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List of works by Etienne C. Hirsch

A new model to study compensatory mechanisms in MPTP-treated monkeys exhibiting recovery

scientific article published on 13 September 2007

Activation of the subventricular zone in multiple sclerosis: evidence for early glial progenitors.

scholarly article

Aging of the dopaminergic system and motor behavior in mice intoxicated with the parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

scientific article published on 11 July 2012

Altered regulation of iron transport and storage in Parkinson's disease.

scientific article published on January 2006

Alzheimer's disease: is the decrease of the cholinergic innervation of the hippocampus related to intrinsic hippocampal pathology?

scientific article published on January 1, 1992

An immunohistochemical study of the distribution of brain-derived neurotrophic factor in the adult human brain, with particular reference to Alzheimer's disease.

scientific article published on January 1999

Analysis of monocyte infiltration in MPTP mice reveals that microglial CX3CR1 protects against neurotoxic over-induction of monocyte-attracting CCL2 by astrocytes

scientific article published on 21 March 2017

Annonacin, a natural mitochondrial complex I inhibitor, causes tau pathology in cultured neurons

scientific article

Apoptosis in dopaminergic neurons of the human substantia nigra during normal aging

scientific article published on July 1, 1997

Autoradiographic study of [125I]epidermal growth factor-binding sites in the mesencephalon of control and parkinsonian brains post-mortem

scientific article published on 01 November 1993

Behavioral consequences of bicuculline injection in the subthalamic nucleus and the zona incerta in rat.

scientific article

Behavioral recovery in MPTP-treated monkeys: neurochemical mechanisms studied by intrastriatal microdialysis.

scientific article

Biochemistry of Parkinson's disease with special reference to the dopaminergic systems.

scientific article published on August 1994

CD95 (APO-1/Fas) and Parkinson's disease

scientific article published on 01 September 1998

Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease.

scholarly article

Caspase-8 is an effector in apoptotic death of dopaminergic neurons in Parkinson's disease, but pathway inhibition results in neuronal necrosis.

scientific article

Changes in GAD67 mRNA expression evidenced by in situ hybridization in the brain of R6/2 transgenic mice.

scientific article published in September 2003

Cholinergic neuronal loss in the globus pallidus of Alzheimer disease patients

scientific article published on February 25, 1991

Cigarette smoke and nicotine protect dopaminergic neurons against the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Parkinsonian toxin.

scientific article published in September 2003

Consequence of nigrostriatal denervation and L-dopa therapy on the expression of glutamic acid decarboxylase messenger RNA in the pallidum

scientific article

Consequences of dopaminergic denervation on the metabolic activity of the cortical neurons projecting to the subthalamic nucleus in the rat.

scientific article published in October 2002

Consequences of nigrostriatal denervation on the functioning of the basal ganglia in human and nonhuman primates: an in situ hybridization study of cytochrome oxidase subunit I mRNA

scientific article published on 01 January 1997

Consequences of nigrostriatal denervation on the gamma-aminobutyric acidic neurons of substantia nigra pars reticulata and superior colliculus in parkinsonian syndromes

scientific article

Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase

scientific article

Decreased choline acetyltransferase mRNA expression in the nucleus basalis of Meynert in Alzheimer disease: an in situ hybridization study

scientific article published on October 15, 1992

Decreased tyrosine hydroxylase content in the dopaminergic neurons of MPTP-intoxicated monkeys: effect of levodopa and GM1 ganglioside therapy

scientific article published on 01 August 1994

Differential vulnerability to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine of dopaminergic and cholinergic neurons in the monkey mesopontine tegmentum

scientific article published on 01 October 1993

Distribution and morphology of nigral axons projecting to the thalamus in primates

scientific article (publication date: 3 June 2002)

Distribution of ataxin-7 in normal human brain and retina

article

Does loss of nerve growth factor receptors precede loss of cholinergic neurons in Alzheimer's disease? An autoradiographic study in the human striatum and basal forebrain

scientific article published on December 1992

Does neuromelanin contribute to the vulnerability of catecholaminergic neurons in monkeys intoxicated with MPTP?

scientific article published on 01 September 1993

Does oxidative stress participate in nerve cell death in Parkinson's disease?

scientific article

Donepezil induces a cholinergic sprouting in basocortical degeneration.

scientific article

Dopamine depletion impairs precursor cell proliferation in Parkinson disease.

scientific article

Dopamine, tremor, and Parkinson's disease

scientific article published on July 11, 1992

Dopaminergic neurons degenerate by apoptosis in Parkinson's disease.

scientific article published in March 1999

Dopaminergic neurons reduced to silence by oxidative stress: an early step in the death cascade in Parkinson's disease?

scientific article published on 25 April 2006

Dopaminergic substantia nigra neurons project topographically organized to the subventricular zone and stimulate precursor cell proliferation in aged primates.

scientific article published in February 2006

Dysfunction of mitochondrial complex I and the proteasome: interactions between two biochemical deficits in a cellular model of Parkinson's disease.

scientific article published in September 2003

Dyskinesia in Parkinson's disease: a clinical complication and an open scientific question

scientific article published on 01 August 2018

Editorial

scientific article published on 27 July 2010

Effect of mitochondrial complex I inhibition on Fe–S cluster protein activity

scientific article published on May 6, 2011

Effects of L-DOPA-therapy on dopamine D2 receptor mRNA expression in the striatum of MPTP-intoxicated parkinsonian monkeys

scientific article published on November 1996

Evidence for a dopaminergic innervation of the pedunculopontine nucleus in monkeys, and its drastic reduction after MPTP intoxication.

scientific article

Evidence of active microglia in substantia nigra pars compacta of parkinsonian monkeys 1 year after MPTP exposure.

scientific article published in May 2004

Evolution of changes in neuronal activity in the subthalamic nucleus of rats with unilateral lesion of the substantia nigra assessed by metabolic and electrophysiological measurements

scientific article published on 01 January 2000

Flavaglines as potent anticancer and cytoprotective agents

scientific article published on 23 October 2012

Functional activity of zona incerta neurons is altered after nigrostriatal denervation in hemiparkinsonian rats

scientific article (publication date: March 2000)

GM-1 ganglioside promotes the recovery of surviving midbrain dopaminergic neurons in MPTP-treated monkeys

scientific article published on 01 October 1993

Gait disorders in parkinsonian monkeys with pedunculopontine nucleus lesions: a tale of two systems.

scientific article

Glial cells and Parkinson's disease.

scientific article

Glial cells and inflammation in Parkinson's disease: a role in neurodegeneration?

scientific article published on 01 September 1998

Glucocerebrosidase deficiency and mitochondrial impairment in experimental Parkinson disease.

scientific article

Glucocorticoid receptor in astrocytes regulates midbrain dopamine neurodegeneration through connexin hemichannel activity

scientific article published on 13 July 2018

Glutaredoxin 1 Downregulation in the Substantia Nigra Leads to Dopaminergic Degeneration in Mice

scientific article published on 03 July 2020

Granulocyte colony-stimulating factor is not protective against selective dopaminergic cell death in vitro.

scientific article published on 13 April 2005

Hepcidin attenuates amyloid beta-induced inflammatory and pro-oxidant responses in astrocytes and microglia.

scientific article

Heterogeneous intracellular localization and expression of ataxin-3.

scientific article published in November 1998

High affinity neurotrophin receptors in cholinergic neurons in the human brain

scientific article published on 01 November 1994

How to improve neuroprotection in Parkinson's disease?

scientific article published on January 2007

How to judge animal models of Parkinson's disease in terms of neuroprotection.

scientific article published on January 2006

In search of innovative therapeutics for neuropsychiatric disorders: the case of neurodegenerative diseases.

scientific article

Increased mRNA expression of cytochrome oxidase in dorsal raphe nucleus of depressive suicide victims.

scientific article published on April 2008

Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease.

scientific article published on 22 December 2008

Inflammation and dopaminergic neuronal loss in Parkinson's disease: a complex matter.

scientific article published on December 2003

Internal pallidum and substantia nigra control different parts of the mesopontine reticular formation in primate

scientific article published on April 5, 2011

Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtin

scientific article

Iron metabolism and Parkinson's disease

scientific article published on January 1, 1998

Is the vulnerability of neurons in the substantia nigra of patients with Parkinson's disease related to their neuromelanin content?

scientific article published on September 1, 1992

Journal of Neural Transmission: a scientific journal devoted since 1950 to the translation of neuroscience into clinical practice

scientific article published on 01 April 2019

Levodopa but not ropinirole induces an internalization of D1 dopamine receptors in parkinsonian rats.

scientific article published in November 2002

Localization of D1a dopamine receptors on cell bodies and axonal endings in the substantia nigra pars reticulata of the rat

scientific journal article

Long-term outcome in neuroZika: When biological diagnosis matters

scientific article published on 26 April 2019

Loss of striatal high affinity NGF binding sites in progressive supranuclear palsy but not in Parkinson's disease

scientific article published on 01 November 1994

Low affinity nerve growth factor receptor, adrenal transplant and Parkinson's disease

scientific article published on 01 December 1993

MFGE8 does not orchestrate clearance of apoptotic neurons in a mouse model of Parkinson's disease.

scientific article published on 27 November 2012

Mechanism and consequences of nerve cell death in Parkinson's disease.

scientific article

Metabolic activity of cerebellar and basal ganglia-thalamic neurons is reduced in parkinsonism.

scientific article

Metabolic activity of excitatory parafascicular and pedunculopontine inputs to the subthalamic nucleus in a rat model of Parkinson's disease.

scientific article published on January 2000

Metabolic activity of the basal ganglia in parkinsonian syndromes in human and non-human primates: a cytochrome oxidase histochemistry study

scientific article published in April 1996

Metabolic effects of nigrostriatal denervation in basal ganglia.

scientific article

Mitochondrial free calcium levels (Rhod-2 fluorescence) and ultrastructural alterations in neuronally differentiated PC12 cells during ceramide-dependent cell death

scientific article published on 01 October 2000

NMDA receptor GluN2A/GluN2B subunit ratio as synaptic trait of levodopa-induced dyskinesias: from experimental models to patients.

scientific article published on 6 July 2015

Neurochemical correlates of parkinsonism. Role of dopaminergic lesions

scientific article published on January 1, 1997

Neuroinflammation in Parkinson's disease.

scientific article published on January 2012

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

scientific article (publication date: April 2009)

Neuroinflammatory processes in Parkinson's disease

scientific article published on 01 June 2005

Neuroinflammatory processes in Parkinson's disease.

scientific article

Neuromelanin associated redox-active iron is increased in the substantia nigra of patients with Parkinson's disease.

scientific article published in September 2003

Neuronal distribution of intranuclear inclusions in Huntington's disease with adult onset.

scientific article published in June 1998

Neuronal plasticity and Parkinson disease

scientific article published on February 1, 1995

Neuroprotection of dopamine neurons by xenon against low-level excitotoxic insults is not reproduced by other noble gases

scientific article published on 05 December 2019

Neuroprotection of midbrain dopamine neurons by nicotine is gated by cytoplasmic Ca2+.

scientific article published on 20 April 2011

Neuroprotective and neurorestorative potential of xenon.

scientific article published on 7 April 2016

New striatal dopamine neurons in MPTP-treated macaques result from a phenotypic shift and not neurogenesis.

scientific article published on 15 February 2006

Nitric oxide synthase and neuronal vulnerability in Parkinson's disease.

scientific article published on 01 May 1996

Nondopaminergic neurons in Parkinson's disease.

scientific article

Normal and pathological gait: what we learn from Parkinson's disease: Figure 1

scientific article published on June 29, 2012

Nuclear translocation of NF-κB in cholinergic neurons of patients with Alzheimerʼs disease

scientific article published on September 8, 1997

Paraxanthine, the primary metabolite of caffeine, provides protection against dopaminergic cell death via stimulation of ryanodine receptor channels

scientific article

Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death.

scientific article published on March 2003

Parkinson disease: mechanisms of cell death

scientific article published on December 1, 2002

Pathogenesis of Parkinson's disease

scientific article published on 23 August 2012

Persistent increase in olfactory type G-protein alpha subunit levels may underlie D1 receptor functional hypersensitivity in Parkinson disease.

scientific article

Piperazine derivatives as iron chelators: a potential application in neurobiology

scientific article published on 26 October 2015

Preservation of midbrain catecholaminergic neurons in very old human subjects

scientific article published in January 2000

Proliferation of microglial cells induced by 1-methyl-4-phenylpyridinium in mesencephalic cultures results from an astrocyte-dependent mechanism: role of granulocyte macrophage colony-stimulating factor.

scientific article published on 31 August 2005

Protection of midbrain dopaminergic neurons by the end-product of purine metabolism uric acid: potentiation by low-level depolarization.

scientific article published on 19 March 2009

Protective action of the peroxisome proliferator-activated receptor-gamma agonist pioglitazone in a mouse model of Parkinson's disease.

scientific article published in August 2002

Quantitative analysis of dopaminergic loss in relation to functional territories in MPTP-treated monkeys.

scientific article published in October 2003

Quantitative evaluation of the human subventricular zone.

scientific article

Re-evaluation of the functional anatomy of the basal ganglia in normal and Parkinsonian states

scientific article

Rescue of mesencephalic dopaminergic neurons in culture by low-level stimulation of voltage-gated sodium channels

scientific article (publication date: 30 June 2004)

Role of pedunculopontine cholinergic neurons in the vulnerability of nigral dopaminergic neurons in Parkinson's disease

scientific article published on 10 November 2015

S29434, a Quinone Reductase 2 Inhibitor: Main Biochemical and Cellular Characterization

scientific article published on 19 December 2018

Seven Solutions for Neuroprotection in Parkinson's Disease

scientific article published on 13 November 2020

Sleep disorders in Parkinsonian macaques: effects of L-dopa treatment and pedunculopontine nucleus lesion

scientific article

Sparing of orexin-A and orexin-B neurons in the hypothalamus and of orexin fibers in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated macaques

scientific article published on 18 October 2014

Special issue in honor of Peter Riederer at the occasion of his 80th birthday

scientific article published in 2022

Specific needs of dopamine neurons for stimulation in order to survive: implication for Parkinson disease.

scientific article published on 22 May 2013

Stathmin: cellular localization of a major phosphoprotein in the adult rat and human CNS.

scientific article

Striatal expression of glutamic acid decarboxylase gene in Alzheimer's disease.

scientific article published in August 1998

Substance P, neurokinins A and B, and synthetic tachykinin peptides protect mesencephalic dopaminergic neurons in culture via an activity-dependent mechanism.

scientific article

Ten Unsolved Questions About Neuroinflammation in Parkinson's Disease

scientific article published on 01 May 2020

Thalamic neuronal activity in dopamine-depleted primates: evidence for a loss of functional segregation within basal ganglia circuits.

scientific article published on February 2005

The Oxygen Paradox, the French Paradox, and age-related diseases.

scientific article

The density of [125I]-transferrin binding sites on perikarya of melanized neurons of the substantia nigra is decreased in Parkinson's disease

scientific article published in February 1997

The global fight against dementia

scientific article published on 01 December 2014

The iron-binding protein lactoferrin protects vulnerable dopamine neurons from degeneration by preserving mitochondrial calcium homeostasis.

scientific article published on 27 September 2013

The mitochondrial complex I inhibitor annonacin is toxic to mesencephalic dopaminergic neurons by impairment of energy metabolism.

scientific article

The neurotransmitter noradrenaline rescues septal cholinergic neurons in culture from degeneration caused by low-level oxidative stress.

scientific article published on 22 March 2005

The noble gas xenon provides protection and trophic stimulation to midbrain dopamine neurons

scientific article published on 11 April 2017

The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration.

scientific article

The pallidosubthalamic projection: an anatomical substrate for nonmotor functions of the subthalamic nucleus in primates.

scientific article published in February 2005

The role of glial reaction and inflammation in Parkinson's disease.

scientific article

The rotenone model of parkinsonism--the five years inspection.

scientific article published on January 2006

The sleep-modulating peptide orexin-B protects midbrain dopamine neurons from degeneration, alone or in cooperation with nicotine.

scientific article published on 31 December 2014

Tremor-related activity of neurons in the 'motor' thalamus: changes in firing rate and pattern in the MPTP vervet model of parkinsonism.

scientific article published on June 2003

Tyrosine kinase B messenger RNA expression in normal human brain and in the substantia nigra of parkinsonian patients: an in situ hybridization study

scientific article published on October 1, 1998

Ultrastructural localization of parkin in the rat brainstem, thalamus and basal ganglia

scientific journal article

Understanding Dopaminergic Cell Death Pathways in Parkinson Disease

scientific article published on May 2016

Xenon-mediated neuroprotection in response to sustained, low-level excitotoxic stress

scientific article published on 16 May 2016

[125I]EGF binding in basal ganglia of patients with Parkinson's disease and progressive supranuclear palsy and in MPTP-treated monkeys.

scientific article published in November 1998

c-fos protein-like immunoreactivity: distribution in the human brain and over-expression in the hippocampus of patients with Alzheimer's disease

scientific article published on January 1, 1992