List of works - Florencia Pereyra

A cell-intrinsic inhibitor of HIV-1 reverse transcription in CD4(+) T cells from elite controllers

scientific article

A high-throughput single-cell analysis of human CD8⁺ T cell functions reveals discordance for cytokine secretion and cytolysis

scientific article

A method for identification of HIV gp140 binding memory B cells in human blood

scientific article

A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells

scientific article

Anti-APOBEC3G activity of HIV-1 Vif protein is attenuated in elite controllers

scientific article

Association study of common genetic variants and HIV-1 acquisition in 6,300 infected cases and 7,200 controls

scientific article

Attenuation of multiple Nef functions in HIV-1 elite controllers

scientific article published on 7 January 2013

Blunted response to combination antiretroviral therapy in HIV elite controllers: an international HIV controller collaboration

scientific article published on 17 January 2014

Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals

scientific article

CCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-independent mechanisms

scientific article

CD4 T-cell regeneration in HIV-1 elite controllers

scientific article published on March 2012

CD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p21

scientific article

CD4-cell count changes after treatment initiation in HIV controllers

article

CTL responses of high functional avidity and broad variant cross-reactivity are associated with HIV control

scientific article (publication date: 2012)

Continuous viral escape and selection by autologous neutralizing antibodies in drug-naive human immunodeficiency virus controllers

scientific article published on 5 November 2008

Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD8+ T-cell epitopes

scientific article published on 24 January 2007

Coordinate linkage of HIV evolution reveals regions of immunological vulnerability

scientific article

Differential levels of soluble inflammatory markers by human immunodeficiency virus controller status and demographics

scientific article

Differential microRNA regulation of HLA-C expression and its association with HIV control

scientific article

Differential neutralization of human immunodeficiency virus (HIV) replication in autologous CD4 T cells by HIV-specific cytotoxic T lymphocytes

scientific article published on 21 January 2009

Differential regulation of toll-like receptor pathways in acute and chronic HIV-1 infection

scientific article published on March 2012

Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection

scientific article

Elite controllers with low to absent effector CD8+ T cell responses maintain highly functional, broadly directed central memory responses

scientific article

Epigenetic regulation of telomerase expression in HIV-1-specific CD8+ T cells

scientific article

Fine-mapping classical HLA variation associated with durable host control of HIV-1 infection in African Americans

scientific article

Frequent and strong antibody-mediated natural killer cell activation in response to HIV-1 Env in individuals with chronic HIV-1 infection

scientific article

Functional characterization of HLA-G⁺ regulatory T cells in HIV-1 infection

scientific article

Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy.

scientific article

Genetic characterization of human immunodeficiency virus type 1 in elite controllers: lack of gross genetic defects or common amino acid changes

scientific article published on 18 June 2008

Genetic interplay between HLA-C and MIR148A in HIV control and Crohn disease

scientific article

HIV control is mediated in part by CD8+ T-cell targeting of specific epitopes

scientific article

HIV controllers

article

HIV-1 persistence in CD4+ T cells with stem cell-like properties

scientific article published on 12 January 2014

HIV-1-specific interleukin-21+ CD4+ T cell responses contribute to durable viral control through the modulation of HIV-specific CD8+ T cell function

scientific article

HIV-specific CD4 T cell responses to different viral proteins have discordant associations with viral load and clinical outcome

scientific article published on 26 October 2011

HLA-B57/B*5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte [corrected] recognition

scientific article published on 30 December 2008

HLA-associated alterations in replication capacity of chimeric NL4-3 viruses carrying gag-protease from elite controllers of human immunodeficiency virus type 1.

scientific article published on 29 October 2008

HLA-associated viral mutations are common in human immunodeficiency virus type 1 elite controllers

scientific article published on 19 January 2009

High-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control

scientific article published on 11 December 2012

High-functional-avidity cytotoxic T lymphocyte responses to HLA-B-restricted Gag-derived epitopes associated with relative HIV control

scientific article published on 13 July 2011

IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells

scientific article published on 13 April 2009

IgG subclass profiles in infected HIV type 1 controllers and chronic progressors and in uninfected recipients of Env vaccines

scientific article

Impaired Nef function is associated with early control of HIV-1 viremia

scientific article published on 25 June 2014

Impaired replication capacity of acute/early viruses in persons who become HIV controllers

scientific article

Impairment of viral replication capacity by nef alleles from HIV elite controllers.

scientific article published on 3 October 2011

Increased HIV-specific CD8+ T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expression

scientific article

Increased coronary atherosclerosis and immune activation in HIV-1 elite controllers

scientific article published on November 2012

Influence of HLA-C expression level on HIV control

scientific article published on April 2013

Inhibition of HIV-1 integration in ex vivo-infected CD4 T cells from elite controllers

scientific article

Inhibitory TCR coreceptor PD-1 is a sensitive indicator of low-level replication of SIV and HIV-1 ⬇️

scientific article

Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1.

scientific article

Intersubtype differences in the effect of a rare p24 gag mutation on HIV-1 replicative fitness

scientific article

LILRB2 interaction with HLA class I correlates with control of HIV-1 infection

scientific article

Leukocyte immunoglobulin-like receptors maintain unique antigen-presenting properties of circulating myeloid dendritic cells in HIV-1-infected elite controllers

scientific article

Ligand-independent exhaustion of killer immunoglobulin-like receptor-positive CD8+ T cells in human immunodeficiency virus type 1 infection

scientific article published on 25 June 2008

Low-level detection and quantitation of cellular HIV-1 DNA and 2-LTR circles using droplet digital PCR.

scientific article published on 4 September 2012

Mutually exclusive T-cell receptor induction and differential susceptibility to human immunodeficiency virus type 1 mutational escape associated with a two-amino-acid difference between HLA class I subtypes

scientific article published on 22 November 2006

Perforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control

scientific article

Persistent low-level viremia in HIV-1 elite controllers and relationship to immunologic parameters

scientific article published in September 2009

Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation

scientific article published on September 2010

Preserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue

scientific article

Prevention and treatment of cytomegalovirus infection in solid organ transplant recipients

scientific article published in August 2004

Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control

scientific article

Reduced replication capacity of NL4-3 recombinant viruses encoding reverse transcriptase-integrase sequences from HIV-1 elite controllers

scientific article published on February 2011

Regulatory T cell frequencies do not correlate with breadth or magnitude of HIV-1-specific T cell responses

scientific article published on 5 April 2012

Responsiveness of HIV-specific CD4 T cells to PD-1 blockade

scientific article

Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding

scientific article

Shelterin dysfunction and p16(INK4a)-mediated growth inhibition in HIV-1-specific CD8 T cells

scientific article

Soluble HLA-G inhibits myeloid dendritic cell function in HIV-1 infection by interacting with leukocyte immunoglobulin-like receptor B2

scientific article

Susceptibility to CD8 T-cell-mediated killing influences the reservoir of latently HIV-1-infected CD4 T cells

scientific article published on January 2014

Systemic inhibition of myeloid dendritic cells by circulating HLA class I molecules in HIV-1 infection

scientific article published on 30 January 2012

TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection

scientific article published on 10 June 2012

Telomerase activity of HIV-1-specific CD8+ T cells: constitutive up-regulation in controllers and selective increase by blockade of PD ligand 1 in progressors

scientific article published on 26 August 2008

Temporal effect of HLA-B*57 on viral control during primary HIV-1 infection

scientific article

The Breadth of Expandable Memory CD8+ T Cells Inversely Correlates with Residual Viral Loads in HIV Elite Controllers

scientific article

The major genetic determinants of HIV-1 control affect HLA class I peptide presentation

scientific article

Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF

scientific article published on 3 October 2010

Transcriptional profiling of CD4 T cells identifies distinct subgroups of HIV-1 elite controllers

scientific article

Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction

scientific article

Viremic control and viral coreceptor usage in two HIV-1-infected persons homozygous for CCR5 Δ32

scientific article published on May 2015

Virus-driven Inflammation Is Associated With the Development of bNAbs in Spontaneous Controllers of HIV.

scientific article published on 3 February 2017

Whole genome deep sequencing of HIV-1 reveals the impact of early minor variants upon immune recognition during acute infection

scientific article published on 8 March 2012

Xenotropic murine leukemia virus-related virus prevalence in patients with chronic fatigue syndrome or chronic immunomodulatory conditions

scientific article

List of works by Florencia Pereyra

A cell-intrinsic inhibitor of HIV-1 reverse transcription in CD4(+) T cells from elite controllers

A high-throughput single-cell analysis of human CD8⁺ T cell functions reveals discordance for cytokine secretion and cytolysis

A method for identification of HIV gp140 binding memory B cells in human blood

A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells

Anti-APOBEC3G activity of HIV-1 Vif protein is attenuated in elite controllers

Association study of common genetic variants and HIV-1 acquisition in 6,300 infected cases and 7,200 controls

Attenuation of multiple Nef functions in HIV-1 elite controllers

Blunted response to combination antiretroviral therapy in HIV elite controllers: an international HIV controller collaboration

Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals

CCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-independent mechanisms

CD4 T-cell regeneration in HIV-1 elite controllers

CD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p21

CD4-cell count changes after treatment initiation in HIV controllers

CTL responses of high functional avidity and broad variant cross-reactivity are associated with HIV control

Continuous viral escape and selection by autologous neutralizing antibodies in drug-naive human immunodeficiency virus controllers

Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD8+ T-cell epitopes

Coordinate linkage of HIV evolution reveals regions of immunological vulnerability

Differential levels of soluble inflammatory markers by human immunodeficiency virus controller status and demographics

Differential microRNA regulation of HLA-C expression and its association with HIV control

Differential neutralization of human immunodeficiency virus (HIV) replication in autologous CD4 T cells by HIV-specific cytotoxic T lymphocytes

Differential regulation of toll-like receptor pathways in acute and chronic HIV-1 infection

Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection

Elite controllers with low to absent effector CD8+ T cell responses maintain highly functional, broadly directed central memory responses

Epigenetic regulation of telomerase expression in HIV-1-specific CD8+ T cells

Fine-mapping classical HLA variation associated with durable host control of HIV-1 infection in African Americans

Frequent and strong antibody-mediated natural killer cell activation in response to HIV-1 Env in individuals with chronic HIV-1 infection

Functional characterization of HLA-G⁺ regulatory T cells in HIV-1 infection

Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy.

Genetic characterization of human immunodeficiency virus type 1 in elite controllers: lack of gross genetic defects or common amino acid changes

Genetic interplay between HLA-C and MIR148A in HIV control and Crohn disease

HIV control is mediated in part by CD8+ T-cell targeting of specific epitopes

HIV controllers

HIV-1 persistence in CD4+ T cells with stem cell-like properties

HIV-1-specific interleukin-21+ CD4+ T cell responses contribute to durable viral control through the modulation of HIV-specific CD8+ T cell function

HIV-specific CD4 T cell responses to different viral proteins have discordant associations with viral load and clinical outcome

HLA-B57/B*5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte [corrected] recognition

HLA-associated alterations in replication capacity of chimeric NL4-3 viruses carrying gag-protease from elite controllers of human immunodeficiency virus type 1.

HLA-associated viral mutations are common in human immunodeficiency virus type 1 elite controllers

High-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control

High-functional-avidity cytotoxic T lymphocyte responses to HLA-B-restricted Gag-derived epitopes associated with relative HIV control

IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells

IgG subclass profiles in infected HIV type 1 controllers and chronic progressors and in uninfected recipients of Env vaccines

Impaired Nef function is associated with early control of HIV-1 viremia

Impaired replication capacity of acute/early viruses in persons who become HIV controllers

Impairment of viral replication capacity by nef alleles from HIV elite controllers.

Increased HIV-specific CD8+ T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expression

Increased coronary atherosclerosis and immune activation in HIV-1 elite controllers

Influence of HLA-C expression level on HIV control

Inhibition of HIV-1 integration in ex vivo-infected CD4 T cells from elite controllers

Inhibitory TCR coreceptor PD-1 is a sensitive indicator of low-level replication of SIV and HIV-1 ⬇️

Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1.

Intersubtype differences in the effect of a rare p24 gag mutation on HIV-1 replicative fitness

LILRB2 interaction with HLA class I correlates with control of HIV-1 infection

Leukocyte immunoglobulin-like receptors maintain unique antigen-presenting properties of circulating myeloid dendritic cells in HIV-1-infected elite controllers

Ligand-independent exhaustion of killer immunoglobulin-like receptor-positive CD8+ T cells in human immunodeficiency virus type 1 infection

Low-level detection and quantitation of cellular HIV-1 DNA and 2-LTR circles using droplet digital PCR.

Mutually exclusive T-cell receptor induction and differential susceptibility to human immunodeficiency virus type 1 mutational escape associated with a two-amino-acid difference between HLA class I subtypes

Perforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control

Persistent low-level viremia in HIV-1 elite controllers and relationship to immunologic parameters

Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation

Preserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue

Prevention and treatment of cytomegalovirus infection in solid organ transplant recipients

Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control

Reduced replication capacity of NL4-3 recombinant viruses encoding reverse transcriptase-integrase sequences from HIV-1 elite controllers

Regulatory T cell frequencies do not correlate with breadth or magnitude of HIV-1-specific T cell responses

Responsiveness of HIV-specific CD4 T cells to PD-1 blockade

Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding

Shelterin dysfunction and p16(INK4a)-mediated growth inhibition in HIV-1-specific CD8 T cells

Soluble HLA-G inhibits myeloid dendritic cell function in HIV-1 infection by interacting with leukocyte immunoglobulin-like receptor B2

Susceptibility to CD8 T-cell-mediated killing influences the reservoir of latently HIV-1-infected CD4 T cells

Systemic inhibition of myeloid dendritic cells by circulating HLA class I molecules in HIV-1 infection

TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection

Telomerase activity of HIV-1-specific CD8+ T cells: constitutive up-regulation in controllers and selective increase by blockade of PD ligand 1 in progressors

Temporal effect of HLA-B*57 on viral control during primary HIV-1 infection

The Breadth of Expandable Memory CD8+ T Cells Inversely Correlates with Residual Viral Loads in HIV Elite Controllers

The major genetic determinants of HIV-1 control affect HLA class I peptide presentation

Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF

Transcriptional profiling of CD4 T cells identifies distinct subgroups of HIV-1 elite controllers

Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction