List of works - Takashi Angata

A human-specific gene in microglia.

scientific article published in September 2005

A second uniquely human mutation affecting sialic acid biology.

scientific article

Association of serum interleukin-27 with the exacerbation of chronic obstructive pulmonary disease

scientific article

Associations of genetic polymorphisms of Siglecs with human diseases

scientific article published on 19 May 2014

Biosynthesis of KDN (2-keto-3-deoxy-D-glycero-D-galacto-nononic acid). Identification and characterization of a KDN-9-phosphate synthetase activity from trout testis

scientific article published on 01 August 1999

Boronate affinity-based photoactivatable magnetic nanoparticles for the oriented and irreversible conjugation of Fc-fused lectins and antibodies

scientific article published on 05 August 2019

CD33/Siglec-3 binding specificity, expression pattern, and consequences of gene deletion in mice

scientific article

Chemical diversity in the sialic acids and related alpha-keto acids: an evolutionary perspective.

scientific article

Chemoenzymatic Synthesis of DSGb5 and Sialylated Globo-series Glycans

scientific article published on 04 July 2019

Cloning and characterization of a novel mouse Siglec, mSiglec-F: differential evolution of the mouse and human (CD33) Siglec-3-related gene clusters.

scientific article

Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia.

scientific article published in May 2002

Cloning, characterization, and phylogenetic analysis of siglec-9, a new member of the CD33-related group of siglecs. Evidence for co-evolution with sialic acid synthesis pathways

scientific article

Detection of anti-Siglec-14 alloantibodies in blood components implicated in nonhaemolytic transfusion reactions

scientific article published on 08 April 2011

Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates

scientific article

Elevated expression of free deaminoneuraminic acid in mammalian cells cultured in mannose-rich media

scientific article published on 01 August 1999

Flagellin/Toll-like receptor 5 response was specifically attenuated by keratan sulfate disaccharide via decreased EGFR phosphorylation in normal human bronchial epithelial cells.

scientific article published on 14 May 2013

Glycoconjugate microarray based on an evanescent-field fluorescence-assisted detection principle for investigation of glycan-binding proteins

scientific article published on 16 July 2008

Glycoproteomic discovery of serological biomarker candidates for HCV/HBV infection-associated liver fibrosis and hepatocellular carcinoma.

scientific article published on 30 April 2013

HLA-B27-mediated activation of TNAP phosphatase promotes pathogenic syndesmophyte formation in ankylosing spondylitis

scientific article published on 01 December 2019

Human C21orf63 is a heparin-binding protein.

scientific article

Identification and characterization of sulfated glycoproteins from small cell lung carcinoma cells assisted by management of molecular charges.

scientific article published on 18 June 2016

Identification of Siglec Ligands Using a Proximity Labeling Method.

scientific article published on 13 September 2017

Identification, characterization, and developmental expression of a novel α2 → 8-KDN-transferase which terminates elongation of α2 → 8-linked oligo-polysialic acid chain synthesis in trout egg polysialoglycoproteins ⬇️

scientific article published on October 1, 1994

Identification, developmental expression and tissue distribution of deaminoneuraminate hydrolase (KDNase) activity in rainbow trout.

scientific article published in August 1994

Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14.

scientific article

Influence of SIGLEC9 polymorphisms on COPD phenotypes including exacerbation frequency

scientific article published on 22 November 2016

Integrated approach toward the discovery of glyco‐biomarkers of inflammation‐related diseases ⬇️

scientific article published on March 1, 2012

Loss of Siglec-14 reduces the risk of chronic obstructive pulmonary disease exacerbation.

scientific article published on 22 March 2013

Metabolically programmed quality control system for dolichol-linked oligosaccharides

scientific journal article

SIGLEC12, a Human-specific Segregating (Pseudo)gene, Encodes a Signaling Molecule Expressed in Prostate Carcinomas ⬇️

scientific article (publication date: July 2011)

Siglec-15 is a potential therapeutic target for postmenopausal osteoporosis

scientific article published in February 2015

Siglec-15: a potential regulator of osteoporosis, cancer, and infectious diseases

scientific article published on 03 January 2020

Siglec-15: an immune system Siglec conserved throughout vertebrate evolution

scientific article

Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus

scientific article

Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily

scientific article (publication date: April 2000)

Soluble Siglec-14 glycan-recognition protein is generated by alternative splicing and suppresses myeloid inflammatory responses

scientific article published in Journal of Biological Chemistry

Strategy for glycoproteomics: identification of glyco-alteration using multiple glycan profiling tools.

scientific article

Streamlined single-cell proteomics by an integrated microfluidic chip and data-independent acquisition mass spectrometry

scientific article published on 10 January 2022

Synthesis of neoglycoconjugates containing deaminated neuraminic acid (KDN) using rat liver alpha2,6-sialyltransferase.

scientific article

The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-β secretion from monocytes/macrophages through the DAP12-Syk pathway.

scientific article

Therapeutic Targeting of Siglecs using Antibody- and Glycan-Based Approaches.

scientific article published on October 2015

[Functions and evolution of siglecs, a family of endogenous sialic acid receptors of vertebrates]

scientific article published on 01 September 2004

[Functions and molecular evolution of Siglecs, a family of sialic acid receptor proteins]

scientific article published on 01 May 2008

α1,6-Fucosyltransferase (Fut8) is implicated in vulnerability to elastase-induced emphysema in mice and a possible non-invasive predictive marker for disease progression and exacerbations in chronic obstructive pulmonary disease (COPD).

scientific article published on 23 June 2012

List of works by Takashi Angata

A human-specific gene in microglia.

A second uniquely human mutation affecting sialic acid biology.

Association of serum interleukin-27 with the exacerbation of chronic obstructive pulmonary disease

Associations of genetic polymorphisms of Siglecs with human diseases

Biosynthesis of KDN (2-keto-3-deoxy-D-glycero-D-galacto-nononic acid). Identification and characterization of a KDN-9-phosphate synthetase activity from trout testis

Boronate affinity-based photoactivatable magnetic nanoparticles for the oriented and irreversible conjugation of Fc-fused lectins and antibodies

CD33/Siglec-3 binding specificity, expression pattern, and consequences of gene deletion in mice

Chemical diversity in the sialic acids and related alpha-keto acids: an evolutionary perspective.

Chemoenzymatic Synthesis of DSGb5 and Sialylated Globo-series Glycans

Cloning and characterization of a novel mouse Siglec, mSiglec-F: differential evolution of the mouse and human (CD33) Siglec-3-related gene clusters.

Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia.

Cloning, characterization, and phylogenetic analysis of siglec-9, a new member of the CD33-related group of siglecs. Evidence for co-evolution with sialic acid synthesis pathways

Detection of anti-Siglec-14 alloantibodies in blood components implicated in nonhaemolytic transfusion reactions

Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates

Elevated expression of free deaminoneuraminic acid in mammalian cells cultured in mannose-rich media

Flagellin/Toll-like receptor 5 response was specifically attenuated by keratan sulfate disaccharide via decreased EGFR phosphorylation in normal human bronchial epithelial cells.

Glycoconjugate microarray based on an evanescent-field fluorescence-assisted detection principle for investigation of glycan-binding proteins

Glycoproteomic discovery of serological biomarker candidates for HCV/HBV infection-associated liver fibrosis and hepatocellular carcinoma.

HLA-B27-mediated activation of TNAP phosphatase promotes pathogenic syndesmophyte formation in ankylosing spondylitis

Human C21orf63 is a heparin-binding protein.

Identification and characterization of sulfated glycoproteins from small cell lung carcinoma cells assisted by management of molecular charges.

Identification of Siglec Ligands Using a Proximity Labeling Method.

Identification, characterization, and developmental expression of a novel α2 → 8-KDN-transferase which terminates elongation of α2 → 8-linked oligo-polysialic acid chain synthesis in trout egg polysialoglycoproteins ⬇️

Identification, developmental expression and tissue distribution of deaminoneuraminate hydrolase (KDNase) activity in rainbow trout.

Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14.

Influence of SIGLEC9 polymorphisms on COPD phenotypes including exacerbation frequency

Integrated approach toward the discovery of glyco‐biomarkers of inflammation‐related diseases ⬇️

Loss of Siglec-14 reduces the risk of chronic obstructive pulmonary disease exacerbation.

Metabolically programmed quality control system for dolichol-linked oligosaccharides

SIGLEC12, a Human-specific Segregating (Pseudo)gene, Encodes a Signaling Molecule Expressed in Prostate Carcinomas ⬇️

Siglec-15 is a potential therapeutic target for postmenopausal osteoporosis

Siglec-15: a potential regulator of osteoporosis, cancer, and infectious diseases

Siglec-15: an immune system Siglec conserved throughout vertebrate evolution

Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus

Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily

Soluble Siglec-14 glycan-recognition protein is generated by alternative splicing and suppresses myeloid inflammatory responses

Strategy for glycoproteomics: identification of glyco-alteration using multiple glycan profiling tools.

Streamlined single-cell proteomics by an integrated microfluidic chip and data-independent acquisition mass spectrometry

Synthesis of neoglycoconjugates containing deaminated neuraminic acid (KDN) using rat liver alpha2,6-sialyltransferase.

The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-β secretion from monocytes/macrophages through the DAP12-Syk pathway.

Therapeutic Targeting of Siglecs using Antibody- and Glycan-Based Approaches.

[Functions and evolution of siglecs, a family of endogenous sialic acid receptors of vertebrates]

[Functions and molecular evolution of Siglecs, a family of sialic acid receptor proteins]

α1,6-Fucosyltransferase (Fut8) is implicated in vulnerability to elastase-induced emphysema in mice and a possible non-invasive predictive marker for disease progression and exacerbations in chronic obstructive pulmonary disease (COPD).