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List of works by Rafick-Pierre Sékaly

A Cure for HIV Infection: "Not in My Lifetime" or "Just Around the Corner"?

scientific article

A Novel Assay to Measure the Magnitude of the Inducible Viral Reservoir in HIV-infected Individuals

scientific article

A Numerically Subdominant CD8 T Cell Response to Matrix Protein of Respiratory Syncytial Virus Controls Infection with Limited Immunopathology

scientific article

A common CD4 gene variant is associated with an increased risk of HIV-1 infection in Kenyan female commercial sex workers

scientific article published in May 2009

A comparative analysis of gene expression patterns and cell phenotypes between cervical and peripheral blood mononuclear cells

scientific article

A randomized controlled trial of HIV therapeutic vaccination using ALVAC with or without Remune ⬇️

scientific article published on March 27, 2011

A randomized controlled trial of palifermin (recombinant human keratinocyte growth factor) for the treatment of inadequate CD4+ T-lymphocyte recovery in patients with HIV-1 infection on antiretroviral therapy

scientific article

A vaccine-induced gene expression signature correlates with protection against SIV and HIV in multiple trials

scientific article published on 01 August 2019

Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy

scientific article (publication date: October 2014)

Adjuvant Dependent Mucosal V2 Responses and RAS Activation in Vaccine Induced Protection from SIVmac251 Acquisition.

scientific article published in October 2014

Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition

scientific article published on 30 May 2016

An open-ended plea for the development of a global database of HIV vaccine responses

scientific article published on January 2012

Antibody-mediated protection against SHIV challenge includes systemic clearance of distal virus

scientific article published on 18 August 2016

Atorvastatin reduces T-cell activation and exhaustion among HIV-infected cART-treated suboptimal immune responders in Uganda: a randomised crossover placebo-controlled trial

scientific article published on 6 January 2015

Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs

scientific article published on 29 March 2013

Beyond adjuvants: Antagonizing inflammation to enhance vaccine immunity

scientific article published on June 2015

CD4 down-regulation by HIV-1 and simian immunodeficiency virus (SIV) Nef proteins involves both internalization and intracellular retention mechanisms.

scientific article

CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART.

scientific article

CTLA-4+PD-1- Memory CD4+ T Cells Critically Contribute to Viral Persistence in Antiretroviral Therapy-Suppressed, SIV-Infected Rhesus Macaques

scientific article

Caspase-3 is a component of Fas death-inducing signaling complex in lipid rafts and its activity is required for complete caspase-8 activation during Fas-mediated cell death

scientific article published in February 2004

Characterization of transcription factor phenotypes within antigen-specific CD4+ T cells using qualitative multiplex single-cell RT-PCR

scientific article published on 4 October 2013

Clonotype and repertoire changes drive the functional improvement of HIV-specific CD8 T cell populations under conditions of limited antigenic stimulation

scientific article published on 30 December 2011

Convergence of TCR and cytokine signaling leads to FOXO3a phosphorylation and drives the survival of CD4+ central memory T cells

scientific article

Correction: Systems Analysis of MVA-C Induced Immune Response Reveals Its Significance as a Vaccine Candidate against HIV/AIDS of Clade C

scientific article published in PLoS ONE

Correction: Systems Analysis of MVA-C Induced Immune Response Reveals Its Significance as a Vaccine Candidate against HIV/AIDS of Clade C.

scientific article published on 17 May 2012

Correction: Systems Analysis of a RIG-I Agonist Inducing Broad Spectrum Inhibition of Virus Infectivity

scientific article published on 8 August 2013

Current topics in HIV-1 pathogenesis: The emergence of deregulated immuno-metabolism in HIV-infected subjects

scientific article published on 08 September 2015

Cutting edge: Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells

scientific article published on 14 June 2013

Dendritic cell inhibition is connected to exhaustion of CD8+ T cell polyfunctionality during chronic hepatitis C virus infection

scientific article published on 19 February 2010

Differential modulation of CCR5-tropic human immunodeficiency virus-1 transfer from macrophages towards T cells under interleukin-4/interleukin-13 microenvironment

scientific article

Diminished Proliferation of Human Immunodeficiency Virus-Specific CD4+T Cells Is Associated with Diminished Interleukin-2 (IL-2) Production and Is Recovered by Exogenous IL-2 ⬇️

scientific article published on October 1, 2003

Diminished Th17 (not Th1) responses underlie multiple sclerosis disease abrogation after hematopoietic stem cell transplantation

scientific article published on 5 March 2013

Down-regulation of CTLA-4 by HIV-1 Nef protein

scientific article published on 23 January 2013

Drug resistance mutations and the cellular immune response: a valuable synergy for the development of novel immune therapies

scientific article published on March 2007

Emergence of individual HIV-specific CD8 T cell responses during primary HIV-1 infection can determine long-term disease outcome

scientific article

Enhancement of HIV-specific CD8 T cell responses by dual costimulation with CD80 and CD137L.

scientific article published in November 2005

Estimate of the total number of CD8+ clonal expansions in healthy adults using a new DNA heteroduplex-tracking assay for CDR3 repertoire analysis

scientific article published in March 2003

Evaluation of OX40 ligand as a costimulator of human antiviral memory CD8 T cell responses: comparison with B7.1 and 4-1BBL.

scientific article published in November 2005

Ex vivo measurement of the cytotoxic capacity of human primary antigen-specific CD8 T cells

scientific article published on 5 October 2011

Follicular CD4 T Helper Cells As a Major HIV Reservoir Compartment: A Molecular Perspective.

scientific article published on 18 June 2018

Foxo3a: an integrator of immune dysfunction during HIV infection

scientific article

FuGEFlow: data model and markup language for flow cytometry

scientific article

GenePattern flow cytometry suite ⬇️

scientific article published on July 3, 2013

HCV RNA Activates APCs via TLR7/TLR8 While Virus Selectively Stimulates Macrophages Without Inducing Antiviral Responses

scientific article

HDAC inhibition induces HIV-1 protein and enables immune-based clearance following latency reversal

scientific article published on 17 August 2017

HIV vaccine candidate activation of hypoxia and the inflammasome in CD14 monocytes is associated with a decreased risk of SIV acquisition

article

HIV-1 viremia prevents the establishment of interleukin 2-producing HIV-specific memory CD4+ T cells endowed with proliferative capacity

scientific article

Human immunodeficiency virus type 1-specific CD8+ T-cell responses during primary infection are major determinants of the viral set point and loss of CD4+ T cells

scientific article published on 20 May 2009

Human memory CD8 T cell effector potential is epigenetically preserved during in vivo homeostasis.

scientific article published on 10 May 2017

Human newborn bacille Calmette-Guérin vaccination and risk of tuberculosis disease: a case-control study

scientific article

Identification of novel HIV-1 dependency factors in primary CCR4(+)CCR6(+)Th17 cells via a genome-wide transcriptional approach

scientific article

Immune activation alters cellular and humoral responses to yellow fever 17D vaccine

scientific article

Impact of multi-targeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection

scientific article

Improved NYVAC-based vaccine vectors

scientific article (publication date: 2011)

Improved innate and adaptive immunostimulation by genetically modified HIV-1 protein expressing NYVAC vectors

scientific article (publication date: 15 February 2011)

Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection

scientific article published in December 2003

Inhibition of HIV-1 transmission in trans from dendritic cells to CD4+ T lymphocytes by natural antibodies to the CRD domain of DC-SIGN purified from breast milk and intravenous immunoglobulins

scientific article

Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells

scientific article published on 12 December 2017

Interleukin-7 promotes HIV persistence during antiretroviral therapy

scientific article published on 15 April 2013

Intrinsic Role of FoxO3a in the Development of CD8+ T Cell Memory ⬇️

scientific article published on December 31, 2012

Kynurenine Reduces Memory CD4 T-Cell Survival by Interfering with Interleukin-2 Signaling Early during HIV-1 Infection

scientific article published on 29 June 2016

Lymph node architecture collapse and consequent modulation of FOXO3a pathway on memory T- and B-cells during HIV infection

scientific article published on June 2008

Lymphoid tissue fibrosis is associated with impaired vaccine responses

scientific article

Maternal BCG scar is associated with increased infant proinflammatory immune responses

scientific article

Microarray analysis of HIV resistant female sex workers reveal a gene expression signature pattern reminiscent of a lowered immune activation state

scientific article

Mucosal Regulatory T Cells and T Helper 17 Cells in HIV-Associated Immune Activation

scientific article published on 20 June 2016

Myeloid Cell Crosstalk Regulates the Efficacy of the DNA/ALVAC/gp120 HIV Vaccine Candidate

article

Myeloid dendritic cells induce HIV-1 latency in non-proliferating CD4+ T cells

scientific article

Nef promotes evasion of human immunodeficiency virus type 1-infected cells from the CTLA-4-mediated inhibition of T-cell activation

scientific article

Next generation DNA vaccines for HIV-1.

scientific article

Novel mechanisms to inhibit HIV reservoir seeding using Jak inhibitors

scientific article published on 21 December 2017

PD-1 blockade potentiates HIV latency reversal ex vivo in CD4 T cells from ART-suppressed individuals

article

Pembrolizumab induces HIV latency reversal in people living with HIV and cancer on antiretroviral therapy

scientific article published on 26 January 2022

Peripheral blood CCR4+CCR6+ and CXCR3+CCR6+CD4+ T cells are highly permissive to HIV-1 infection

scientific article

Persistence and fitness of multidrug-resistant human immunodeficiency virus type 1 acquired in primary infection

scientific article

Poly(I:C) and Lipopolysaccharide Innate Sensing Functions of Circulating Human Myeloid Dendritic Cells Are Affected In Vivo in Hepatitis C Virus-Infected Patients

scientific article (publication date: June 2007)

Profound metabolic, functional, and cytolytic differences characterize HIV-specific CD8 T cells in primary and chronic HIV infection

scientific article published on 6 September 2012

Programmed death 1: a critical regulator of T-cell function and a strong target for immunotherapies for chronic viral infections

scientific article published on May 2007

Programmed death-1 expression on CD4⁺ and CD8⁺ T cells in treated and untreated HIV disease

scientific article

Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection

scientific article

Quantifying and predicting the effect of exogenous interleukin-7 on CD4+ T cells in HIV-1 infection

scientific article

Rapid Inflammasome Activation following Mucosal SIV Infection of Rhesus Monkeys

scientific article published on 11 April 2016

Recognition of a defined region within p24 gag by CD8+ T cells during primary human immunodeficiency virus type 1 infection in individuals expressing protective HLA class I alleles

scientific article published on 9 May 2007

Reduced Chronic Lymphocyte Activation following Interferon Alpha Blockade during the Acute Phase of Simian Immunodeficiency Virus Infection in Rhesus Macaques

scientific article

Residual immune dysregulation syndrome in treated HIV infection

scientific article

Sequential Infection with Common Pathogens Promotes Human-like Immune Gene Expression and Altered Vaccine Response

scientific article published on 18 April 2016

Short Communication: Human Immunodeficiency Virus Rebound in Blood and Seminal Plasma Following Discontinuation of Antiretroviral Therapy ⬇️

scientific article published on September 25, 2012

Standardization of cytokine flow cytometry assays

scientific article

Support for the RV144 HIV vaccine trial.

scientific article

Systems analysis of MVA-C induced immune response reveals its significance as a vaccine candidate against HIV/AIDS of clade C.

scientific article

Systems analysis of a RIG-I agonist inducing broad spectrum inhibition of virus infectivity

scientific article

Systems biology and the quest for correlates of protection to guide the development of an HIV vaccine

scientific article

Systems biology in understanding HIV pathogenesis and guiding vaccine development

scientific article

TCR γ Chain Expression on Human Peripheral Blood T Lymphocytes

Temporal effect of HLA-B*57 on viral control during primary HIV-1 infection

scientific article

Th17 lineage commitment and HIV-1 pathogenesis

scientific article published on March 2010

The failed HIV Merck vaccine study: a step back or a launching point for future vaccine development? ⬇️

scientific article

The immunological synapse: the gateway to the HIV reservoir

scientific article

The interferon paradox: can inhibiting an antiviral mechanism advance an HIV cure?

scientific article published on 12 December 2016

The sooner the better: innate immunity as a path toward the HIV cure

scientific article

Tn-MUC1 DC Vaccination of Rhesus Macaques and a Phase I/II Trial in Patients with Nonmetastatic Castrate-Resistant Prostate Cancer

scientific article published on 7 September 2016

Transcription factor FOXO3a controls the persistence of memory CD4(+) T cells during HIV infection

scientific article published on 2 March 2008

Transmission and long-term stability of compensated CD8 escape mutations

scientific article published on 17 December 2008

Type I IFN induced by adenovirus serotypes 28 and 35 has multiple effects on T cell immunogenicity

scientific article

Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction

scientific article

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