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List of works by Poul Nielsen

3′,4′-trans-Linked bicyclic nucleosides locked in S-type conformations

scientific article published on 01 September 2002

A click chemistry approach to pleuromutilin derivatives, part 2: conjugates with acyclic nucleosides and their ribosomal binding and antibacterial activity.

scientific article

A click chemistry approach to pleuromutilin derivatives. Part 3: extended footprinting analysis and excellent MRSA inhibition for a derivative with an adenine phenyl side chain.

scientific article

A double-headed nucleotide with two cytosines: DNA with condensed information and improved duplex stability

scientific article published on 05 January 2019

Additional base-pair formation in DNA duplexes by a double-headed nucleotide

scientific article published on 24 April 2012

Allele-Selective Inhibition of Mutant Huntingtin with 2-Thio- and C5- Triazolylphenyl-Deoxythymidine-Modified Antisense Oligonucleotides

scientific article published on 29 July 2015

Alpha-LNA (alpha-D-configured locked nucleic acid)

scientific article published on 01 May 2003

Base-Pairing Properties of Double-Headed Nucleotides

scientific article published on 07 May 2019

Bi- and tricyclic nucleoside derivatives restricted in S-type conformations and obtained by RCM-reactions

scientific article published on 01 May 2003

Bicyclic nucleosides; stereoselective dihydroxylation and 2'-deoxygenation

scientific article published on 01 March 2003

Collision-induced dissociation of cytidine and its derivatives

scientific article published on 01 January 2007

Condensing the information in DNA with double-headed nucleotides

scientific article published on 01 August 2017

Conformationally restricted dinucleotides: tandem ring-closing metathesis and hydrogenation approach

scientific article published on 01 May 2003

Design, synthesis and ribosome binding of chloramphenicol nucleotide and intercalator conjugates.

scientific article

Discovery of a Potent Adenine-Benzyltriazolo-Pleuromutilin Conjugate with Pronounced Antibacterial Activity against MRSA

scientific article published on 16 December 2020

Double-headed nucleotides as xeno nucleic acids: information storage and polymerase recognition

scientific article published on 10 September 2020

Double-headed nucleotides introducing thymine nucleobases in the major groove of nucleic acid duplexes

scientific article published on 05 June 2015

Double-headed nucleotides with arabino configuration: synthesis and hybridization properties

scientific article published on 21 November 2014

Duplex and triplex formation of mixed pyrimidine oligonucleotides with stacking of phenyl-triazole moieties in the major groove

scientific article published on 01 July 2011

High-Affinity DNA Targeting Using Readily Accessible Mimics of N2′-Functionalized 2′-Amino-α-L-LNA ⬇️

scientific article published on August 9, 2011

Incorporation of (R)- and (S)-3',4'-seco-thymidine into oligodeoxynucleotides: hybridization properties and enzymatic stability.

scientific article published on March 1994

Incorporation of alpha- and beta-LNA (locked nucleic acid) monomers in oligodeoxynucleotides with polarity reversals.

scientific article

Increasing the Stability of DNA:RNA Duplexes by Introducing Stacking Phenyl-Substituted Pyrazole, Furan, and Triazole Moieties in the Major Groove

scientific article published on 03 September 2015

LNA (locked nucleic acid) and analogs as triplex-forming oligonucleotides

scientific article published on 22 June 2007

NMR solution structure of dsDNA containing a bicyclic D-arabino-configured nucleotide fixed in an O4'-endo sugar conformation

scientific article

New ruthenium-based protocol for cleavage of terminal olefins to primary alcohols: improved synthesis of a bicyclic nucleoside

scientific article published on 01 August 2004

Nucleic acid secondary structures containing the double-headed nucleoside 5'(S)-C-(2-(thymin-1-yl)ethyl)thymidine.

scientific article

One- and two-photon solvatochromism of the fluorescent dye Nile Red and its CF3, F and Br-substituted analogues

scientific article published on 01 September 2020

Palladium-catalyzed three-component approach to promazine with formation of one carbon-sulfur and two carbon-nitrogen bonds.

scientific article published in January 2008

Parallel nucleic acid recognition by the LNA (locked nucleic acid) stereoisomers beta-L-LNA and alpha-D-LNA; studies in the mirror image world

scientific article published on 19 December 2003

Ring-closing metathesis reactions in nucleic acid chemistry-cyclic dinucleotides for targeting secondary nucleic acid structures

scientific article published on 01 January 2005

Structural basis of cleavage by RNase H of hybrids of arabinonucleic acids and RNA

scientific article

Substituted 9-Diethylaminobenzo[<i>a</i>]phenoxazin-5-ones (Nile Red Analogues): Synthesis and Photophysical Properties

scientific article published on 28 December 2020

Sulfonamide bearing oligonucleotides: simple synthesis and efficient RNA recognition

scientific article published on 23 April 2012

Synthesis and NMR-analysis of tricyclic nucleosides

scientific article published on 01 April 2001

Synthesis of 2′-O-(thymin-1-yl)methyluridine and its incorporation into secondary nucleic acid structures

scientific article

Synthesis of a branched locked nucleic acid (LNA) analogue.

scientific article published in January 2007

Synthesis of bicyclic 2'-deoxynucleosides with alpha-L-ribo- and beta-D-xylo-configurations and restricted S- and N-type conformations.

scientific article published in February 2009

Synthesis of conformationally restricted dinucleotides by ring-closing metathesis

scientific article published on 01 December 2000

Synthesis of conformationally restricted nucleic acid fragments using ring-closing alkene and enyne metathesis reactions.

scientific article published in January 2005

Synthesis of functionalized carbocyclic locked nucleic acid analogues by ring-closing diene and enyne metathesis and their influence on nucleic acid stability and structure.

scientific article

Synthesis of hydroxymethyl branched [3.2.0]bicyclic nucleosides using a regioselective oxetane ring-formation.

scientific article

Synthesis of new C-5-triazolyl-functionalized thymidine analogs and their ability to engage in aromatic stacking in DNA : DNA and DNA : RNA duplexes

scientific article published on 01 May 2016

Synthesis of nucleosides with additional nucleobases.

scientific article published in January 2007

Synthesis, hybridization and fluorescence properties of a 2'-C-pyrene-triazole modified arabino-uridine nucleotide.

scientific article published on 9 February 2017

The Eight Stereoisomers of LNA (Locked Nucleic Acid): A Remarkable Family of Strong RNA Binding Molecules We acknowledge the Danish Natural Science Research Council, the Danish Technical Research Council, and Exiqon A/S for financial support. Ms Bri

scientific article published on May 2000

The extension of a DNA double helix by an additional Watson-Crick base pair on the same backbone

scientific article published on 24 May 2013

The synthesis of double-headed nucleosides by the CuAAC reaction and their effect in secondary nucleic acid structures

scientific article published on 05 January 2011

Three Pyrene-Modified Nucleotides: Synthesis and Effects in Secondary Nucleic Acid Structures ⬇️

scientific article published on October 23, 2012

Three new double-headed nucleotides with additional nucleobases connected to C-5 of pyrimidines; synthesis, duplex and triplex studies

scientific article published on 24 December 2015

Two carbocyclic locked nucleic acid analogues give structural information about the role of hydration in A-type duplexes.

scientific article published in January 2007

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