List of works - Goutham Narla

A Germline DNA Polymorphism Enhances Alternative Splicing of theKLF6Tumor Suppressor Gene and Is Associated with Increased Prostate Cancer Risk

article

A functional role for KLF6-SV1 in lung adenocarcinoma prognosis and chemotherapy response.

scientific article published on 4 February 2008

Activation of PP2A and inhibition of mTOR synergistically reduce MYC signaling and decrease tumor growth in pancreatic ductal adenocarcinoma

scientific article published on 02 November 2018

Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth.

scientific article

All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase

scientific article

Bisphosphonates inactivate human EGFRs to exert antitumor actions

scientific article

Carcinogen-induced hepatic tumors in KLF6+/- mice recapitulate aggressive human hepatocellular carcinoma associated with p53 pathway deregulation.

scientific article

Challenges and Reinterpretation of Antibody-Based Research on Phosphorylation of Tyr307 on PP2Ac

scientific article published on 01 March 2020

Comment on "PP2A inhibition sensitizes cancer stem cells to ABL tyrosine kinase inhibitors in BCR-ABL human leukemia"

scientific article published on 01 July 2019

Corrigendum to "Reengineered tricyclic anti-cancer agents" [Bioorg. Med. Chem. 23 (2015) 6528-6534].

scientific article

Cyclin-dependent kinase inhibition by the KLF6 tumor suppressor protein through interaction with cyclin D1.

scientific article published in June 2004

Deregulating MYC in a model of HER2+ breast cancer mimics human intertumoral heterogeneity

scientific article published on 01 January 2020

Direct activation of PP2A for the treatment of tyrosine kinase inhibitor-resistant lung adenocarcinoma

scientific article published on 21 February 2019

Downregulation of KLF6 is an early event in hepatocarcinogenesis, and stimulates proliferation while reducing differentiation.

scientific article

E-cadherin is a novel transcriptional target of the KLF6 tumor suppressor.

scientific article published on 15 May 2006

IKKα negatively regulates ASC-dependent inflammasome activation

scientific article

In vivo regulation of p21 by the Kruppel-like factor 6 tumor-suppressor gene in mouse liver and human hepatocellular carcinoma

scientific article published on 05 February 2007

Inactivation of PP2A by a recurrent mutation drives resistance to MEK inhibitors

scientific article published on 20 September 2019

Increased alternative splicing of the KLF6 tumour suppressor gene correlates with prognosis and tumour grade in patients with pancreatic cancer.

scientific article

KLF6 allelic loss is associated with tumor recurrence and markedly decreased survival in head and neck squamous cell carcinoma.

scientific article

KLF6 degradation after apoptotic DNA damage.

scientific article published on 13 November 2006

KLF6 is one transcription factor involved in regulating acid ceramidase gene expression.

scientific article published on December 2005

KLF6-SV1 is a novel antiapoptotic protein that targets the BH3-only protein NOXA for degradation and whose inhibition extends survival in an ovarian cancer model.

scientific article

KLF6-SV1 overexpression accelerates human and mouse prostate cancer progression and metastasis.

scientific article

Kruppel-like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer.

scientific article

Kruppel-like transcription factor 6 regulates inflammatory macrophage polarization

scientific article

Krüppel cripples prostate cancer: KLF6 progress and prospects

scientific article

Krüppel-like factor 6 regulates mitochondrial function in the kidney

scientific article

Loss of hepatic aldolase B activates Akt and promotes hepatocellular carcinogenesis by destabilizing the Aldob/Akt/PP2A protein complex

scientific article published on 04 December 2020

Loss of matrix metalloproteinase-2 amplifies murine toxin-induced liver fibrosis by upregulating collagen I expression

scientific article

Lulling the Cancer Cell into an Eternal Sleep

scientific article published on 01 April 2019

Mistletoe extract Fraxini inhibits the proliferation of liver cancer by down-regulating c-Myc expression

scientific article published on 23 April 2019

PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells

scientific article published on 01 July 2018

Phosphoproteomics Profiling of Nonsmall Cell Lung Cancer Cells Treated with a Novel Phosphatase Activator

scientific article

Protein phosphatase 2A Aα regulates Aβ protein expression and stability

scientific article published on 22 February 2019

Protein phosphatase 2A activation as a therapeutic strategy for managing MYC-driven cancers

scientific article published on 10 December 2019

Protein phosphatase 2A controls ongoing DNA replication by binding to and regulating cell division cycle 45 (CDC45)

scientific article published on 27 September 2019

Quinacrine overcomes resistance to erlotinib by inhibiting FACT, NF-κB, and cell-cycle progression in non-small cell lung cancer

scientific article

RABL6A inhibits tumor-suppressive PP2A/AKT signaling to drive pancreatic neuroendocrine tumor growth

scientific article published on 04 March 2019

Ras promotes growth by alternative splicing-mediated inactivation of the KLF6 tumor suppressor in hepatocellular carcinoma.

scientific article published on 13 February 2008

Reengineered tricyclic anti-cancer agents.

scientific article published on 30 July 2015

Regulation of Kruppel-like factor 6 tumor suppressor activity by acetylation.

scientific article

Repurposing of bisphosphonates for the prevention and therapy of nonsmall cell lung and breast cancer

scientific article

Ribosomal protein S19 expression during erythroid differentiation.

scientific article published on August 2002

Sex steroids have differential effects on growth and gene expression in primary human prostatic epithelial cell cultures derived from the peripheral versus transition zones.

scientific article published on 25 August 2005

Small molecule activators of protein phosphatase 2A for the treatment of castration-resistant prostate cancer

scientific article published on 22 January 2018

Specificity of research antibodies: "trust is good, validation is better".

scientific article published on 13 December 2017

Sprague Dawley Rag2-Null Rats Created from Engineered Spermatogonial Stem Cells Are Immunodeficient and Permissive to Human Xenografts

scientific article published on 11 September 2018

Suppression of glioblastoma tumorigenicity by the Kruppel-like transcription factor KLF6.

scientific article

Targeted inhibition of the KLF6 splice variant, KLF6 SV1, suppresses prostate cancer cell growth and spread.

scientific article published in July 2005

Targeted reduction of KLF6-SV1 restores chemotherapy sensitivity in resistant lung adenocarcinoma.

scientific article

Targeting PP2A in cancer: Combination therapies

scientific article published on 01 September 2018

Targeting the FOXO1/KLF6 axis regulates EGFR signaling and treatment response.

scientific article

The Highly Recurrent PP2A Aα-Subunit Mutation P179R Alters Protein Structure and Impairs PP2A Enzyme Function to Promote Endometrial Tumorigenesis

scientific article published on 29 May 2019

The Kruppel-like factor 6 genotype is associated with fibrosis in nonalcoholic fatty liver disease

scientific article

The Sustained Induction of c-MYC Drives Nab-Paclitaxel Resistance in Primary Pancreatic Ductal Carcinoma Cells

scientific article published on 04 June 2019

The Transcriptional Activator Krüppel-like Factor-6 Is Required for CNS Myelination

scientific article (publication date: May 2016)

The apolipoprotein(a) gene is regulated by sex hormones and acute-phase inducers in YAC transgenic mice.

scientific article published in April 1995

The impact of phosphatases on proliferative and survival signaling in cancer.

scientific article

Therapeutic Targeting of PP2A.

scientific article

Transcriptional activation of the insulin-like growth factor I receptor gene by the Kruppel-like factor 6 (KLF6) tumor suppressor protein: potential interactions between KLF6 and p53.

scientific article

microRNA-181a has a critical role in ovarian cancer progression through the regulation of the epithelial-mesenchymal transition.

scientific article published on January 2014

List of works by Goutham Narla

A Germline DNA Polymorphism Enhances Alternative Splicing of theKLF6Tumor Suppressor Gene and Is Associated with Increased Prostate Cancer Risk

A functional role for KLF6-SV1 in lung adenocarcinoma prognosis and chemotherapy response.

Activation of PP2A and inhibition of mTOR synergistically reduce MYC signaling and decrease tumor growth in pancreatic ductal adenocarcinoma

Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth.

All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase

Bisphosphonates inactivate human EGFRs to exert antitumor actions

Carcinogen-induced hepatic tumors in KLF6+/- mice recapitulate aggressive human hepatocellular carcinoma associated with p53 pathway deregulation.

Challenges and Reinterpretation of Antibody-Based Research on Phosphorylation of Tyr307 on PP2Ac

Comment on "PP2A inhibition sensitizes cancer stem cells to ABL tyrosine kinase inhibitors in BCR-ABL human leukemia"

Corrigendum to "Reengineered tricyclic anti-cancer agents" [Bioorg. Med. Chem. 23 (2015) 6528-6534].

Cyclin-dependent kinase inhibition by the KLF6 tumor suppressor protein through interaction with cyclin D1.

Deregulating MYC in a model of HER2+ breast cancer mimics human intertumoral heterogeneity

Direct activation of PP2A for the treatment of tyrosine kinase inhibitor-resistant lung adenocarcinoma

Downregulation of KLF6 is an early event in hepatocarcinogenesis, and stimulates proliferation while reducing differentiation.

E-cadherin is a novel transcriptional target of the KLF6 tumor suppressor.

IKKα negatively regulates ASC-dependent inflammasome activation

In vivo regulation of p21 by the Kruppel-like factor 6 tumor-suppressor gene in mouse liver and human hepatocellular carcinoma

Inactivation of PP2A by a recurrent mutation drives resistance to MEK inhibitors

Increased alternative splicing of the KLF6 tumour suppressor gene correlates with prognosis and tumour grade in patients with pancreatic cancer.

KLF6 allelic loss is associated with tumor recurrence and markedly decreased survival in head and neck squamous cell carcinoma.

KLF6 degradation after apoptotic DNA damage.

KLF6 is one transcription factor involved in regulating acid ceramidase gene expression.

KLF6-SV1 is a novel antiapoptotic protein that targets the BH3-only protein NOXA for degradation and whose inhibition extends survival in an ovarian cancer model.

KLF6-SV1 overexpression accelerates human and mouse prostate cancer progression and metastasis.

Kruppel-like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer.

Kruppel-like transcription factor 6 regulates inflammatory macrophage polarization

Krüppel cripples prostate cancer: KLF6 progress and prospects

Krüppel-like factor 6 regulates mitochondrial function in the kidney

Loss of hepatic aldolase B activates Akt and promotes hepatocellular carcinogenesis by destabilizing the Aldob/Akt/PP2A protein complex

Loss of matrix metalloproteinase-2 amplifies murine toxin-induced liver fibrosis by upregulating collagen I expression

Lulling the Cancer Cell into an Eternal Sleep

Mistletoe extract Fraxini inhibits the proliferation of liver cancer by down-regulating c-Myc expression

PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells

Phosphoproteomics Profiling of Nonsmall Cell Lung Cancer Cells Treated with a Novel Phosphatase Activator

Protein phosphatase 2A Aα regulates Aβ protein expression and stability

Protein phosphatase 2A activation as a therapeutic strategy for managing MYC-driven cancers

Protein phosphatase 2A controls ongoing DNA replication by binding to and regulating cell division cycle 45 (CDC45)

Quinacrine overcomes resistance to erlotinib by inhibiting FACT, NF-κB, and cell-cycle progression in non-small cell lung cancer

RABL6A inhibits tumor-suppressive PP2A/AKT signaling to drive pancreatic neuroendocrine tumor growth

Ras promotes growth by alternative splicing-mediated inactivation of the KLF6 tumor suppressor in hepatocellular carcinoma.

Reengineered tricyclic anti-cancer agents.

Regulation of Kruppel-like factor 6 tumor suppressor activity by acetylation.

Repurposing of bisphosphonates for the prevention and therapy of nonsmall cell lung and breast cancer

Ribosomal protein S19 expression during erythroid differentiation.

Sex steroids have differential effects on growth and gene expression in primary human prostatic epithelial cell cultures derived from the peripheral versus transition zones.

Small molecule activators of protein phosphatase 2A for the treatment of castration-resistant prostate cancer

Specificity of research antibodies: "trust is good, validation is better".

Sprague Dawley Rag2-Null Rats Created from Engineered Spermatogonial Stem Cells Are Immunodeficient and Permissive to Human Xenografts

Suppression of glioblastoma tumorigenicity by the Kruppel-like transcription factor KLF6.

Targeted inhibition of the KLF6 splice variant, KLF6 SV1, suppresses prostate cancer cell growth and spread.

Targeted reduction of KLF6-SV1 restores chemotherapy sensitivity in resistant lung adenocarcinoma.

Targeting PP2A in cancer: Combination therapies

Targeting the FOXO1/KLF6 axis regulates EGFR signaling and treatment response.

The Highly Recurrent PP2A Aα-Subunit Mutation P179R Alters Protein Structure and Impairs PP2A Enzyme Function to Promote Endometrial Tumorigenesis

The Kruppel-like factor 6 genotype is associated with fibrosis in nonalcoholic fatty liver disease

The Sustained Induction of c-MYC Drives Nab-Paclitaxel Resistance in Primary Pancreatic Ductal Carcinoma Cells

The Transcriptional Activator Krüppel-like Factor-6 Is Required for CNS Myelination

The apolipoprotein(a) gene is regulated by sex hormones and acute-phase inducers in YAC transgenic mice.

The impact of phosphatases on proliferative and survival signaling in cancer.

Therapeutic Targeting of PP2A.

Transcriptional activation of the insulin-like growth factor I receptor gene by the Kruppel-like factor 6 (KLF6) tumor suppressor protein: potential interactions between KLF6 and p53.

microRNA-181a has a critical role in ovarian cancer progression through the regulation of the epithelial-mesenchymal transition.