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List of works by K. Sandy Pang

1 ,25-Dihydroxyvitamin D3 Up-Regulates P-Glycoprotein via the Vitamin D Receptor and Not Farnesoid X Receptor in Both fxr(-/-) and fxr(+/+) Mice and Increased Renal and Brain Efflux of Digoxin in Mice In Vivo

scientific article published on 18 March 2011

1alpha,25-Dihydroxyvitamin D(3) triggered vitamin D receptor and farnesoid X receptor-like effects in rat intestine and liver in vivo.

scientific article published in November 2009

1α,25-Dihydroxyvitamin D3 reduces cerebral amyloid-β accumulation and improves cognition in mouse models of Alzheimer's disease

scientific article published in May 2014

1α,25-Dihydroxyvitamin D3-liganded vitamin D receptor increases expression and transport activity of P-glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endothelial cells

scientific article published on November 2012

1α,25-dihydroxyvitamin D3 on intestinal transporter function: studies with the rat everted intestinal sac.

scientific article published on 14 January 2011

A catenary model to study transport and conjugation of baicalein, a bioactive flavonoid, in the Caco-2 cell monolayer: demonstration of substrate inhibition.

scientific article published on 2 April 2008

Acinar Factors in Drug Processing: Protein Binding, Futile Cycling, and Cosubstrate ⬇️

scientific article published on January 1, 1995

Advanced pharmacokinetic models based on organ clearance, circulatory, and fractal concepts

scientific article published on 29 June 2007

Alterations in Gene Expression in Vitamin D-Deficiency: Down-Regulation of Liver Cyp7a1 and Renal Oat3 in Mice.

scientific article

An integrated approach to model hepatic drug clearance.

scientific article published on 22 May 2006

Application of the dispersion model for description of the outflow dilution profiles of noneliminated reference indicators in rat liver perfusion studies

scientific article published on April 1, 1998

Binding of acellular, native and cross-linked human hemoglobins to haptoglobin: enhanced distribution and clearance in the rat.

scientific article published in June 2005

Carrier-mediated entry of 4-methylumbelliferyl sulfate: characterization by the multiple-indicator dilution technique in perfused rat liver

scientific article published on 01 January 1998

Combined recirculation of the rat liver and kidney: studies with enalapril and enalaprilat

scientific article published on 01 August 1993

Commentary on "The Universally Unrecognized Assumption in Predicting Drug Clearance and Organ Extraction Ratio".

scientific article published on 14 November 2017

Commentary: theoretical predictions of flow effects on intestinal and systemic availability in physiologically based pharmacokinetic intestine models: the traditional model, segregated flow model, and QGut model.

scientific article published on 27 June 2012

Comparative changes in renal gene expressions in chronic kidney disease and vitamin D deficient mouse models

scholarly article

Comparative effects of 1α-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on transporters and enzymes in fxr(+/+) and fxr(-/-) mice

scientific article published on 16 September 2013

Comparative effects of doxercalciferol (1α-hydroxyvitamin D₂) versus calcitriol (1α,25-dihydroxyvitamin D₃) on the expression of transporters and enzymes in the rat in vivo

scientific article published on 21 October 2010

Comparative pharmacophore modeling of organic anion transporting polypeptides: a meta-analysis of rat Oatp1a1 and human OATP1B1.

scientific article

Comparing early liver graft function from heart beating and living-donors: A pilot study aiming to identify new biomarkers of liver injury.

scientific article published on 19 January 2017

Comparison of effects of VDR versus PXR, FXR and GR ligands on the regulation of CYP3A isozymes in rat and human intestine and liver

scientific article published on 30 January 2009

Current Evidence and Future Directions of Tranexamic Acid Use, Efficacy, and Dosing for Major Surgical Procedures

scientific article published on 04 July 2019

Dealing with the complex drug-drug interactions: towards mechanistic models.

scientific article published on 10 February 2015

Disparity in intestine disposition between formed and preformed metabolites and implications: a theoretical study

scientific article published on 23 October 2008

Disrupted Murine Gut-to-Human Liver Signaling Alters Bile Acid Homeostasis in Humanized Mouse Liver Models.

scientific article published on 27 October 2016

Dynamics of drug distribution. I. Role of the second and third curve moments

scientific article published on June 1, 1992

Effects of 1alpha,25-dihydroxyvitamin D3 on transporters and enzymes of the rat intestine and kidney in vivo

scientific journal article

Effects of 1α,25-dihydroxyvitamin D3 , the natural vitamin D receptor ligand, on the pharmacokinetics of cefdinir and cefadroxil, organic anion transporter substrates, in rat

scientific article published on 29 September 2014

Effects of 1α,25-dihydroxyvitamin D3 on transport and metabolism of adefovir dipivoxil and its metabolites in Caco-2 cells ⬇️

scientific article published on March 3, 2012

Evaluation of Exposure Change of Nonrenally Eliminated Drugs in Patients With Chronic Kidney Disease Using Physiologically Based Pharmacokinetic Modeling and Simulation ⬇️

scientific article published on January 1, 2012

Expression and regulation of the bile acid transporter, OSTalpha-OSTbeta in rat and human intestine and liver.

scientific article published in July 2009

Factors that influence tranexamic acid overdose in cardiac surgical patients with chronic renal dysfunction

scholarly article

Finding Tmax and Cmax in Multicompartmental Models

scientific article published on 22 August 2018

First-Pass Effect: Significance of the Intestine for Absorption and Metabolism ⬇️

scientific article published on November 1, 1997

Formed and preformed metabolite excretion clearances in liver, a metabolite formation organ: studies on enalapril and enalaprilat in the single-pass and recirculating perfused rat liver

scientific article published on 01 August 1993

Formed and preformed metabolites: facts and comparisons.

scientific article published on October 2008

Fraction absorbed (Fabs ): different connotations and confusion for the literature?

scientific article published on 01 June 2011

Functional Integrity of the Chimeric (Humanized) Mouse Liver: Enzyme Zonation, Physiologic Spaces, and Hepatic Enzymes and Transporters.

scientific article published on 24 June 2016

Glutathione conjugation of bromosulfophthalein in relation to hepatic glutathione content in the rat in vivo and in the perfused rat liver

scientific article published on 01 May 1995

Hepatic clearance concepts and misconceptions: Why the well-stirred model is still used even though it is not physiologic reality?

scientific article published on 06 August 2019

Highlighting Vitamin D Receptor-Targeted Activities of 1α,25-Dihydroxyvitamin D3 in Mice via Physiologically Based Pharmacokinetic-Pharmacodynamic Modeling

scientific article published on 30 October 2017

Human amyloid-beta 1-40 disposition after intravenous and intracerebral injections in the rat

scholarly article

Human β-Amyloid 40 (hAβ40) Kinetics after Intravenous (IV) and Intracerebroventricular (ICV) Injections and Calcitriol Treatment in Rats in vivo

scientific article published on 05 August 2020

ITC recommendations for transporter kinetic parameter estimation and translational modeling of transport-mediated PK and DDIs in humans

scientific article

Increased estrogen sulfation of estradiol 17beta-D-glucuronide in metastatic tumor rat livers

scientific article published on 08 August 2006

Influence of P-glycoprotein, transfer clearances, and drug binding on intestinal metabolism in Caco-2 cell monolayers or membrane preparations: a theoretical analysis.

scientific article published in October 2003

Interplay of phase II enzymes and transporters in futile cycling: influence of multidrug resistance-associated protein 2-mediated excretion of estradiol 17beta-D-glucuronide and its 3-sulfate metabolite on net sulfation in perfused TR(-) and Wistar

scientific article published on 02 February 2010

Interplay of transporters and enzymes in drug and metabolite processing.

scientific article

Interplay of transporters and enzymes in the Caco-2 cell monolayer: I. effect of altered apical secretion

scientific article published on 01 May 2010

Metabolite Kinetics: The Segregated Flow Model for Intestinal and Whole Body Physiologically Based Pharmacokinetic Modeling to Describe Intestinal and Hepatic Glucuronidation of Morphine in Rats In Vivo

scientific article

Methods for the quantitation of bromosulfophthalein and its glutathione conjugate in biological fluids

scientific article published on 01 July 1993

Modeling of intestinal drug absorption: roles of transporters and metabolic enzymes (for the Gillette Review Series).

scientific article published on December 2003

Moment analysis of metabolic heterogeneity: conjugation of benzoate with glycine in rat liver studied by multiple indicator dilution technique.

scientific article published in April 2003

Noteworthy idiosyncrasies of 1α,25-dihydroxyvitamin D3 kinetics for extrapolation from mouse to man: Commentary

scientific article published on 01 March 2020

Organ clearance concepts: new perspectives on old principles

scientific article published on August 1, 1997

P-glycoprotein and an unstirred water layer barring digoxin absorption in the vascularly perfused rat small intestine preparation: induction studies with pregnenolone-16alpha-carbonitrile

scientific article published on 02 June 2006

PBPK modeling of intestinal and liver enzymes and transporters in drug absorption and sequential metabolism

scientific article

PBPK modeling to unravel nonlinear pharmacokinetics of verapamil to estimate the fractional clearance for verapamil N-demethylation in the recirculating rat liver preparation.

scientific article published on 3 February 2015

PKPD modelling to predict altered disposition of 1α,25-dihydroxyvitamin D3 in mice due to dose-dependent regulation of CYP27B1 on synthesis and CYP24A1 on degradation.

scientific article published on 15 May 2015

Permeability, transport, and metabolism of solutes in Caco-2 cell monolayers: a theoretical study

scientific article published on 11 October 2007

Pharmacokinetic modeling of tranexamic acid for patients undergoing cardiac surgery with normal renal function and model simulations for patients with renal impairment

scientific article published on 21 April 2015

Physiological modeling to understand the impact of enzymes and transporters on drug and metabolite data and bioavailability estimates

scientific article

Physiologically based pharmacokinetic (PBPK) modeling: it is here to stay!

scientific article published on 05 March 2012

Physiologically based pharmacokinetic modeling revealed minimal codeine intestinal metabolism in first-pass removal in rats.

scientific article published on 7 December 2016

Physiologically-Based Pharmacokinetic-Pharmacodynamic Modeling of 1α,25-Dihydroxyvitamin D3 in Mice.

scientific article published on 19 November 2015

Physiologically-based pharmacokinetic modeling for absorption, transport, metabolism and excretion.

scientific article published on 14 December 2010

Polymer-lipid hybrid nanoparticles synchronize pharmacokinetics of co-encapsulated doxorubicin-mitomycin C and enable their spatiotemporal co-delivery and local bioavailability in breast tumor.

scientific article published on 7 January 2016

Potencies of vitamin D analogs, 1α-hydroxyvitamin D , 1α-hydroxyvitamin D and 25-hydroxyvitamin D , in lowering cholesterol in hypercholesterolemic mice in vivo

scientific article published on 01 April 2018

Professor Yuichi Sugiyama: A Brilliant, Creative, Amicable, Charming, and Humorous Pharmaceutical Scientist.

scientific article

Response to letter to the editor on "fractional clearance for verapamil N-demethylation in the isolated rat liver preparation"

scientific article published on 11 May 2015

Retention of transporter activities in cryopreserved, isolated rat hepatocytes.

scientific article published in April 2003

Revisiting the role of gut wall in the fate of orally administered drugs: Why now and to what effect?

scientific article published in March 2017

Role of haptoglobin on the uptake of native and beta-chain [trimesoyl-(Lys82)beta-(Lys82)beta] cross-linked human hemoglobins in isolated perfused rat livers

scientific article

Route-dependent metabolism of morphine in the vascularly perfused rat small intestine preparation

scientific article published on 01 March 2000

Safety testing of metabolites: Expectations and outcomes.

scientific article published on 23 September 2008

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice.

scientific article published on 5 October 2017

Segmental intestinal transporters and metabolic enzymes on intestinal drug absorption.

scientific article

Strategies and limitations associated with in vitro characterization of vitamin D receptor activators

scientific article published on 18 July 2018

Substrate specificities of rat oatp1 and ntcp: implications for hepatic organic anion uptake

scientific article published on 3 July 2003

Sulfation of acetaminophen by the perfused rat liver: The effect of red blood cell carriage ⬇️

scientific article published on 01 July 1995

Temporal changes in tissue 1α,25-dihydroxyvitamin D3, vitamin D receptor target genes, and calcium and PTH levels after 1,25(OH)2D3treatment in mice ⬇️

scientific article published on March 12, 2013

The Caco-2 cell monolayer: usefulness and limitations

scientific article published on 01 April 2008

The Segregated Intestinal Flow Model (SFM) for Drug Absorption and Drug Metabolism: Implications on Intestinal and Liver Metabolism and Drug-Drug Interactions

scientific article published on 01 April 2020

The modified dipeptide, enalapril, an angiotensin-converting enzyme inhibitor, is transported by the rat liver organic anion transport protein.

scientific article published on November 1998

The role of lithocholic acid in the regulation of bile acid detoxication, synthesis, and transport proteins in rat and human intestine and liver slices.

scientific article published on October 2010

The roles of transporters and enzymes in hepatic drug processing

scientific article published in October 2004

Theoretical consideration of the properties of intestinal flow models on route-dependent drug removal: Segregated Flow (SFM) vs. Traditional (TM)

scientific article published on 01 May 2019

To the Editor

scientific article published on 01 June 2019

Tranexamic Acid Dosing for Cardiac Surgical Patients With Chronic Renal Dysfunction: A New Dosing Regimen.

scientific article published on 5 January 2018

Transactivation of rat apical sodium-dependent bile acid transporter and increased bile acid transport by 1alpha,25-dihydroxyvitamin D3 via the vitamin D receptor

scientific journal article

Transport is not rate-limiting in morphine glucuronidation in the single-pass perfused rat liver preparation.

scientific article published on 7 February 2006

Transport of 5,5-diphenylbarbituric acid and its precursors and their effect on P-gp, MRP2 and CYP3A4 in Caco-2 and LS180 cells ⬇️

scientific article published on October 16, 2010

Transport of the sulfated, amidated bile acid, sulfolithocholyltaurine, into rat hepatocytes is mediated by Oatp1 and Oatp2

scientific journal article

Transporters, enzymes, and enalapril removal in a rat (CC531-induced) liver metastatic model

scientific article published on 13 September 2007

Unequivocal evidence supporting the segregated flow intestinal model that discriminates intestine versus liver first-pass removal with PBPK modeling.

scientific article

Up-regulation of transporters and enzymes by the vitamin D receptor ligands, 1alpha,25-dihydroxyvitamin D3 and vitamin D analogs, in the Caco-2 cell monolayer.

scientific article published on 4 May 2009

Utility of a physiologically-based pharmacokinetic (PBPK) modeling approach to quantitatively predict a complex drug-drug-disease interaction scenario for rivaroxaban during the drug review process: implications for clinical practice.

scientific article published on 04 March 2012

Vascular binding, blood flow, transporter, and enzyme interactions on the processing of digoxin in rat liver.

scientific article published on 30 June 2005

Vectorial transport of enalapril by Oatp1a1/Mrp2 and OATP1B1 and OATP1B3/MRP2 in rat and human livers.

scientific article published on 20 April 2006

Vitamin D receptor activation down-regulates the small heterodimer partner and increases CYP7A1 to lower cholesterol.

scientific article

Vitamin D receptor activation induces P-glycoprotein and increases brain efflux of quinidine: an intracerebral microdialysis study in conscious rats

scientific article published on 16 October 2014

Why We Need Proper PBPK Models to Examine Intestine and Liver Oral Drug Absorption

scientific article published on January 1, 2013

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