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List of works by John Whitelock

A central function for perlecan in skeletal muscle and cardiovascular development

scientific article

Ablation of Perlecan Domain 1 Heparan Sulfate Reduces Progressive Cartilage Degradation, Synovitis, and Osteophyte Size in a Preclinical Model of Posttraumatic Osteoarthritis.

scientific article published on 4 December 2015

Altered decorin leads to disrupted endothelial cell function: a possible mechanism in the pathogenesis of fetal growth restriction?

scientific article

Antisense targeting of perlecan blocks tumor growth and angiogenesis in vivo

scientific article

Bioengineered heparin: is there a future for this form of the successful therapeutic?

scientific article published on 5 June 2014

Bioengineered human heparin with anticoagulant activity.

scientific article published on 18 July 2016

CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

scientific article published on 12 August 2019

Can we produce heparin/heparan sulfate biomimetics using "mother-nature" as the gold standard?

scientific article published on 5 March 2015

Cell surface chondroitin sulphate proteoglycan 4 (CSPG4) binds to the basement membrane heparan sulphate proteoglycan, perlecan, and is involved in cell adhesion.

scientific article published on 15 February 2018

Cellular uptake and reactive oxygen species modulation of cerium oxide nanoparticles in human monocyte cell line U937.

scientific article

Characterization and purification of glycosaminoglycans from crude biological samples.

scientific article published on 29 December 2007

Colocalization in vivo and association in vitro of perlecan and elastin.

scientific article

Current serological possibilities for the diagnosis of arthritis with special focus on proteins and proteoglycans from the extracellular matrix.

scientific article

Decreased placental glypican expression is associated with human fetal growth restriction

scientific article published on 21 December 2018

Diverse cell signaling events modulated by perlecan.

scientific article published on October 2008

Effects of base material, plasma proteins and FGF2 on endothelial cell adhesion and growth

scientific article published on 01 January 2002

Electrophoretic, biosensor, and bioactivity analyses of perlecans of different cellular origins.

scientific article

Endocytosis of cerium oxide nanoparticles and modulation of reactive oxygen species in human ovarian and colon cancer cells

scientific article published on 8 December 2016

Endorepellin, the angiostatic module of perlecan, interacts with both the α2β1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): a dual receptor antagonism

scientific article

Epac1 increases migration of endothelial cells and melanoma cells via FGF2-mediated paracrine signaling

scientific article published on 9 May 2014

Expression of Biglycan in First Trimester Chorionic Villous Sampling Placental Samples and Altered Function in Telomerase-Immortalized Microvascular Endothelial Cells

scientific article

Fibrinogen adsorption and platelet adhesion to silica surfaces with stochastic nanotopography.

scientific article published on December 2014

Glycosaminoglycan and Proteoglycan-Based Biomaterials: Current Trends and Future Perspectives.

scientific article published on 6 December 2017

Glycosaminoglycan functionalized nanoparticles exploit glycosaminoglycan functions

scientific article published in January 2015

Graphitized carbon LC-MS characterization of the chondroitin sulfate oligosaccharides of aggrecan

scientific article published on 06 April 2007

Harnessing chondroitin sulphate in composite scaffolds to direct progenitor and stem cell function for tissue repair

scientific article published on 01 May 2018

Heparan sulfate proteoglycans in healthy and diseased systems

scientific article published on 01 April 2011

Heparan sulfate-dependent signaling of fibroblast growth factor 18 by chondrocyte-derived perlecan.

scientific article

Heparin fails to inhibit the proliferation of human vascular smooth muscle cells in the presence of human serum

scientific article published on 01 November 1998

Human perlecan immunopurified from different endothelial cell sources has different adhesive properties for vascular cells.

scientific article published on April 1999

Human synovial lubricin expresses sialyl Lewis x determinant and has L-selectin ligand activity

scientific article

Hyaluronan coated cerium oxide nanoparticles modulate CD44 and reactive oxygen species expression in human fibroblasts

scientific article

Hyaluronidase-4 is produced by mast cells and can cleave serglycin chondroitin sulfate chains into lower molecular weight forms ⬇️

scientific article published on 07 June 2019

INHIBITION OF PHENOTYPE MODULATION, GROWTH, AND MIGRATION OF VASCULAR SMOOTH MUSCLE CELLS BY A GUANOSINE-RICH 30-MER PHOSPHOROTHIOATE OLIGODEOXYNUCLEOTIDE

scientific article published on 01 September 1997

Inhibition of endothelial cell adhesion and proliferation by extracellular matrix from vascular smooth muscle cells: role of type V collagen

scientific article published on 01 November 1998

Isolation and purification of proteoglycans.

scientific article published on January 2002

LTBP-2 has multiple heparin/heparan sulfate binding sites.

scientific article published on 9 April 2010

Mast Cells Produce a Unique Chondroitin Sulfate Epitope

scientific article published on 19 November 2015

Mast cells produce novel shorter forms of perlecan that contain functional endorepellin: a role in angiogenesis and wound healing.

scientific article published on 12 December 2012

Matrix components and scaffolds for sustained islet function.

scientific article published on 25 May 2011

Mechanisms and consequences of oxidative damage to extracellular matrix.

scientific article published on October 2011

Nitration of tyrosines in complement factor H domains alters its immunological activity and mediates a pathogenic role in age related macular degeneration

scientific article published on February 2017

Optimization of bioengineered heparin/heparan sulfate production for therapeutic applications.

scientific article published on 10 April 2017

Oxidation modifies the structure and function of the extracellular matrix generated by human coronary artery endothelial cells.

scientific article

Oxidative damage to extracellular matrix and its role in human pathologies.

scientific article published on 08 April 2008

Pathogenesis of abdominal aortic aneurysms: possible role of differential production of proteoglycans by smooth muscle cells

scientific article published on 01 October 1998

Perlecan and vascular endothelial growth factor-encoding DNA-loaded chitosan scaffolds promote angiogenesis and wound healing.

scientific article published on 9 February 2017

Perlecan displays variable spatial and temporal immunolocalisation patterns in the articular and growth plate cartilages of the ovine stifle joint

scientific article published on 17 June 2005

Perlecan expression influences the keratin 15-positive cell population fate in the epidermis of aging skin

scientific article published on 17 March 2016

Perlecan from human epithelial cells is a hybrid heparan/chondroitin/keratan sulfate proteoglycan.

scientific article published on September 2005

Perlecan immunolocalizes to perichondrial vessels and canals in human fetal cartilaginous primordia in early vascular and matrix remodeling events associated with diarthrodial joint development.

scientific article

Perlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis.

scientific article

Perlecan up-regulation of FRNK suppresses smooth muscle cell proliferation via inhibition of FAK signaling

scientific article

Perlecan, the "jack of all trades" proteoglycan of cartilaginous weight-bearing connective tissues.

scientific article published on May 2008

Perlecan, the multidomain heparan sulfate proteoglycan of basement membranes, is also a prominent component of the cartilaginous primordia in the developing human fetal spine.

scientific article published in October 2003

Perlecan-induced suppression of smooth muscle cell proliferation is mediated through increased activity of the tumor suppressor PTEN

scientific journal article

Peroxynitrite modifies the structure and function of the extracellular matrix proteoglycan perlecan by reaction with both the protein core and the heparan sulfate chains

scientific article

Perspectives on the use of biomaterials to store platelets for transfusion

scientific article published on 27 June 2016

Platelet Factor 4 Binds to Vascular Proteoglycans and Controls Both Growth Factor Activities and Platelet Activation.

scientific article published on 23 January 2017

Proteoglycans: Potential Agents in Mammographic Density and the Associated Breast Cancer Risk

scientific article

Recombinant Domain V of Human Perlecan Is a Bioactive Vascular Proteoglycan.

scientific article

Recombinant production of proteoglycans and their bioactive domains.

scientific article published on 18 March 2013

Silk biomaterials functionalized with recombinant domain V of human perlecan modulate endothelial cell and platelet interactions for vascular applications.

scientific article published on 23 August 2016

Similarity of Recombinant Human Perlecan Domain 1 by Alternative Expression Systems Bioactive Heterogenous Recombinant Human Perlecan D1 ⬇️

scientific article published on September 9, 2010

Specific affinity depletion of cell adhesion molecules and growth factors from serum

scientific article published on 01 January 2001

Structure-Activity Relationships of Bioengineered Heparin/Heparan Sulfates Produced in Different Bioreactors

scientific article published on 15 May 2017

Syndecan-4 is associated with beta-cells in the pancreas and the MIN6 beta-cell line.

scientific article

Targeted Delivery and Redox Activity of Folic Acid-Functionalized Nanoceria in Tumor Cells.

scientific article published on 4 February 2018

The Role of Heparan Sulfate in Inflammation, and the Development of Biomimetics as Anti-Inflammatory Strategies.

scientific article published in November 2017

The cartilage extracellular matrix as a transient developmental scaffold for growth plate maturation.

scientific article

The cartilage matrix molecule components produced by human foetal cartilage rudiment cells within scaffolds and the role of exogenous growth factors ⬇️

scientific article published on March 3, 2012

The effect of human endothelial cell-derived proteoglycans on human smooth muscle cell growth

scientific article published on 01 March 1997

The glycosylation of human synovial lubricin: implications for its role in inflammation

article

The identification, purification and characterisation of an inhibitor of collagenase (20K) produced by neoplastic epithelial cells ⬇️

scientific article published on January 23, 1991

The localisation of inflammatory cells and expression of associated proteoglycans in response to implanted chitosan

scientific article published on 15 November 2013

The modulation of platelet adhesion and activation by chitosan through plasma and extracellular matrix proteins.

scientific article

The modulation of platelet and endothelial cell adhesion to vascular graft materials by perlecan

scientific article published on 21 June 2009

The multifaceted roles of perlecan in fibrosis

scientific article published on 20 February 2018

The role of vascular-derived perlecan in modulating cell adhesion, proliferation and growth factor signaling.

scientific article published on 06 February 2014

The structure, location, and function of perlecan, a prominent pericellular proteoglycan of fetal, postnatal, and mature hyaline cartilages

scientific article published on 19 September 2006

Transcriptional complexity of the HSPG2 gene in the human mast cell line, HMC-1.

scientific article published on 21 December 2013

Unregulated and Independent Expression of Collagenase and Transin Related to Tumor Progression

scientific article published on 01 September 1993

Use of graphitised carbon negative ion LC–MS to analyse enzymatically digested glycosaminoglycans

scientific article published on 01 September 2005

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