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List of works by Philip J. R. Goulder

'Unleashed' natural killers hinder HIV.

scientific article published in June 2007

A randomised, placebo-controlled, first-in-human study of a novel clade C therapeutic peptide vaccine administered ex vivo to autologous white blood cells in HIV infected individuals

scientific article

Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes

scientific article

Adaptation of HIV-1 to human leukocyte antigen class I

scientific article published on 25 February 2009

Additive contribution of HLA class I alleles in the immune control of HIV-1 infection

scientific article published on 21 July 2010

Amino-acid co-variation in HIV-1 Gag subtype C: HLA-mediated selection pressure and compensatory dynamics

scientific article

An HLA-I signature favouring KIR-educated Natural Killer cells mediates immune control of HIV in children and contrasts with the HLA-B-restricted CD8+ T-cell-mediated immune control in adults

scientific article published on 18 November 2021

Broad and Gag-biased HIV-1 epitope repertoires are associated with lower viral loads

scientific article

CD8 T cell response and evolutionary pressure to HIV-1 cryptic epitopes derived from antisense transcription

scientific article

CD8+ T Cell Breadth and Ex Vivo Virus Inhibition Capacity Distinguish between Viremic Controllers with and without Protective HLA Class I Alleles

scientific article

CD8+ T-cell responses to different HIV proteins have discordant associations with viral load

scientific article published on 17 December 2006

CD8+ TCR Bias and Immunodominance in HIV-1 Infection

scientific article published on 24 April 2015

Central role of reverting mutations in HLA associations with human immunodeficiency virus set point

scientific article published on 2 July 2008

Characterizing the epidemiology and interaction between HIV-1 and HBV co-infection in South Africa

scholarly article by Philippa C Matthews et al published 2014 in BMC Infectious Diseases

Co-operative additive effects between HLA alleles in control of HIV-1

scientific article published on 19 October 2012

Comparison of overlapping peptide sets for detection of antiviral CD8 and CD4 T cell responses

scientific article published in April 2003

Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection

scientific article

Consistent cytotoxic-T-lymphocyte targeting of immunodominant regions in human immunodeficiency virus across multiple ethnicities

scientific article published on March 2004

Consistent patterns in the development and immunodominance of human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T-cell responses following acute HIV-1 infection

scientific article

Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes

scientific article published on 20 December 2005

Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD8+ T-cell epitopes

scientific article published on 24 January 2007

Correction for Thobakgale et al., Impact of HLA in Mother and Child on Disease Progression of Pediatric Human Immunodeficiency Virus Type 1 Infection

scientific article published on 8 July 2015

Cytotoxic T lymphocytes and viral adaptation in HIV infection

scientific article published on May 2006

Definition of the viral targets of protective HIV-1-specific T cell responses

scientific article published on 7 December 2011

Differences in the expressed HLA class I alleles effect the differential clustering of HIV type 1-specific T cell responses in infected Chinese and caucasians

scientific article published in May 2004

Differential Immunodominance Hierarchy of CD8+ T-Cell Responses in HLA-B*27:05- and -B*27:02-Mediated Control of HIV-1 Infection

scientific article published on 22 November 2017

Differential Immunogenicity of HIV‐1 Clade C Proteins in Eliciting CD8+and CD4+Cell Responses

article

Differential Pathogen-Specific Immune Reconstitution in Antiretroviral Therapy-Treated Human Immunodeficiency Virus-Infected Children

scholarly article by Maximilian Muenchhoff et al published 16 April 2019 in Journal of Infectious Diseases

Differential clade-specific HLA-B*3501 association with HIV-1 disease outcome is linked to immunogenicity of a single Gag epitope

scientific article published on 12 September 2012

Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype

scientific article published in October 2006

Dimethyl sulfoxide (DMSO) exposure to human peripheral blood mononuclear cells (PBMCs) abolish T cell responses only in high concentrations and following coincubation for more than two hours

scientific article published on 13 February 2010

Discordant Impact of HLA on Viral Replicative Capacity and Disease Progression in Pediatric and Adult HIV Infection

scientific article published on 15 June 2015

Disease progression despite protective HLA expression in an HIV-infected transmission pair

scientific article published on 30 June 2015

Divergent trajectories of antiviral memory after SARS-CoV-2 infection

scientific article published on 10 March 2022

Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA.

scientific article published in December 2004

Early and nonreversible decrease of CD161++ /MAIT cells in HIV infection

scientific article published on 18 December 2012

Early antigen presentation of protective HIV-1 KF11Gag and KK10Gag epitopes from incoming viral particles facilitates rapid recognition of infected cells by specific CD8+ T cells

scientific article published on 19 December 2012

Early virological suppression despite high frequency NNRTI resistance following perinatal prophylaxis in HIV-infected African infants

article

Early virological suppression with three-class antiretroviral therapy in HIV-infected African infants

scientific article published in July 2008

Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells

scientific article published on 4 January 2018

Enhanced detection of human immunodeficiency virus type 1-specific T-cell responses to highly variable regions by using peptides based on autologous virus sequences

scientific article

Epidemiology and impact of HIV coinfection with hepatitis B and hepatitis C viruses in Sub-Saharan Africa.

scientific article

Erratum: addendum: HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus

scientific article published in Nature

Evolution and transmission of stable CTL escape mutations in HIV infection

scientific article published in Nature

Evolution of HLA-B*5703 HIV-1 escape mutations in HLA-B*5703-positive individuals and their transmission recipients

scientific article published on 23 March 2009

Extensive intrasubtype recombination in South African human immunodeficiency virus type 1 subtype C infections

scientific article published on 21 February 2007

Factors influencing T cell activation and programmed death 1 expression in HIV-infected children

scientific article published on 7 September 2011

Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1

scientific article

Gag-protease-mediated replication capacity in HIV-1 subtype C chronic infection: associations with HLA type and clinical parameters

scientific article

HBV vaccination and PMTCT as elimination tools in the presence of HIV: insights from a clinical cohort and dynamic model

HIV and HLA Class I: An Evolving Relationship ⬇️

scientific article published on September 21, 2012

HIV control through a single nucleotide on the HLA-B locus

scientific article published on 15 August 2012

HIV control: Is getting there the same as staying there?

article

HIV escape and attenuation by cytotoxic T lymphocytes

scientific article published on January 2006

HIV subtype influences HLA-B*07:02-associated HIV disease outcome

scientific article

HIV-1 Subtype C-Infected Children with Exceptional Neutralization Breadth Exhibit Polyclonal Responses Targeting Known Epitopes

article

HIV-1 infection is characterized by profound depletion of CD161+ Th17 cells and gradual decline in regulatory T cells

scientific article published in February 2010

HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus

scientific article published in November 2002

HIV-1 viral escape in infancy followed by emergence of a variant-specific CTL response

scientific article published in June 2005

HLA class I-driven evolution of human immunodeficiency virus type 1 subtype c proteome: immune escape and viral load

scientific article published on 23 April 2008

HLA contributes to immune control of hepatitis B in HIV-positive African adults

article

HLA footprints on human immunodeficiency virus type 1 are associated with interclade polymorphisms and intraclade phylogenetic clustering

scientific article published on 25 February 2009

HLA-A is a Predictor of Hepatitis B e Antigen Status in HIV-Positive African Adults

scientific article published on 9 December 2015

HLA-A*68:02-restricted Gag-specific cytotoxic T lymphocyte responses can drive selection pressure on HIV but are subdominant and ineffective

scientific article published on July 2013

HLA-A*7401-mediated control of HIV viremia is independent of its linkage disequilibrium with HLA-B*5703

scientific article published on 15 April 2011

HLA-B*14:02-Restricted Env-Specific CD8+ T-Cell Activity Has Highly Potent Antiviral Efficacy Associated with Immune Control of HIV Infection

scientific article published on 6 September 2017

HLA-B*35: 05 is a protective allele with a unique structure among HIV-1 CRF01_AE-infected Thais, in whom the B*57 frequency is low.

scientific article

HLA-B*57 Micropolymorphism shapes HLA allele-specific epitope immunogenicity, selection pressure, and HIV immune control

scientific article published on 16 November 2011

HLA-B63 presents HLA-B57/B58-restricted cytotoxic T-lymphocyte epitopes and is associated with low human immunodeficiency virus load

scientific article

HLA-Cw*03-restricted CD8+ T-cell responses targeting the HIV-1 gag major homology region drive virus immune escape and fitness constraints compensated for by intracodon variation

scientific article published on 25 August 2010

HLA-specific intracellular epitope processing shapes an immunodominance pattern for HLA-B*57 that is distinct from HLA-B*58:01

scientific article published on 17 July 2013

HLArestrictor--a tool for patient-specific predictions of HLA restriction elements and optimal epitopes within peptides

scientific article published on 16 November 2010

Heat shock protein-mediated cross-presentation of exogenous HIV antigen on HLA class I and class II.

scientific article published on August 2004

High frequency of rapid immunological progression in African infants infected in the era of perinatal HIV prophylaxis

scientific article published in June 2007

High-Frequency, Functional HIV-Specific T-Follicular Helper and Regulatory Cells Are Present Within Germinal Centers in Children but Not Adults

article

Human immunodeficiency virus-specific CD8+ T-cell activity is detectable from birth in the majority of in utero-infected infants

scientific article

IVA: accurate de novo assembly of RNA virus genomes

scientific article

Identification of conserved subdominant HIV Type 1 CD8(+) T Cell epitopes restricted within common HLA Supertypes for therapeutic HIV Type 1 vaccines

scientific article

Immune control of HIV-1 after early treatment of acute infection

scientific article published in Nature

Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection

scientific article

Immunodominant HIV-1 Cd4+ T cell epitopes in chronic untreated clade C HIV-1 infection

scientific article

Immunodominant HIV-1-specific HLA-B- and HLA-C-restricted CD8+ T cells do not differ in polyfunctionality

scientific article

Impact of HLA Allele-KIR Pairs on HIV Clinical Outcome in South Africa

scientific article published in 2019

Impact of HLA in mother and child on disease progression of pediatric human immunodeficiency virus type 1 infection

scientific article published on 15 July 2009

Impact of HLA selection pressure on HIV fitness at a population level in Mexico and Barbados

scientific article

Impact of HLA-B*35 subtype differences on HIV disease outcome in Mexico

scientific article published on July 2014

Impact of HLA-driven HIV adaptation on virulence in populations of high HIV seroprevalence

scientific article published in December 2014

Impact of intrapeptide epitope location on CD8 T cell recognition

Impact of select immunologic and virologic biomarkers on CD4 cell count decrease in patients with chronic HIV-1 subtype C infection: results from Sinikithemba Cohort, Durban, South Africa

scientific article published on September 2009

Impairment of CD1d-restricted natural killer T cells in chronic HIV type 1 clade C infection

scientific article

Important contribution of p15 Gag-specific responses to the total Gag-specific CTL responses

scientific article published on February 2002

Increased Regulatory T-Cell Activity and Enhanced T-Cell Homeostatic Signaling in Slow Progressing HIV-infected Children

article

Influence of Gag-protease-mediated replication capacity on disease progression in individuals recently infected with HIV-1 subtype C.

scientific article

Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection

scientific article published in December 2003

Influence of HLA-C expression level on HIV control

scientific article published on April 2013

Inter-Continental Patterns of HIV-1 Control: HLA and the Quest for a T Cell Vaccine

article

International perspectives, progress, and future challenges of paediatric HIV infection

scientific article published on July 2007

KIR-HLA footprints and NK cell-mediated recognition of HIV-1.

scientific article published on 13 September 2012

Lack of association between HLA class II alleles and in vitro replication capacities of recombinant viruses encoding HIV-1 subtype C Gag-protease from chronically infected individuals

scientific article published on 16 November 2011

Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes

scientific article published on 15 May 2006

Long-term control of HIV-1 in hemophiliacs carrying slow-progressing allele HLA-B*5101

scientific article

Longitudinal analysis of CD8 T-cell responses to HIV and hepatitis C virus in a cohort of co-infected haemophiliacs

scientific article

Low Replication Capacity Virus Is Preferentially Transmitted In Mother-To-Child-Transmission But Not In Adult-To-Adult-Transmission Of HIV-1

article

Lower Viral Loads and Slower CD4+ T-Cell Count Decline in MRKAd5 HIV-1 Vaccinees Expressing Disease-Susceptible HLA-B*58:02

scientific article published on 06 March 2016

Magnitude and Kinetics of CD8+ T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point

scientific article published on 5 September 2015

Major TCR Repertoire Perturbation by Immunodominant HLA-B44:03-Restricted CMV-Specific T Cells

Malnutrition in HIV-Infected Children Is an Indicator of Severe Disease with an Impaired Response to Antiretroviral Therapy

scientific article published on 2 July 2017

Molecular Analyses Define Vα7.2-Jα33+ MAIT Cell Depletion in HIV Infection: A Case-Control Study

scientific article

Mother-to-Child HIV Transmission Bottleneck Selects for Consensus Virus with Lower Gag-Protease-Driven Replication Capacity

scientific article

Motif inference reveals optimal CTL epitopes presented by HLA class I alleles highly prevalent in southern Africa

scientific article

Mutually exclusive T-cell receptor induction and differential susceptibility to human immunodeficiency virus type 1 mutational escape associated with a two-amino-acid difference between HLA class I subtypes

scientific article published on 22 November 2006

Nef-mediated down-regulation of CD4 and HLA class I in HIV-1 subtype C infection: association with disease progression and influence of immune pressure

scientific article published on 3 September 2014

Nef-specific CD8+ T cell responses contribute to HIV-1 immune control

scientific article

Non-immunogenicity of overlapping gag peptides pulsed on autologous cells after vaccination of HIV infected individuals ⬇️

scientific article published on 04 October 2013

Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection

scientific article published in September 2016

Ongoing burden of disease and mortality from HIV/CMV coinfection in Africa in the antiretroviral therapy era

scientific article

PARV4 prevalence, phylogeny, immunology and coinfection with HIV, HBV and HCV in a multicentre African cohort

scientific article

Paediatric PARV4 infection in South Africa: relationship to age, maternal PARV4 status, and HIV infection.

scientific article published on 23 May 2014

Phylogenetic dependency networks: inferring patterns of CTL escape and codon covariation in HIV-1 Gag.

scientific article

Possession of HLA class II DRB1*1303 associates with reduced viral loads in chronic HIV-1 clade C and B infection

scientific article

Post-treatment control or treated controllers? Viral remission in treated and untreated primary HIV infection

scientific article published on 04 January 2017

Potential for immune-driven viral polymorphisms to compromise antiretroviral-based preexposure prophylaxis for prevention of HIV-1 infection

scientific article

Prevalence and Characteristics of Hepatitis B Virus (HBV) Coinfection among HIV-Positive Women in South Africa and Botswana

scientific article

Proceedings of the Frontiers of Retrovirology Conference 2016.

scientific article published on 26 September 2016

Programmed death-1 expression on HIV-1-specific CD8+ T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen load

scientific article

Progression to AIDS in South Africa is associated with both reverting and compensatory viral mutations

scientific article

Proliferative capacity of epitope-specific CD8 T-cell responses is inversely related to viral load in chronic human immunodeficiency virus type 1 infection

scientific article published on 18 October 2006

Rare HLA drive additional HIV evolution compared to more frequent alleles

scientific article published on March 2009

Recovery of effective hiv-specific cd4+ t-cell activity following antiretroviral therapy in paediatric infection requires sustained suppression of viraemia

scientific article

Replicative capacity of human immunodeficiency virus type 1 transmitted from mother to child is associated with pediatric disease progression rate

scientific article

Reply to eisenhut

scientific article published on 26 August 2014

Resistance of Major Histocompatibility Complex Class B (MHC-B) to Nef-Mediated Downregulation Relative to that of MHC-A Is Conserved among Primate Lentiviruses and Influences Antiviral T Cell Responses in HIV-1-Infected Individuals

scientific article published on 18 October 2017

Role of HIV-specific CD8(+) T cells in pediatric HIV cure strategies after widespread early viral escape.

scientific article published on 5 October 2017

Saporin-conjugated tetramers identify efficacious anti-HIV CD8+ T-cell specificities

scientific article published on 11 October 2017

Screening, characterisation and prevention of Hepatitis B virus (HBV) co-infection in HIV-positive children in South Africa

scientific article published on 31 October 2016

Selection of an HLA-C*03:04-Restricted HIV-1 p24 Gag Sequence Variant Is Associated with Viral Escape from KIR2DL3+ Natural Killer Cells: Data from an Observational Cohort in South Africa

scientific article

Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infection

scientific article

Sex Differences in Antiretroviral Therapy Initiation in Pediatric HIV Infection

scientific article published on 7 July 2015

Short communication: CD8(+) T cell polyfunctionality profiles in progressive and nonprogressive pediatric HIV type 1 infection

scientific article published on 21 March 2011

Statistical resolution of ambiguous HLA typing data

scientific article

The hypervariable HIV-1 capsid protein residues comprise HLA-driven CD8+ T-cell escape mutations and covarying HLA-independent polymorphisms

scientific article published on 24 November 2010

The majority of currently circulating human immunodeficiency virus type 1 clade B viruses fail to prime cytotoxic T-lymphocyte responses against an otherwise immunodominant HLA-A2-restricted epitope: implications for vaccine design

scientific article

Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA.

scientific article

Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipients

scientific article published on 21 April 2008

Viral control in chronic HIV-1 subtype C infection is associated with enrichment of p24 IgG1 with Fc effector activity

scientific article published on 3 April 2018

Widespread impact of HLA restriction on immune control and escape pathways of HIV-1

scientific article published on 29 February 2012

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