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List of works by Wei Zheng

17-Hydroxy Wortmannin Restores TRAIL's Response by Ameliorating Increased Beclin 1 Level and Autophagy Function in TRAIL-Resistant Colon Cancer Cells

scientific article published on 15 May 2019

5-(4-(4-Acetylphenyl)piperazin-1-ylsulfonyl)indolin-2-one Analogs as Inhibitors of Acid alpha-Glucosidase for Potential Chaperone Treatment of Pompe Disease or Intervention for Diabetes Mellitus Type 2

A 1536-well cAMP assay for Gs- and Gi-coupled receptors using enzyme fragmentation complementation.

scientific article published in February 2004

A High-Throughput Assay for Developing Inhibitors of PhoP, a Virulence Factor of Mycobacterium tuberculosis

scientific article

A High-Throughput, Multi-Cell Phenotype Assay for the Identification of Novel Inhibitors of Chemotaxis/Migration

scientific article

A New Glucocerebrosidase Chaperone Reduces α-Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism

scientific article published on July 2016

A cell-based PDE4 assay in 1536-well plate format for high-throughput screening

scientific article published on 30 June 2008

A cell-based ultra-high-throughput screening assay for identifying inhibitors of D-amino acid oxidase

scientific article

A collaborative screening program for the discovery of inhibitors of HCV NS2/3 cis-cleaving protease activity

scientific article published in April 2002

A cost-effective and efficient reprogramming platform for large-scale production of integration-free human induced pluripotent stem cells in chemically defined culture

scientific article published on 11 June 2015

A high throughput glucocerebrosidase assay using the natural substrate glucosylceramide

scientific article

A high throughput screening assay system for the identification of small molecule inhibitors of gsp

scientific article

A high-throughput screening assay for assessing the viability of Cryptococcus neoformans under nutrient starvation conditions.

scientific article

A high-throughput screening assay for determining cellular levels of total tau protein

scientific article

A high-throughput screening assay for fungicidal compounds against Cryptococcus neoformans

scientific article

A high-throughput sphingomyelinase assay using natural substrate.

scientific article

A homogenous luminescence assay reveals novel inhibitors for giardia lamblia carbamate kinase

scientific article published on 31 December 2012

A miniaturized glucocorticoid receptor translocation assay using enzymatic fragment complementation evaluated with qHTS.

scientific article published on August 2008

A multiplex calcium assay for identification of GPCR agonists and antagonists

scientific article

A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel

scientific article

A new resorufin-based alpha-glucosidase assay for high-throughput screening

scientific article published on 14 April 2009

A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats

scientific journal article

A novel quantitative high-throughput screen identifies drugs that both activate SUMO conjugation via the inhibition of microRNAs 182 and 183 and facilitate neuroprotection in a model of oxygen and glucose deprivation

scientific article published on 23 October 2015

A phenotypic compound screening assay for lysosomal storage diseases

scientific article published on 27 August 2013

A quantitative high throughput assay for identifying gametocytocidal compounds

scientific article

A robotic platform for quantitative high-throughput screening

scientific article

A short-incubation reporter-gene assay for high-throughput screening of estrogen receptor-alpha antagonists

scientific article published in August 2005

Advancing precision medicine with personalized drug screening

scientific article published on 17 August 2018

An AlphaScreen-based high-throughput screen to identify inhibitors of Hsp90-cochaperone interaction

scientific article

An alternative direct compound dispensing method using the HP D300 digital dispenser

scientific article

Analytical Characterization of Methyl-β-Cyclodextrin for Pharmacological Activity to Reduce Lysosomal Cholesterol Accumulation in Niemann-Pick Disease Type C1 Cells.

scientific article

Application of division arrest technology to cell-based HTS: comparison with frozen and fresh cells

scientific article

Application of real-time cell electronic sensing (RT-CES) technology to cell-based assays

scientific article published on August 2004

Automated high-content screening for compounds that disassemble the perinucleolar compartment

scientific article

Calcium channels in smooth muscle. Properties and regulation

scientific article

Cardiac glycosides inhibit p53 synthesis by a mechanism relieved by Src or MAPK inhibition

scientific article

Cell-based no-wash fluorescence assays for compound screens using a fluorescence cytometry plate reader

scientific article published on 12 June 2020

Chemical signatures and new drug targets for gametocytocidal drug development

scientific article published on 17 January 2014

Collaborative development of 2-hydroxypropyl-β-cyclodextrin for the treatment of Niemann-Pick type C1 disease

scientific article

Comparison on functional assays for Gq-coupled GPCRs by measuring inositol monophospate-1 and intracellular calcium in 1536-well plate format

scientific article published on 11 July 2008

Compound Management for Quantitative High-Throughput Screening

scientific article

Continuous versus intermittent nitroglycerin administration in experimental heart failure: vascular relaxation and radioligand binding to adrenoceptors and ion channels

scientific article published on 01 October 1993

Correction: Rapid Identification of Antifungal Compounds against Exserohilum rostratum Using High Throughput Drug Repurposing Screens

scientific article (publication date: 10 September 2013)

Correction: Rapid Identification of Antifungal Compounds against Exserohilum rostratum Using High Throughput Drug Repurposing Screens

scientific article (publication date: 17 October 2013)

Discovery and Development of Small Molecules That Reduce PNC Prevalence

Discovery of Small Molecule Influenza Virus NS1 Antagonist

Discovery of a novel noniminosugar acid α glucosidase chaperone series

scientific article

Discovery of novel antigiardiasis drug candidates

scientific article

Discovery, Optimization, and Characterization of Novel Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection.

scientific article published on 24 November 2015

Discovery, SAR and Biological Evaluation of Aryl-thiazol-piperidines as SMN Modulators

scientific article published in October 2011

Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase

Discovery, SAR, and Biological Evaluation of a Non-Inhibitory Chaperone for Acid Alpha Glucosidase

Discovery, optimization, and biological activity of the first potent and selective small-molecule agonist series of human relaxin receptor 1 (RXFP1)

Discovery, optimization, and characterization of a novel series of dopamine D2 versus D3 receptor selective antagonists

Discovery, optimization, and characterization of novel D2 dopamine receptor selective antagonists

scientific article

Discovery, structure-activity relationship, and biological evaluation of noninhibitory small molecule chaperones of glucocerebrosidase

scientific article

Discovery, synthesis, and biological evaluation of novel SMN protein modulators

scientific article

Disease models for the development of therapies for lysosomal storage diseases

scientific article published on 04 May 2016

Drug combination therapy increases successful drug repositioning

scientific article published on 27 May 2016

Drug repurposing screens and synergistic drug-combinations for infectious diseases

scientific article published on 07 July 2017

ERK Regulates HIF1α-Mediated Platinum Resistance by Directly Targeting PHD2 in Ovarian Cancer

scientific article published on 08 July 2019

ERK and β-arrestin interaction: a converging point of signaling pathways for multiple types of cell surface receptors

scientific article published on 31 October 2014

Editorial

scientific article (publication date: 25 February 2008)

Elabela-apelin receptor signaling pathway is functional in mammalian systems

scientific article published on 2 February 2015

Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry.

scientific article published on 5 June 2018

Evaluation of 2-thioxo-2,3,5,6,7,8-hexahydropyrimido[4,5-d]pyrimidin-4(1H)-one analogues as GAA activators

scientific article

Evaluation of Cholesterol Reduction Activity of Methyl-β-cyclodextrin Using Differentiated Human Neurons and Astrocytes ⬇️

scientific article published on August 24, 2012

Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity

scientific article

Fabry disease - current treatment and new drug development

scientific article

Fluorescent protein-based cellular assays analyzed by laser-scanning microplate cytometry in 1536-well plate format

scientific article

Generation of an induced pluripotent stem cell line (TRNDi030-A) from a patient with Farber disease carrying a homozygous p. Y36C (c. 107 A>G) mutation in ASAH1

scientific article published on 12 May 2021

HTS for Identification of Inhibitors against the ERK Signaling Pathway using a Homogenous Cell-based Assay

High throughput assay technologies for ion channel drug discovery.

scientific article

High throughput cell-based assay for identification of glycolate oxidase inhibitors as a potential treatment for Primary Hyperoxaluria Type 1

scientific article

High throughput screening for SMA

High throughput screening for inhibitors of alpha-galactosidase

scientific article

High throughput screening for small molecule therapy for Gaucher disease using patient tissue as the source of mutant glucocerebrosidase

scientific article

High-Throughput Multiplexed Quantitation of Protein Aggregation and Cytotoxicity in a Huntington's Disease Model

scientific article

High-Throughput Phenotypic Screening of Human Astrocytes to Identify Compounds That Protect Against Oxidative Stress

scientific article published on 31 March 2016

High-Throughput Screening to Identify Compounds That Increase Fragile X Mental Retardation Protein Expression in Neural Stem Cells Differentiated From Fragile X Syndrome Patient-Derived Induced Pluripotent Stem Cells

scientific article published on 21 May 2015

High-Throughput Screening, Discovery, and Optimization To Develop a Benzofuran Class of Hepatitis C Virus Inhibitors

scientific article published on 2 September 2015

High-content screening identifies small molecules that remove nuclear foci, affect MBNL distribution and CELF1 protein levels via a PKC-independent pathway in myotonic dystrophy cell lines

scientific article

High-throughput Giardia lamblia viability assay using bioluminescent ATP content measurements

scientific article

High-throughput cell-based screening using scintillation proximity assay for the discovery of inositol phosphatase inhibitors.

scientific article published in March 2004

High-throughput screening assays for the identification of chemical probes

scientific article published on August 2007

High-throughput screening of 11beta-hydroxysteroid dehydrogenase type 1 in scintillation proximity assay format

scientific article published in August 2005

High-throughput viability assay using an autonomously bioluminescent cell line with a bacterial Lux reporter

scientific article

Human recombinant lysosomal β-Hexosaminidases produced in Pichia pastoris efficiently reduced lipid accumulation in Tay-Sachs fibroblasts

scientific article published on 27 October 2020

Identification and Characterization of Small Molecule Functional Antagonists of the CCR1 Chemokine Receptor ⬇️

scientific article published on June 19, 1998

Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1.

scientific article

Identification of 4-phenylquinolin-2(1H)-one as a specific allosteric inhibitor of Akt.

scientific article published on 15 September 2017

Identification of 53 compounds that block Ebola virus-like particle entry via a repurposing screen of approved drugs

scientific article

Identification of Functionally Selective Small Molecule Antagonists of the Neuropeptide-S Receptor: Naphthopyranopyrimidines

Identification of HDAC Inhibitors Using a Cell-Based HDAC I/II Assay

scientific article

Identification of Modulators of the N370S Mutant Form of Glucocerebrosidase as a Potential Therapy for Gaucher Disease - Chemotype 1

Identification of Modulators of the N370S Mutant Form of Glucocerebrosidase as a Potential Therapy for Gaucher Disease - Chemotype 2

Identification of Multiple Cryptococcal Fungicidal Drug Targets by Combined Gene Dosing and Drug Affinity Responsive Target Stability Screening

scientific article published on 02 August 2016

Identification of Potent and Selective Thyroid Stimulating Hormone Receptor Agonists

Identification of Small Molecule Antagonists of the Neuropeptide-S Receptor

Identification of Thyroid Stimulating Hormone Receptor Inverse Agonists

scientific article published on 10 May 2013

Identification of a selective small-molecule inhibitor series targeting the eyes absent 2 (Eya2) phosphatase activity

scientific article

Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction

scientific article

Identification of compounds which inhibit cytotoxicity associated with mutant Huntingtin protein expression

Identification of novel anti-hepatitis C virus agents by a quantitative high throughput screen in a cell-based infection assay

scientific article published on 26 October 2015

Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels

scientific article

Identification of small molecule antagonists of the human mas-related gene-X1 receptor

scientific article published on 3 February 2006

Identification of small-molecule agonists of human relaxin family receptor 1 (RXFP1) by using a homogenous cell-based cAMP assay

scientific article

Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen

scientific article

In vitro evaluation of imidazo[4,5-c]quinolin-2-ones as gametocytocidal antimalarial agents

scientific article published on 19 April 2016

Increased expression of the cardiac L-type calcium channel in estrogen receptor-deficient mice

scientific article

Induced Pluripotent Stem Cells for Disease Modeling and Evaluation of Therapeutics for Niemann-Pick Disease Type A

scientific article

Induced pluripotent stem cells for neural drug discovery

scientific article published on 18 January 2019

Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules.

scientific article

Inhibition of HERG potassium channels by domiphen bromide and didecyl dimethylammonium bromide

scientific article published on 15 May 2014

Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia.

scientific article published on June 2015

Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction

scientific article published on 10 May 2013

Interactions of analogs of the 1,4-dihydropyridine tiamdipine in cardiac and smooth muscle.

scientific article

Lomofungin and dilomofungin: inhibitors of MBNL1-CUG RNA binding with distinct cellular effects

scientific article

ML223: A Small Molecule Probe With In Vivo Activity Against Acute Myeloid Leukemia Subtype M4Eo

scientific article published on 10 May 2013

ML372 blocks SMN ubiquitination and improves spinal muscular atrophy pathology in mice

scientific article

Macrophage models of Gaucher disease for evaluating disease pathogenesis and candidate drugs

scientific article

Maduramicin Rapidly Eliminates Malaria Parasites and Potentiates the Gametocytocidal Activity of the Pyrazoleamide PA21A050.

scientific article published on 28 December 2015

Mechanism of HERG potassium channel inhibition by tetra-n-octylammonium bromide and benzethonium chloride

scientific article published on 08 January 2013

Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis.

scientific article published in May 2018

Methyl-β-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK.

scientific article

Miniaturization of a hepatitis C virus RNA polymerase assay using a -102 degrees C cooled CCD camera-based imaging system

scientific article published in March 2001

Mitochondrial DNA damage by bleomycin induces AML cell death

scientific article

Modeling CNS Involvement in Pompe Disease Using Neural Stem Cells Generated from Patient-Derived Induced Pluripotent Stem Cells

scientific article published on 22 December 2020

Molecular signatures associated with ZIKV exposure in human cortical neural progenitors

scientific article

Multi-gram scale synthesis of FR180204.

scientific article

N4-phenyl modifications of N2-(2-hydroxyl)ethyl-6-(pyrrolidin-1-yl)-1,3,5-triazine-2,4-diamines enhance glucocerebrosidase inhibition by small molecules with potential as chemical chaperones for Gaucher disease

scientific article

Neural stem cells for disease modeling and evaluation of therapeutics for Tay-Sachs disease

scientific article published on 17 September 2018

Neural stem cells for disease modeling and evaluation of therapeutics for infantile (CLN1/PPT1) and late infantile (CLN2/TPP1) neuronal ceroid lipofuscinoses

scientific article published on 10 April 2018

Neural stem cells for disease modeling of Wolman disease and evaluation of therapeutics

scientific article

Niemann-Pick Disease Type C: Induced Pluripotent Stem Cell-Derived Neuronal Cells for Modeling Neural Disease and Evaluating Drug Efficacy

scientific article

Non-iminosugar glucocerebrosidase small molecule chaperones

scientific article

Novel Cell-Based Hepatitis C Virus Infection Assay for Quantitative High-Throughput Screening of Anti-Hepatitis C Virus Compounds.

scientific article

Novel cell-based hepatitis C virus infection assay for quantitative high-throughput screening of anti-hepatitis C virus compounds

scientific article

Novel lead structures with both Plasmodium falciparum gametocytocidal and asexual blood stage activity identified from high throughput compound screening

scientific article

Novel patient cell-based HTS assay for identification of small molecules for a lysosomal storage disease

scientific article

One-Step Seeding of Neural Stem Cells with Vitronectin-Supplemented Medium for High-Throughput Screening Assays

scientific article published on 19 September 2016

Optimization and validation of two miniaturized glucocerebrosidase enzyme assays for high throughput screening

scientific article published in December 2008

Pharmacologic and radioligand binding studies of 1,4-dihydropyridines in rat cardiac and vascular preparations: stereoselectivity and voltage dependence of antagonist and activator interactions

scientific article published on March 1992

Pharmacological, radioligand binding, and electrophysiological characteristics of FPL 64176, a novel nondihydropyridine Ca2+ channel activator, in cardiac and vascular preparations

scientific article

Phenotypic screens as a renewed approach for drug discovery

scientific article

Phosphocyclocreatine is the dominant form of cyclocreatine in control and creatine transporter deficiency patient fibroblasts

scientific article published on 01 December 2019

Phosphodiesterase 4 inhibitors enhance sexual pleasure-seeking activity in rodents

scientific article

Plasma and tissue concentrations of α-tocopherol and δ-tocopherol following high dose dietary supplementation in mice

scientific article

Potential-dependent interactions of nitrendipine and related 1,4-dihydropyridines in functional smooth muscle preparations.

scientific article published in January 1988

Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death

scientific article

Quantitative high-throughput screening using a live-cell cAMP assay identifies small-molecule agonists of the TSH receptor

scientific article

Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries

scientific article

RNA-Dependent RNA Polymerase as a Target for COVID-19 Drug Discovery

scientific article published on 13 July 2020

Rapid antimicrobial susceptibility test for identification of new therapeutics and drug combinations against multidrug-resistant bacteria

scientific article

Rapid identification of antifungal compounds against Exserohilum rostratum using high throughput drug repurposing screens

scientific article

Repurposing a novel parathyroid hormone (PTH) analog to treat hypoparathyroidism

scientific article published on 12 September 2017

Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection.

scientific article

SMN Modulator ML372 Increases SMN Protein Abundance, Body Weight, Lifespan, and Rescues Motor Function in SMNΔ7 SMA Mice

SU9516 Increases α7β1 Integrin and Ameliorates Disease Progression in the mdx Mouse Model of Duchenne Muscular Dystrophy

scientific article published on 5 April 2017

Scintillation proximity assay of inositol phosphates in cell extracts: high-throughput measurement of G-protein-coupled receptor activation

scientific article published on February 2003

Selective Modulation of Gq/Gs pathways by Naphtho Pyrano Pyrimidines as antagonists of the Neuropeptide S Receptor

scientific article

Small Molecules Identified from a Quantitative Drug Combinational Screen Resensitize Cisplatin's Response in Drug-Resistant Ovarian Cancer Cells.

scientific article published on 4 July 2018

Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents

scientific article

Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice

scientific article published on 10 July 2009

Structural Basis for Inactivation of Giardia lamblia Carbamate Kinase by Disulfiram

scientific article

Structural interaction between DISC1 and ATF4 underlying transcriptional and synaptic dysregulation in an iPSC model of mental disorders

scientific article published on 23 August 2019

Structure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide s receptor

scientific article (publication date: 27 November 2013)

Synergistic drug combination effectively blocks Ebola virus infection

scientific article

Synthesis and characterization of a new fluorogenic substrate for alpha-galactosidase

scientific article published on 13 June 2009

Synthetic organic ligands active at voltage-gated calcium channels

scientific article

Targeting Wolman Disease and Cholesteryl Ester Storage Disease: Disease Pathogenesis and Therapeutic Development

scientific article published on 30 January 2017

The SARS-CoV-2 Cytopathic Effect Is Blocked by Lysosome Alkalizing Small Molecules

scientific article published on 21 December 2020

The SARS-CoV-2 cytopathic effect is blocked with autophagy modulators

scientific article published on 21 May 2020

The Synthesis and Evaluation of Dihydroquinazolin-4-ones and Quinazolin-4-ones as Thyroid Stimulating Hormone Receptor Agonists

scientific article published on October 2011

The interactions of 1,4-dihydropyridines bearing a 2-(2-aminoethylthio)methyl substituent at voltage-dependent Ca2+ channels of smooth muscle, cardiac muscle and neuronal tissues

scientific article published in January 1990

The pilot phase of the NIH Chemical Genomics Center

scientific article

Thermodynamic and kinetic aspects of agonist and antagonist binding to 1,4-dihydropyridine receptors

scientific article published in October 1991

Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease

scientific article

Treatment Paradigms for Retinal and Macular Diseases Using 3-D Retina Cultures Derived From Human Reporter Pluripotent Stem Cell Lines

scientific article published on April 2016

Two high-throughput screening assays for aberrant RNA-protein interactions in myotonic dystrophy type 1.

scientific article

δ-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders

scientific article

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