenosine Receptor

scientific article published on 27 December 2017

Allosteric sodium in class A GPCR signaling

scientific article

An electrostatic mechanism for Ca(2+)-mediated regulation of gap junction channels

scientific article

An online resource for GPCR structure determination and analysis

scientific article published on 21 January 2019

Asia growth in membrane protein structure

scientific article published on 24 July 2013

Author Correction: Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y and P2Y receptors

scientific article published in Scientific Reports

Automation of X-ray crystallography

scientific article

Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR.

scientific article published on 19 January 2012

Biophysical and ion channel functional characterization of the Torpedo californica nicotinic acetylcholine receptor in varying detergent-lipid environments

scientific article published on May 2008

Biopterin responsive phenylalanine hydroxylase deficiency

scientific article

Chemical Diversity in the G Protein-Coupled Receptor Superfamily

scientific article published on 22 March 2018

Chemotype-selective modes of action of κ-opioid receptor agonists

scientific article published on 11 October 2013

Common activation mechanism of class A GPCRs

scientific article published on 19 December 2019

Comparative structural analysis of a novel glutathioneS-transferase (ATU5508) from Agrobacterium tumefaciens at 2.0 A resolution

scientific article published in November 2006

Computational design of thermostabilizing point mutations for G protein-coupled receptors.

scientific article published on 21 June 2018

Conserved Binding Mode of Human β 2 Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray Crystallography

scientific article

Constitutive phospholipid scramblase activity of a G protein-coupled receptor

scientific article published on 8 October 2014

Coordinating the impact of structural genomics on the human α-helical transmembrane proteome

scientific article

Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations

scholarly article

Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1

scientific article published on June 2015

Crystal Structure of Botulinum Neurotoxin Type A in Complex with the Cell Surface Co-Receptor GT1b—Insight into the Toxin–Neuron Interaction

scientific article

Crystal Structure of a Lipid G Protein–Coupled Receptor ⬇️

scientific article published on February 17, 2012

Crystal Structure of the Human Cannabinoid Receptor CB1.

scientific article

Crystal structure of 2-keto-3-deoxygluconate kinase (TM0067) from Thermotoga maritima at 2.05 A resolution

scientific article

Crystal structure of 2-phosphosulfolactate phosphatase (ComB) from Clostridium acetobutylicum at 2.6 A resolution reveals a new fold with a novel active site

scientific article

Crystal structure of Hsp33 chaperone (TM1394) from Thermotoga maritima at 2.20 Å resolution

article

Crystal structure of O-acetylserine sulfhydrylase (TM0665) from Thermotoga maritima at 1.8 A resolution

scientific article published in August 2004

Crystal structure of S-adenosylmethionine:tRNA ribosyltransferase-isomerase (QueA) from Thermotoga maritima at 2.0 A resolution reveals a new fold

scientific article

Crystal structure of TM1367 from Thermotoga maritima at 1.90 A resolution reveals an atypical member of the cyclophilin (peptidylprolyl isomerase) fold

scientific article published in June 2006

Crystal structure of a PIN (PilT N-terminus) domain (AF0591) from Archaeoglobus fulgidus at 1.90 A resolution

scientific article

Crystal structure of a conserved hypothetical protein (gi: 13879369) from Mouse at 1.90 Å resolution reveals a new fold

article

Crystal structure of a formiminotetrahydrofolate cyclodeaminase (TM1560) from Thermotoga maritima at 2.80 A resolution reveals a new fold

scientific article

Crystal structure of a glycerate kinase (TM1585) from Thermotoga maritima at 2.70 Å resolution reveals a new fold

article

Crystal structure of a glycerophosphodiester phosphodiesterase (GDPD) from Thermotoga maritima (TM1621) at 1.60 A resolution

scientific article published in July 2004

Crystal structure of a methionine aminopeptidase (TM1478) from Thermotoga maritima at 1.9 A resolution

scientific article

Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand

scientific article

Crystal structure of a novel Thermotoga maritima enzyme (TM1112) from the cupin family at 1.83 A resolution

scientific article published in August 2004

Crystal structure of a novel manganese-containing cupin (TM1459) from Thermotoga maritima at 1.65 A resolution

scientific article

Crystal structure of a phosphoribosylaminoimidazole mutase PurE (TM0446) from Thermotoga maritima at 1.77-A resolution

scientific article published in May 2004

Crystal structure of a putative NADPH-dependent oxidoreductase (GI: 18204011) from mouse at 2.10 A resolution

scientific article

Crystal structure of a putative PII-like signaling protein (TM0021) from Thermotoga maritima at 2.5 A resolution

scientific article published in March 2004

Crystal structure of a putative glutamine amido transferase (TM1158) from Thermotoga maritima at 1.7 A resolution

scientific article published in March 2004

Crystal structure of a putative modulator of DNA gyrase (pmbA) from Thermotoga maritima at 1.95 A resolution reveals a new fold

scientific article

Crystal structure of a putative oxalate decarboxylase (TM1287) from Thermotoga maritima at 1.95 A resolution

scientific journal article

Crystal structure of a ribose-5-phosphate isomerase RpiB (TM1080) from Thermotoga maritima at 1.90 A resolution

scientific article

Crystal structure of a single-stranded DNA-binding protein (TM0604) from Thermotoga maritima at 2.60 Å resolution

article

Crystal structure of a tandem cystathionine-beta-synthase (CBS) domain protein (TM0935) from Thermotoga maritima at 1.87 A resolution

scientific article

Crystal structure of a type II quinolic acid phosphoribosyltransferase (TM1645) from Thermotoga maritima at 2.50 A resolution.

scientific article published in May 2004

Crystal structure of a zinc-containing glycerol dehydrogenase (TM0423) from Thermotoga maritima at 1.5 A resolution

scientific article

Crystal structure of acireductone dioxygenase (ARD) from Mus musculus at 2.06 angstrom resolution

scientific article

Crystal structure of an Apo mRNA decapping enzyme (DcpS) from Mouse at 1.83 A resolution

scientific article

Crystal structure of an HEPN domain protein (TM0613) from Thermotoga maritima at 1.75 A resolution

scientific article published in March 2004

Crystal structure of an ORFan protein (TM1622) fromThermotoga maritimaat 1.75 Å resolution reveals a fold similar to the Ran-binding protein Mog1p

article

Crystal structure of an Udp-n-acetylmuramate-alanine ligase MurC (TM0231) from Thermotoga maritima at 2.3 A resolution

scientific article published in June 2004

Crystal structure of an alanine-glyoxylate aminotransferase from Anabaena sp. at 1.70 A resolution reveals a noncovalently linked PLP cofactor

scientific article published in March 2005

Crystal structure of an allantoicase (YIR029W) from Saccharomyces cerevisiae at 2.4 A resolution

scientific article

Crystal structure of an alpha/beta serine hydrolase (YDR428C) from Saccharomyces cerevisiae at 1.85 A resolution

scientific article

Crystal structure of an aspartate aminotransferase (TM1255) from Thermotoga maritima at 1.90 A resolution

scientific article published in May 2004

Crystal structure of an indigoidine synthase A (IndA)-like protein (TM1464) from Thermotoga maritima at 1.90 Å resolution reveals a new fold

article

Crystal structure of an iron-containing 1,3-propanediol dehydrogenase (TM0920) from Thermotoga maritima at 1.3 A resolution

scientific article

Crystal structure of an orphan protein (TM0875) from Thermotoga maritima at 2.00-A resolution reveals a new fold

scientific article published in August 2004

Crystal structure of botulinum neurotoxin type A and implications for toxicity

scientific article

Crystal structure of botulinum neurotoxin type G light chain: serotype divergence in substrate recognition

scientific article published on July 2005

Crystal structure of gamma-glutamyl phosphate reductase (TM0293) from Thermotoga maritima at 2.0 A resolution

scientific article

Crystal structure of misoprostol bound to the labor inducer prostaglandin E2 receptor

scientific article published on 03 December 2018

Crystal structure of phosphoribosylformyl-glycinamidine synthase II, PurS subunit (TM1244) from Thermotoga maritima at 1.90 A resolution

scientific article published in October 2006

Crystal structure of phosphoribosylformylglycinamidine synthase II (smPurL) from Thermotoga maritima at 2.15 A resolution

scientific article

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

scientific article

Crystal structure of the ApbE protein (TM1553) from Thermotoga maritima at 1.58 Å resolution

article

Crystal structure of the Frizzled 4 receptor in a ligand-free state

scientific article published in Nature

Crystal structure of the global regulatory protein CsrA from Pseudomonas putida at 2.05 A resolution reveals a new fold

scientific article published in November 2005

Crystal structure of thy1, a thymidylate synthase complementing protein from Thermotoga maritima at 2.25 A resolution

scientific article

Crystal structure of uronate isomerase (TM0064) from Thermotoga maritima at 2.85 A resolution

scientific article

Crystal structure of virulence factor CJ0248 from Campylobacter jejuni at 2.25 A resolution reveals a new fold

scientific article

Crystal structures of agonist-bound human cannabinoid receptor CB1.

scientific article published on 05 July 2017

Crystallization data mining in structural genomics: using positive and negative results to optimize protein crystallization screens

scientific article

Design, synthesis, pharmacological characterization of a fluorescent agonist of the P2Y₁₄ receptor

scientific article

Designing Facial Amphiphiles for the Stabilization of Integral Membrane Proteins

scientific article published on 01 January 2007

Determination of the melanocortin-4 receptor structure identifies Ca2+ as a cofactor for ligand binding

scientific article published on 01 April 2020

Development of pegylated forms of recombinant Rhodosporidium toruloides phenylalanine ammonia-lyase for the treatment of classical phenylketonuria

scientific article published in June 2005

Diversity and modularity of G protein-coupled receptor structures

scientific article

Dynamic Strategic Bond Analysis Yields a Ten-Step Synthesis of 20-nor-Salvinorin A, a Potent κ-OR Agonist

scientific article published on 13 December 2017

Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists

scientific article published on 27 November 2019

Emerging Structural Biology of Lipid G-Protein Coupled Receptors

scientific article published on 01 February 2019

Engineered nanostructured β-sheet peptides protect membrane proteins

scientific article published on 30 June 2013

Evaluation of molecular modeling of agonist binding in light of the crystallographic structure of an agonist-bound A₂A adenosine receptor

scientific article published on 12 December 2011

Exploring a 2-naphthoic acid template for the structure-based design of P2Y14 receptor antagonist molecular probes

scientific article

Extending the Structural View of Class B GPCRs.

scientific article

Extrinsic Tryptophans as NMR Probes of Allosteric Coupling in Membrane Proteins: Application to the A2A Adenosine Receptor

scientific article published on 20 June 2018

Fluorine-19 NMR of integral membrane proteins illustrated with studies of GPCRs

scientific article published on 07 August 2013

Functional Proteomic and Structural Insights into Molecular Recognition in the Nitrilase Family Enzymes † ‡

scientific article

GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function

scientific article

Generation of an Orthogonal Protein-Protein Interface with a Noncanonical Amino Acid.

scientific article

Generic GPCR residue numbers - aligning topology maps while minding the gaps

scientific article

Genetically encoded chemical probes in cells reveal the binding path of urocortin-I to CRF class B GPCR

scientific journal article

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

scientific article

High-throughput identification of G protein-coupled receptor modulators through affinity mass spectrometry screening.

scientific article published on 20 February 2018

How Ligands Illuminate GPCR Molecular Pharmacology

scientific article

Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators

scientific article

Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography

scientific article published in Nature Communications

Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors.

scientific article published on July 2017

Identification of fibroblast growth factor receptor 3 (FGFR3) as a protein receptor for botulinum neurotoxin serotype A (BoNT/A).

scientific article

Identification of natural products as novel ligands for the human 5-HT2C receptor.

scientific article published on 9 March 2018

In situ data collection and structure refinement from microcapillary protein crystallization

scientific article

In vitro expression and analysis of the 826 human G protein-coupled receptors

scientific article published on 16 April 2016

Insights into the structure of class B GPCRs

scientific article

LCP-FRAP Assay for Pre-Screening Membrane Proteins for in Meso Crystallization

scientific article published on January 2008

Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography

scientific article

Mechanisms underlying responsiveness to tetrahydrobiopterin in mild phenylketonuria mutations

scientific article published in November 2004

Microscale NMR screening of new detergents for membrane protein structural biology

scientific article

Microscale fluorescent thermal stability assay for membrane proteins

scientific article

Modeling ligand recognition at the P2Y12 receptor in light of X-ray structural information

scientific article

Molecular control of δ-opioid receptor signalling

scientific article

Monolayer properties of monosialioganglioside in the mixed diacetylene lipid films on the air/water interface

article published in 1997

Mutations in the Regulatory Domain of Phenylalanine Hydroxylase and Response to Tetrahydrobiopterin

article

NMR screening and crystal quality of bacterially expressed prokaryotic and eukaryotic proteins in a structural genomics pipeline

scientific article

Native phasing of x-ray free-electron laser data for a G protein-coupled receptor.

scientific article

Nuclear Magnetic Resonance Structure of the N-Terminal Domain of Nonstructural Protein 3 from the Severe Acute Respiratory Syndrome Coronavirus

scientific article

Nucleotides Acting at P2Y Receptors: Connecting Structure and Function

scientific article published on 2 April 2015

Opportunities and Challenges in Building a Spatiotemporal Multi-scale Model of the Human Pancreatic β Cell

scientific article published in March 2018

Opportunities for functional selectivity in GPCR antibodies

scientific article

Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening

scientific article

PAHdb 2003: what a locus-specific knowledgebase can do.

scientific article

Preclinical evaluation of multiple species of PEGylated recombinant phenylalanine ammonia lyase for the treatment of phenylketonuria

scholarly article

Protein crystallization in restricted geometry: advancing old ideas for modern times in structural proteomics

scientific article published on January 2008

Proteomics analysis unravels the functional repertoire of coronavirus nonstructural protein 3.

scientific article published on 26 March 2008

Publisher Correction: Crystal structure of misoprostol bound to the labor inducer prostaglandin E2 receptor

scientific article published on 01 February 2019

Rapid refinement of crystallographic protein construct definition employing enhanced hydrogen/deuterium exchange MS.

scholarly article

Rational Design of Fatty Acid Amide Hydrolase Inhibitors That Act by Covalently Bonding to Two Active Site Residues

scientific article

Response of patients with phenylketonuria in the US to tetrahydrobiopterin.

scientific article published on 6 September 2005

Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y1 and P2Y12 receptors.

scientific article

Serial Femtosecond Crystallography of G Protein-Coupled Receptors

scientific article

Shotgun Crystallization Strategy for Structural Genomics II: Crystallization Conditions that Produce High Resolution Structures for T. maritima Proteins

scientific article published on 01 January 2005

Small-scale approach for precrystallization screening in GPCR X-ray crystallography

scientific article published on 29 November 2019

Sodium ion binding pocket mutations and adenosine A2A receptor function.

scientific article published on 3 December 2014

Sphingosine-1-phosphate and its receptors: structure, signaling, and influence

scientific article published on 18 March 2013

Stabilization of the human beta2-adrenergic receptor TM4-TM3-TM5 helix interface by mutagenesis of Glu122(3.41), a critical residue in GPCR structure

scientific article published on 23 December 2007

Steroid-based facial amphiphiles for stabilization and crystallization of membrane proteins

scientific article

Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions

scientific article

Structural Basis for Apelin Control of the Human Apelin Receptor

scientific article published on 11 May 2017

Structural Basis for Ligand Recognition and Functional Selectivity at Angiotensin Receptor

scientific article

Structural Basis for Molecular Recognition at Serotonin Receptors

scientific article

Structural Connection between Activation Microswitch and Allosteric Sodium Site in GPCR Signaling

scientific article published on 26 January 2018

Structural Determinants of Binding the Seven-transmembrane Domain of the Glucagon-like Peptide-1 Receptor (GLP-1R)

scientific article

Structural Features for Functional Selectivity at Serotonin Receptors

scientific article

Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling

scientific article

Structural and Biochemical Characterization of the Therapeutic Anabaena variabilis Phenylalanine Ammonia Lyase

scientific article

Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs

scientific article

Structural basis for bifunctional peptide recognition at human δ-opioid receptor

scientific article

Structural basis for selectivity and diversity in angiotensin II receptors

scientific article

Structural basis for signal recognition and transduction by platelet-activating-factor receptor

scientific article published on 28 May 2018

Structural basis of ligand binding modes at the neuropeptide Y Y1 receptor

scientific article published on 18 April 2018

Structural basis of ligand recognition at the human MT1 melatonin receptor

scientific article published on 24 April 2019

Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline

scientific article

Structural genomics of the severe acute respiratory syndrome coronavirus: nuclear magnetic resonance structure of the protein nsP7

scientific article

Structural insights into the extracellular recognition of the human serotonin 2B receptor by an antibody

scientific article published on 17 July 2017

Structure and Function of Peptide-Binding G Protein-Coupled Receptors

scientific article published on 10 July 2017

Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry by HIV.

scientific article published on June 2017

Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists

scientific article published on 07 December 2016

Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator

scientific article

Structure of an agonist-bound human A2A adenosine receptor

scientific article

Structure of botulinum neurotoxin type D light chain at 1.65 A resolution: repercussions for VAMP-2 substrate specificity

scientific article published in March 2006

Structure of the Angiotensin receptor revealed by serial femtosecond crystallography.

scientific article published on 23 April 2015

Structure of the CCR5 Chemokine Receptor-HIV Entry Inhibitor Maraviroc Complex

scientific article

Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

scientific article

Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.

scientific article published on 3 January 2018

Structure of the full-length glucagon class B G-protein-coupled receptor

scientific article

Structure of the glucagon receptor in complex with a glucagon analogue

scientific article published in January 2018

Structure of the human P2Y12 receptor in complex with an antithrombotic drug

scientific article

Structure of the human glucagon class B G-protein-coupled receptor

scientific article

Structure of the human histamine H1 receptor complex with doxepin

scientific article

Structure of the human smoothened receptor bound to an antitumour agent

scientific article

Structure of the human κ-opioid receptor in complex with JDTic

scientific article

Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic

scientific article

Structure-Based Discovery of New Antagonist and Biased Agonist Chemotypes for the Kappa Opioid Receptor

scientific article

Structure-based chemical modification strategy for enzyme replacement treatment of phenylketonuria

scientific article published on 11 July 2005

Structure-based epitope and PEGylation sites mapping of phenylalanine ammonia-lyase for enzyme substitution treatment of phenylketonuria

scientific article published on 8 June 2007

Structure-based ligand discovery targeting orthosteric and allosteric pockets of dopamine receptors

scientific article

Structure-function of the G protein-coupled receptor superfamily

scientific article

Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists

scientific article

Synthesis of site-specific antibody-drug conjugates by ADP-ribosyl cyclases

scientific article published on 03 June 2020

The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist

scientific article

The GPCR Network: a large-scale collaboration to determine human GPCR structure and function

scientific article published on 14 December 2012

The Molecular Mechanism of P2Y1 Receptor Activation

scientific article published on 27 July 2016

The N-Terminal Sequence of Tyrosine Hydroxylase Is a Conformationally Versatile Motif That Binds 14-3-3 Proteins and Membranes

scientific article

The human D1A dopamine receptor: heterologous expression in Saccharomyces cerevisiae and purification of the functional receptor

scientific article

The interplay between binding energy and catalysis in the evolution of a catalytic antibody ⬇️

scientific article published on September 18, 1997

The role of a sodium ion binding site in the allosteric modulation of the A(2A) adenosine G protein-coupled receptor

scientific article

Time-controlled microfluidic seeding in nL-volume droplets to separate nucleation and growth stages of protein crystallization

scientific article published on December 2006

Towards miniaturization of a structural genomics pipeline using micro-expression and microcoil NMR.

scientific article published on 9 November 2005

Transition states. Trapping a transition state in a computationally designed protein bottle

scientific article

Two disparate ligand-binding sites in the human P2Y1 receptor

scientific article

Visualizing insulin vesicle neighborhoods in β cells by cryo-electron tomography

scientific article published on 09 December 2020

Visualizing subcellular rearrangements in intact β cells using soft x-ray tomography

scientific article published on 09 December 2020

X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex

scientific article

XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity

scientific article published on 24 April 2019

β2-Adrenergic Receptor Conformational Response to Fusion Protein in the Third Intracellular Loop

scientific article published on 8 November 2016

β2-Adrenergic receptor solutions for structural biology analyzed with microscale NMR diffusion measurements

scientific article published on 24 October 2012

β₂-adrenergic receptor activation by agonists studied with ¹⁹F NMR spectroscopy

scientific article published on 16 August 2013

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