List of works - Paul Hruz

3-Hydroxy-3-methylglutaryl coenzyme A lyase (HL): cloning and characterization of a mouse liver HL cDNA and subchromosomal mapping of the human and mouse HL genes

scientific article

3-Hydroxy-3-methylglutaryldithio-CoA: utility of an alternative substrate in elucidation of a role for HMG-CoA lyase's cation activator

scientific article published on 01 March 1993

A structural basis for the acute effects of HIV protease inhibitors on GLUT4 intrinsic activity.

scientific article

Acute sulfonylurea therapy at disease onset can cause permanent remission of KATP-induced diabetes.

scientific article

Avian 3-hydroxy-3-methylglutaryl-CoA lyase: sensitivity of enzyme activity to thiol/disulfide exchange and identification of proximal reactive cysteines ⬇️

scientific article published on September 1, 1992

Commentary

scientific article published on 01 December 2015

Contribution of systemic inflammation to permanence of KATP-induced neonatal diabetes in mice

scientific article published on 18 September 2018

Deficiencies in Scientific Evidence for Medical Management of Gender Dysphoria

scientific article published on 20 September 2019

Delayed hepatocellular mitotic progression and impaired liver regeneration in early growth response-1-deficient mice.

scientific article

Development of GLUT4-selective antagonists for multiple myeloma therapy.

scientific article published on 14 August 2017

Direct comparison of the acute in vivo effects of HIV protease inhibitors on peripheral glucose disposal

scientific article

Disruption of hepatic adipogenesis is associated with impaired liver regeneration in mice.

scientific article published in December 2004

Evaluating the Efficacy of GLUT Inhibitors Using a Seahorse Extracellular Flux Analyzer.

scientific article published in January 2018

Expression, purification, and functional characterization of the insulin-responsive facilitative glucose transporter GLUT4.

scientific article published on 24 September 2015

GLUT4, GLUT1, and GLUT8 are the dominant GLUT transcripts expressed in the murine left ventricle ⬇️

scientific article published on June 8, 2012

GS-8374, a novel HIV protease inhibitor, does not alter glucose homeostasis in cultured adipocytes or in a healthy-rodent model system.

scientific article

HIV Protease Inhibitors Act as Competitive Inhibitors of the Cytoplasmic Glucose Binding Site of GLUTs with Differing Affinities for GLUT1 and GLUT4 ⬇️

scientific article published on September 23, 2011

HIV and endocrine disorders.

scientific article published in September 2014

HIV protease inhibitors acutely impair glucose-stimulated insulin release.

scientific article

HIV protease inhibitors and insulin resistance: lessons from in-vitro, rodent and healthy human volunteer models

scientific article

Identification of druggable small molecule antagonists of the Plasmodium falciparum hexose transporter PfHT and assessment of ligand access to the glucose permeation pathway via FLAG-mediated protein engineering

scientific article published on 09 May 2019

In Silico Modeling-based Identification of Glucose Transporter 4 (GLUT4)-selective Inhibitors for Cancer Therapy.

scientific article published on 6 April 2015

Indinavir induces acute and reversible peripheral insulin resistance in rats.

scientific article published in April 2002

Investigating the cellular targets of HIV protease inhibitors: implications for metabolic disorders and improvements in drug therapy.

scientific article

Isoform-selective inhibition of facilitative glucose transporters: elucidation of the molecular mechanism of HIV protease inhibitor binding.

scientific article

Letter to the Editor: "Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society Clinical Practice Guideline"

scientific article published on 01 March 2019

Liver regeneration is impaired in lipodystrophic fatty liver dystrophy mice.

scientific article published on 21 October 2010

MEPicides: potent antimalarial prodrugs targeting isoprenoid biosynthesis.

scientific article

Mammalian Glucose Transporter Activity Is Dependent upon Anionic and Conical Phospholipids

scientific article

Metabolic and Cardiac Adaptation to Chronic Pharmacologic Blockade of Facilitative Glucose Transport in Murine Dilated Cardiomyopathy and Myocardial Ischemia.

scientific article published on 24 April 2018

Molecular Mechanisms for Altered Glucose Homeostasis in HIV Infection

scientific article

Molecular mechanisms for insulin resistance in treated HIV-infection ⬇️

scientific article published on June 1, 2011

Rosiglitazone inhibits mouse liver regeneration

scientific article published on 31 October 2006

SLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy.

scientific article published on 06 December 2016

Saxagliptin Improves Glucose Tolerance but not Survival in a Murine Model of Dilated Cardiomyopathy

scientific article published on December 2012

TFEB-dependent induction of thermogenesis by the hepatocyte SLC2A inhibitor trehalose

scientific article published on 06 August 2018

The Glucose Transporter PfHT1 Is an Antimalarial Target of the HIV Protease Inhibitor Lopinavir.

scientific article

The mechanism of insulin resistance caused by HIV protease inhibitor therapy.

scientific article published on July 2000

The role of protease inhibitors in the pathogenesis of HIV-associated lipodystrophy: cellular mechanisms and clinical implications

scientific article

Tipranavir without ritonavir does not acutely induce peripheral insulin resistance in a rodent model

scientific article published on 01 December 2006

Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis

scientific article published on 23 February 2016

List of works by Paul Hruz

3-Hydroxy-3-methylglutaryl coenzyme A lyase (HL): cloning and characterization of a mouse liver HL cDNA and subchromosomal mapping of the human and mouse HL genes

3-Hydroxy-3-methylglutaryldithio-CoA: utility of an alternative substrate in elucidation of a role for HMG-CoA lyase's cation activator

A structural basis for the acute effects of HIV protease inhibitors on GLUT4 intrinsic activity.

Acute sulfonylurea therapy at disease onset can cause permanent remission of KATP-induced diabetes.

Avian 3-hydroxy-3-methylglutaryl-CoA lyase: sensitivity of enzyme activity to thiol/disulfide exchange and identification of proximal reactive cysteines ⬇️

Commentary

Contribution of systemic inflammation to permanence of KATP-induced neonatal diabetes in mice

Deficiencies in Scientific Evidence for Medical Management of Gender Dysphoria

Delayed hepatocellular mitotic progression and impaired liver regeneration in early growth response-1-deficient mice.

Development of GLUT4-selective antagonists for multiple myeloma therapy.

Direct comparison of the acute in vivo effects of HIV protease inhibitors on peripheral glucose disposal

Disruption of hepatic adipogenesis is associated with impaired liver regeneration in mice.

Evaluating the Efficacy of GLUT Inhibitors Using a Seahorse Extracellular Flux Analyzer.

Expression, purification, and functional characterization of the insulin-responsive facilitative glucose transporter GLUT4.

GLUT4, GLUT1, and GLUT8 are the dominant GLUT transcripts expressed in the murine left ventricle ⬇️

GS-8374, a novel HIV protease inhibitor, does not alter glucose homeostasis in cultured adipocytes or in a healthy-rodent model system.

HIV Protease Inhibitors Act as Competitive Inhibitors of the Cytoplasmic Glucose Binding Site of GLUTs with Differing Affinities for GLUT1 and GLUT4 ⬇️

HIV and endocrine disorders.

HIV protease inhibitors acutely impair glucose-stimulated insulin release.

HIV protease inhibitors and insulin resistance: lessons from in-vitro, rodent and healthy human volunteer models

Identification of druggable small molecule antagonists of the Plasmodium falciparum hexose transporter PfHT and assessment of ligand access to the glucose permeation pathway via FLAG-mediated protein engineering

In Silico Modeling-based Identification of Glucose Transporter 4 (GLUT4)-selective Inhibitors for Cancer Therapy.

Indinavir induces acute and reversible peripheral insulin resistance in rats.

Investigating the cellular targets of HIV protease inhibitors: implications for metabolic disorders and improvements in drug therapy.

Isoform-selective inhibition of facilitative glucose transporters: elucidation of the molecular mechanism of HIV protease inhibitor binding.

Letter to the Editor: "Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society Clinical Practice Guideline"

Liver regeneration is impaired in lipodystrophic fatty liver dystrophy mice.

MEPicides: potent antimalarial prodrugs targeting isoprenoid biosynthesis.

Mammalian Glucose Transporter Activity Is Dependent upon Anionic and Conical Phospholipids

Metabolic and Cardiac Adaptation to Chronic Pharmacologic Blockade of Facilitative Glucose Transport in Murine Dilated Cardiomyopathy and Myocardial Ischemia.

Molecular Mechanisms for Altered Glucose Homeostasis in HIV Infection

Molecular mechanisms for insulin resistance in treated HIV-infection ⬇️

Rosiglitazone inhibits mouse liver regeneration

SLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy.

Saxagliptin Improves Glucose Tolerance but not Survival in a Murine Model of Dilated Cardiomyopathy

TFEB-dependent induction of thermogenesis by the hepatocyte SLC2A inhibitor trehalose

The Glucose Transporter PfHT1 Is an Antimalarial Target of the HIV Protease Inhibitor Lopinavir.

The mechanism of insulin resistance caused by HIV protease inhibitor therapy.

The role of protease inhibitors in the pathogenesis of HIV-associated lipodystrophy: cellular mechanisms and clinical implications

Tipranavir without ritonavir does not acutely induce peripheral insulin resistance in a rodent model

Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis