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List of works by Santiago Castanys

4-amino bis-pyridinium derivatives as novel antileishmanial agents.

scientific article published on 5 May 2014

A new ABC half-transporter in Leishmania major is involved in resistance to antimony.

scientific article published on 28 May 2013

A new member of YER057c family in Trypanosoma cruzi is adjacent to an ABC-transporter.

scientific article published in October 1998

A pteridine reductase gene ptr1 contiguous to a P-glycoprotein confers resistance to antifolates in Trypanosoma cruzi.

scientific article published on December 1997

Alkyl-lysophospholipid resistance in multidrug-resistant Leishmania tropica and chemosensitization by a novel P-glycoprotein-like transporter modulator

scientific article

Altered drug membrane permeability in a multidrug-resistant Leishmania tropica line.

scientific article

Bis-pyranobenzoquinones as a new family of reversal agents of the multidrug resistance phenotype mediated by P-glycoprotein in mammalian cells and the protozoan parasite Leishmania.

scientific article

CDC50A plays a key role in the uptake of the anticancer drug perifosine in human carcinoma cells

scientific article

Celastraceae sesquiterpenes as a new class of modulators that bind specifically to human P-glycoprotein and reverse cellular multidrug resistance.

scientific article published on October 2004

Characterization of a new ATP-binding cassette transporter in Trypanosoma cruzi associated to a L1Tc retrotransposon.

scientific article published on December 1999

Characterization of an ABCA-like transporter involved in vesicular trafficking in the protozoan parasite Trypanosoma cruzi.

scientific article published in November 2004

Decreased antimony uptake and overexpression of genes of thiol metabolism are associated with drug resistance in a canine isolate of Leishmania infantum.

scientific article published on 4 June 2016

Design, synthesis and anti-leishmanial activity of novel symmetrical bispyridinium cyclophanes.

scientific article

Dihydro-beta-agarofuran sesquiterpenes: a new class of reversal agents of the multidrug resistance phenotype mediated by P-glycoprotein in the protozoan parasite Leishmania.

scientific article

Experimental resistance to drug combinations in Leishmania donovani: metabolic and phenotypic adaptations.

scientific article

Fitness of Leishmania donovani parasites resistant to drug combinations

scientific article (publication date: April 2015)

Flavonoid structure-activity studies identify 6-prenylchrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2.

scientific article published on June 2005

Functional role of evolutionarily highly conserved residues, N-glycosylation level and domains of the Leishmania miltefosine transporter-Cdc50 subunit

scientific article published on 01 April 2014

Functional role of highly-conserved residues of the N-terminal tail and first transmembrane segment of a P4-ATPase.

scientific article published on 7 February 2018

Genomic and Molecular Characterization of Miltefosine Resistance in Leishmania infantum Strains with Either Natural or Acquired Resistance through Experimental Selection of Intracellular Amastigotes

scientific article

High-throughput screening platform for natural product-based drug discovery against 3 neglected tropical diseases: human African trypanosomiasis, leishmaniasis, and Chagas disease.

scientific article

Identification of specific reversal agents for Leishmania ABCI4-mediated antimony resistance by flavonoid and trolox derivative screening

scientific article published on 14 October 2013

Increased P-Type ATPase Activity in Leishmania tropica Resistant to Methotrexate

scientific article published on 01 March 1994

Increased glycolytic ATP synthesis is associated with tafenoquine resistance in Leishmania major

scientific article published on 3 January 2011

Insights into the molecular mechanism of action of Celastraceae sesquiterpenes as specific, non-transported inhibitors of human P-glycoprotein.

scientific article published on 11 January 2006

LABCG2, a new ABC transporter implicated in phosphatidylserine exposure, is involved in the infectivity and pathogenicity of Leishmania

scientific article

Leishmania LABCG1 and LABCG2 transporters are involved in virulence and oxidative stress: functional linkage with autophagy.

scientific article

Leishmania LABCG2 transporter is involved in ATP-dependent transport of thiols

scientific article

Leishmanicidal and Reversal Multidrug Resistance Constituents fromAeonium lindleyi

scientific article published on 21 July 2010

Mechanisms of action of substituted β-amino alkanols on Leishmania donovani.

scientific article

New Natural Sesquiterpenes as Modulators of Daunomycin Resistance in a Multidrug-ResistantLeishmaniatropicaLine‖,⊥

scientific article published on 01 October 1999

New terpenoids from Maytenus apurimacensis as MDR reversal agents in the parasite Leishmania

scientific article published on 26 November 2007

Non-reducing trisaccharide fatty acid monoesters: Novel detergents in membrane biochemistry

scientific article published on 03 December 2010

Optimization by Molecular Fine Tuning of Dihydro-β-agarofuran Sesquiterpenoids as Reversers of P-Glycoprotein-Mediated Multidrug Resistance.

scientific article published on 2 February 2016

Oxazolo[3,2-a]pyridine. A new structural scaffold for the reversal of multi-drug resistance in Leishmania

scientific article published on 10 August 2012

Phospholipid translocation and miltefosine potency require both L. donovani miltefosine transporter and the new protein LdRos3 in Leishmania parasites.

scientific article published on 19 June 2006

Purification of metacyclic forms ofTrypanosoma cruzi by Percoll discontinuous gradient centrifugation

scientific article published on 01 January 1984

Restoration of Chemosensitivity in P-Glycoprotein-Dependent Multidrug-Resistant Cells by Dihydro-β-agarofuran Sesquiterpenes from Celastrus vulcanicola

scientific article published on 19 February 2015

SAR studies of dihydro-beta-agarofuran sesquiterpenes as inhibitors of the multidrug-resistance phenotype in a Leishmania tropica line overexpressing a P-glycoprotein-like transporter.

scientific article

Sitamaquine overcomes ABC-mediated resistance to miltefosine and antimony in Leishmania.

scientific article published on 6 June 2011

Sitamaquine sensitivity in Leishmania species is not mediated by drug accumulation in acidocalcisomes.

scientific article published on 15 September 2008

Tafenoquine, an antiplasmodial 8-aminoquinoline, targets leishmania respiratory complex III and induces apoptosis

scientific article published on 13 September 2010

Terpenoids from Maytenus Species and Assessment of Their Reversal Activity against a Multidrug-Resistant Leishmania tropica Line ⬇️

scientific article published on 01 December 2011

The LABCG2 Transporter from the Protozoan Parasite Leishmania Is Involved in Antimony Resistance.

scientific article

The anti-tumor alkylphospholipid perifosine is internalized by an ATP-dependent translocase activity across the plasma membrane of human KB carcinoma cells.

scientific article published on 25 October 2007

The overexpression of a new ABC transporter in Leishmania is related to phospholipid trafficking and reduced infectivity.

scientific article published in June 2003

Trypanosoma cruzi: sequence of the ATP-binding site of a P-glycoprotein gene.

scientific article published on August 1994

Two casein kinase 1 isoforms are differentially expressed in Trypanosoma cruzi.

scientific article published in September 2002

Uptake of the antileishmania drug tafenoquine follows a sterol-dependent diffusion process in Leishmania

scientific article published on 16 August 2011

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