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List of works by J T Littleton

A Drosophila temperature-sensitive seizure mutant in phosphoglycerate kinase disrupts ATP generation and alters synaptic function.

scientific article

A presynaptic endosomal trafficking pathway controls synaptic growth signaling ⬇️

scientific article

A synaptotagmin suppressor screen indicates SNARE binding controls the timing and Ca2+ cooperativity of vesicle fusion.

scientific article published on 12 September 2017

Absence of synaptotagmin disrupts excitation-secretion coupling during synaptic transmission.

scientific article published in October 1994

Altered gene regulation and synaptic morphology in Drosophila learning and memory mutants ⬇️

scientific article published on March 21, 2011

Astrocyte Ca2+ Influx Negatively Regulates Neuronal Activity.

scientific article published on 10 March 2017

Calcium dependence of neurotransmitter release and rate of spontaneous vesicle fusions are altered in Drosophila synaptotagmin mutants

scientific article published in November 1994

Characterization of a hypercontraction-induced myopathy in Drosophila caused by mutations in Mhc.

scientific article

Characterization of developmental and molecular factors underlying release heterogeneity at synapses

scientific article published on 10 July 2018

Characterization of the role of the Synaptotagmin family as calcium sensors in facilitation and asynchronous neurotransmitter release

scholarly article

Comparative analysis of Drosophila and mammalian complexins as fusion clamps and facilitators of neurotransmitter release.

scientific article published on 30 July 2010

Complexin Mutants Reveal Partial Segregation between Recycling Pathways That Drive Evoked and Spontaneous Neurotransmission

scientific article published on January 2017

Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease.

scholarly article

Development of a Drosophila seizure model for in vivo high-throughput drug screening.

scientific article published in October 2006

Differential regulation of evoked and spontaneous neurotransmitter release by C-terminal modifications of complexin

scientific article published on 16 November 2012

Differential regulation of synchronous versus asynchronous neurotransmitter release by the C2 domains of synaptotagmin 1 ⬇️

scientific article published on August 2, 2010

Drosophila Synaptotagmin 7 negatively regulates synaptic vesicle release and replenishment in a dosage-dependent manner

scientific article published on 28 April 2020

Expression profiling of a hypercontraction-induced myopathy in Drosophila suggests a compensatory cytoskeletal remodeling response.

scientific article

Genetic analysis of the Complexin trans-clamping model for cross-linking SNARE complexes in vivo

scientific article

Glial Casignaling links endocytosis to K buffering around neuronal somas to regulate excitability

scientific article published on 26 April 2019

High-Content Chemical and RNAi Screens for Suppressors of Neurotoxicity in a Huntington's Disease Model ⬇️

scientific article published on August 31, 2011

Huntingtin aggregation kinetics and their pathological role in a Drosophila Huntington's disease model

scientific article published on 17 November 2011

Interaction of the Complexin Accessory Helix with the C-Terminus of the SNARE Complex: Molecular-Dynamics Model of the Fusion Clamp ⬇️

scientific article published on August 6, 2013

Is synaptotagmin the calcium sensor?

scientific article

Mixing and matching during synaptic vesicle endocytosis.

scientific article published on July 2006

Modeling Huntington disease in Drosophila: Insights into axonal transport defects and modifiers of toxicity.

scientific article published on 10 September 2013

Mutation of a NCKX Eliminates Glial Microdomain Calcium Oscillations and Enhances Seizure Susceptibility ⬇️

scientific article published on January 16, 2013

Mutational analysis of Drosophila synaptotagmin demonstrates its essential role in Ca(2+)-activated neurotransmitter release.

scientific article

Nervous wreck and Cdc42 cooperate to regulate endocytic actin assembly during synaptic growth.

scientific article

Neurobiology and the Drosophila genome.

scientific article

Neurons regulate synaptic strength through homeostatic scaling of active zones

scientific article published on 12 April 2019

Pathogenic Huntington Alters BMP Signaling and Synaptic Growth through Local Disruptions of Endosomal Compartments.

scientific article

Phosphorylation of Complexin by PKA Regulates Activity-Dependent Spontaneous Neurotransmitter Release and Structural Synaptic Plasticity

scientific article published on November 2015

Postsynaptic Syntaxin 4 negatively regulates the efficiency of neurotransmitter release

scientific article published on 03 September 2018

Postsynaptic actin regulates active zone spacing and glutamate receptor apposition at the Drosophila neuromuscular junction.

scientific article

Postsynaptic regulation of synaptic plasticity by synaptotagmin 4 requires both C2 domains.

scientific article published on 12 October 2009

Presynaptic N-type calcium channels regulate synaptic growth.

scientific article published in August 2003

ROP, the Drosophila Sec1 homolog, interacts with syntaxin and regulates neurotransmitter release in a dosage-dependent manner.

scientific article published on January 1998

Retrograde BMP signaling modulates rapid activity-dependent synaptic growth via presynaptic LIM kinase regulation of cofilin.

scientific article published on March 2014

Retrograde signaling by Syt 4 induces presynaptic release and synapse-specific growth.

scientific article published in November 2005

SNARE-complex disassembly by NSF follows synaptic-vesicle fusion

scientific article

Semantic Congruence Accelerates the Onset of the Neural Signals of Successful Memory Encoding.

scientific article published on January 2017

Shank Modulates Postsynaptic Wnt Signaling to Regulate Synaptic Development.

scientific article published on May 2016

Spontaneous and evoked release are independently regulated at individual active zones

scientific article published on October 2013

Synapse development in health and disease.

scientific article published on 27 January 2011

Synapses unplugged

scientific article published in Nature

Synaptic endocytosis: illuminating the role of clathrin assembly.

scientific article published in March 2008

Synaptic growth: dancing with adducin.

scientific article

Synaptic plasticity induced by differential manipulation of tonic and phasic motoneurons in Drosophila

scientific article published on 06 July 2020

Synaptotagmins are trafficked to distinct subcellular domains including the postsynaptic compartment.

scientific article

The Drosophila ARC homolog regulates behavioral responses to starvation

scientific article

The postsynaptic t-SNARE Syntaxin 4 controls traffic of Neuroligin 1 and Synaptotagmin 4 to regulate retrograde signaling.

scientific article published on 25 May 2016

Therapeutic prospects for the prevention of neurodegeneration in Huntington's disease and the polyglutamine repeat disorders.

scientific article published on January 2007

Transmembrane tethering of synaptotagmin to synaptic vesicles controls multiple modes of neurotransmitter release

scientific article

Transmission, Development, and Plasticity of Synapses.

scientific article

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