List of works - Juro Sakai

A small molecule that blocks fat synthesis by inhibiting the activation of SREBP.

scientific article

Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome

scientific journal article

Analysis of PPAR alpha function in human kidney cell line using siRNA.

scientific article published on January 2006

Analysis of the subcellular localization of the human histone methyltransferase SETDB1.

scientific article published on 18 August 2015

COUP-TFII acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis.

scholarly article

Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies

scientific journal article

Cooperative interaction between hepatocyte nuclear factor 4 alpha and GATA transcription factors regulates ATP-binding cassette sterol transporters ABCG5 and ABCG8.

scientific article published on 2 April 2007

Degradation of human Lipin-1 by BTRC E3 ubiquitin ligase

scientific article published on 5 May 2017

Direct evidence for pitavastatin induced chromatin structure change in the KLF4 gene in endothelial cells

scientific article

Discovery of peroxisome proliferator-activated receptor α (PPARα) activators with a ligand-screening system using a human PPARα-expressing cell line.

scientific article published on 15 May 2018

Downregulation of ERG and FLI1 expression in endothelial cells triggers endothelial-to-mesenchymal transition

scientific article published on 30 November 2018

Dynamic change of chromatin conformation in response to hypoxia enhances the expression of GLUT3 (SLC2A3) by cooperative interaction of hypoxia-inducible factor 1 and KDM3A.

scientific article

Dysregulated expression of P1 and P2 promoter-driven hepatocyte nuclear factor-4alpha in the pathogenesis of human cancer

scientific article published on 01 April 2006

ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function

scientific article published on 19 June 2021

Endoplasmic reticulum protein quality control is determined by cooperative interactions between Hsp/c70 protein and the CHIP E3 ligase

scientific article

Evidence of macrophage foam cell formation by very low-density lipoprotein receptor: interferon-gamma inhibition of very low-density lipoprotein receptor expression and foam cell formation in macrophages

scientific article published on 01 February 2001

Expression cloning and characterization of a novel glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein, GPI-HBP1

scientific journal article

Expression of liver X receptor alpha and lipid metabolism in granulocyte-macrophage colony-stimulating factor-induced human monocyte-derived macrophage.

scientific article published in March 2009

Expression of liver X receptor alpha in rat fetal tissues at different developmental stages.

scientific article published on 6 March 2007

Extracellular Acidic pH Activates the Sterol Regulatory Element-Binding Protein 2 to Promote Tumor Progression.

scientific article published in February 2017

Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2.

scientific article published in February 2009

H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation.

scientific article published on November 2015

Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch.

scientific article published on 19 April 2018

Identification of Complexes between the COOH-terminal Domains of Sterol Regulatory Element-binding Proteins (SREBPs) and SREBP Cleavage-Activating Protein ⬇️

scientific article published on August 8, 1997

Identification of human low-density lipoprotein receptor as a novel target gene regulated by liver X receptor alpha.

scientific article published on 14 August 2006

Impact of histone demethylase KDM3A-dependent AP-1 transactivity on hepatotumorigenesis induced by PI3K activation.

scientific article published on 10 July 2017

JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis

scientific article published on 7 May 2015

KDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability

scientific article published on 28 February 2017

Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion

scientific article

Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product

scientific article

Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells

scientific article

New therapeutic target for metabolic syndrome: PPARdelta.

scientific article published on 3 April 2007

Novel repressor regulates insulin sensitivity through interaction with Foxo1

scientific article

Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice.

scientific article

Overexpression of p54nrb/NONO induces differential EPHA6 splicing and contributes to castration-resistant prostate cancer growth.

scientific article published on 8 January 2018

Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2

scientific article published on 01 October 2019

QRFP-Deficient Mice Are Hypophagic, Lean, Hypoactive and Exhibit Increased Anxiety-Like Behavior.

scientific article

RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression

scientific article published in October 2023

Role of histone methylation and demethylation in adipogenesis and obesity.

scientific article published on January 2010

SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice.

scientific article

Spatiotemporal dynamics of SETD5-containing NCoR-HDAC3 complex determines enhancer activation for adipogenesis

scientific article published on 02 December 2021

Sterol-regulatory-element-binding protein 2 and nuclear factor Y control human farnesyl diphosphate synthase expression and affect cell proliferation in hepatoblastoma cells.

scientific article published on July 2010

Structure, chromosome location, and expression of the human very low density lipoprotein receptor gene.

scientific article published on January 1994

The FBXL10/KDM2B scaffolding protein associates with novel polycomb repressive complex-1 to regulate adipogenesis

scientific article published on 22 December 2014

The H3K9 methyltransferase Setdb1 regulates TLR4-mediated inflammatory responses in macrophages

scientific article published on 28 June 2016

The KDM3A-KLF2-IRF4 axis maintains myeloma cell survival

scientific article published on 5 January 2016

The very low density lipoprotein (VLDL) receptor--a peripheral lipoprotein receptor for remnant lipoproteins into fatty acid active tissues.

scientific article

Transcriptional and epigenetic control of brown and beige adipose cell fate and function

scientific article published on 12 July 2017

Transcriptional and epigenetic control of brown and beige adipose cell fate and function.

scientific article

Transcriptional regulation of the murine acetyl-CoA synthetase 1 gene through multiple clustered binding sites for sterol regulatory element-binding proteins and a single neighboring site for Sp1

scientific article (publication date: 7 September 2001)

Transcriptome Analysis of K-877 (a Novel Selective PPARα Modulator (SPPARMα))-Regulated Genes in Primary Human Hepatocytes and the Mouse Liver.

scientific article published on 4 June 2015

Ubiquitination of Lysine 867 of the Human SETDB1 Protein Upregulates Its Histone H3 Lysine 9 (H3K9) Methyltransferase Activity

scientific article (publication date: 2016)

Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP.

scientific article

List of works by Juro Sakai

A small molecule that blocks fat synthesis by inhibiting the activation of SREBP.

Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome

Analysis of PPAR alpha function in human kidney cell line using siRNA.

Analysis of the subcellular localization of the human histone methyltransferase SETDB1.

COUP-TFII acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis.

Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies

Cooperative interaction between hepatocyte nuclear factor 4 alpha and GATA transcription factors regulates ATP-binding cassette sterol transporters ABCG5 and ABCG8.

Degradation of human Lipin-1 by BTRC E3 ubiquitin ligase

Direct evidence for pitavastatin induced chromatin structure change in the KLF4 gene in endothelial cells

Discovery of peroxisome proliferator-activated receptor α (PPARα) activators with a ligand-screening system using a human PPARα-expressing cell line.

Downregulation of ERG and FLI1 expression in endothelial cells triggers endothelial-to-mesenchymal transition

Dynamic change of chromatin conformation in response to hypoxia enhances the expression of GLUT3 (SLC2A3) by cooperative interaction of hypoxia-inducible factor 1 and KDM3A.

Dysregulated expression of P1 and P2 promoter-driven hepatocyte nuclear factor-4alpha in the pathogenesis of human cancer

ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function

Endoplasmic reticulum protein quality control is determined by cooperative interactions between Hsp/c70 protein and the CHIP E3 ligase

Evidence of macrophage foam cell formation by very low-density lipoprotein receptor: interferon-gamma inhibition of very low-density lipoprotein receptor expression and foam cell formation in macrophages

Expression cloning and characterization of a novel glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein, GPI-HBP1

Expression of liver X receptor alpha and lipid metabolism in granulocyte-macrophage colony-stimulating factor-induced human monocyte-derived macrophage.

Expression of liver X receptor alpha in rat fetal tissues at different developmental stages.

Extracellular Acidic pH Activates the Sterol Regulatory Element-Binding Protein 2 to Promote Tumor Progression.

Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2.

H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation.

Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch.

Identification of Complexes between the COOH-terminal Domains of Sterol Regulatory Element-binding Proteins (SREBPs) and SREBP Cleavage-Activating Protein ⬇️

Identification of human low-density lipoprotein receptor as a novel target gene regulated by liver X receptor alpha.

Impact of histone demethylase KDM3A-dependent AP-1 transactivity on hepatotumorigenesis induced by PI3K activation.

JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis

KDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability

Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion

Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product

Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells

New therapeutic target for metabolic syndrome: PPARdelta.

Novel repressor regulates insulin sensitivity through interaction with Foxo1

Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice.

Overexpression of p54nrb/NONO induces differential EPHA6 splicing and contributes to castration-resistant prostate cancer growth.

Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2

QRFP-Deficient Mice Are Hypophagic, Lean, Hypoactive and Exhibit Increased Anxiety-Like Behavior.

RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression

Role of histone methylation and demethylation in adipogenesis and obesity.

SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice.

Spatiotemporal dynamics of SETD5-containing NCoR-HDAC3 complex determines enhancer activation for adipogenesis

Sterol-regulatory-element-binding protein 2 and nuclear factor Y control human farnesyl diphosphate synthase expression and affect cell proliferation in hepatoblastoma cells.

Structure, chromosome location, and expression of the human very low density lipoprotein receptor gene.

The FBXL10/KDM2B scaffolding protein associates with novel polycomb repressive complex-1 to regulate adipogenesis

The H3K9 methyltransferase Setdb1 regulates TLR4-mediated inflammatory responses in macrophages

The KDM3A-KLF2-IRF4 axis maintains myeloma cell survival

The very low density lipoprotein (VLDL) receptor--a peripheral lipoprotein receptor for remnant lipoproteins into fatty acid active tissues.

Transcriptional and epigenetic control of brown and beige adipose cell fate and function

Transcriptional and epigenetic control of brown and beige adipose cell fate and function.

Transcriptional regulation of the murine acetyl-CoA synthetase 1 gene through multiple clustered binding sites for sterol regulatory element-binding proteins and a single neighboring site for Sp1

Transcriptome Analysis of K-877 (a Novel Selective PPARα Modulator (SPPARMα))-Regulated Genes in Primary Human Hepatocytes and the Mouse Liver.

Ubiquitination of Lysine 867 of the Human SETDB1 Protein Upregulates Its Histone H3 Lysine 9 (H3K9) Methyltransferase Activity

Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP.