List of works - Claude Cochet

2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 1. Identification of an Allosteric Binding Site

scientific article published on 18 February 2019

2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 2. Structure-Based Optimization and Investigation of Effects Specific to the Allosteric Mode of Action

scientific article published on 13 February 2019

A new specific endogenous inhibitor of a cyclic nucleotide independent (G type) protein kinase ⬇️

scientific article published on February 15, 1979

A rapid method for screening inhibitor effects: Determination of I50 and its standard deviation

scientific article published on January 1, 1978

A soluble glucocorticoid binding protein in the bovine adrenal cortex

scientific article published on April 15, 1977

Adenosine 3′,5′-Monophosphate-Independent Protein Kinase Activities in the Bovine Adrenal Cortex Cytosol* ⬇️

scientific article published on March 1, 1980

Antitumor activity of pyridocarbazole and benzopyridoindole derivatives that inhibit protein kinase CK2

scientific article

Antitumoral activity of allosteric inhibitors of protein kinase CK2.

scientific article

Autocrine regulation of adrenal steroidogenesis by growth factor transforming TGF-beta 1

scientific article published on January 1, 1991

Binding of Polyamines to an Autonomous Domain of the Regulatory Subunit of Protein Kinase CK2 Induces a Conformational Change in the Holoenzyme

scientific article published in Journal of Biological Chemistry

C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor-stimulated tyrosine protein kinase activity ⬇️

scientific article published on February 25, 1984

Casein kinase 2 and the cell response to growth factors

scientific article published on 01 January 1994

Casein kinase II and the tumor suppressor protein P53 associate in a molecular complex that is negatively regulated upon P53 phosphorylation ⬇️

scientific article published on October 15, 1992

Characterization of a cyclic AMP-independent protein kinase in the bovine adrenal cortex ⬇️

scientific article published on November 1, 1977

Characterization of an endogenous substrate of protein kinases in the bovine adrenal cortex

scientific article published on November 1, 1977

Characterization of steroid-binding macromolecules in small biological samples by a rapid minigel filtration method

scientific article published on 01 November 1976

Characterization of two different cytoplasmic protein tyrosine kinases from human breast cancer ⬇️

scientific article published on August 1, 1997

Chemical features of the protein kinase CK2 polyamine binding site.

scientific article published in February 1997

Combined inhibition of PI3K and Src kinases demonstrates synergistic therapeutic efficacy in clear-cell renal carcinoma

scientific article published on 10 July 2018

Crystallization and preliminary x-ray diffraction analysis of the regulatory subunit of human protein kinase CK2

scientific article published on 01 April 1999

Cyclic AMP-dependent and -independent protein kinases in the adrenal cortex

scientific article published on 01 January 1983

Cysteine oxidation in the mitogenic S100B protein leads to changes in phosphorylation by catalytic CKII-alpha subunit.

scientific article

DNA topoisomerase II and casein kinase II associate in a molecular complex that is catalytically active.

scientific article

Demonstration of high affinity binding of estradiol in adrenal cortex tissue

scientific article published on 01 April 1977

Disruption of CK2beta in embryonic neural stem cells compromises proliferation and oligodendrogenesis in the mouse telencephalon

scientific article

Disruption of the regulatory beta subunit of protein kinase CK2 in mice leads to a cell-autonomous defect and early embryonic lethality

scientific article

Dissecting subdomains involved in multiple functions of the CK2beta subunit

scientific article published on 01 January 1999

Dynamic localization/association of protein kinase CK2 subunits in living cells: a role in its cellular regulation?

scientific article published on November 2002

Engrailed homeoprotein secretion is a regulated process.

scientific article

Expanding the chemical diversity of CK2 inhibitors.

scientific article

Functional analysis of protein kinase CK2 of the human malaria parasite Plasmodium falciparum

scientific article (publication date: March 2009)

Glucocorticoid binding in the chicken liver cytosol. Characterization of five macromolecular binding components

scientific article published on August 24, 1976

Growth factors and pericellular components as a local signalling relay in the action of systemic hormones

scientific article published on 01 January 1994

High affinity binding of dexamethasone to chicken plasma proteins: Some characteristics of chicken corticosteroid binding globulin ⬇️

scientific article published on January 1, 1976

In Search of Small Molecule Inhibitors Targeting the Flexible CK2 Subunit Interface

scientific article published on 03 February 2017

In vitro and in vivo assays of protein kinase CK2 activity.

scientific article published on January 2010

Joining the cell survival squad: an emerging role for protein kinase CK2.

scientific article

Live-cell fluorescence imaging reveals the dynamics of protein kinase CK2 individual subunits.

scientific article

Mitotic phosphorylation of DNA topoisomerase II alpha by protein kinase CK2 creates the MPM-2 phosphoepitope on Ser-1469

scientific article published on 01 November 2000

Modulation of the molecular organization and activity of casein kinase 2 by naturally occurring polyamines.

scientific article published in January 1994

Modulatory role of the anti-apoptotic protein kinase CK2 in the sub-cellular localization of Fas associated death domain protein (FADD).

scientific article published on 4 August 2015

Monoclonal anti-epidermal growth factor receptor antibodies which are inhibitors of epidermal growth factor binding and antagonists of epidermal growth factor binding and antagonists of epidermal growth factor-stimulated tyrosine protein kinase acti ⬇️

scientific article published on June 25, 1984

NF-κB-Mediated Modulation of Inducible Nitric Oxide Synthase Activity Controls Induction of the Epstein-Barr Virus Productive Cycle by Transforming Growth Factor Beta 1 ⬇️

scientific article published on April 20, 2011

New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights

scientific article

New protein kinase CK2 inhibitors: jumping out of the catalytic box.

scientific article published on February 2009

Nuclear localization of protein kinase CK2 catalytic subunit (CK2alpha) is associated with poor prognostic factors in human prostate cancer

scientific article published on 30 January 2007

Oligomeric casein kinase II isoforms are expressed in bovine tissues and adrenocortical cells in culture

scientific article published on 01 January 1994

Phosphorylation by CK2 and MAPK enhances calnexin association with ribosomes.

scientific article

Phosphorylation of the C subunit (p66) of human DNA polymerase delta.

scientific article published on 26 December 2007

Polyamine-mediated protein phosphorylations: a possible target for intracellular polyamine action.

scientific article

Protein kinase CK2 and cell polarity.

scientific article

Protein kinase CK2 controls T-cell polarization through dendritic cell activation in response to contact sensitizers.

scientific article published on 5 October 2016

Protein kinase CK2 in breast cancer: the CK2β regulatory subunit takes center stage in epithelial plasticity

scientific article published on 20 May 2015

Protein kinase CK2 in health and disease: Cellular functions of protein kinase CK2: a dynamic affair.

scientific article published on June 2009

Protein kinase CK2 phosphorylation of EB2 regulates its function in the production of Epstein-Barr virus infectious viral particles.

scientific article published on 15 August 2007

Protein kinase CK2 regulates CDC25B phosphatase activity

scientific article (publication date: 16 January 2003)

Protein kinase CK2α subunit over-expression correlates with metastatic risk in breast carcinomas: quantitative immunohistochemistry in tissue microarrays

scientific article published on 29 December 2010

Protein kinases curb cell death.

scientific article published on 10 May 2011

Quaternary structure of casein kinase 2. Characterization of multiple oligomeric states and relation with its catalytic activity.

scientific article published in April 1995

Regulation of epithelial to mesenchymal transition: CK2β on stage.

scientific article published on 14 July 2011

Relationship between the MAP kinase activity and the dual effect of EGF on A431 cell proliferation.

scientific article

Salicylaldehyde derivatives as new protein kinase CK2 inhibitors.

scientific article

Searching interaction partners of protein kinase CK2beta subunit by two-hybrid screening.

scientific article

Selective inhibition of a cyclic nucleotide-independent protein kinase (G-type casein kinase) by naturally occurring glycosaminoglycans

scientific article published on 01 November 1980

Stem Cell-Like Properties of CK2β-down Regulated Mammary Cells.

scientific article published on 31 August 2017

Strength and specificity of the CMBA screening platform for bioactive molecules discovery

scientific article

Structure-based discovery of small molecules targeting different surfaces of protein-kinase CK2.

scientific article published on 18 September 2009

Structure-function analysis of the beta regulatory subunit of protein kinase CK2 by targeting embryonic stem cell.

scientific article

TRIM17 and TRIM28 antagonistically regulate the ubiquitination and anti-apoptotic activity of BCL2A1

scientific article published on 24 July 2018

The antiapoptotic protein ICBP90 is a target for protein kinase 2.

scientific article published in December 2004

The binding of the alpha subunit of protein kinase CK2 and RAP74 subunit of TFIIF to protein-coding genes in living cells is DRB sensitive.

scientific article published on January 1999

The tight association of protein kinase CK2 with plasma membranes is mediated by a specific domain of its regulatory β-subunit ⬇️

scientific article published on June 22, 1998

The tyrosine-kinase inhibitor sunitinib targets vascular endothelial (VE)-cadherin: a marker of response to antitumoural treatment in metastatic renal cell carcinoma

scientific article published on 22 March 2018

Unbalanced expression of CK2 kinase subunits is sufficient to drive epithelial-to-mesenchymal transition by Snail1 induction.

scientific article

Visualization and molecular analysis of nuclear import of protein kinase CK2 subunits in living cells.

scientific article published on November 2001

[Protein kinase CK2 and cancer: further clues are accumulating]

scientific article published on 01 March 2002

[Protein kinase CK2: an enzyme that likes to be different]

scientific article published on 01 June 2003

[Therapeutic agents targetting protein-protein interactions: myth or reality?]

scientific article published on 01 March 2007

p53-dependent inhibition of mammalian cell survival by a genetically selected peptide aptamer that targets the regulatory subunit of protein kinase CK2.

scientific article published on 5 June 2006

List of works by Claude Cochet

2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 1. Identification of an Allosteric Binding Site

2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 2. Structure-Based Optimization and Investigation of Effects Specific to the Allosteric Mode of Action

A new specific endogenous inhibitor of a cyclic nucleotide independent (G type) protein kinase ⬇️

A rapid method for screening inhibitor effects: Determination of I50 and its standard deviation

A soluble glucocorticoid binding protein in the bovine adrenal cortex

Adenosine 3′,5′-Monophosphate-Independent Protein Kinase Activities in the Bovine Adrenal Cortex Cytosol* ⬇️

Antitumor activity of pyridocarbazole and benzopyridoindole derivatives that inhibit protein kinase CK2

Antitumoral activity of allosteric inhibitors of protein kinase CK2.

Autocrine regulation of adrenal steroidogenesis by growth factor transforming TGF-beta 1

Binding of Polyamines to an Autonomous Domain of the Regulatory Subunit of Protein Kinase CK2 Induces a Conformational Change in the Holoenzyme

C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor-stimulated tyrosine protein kinase activity ⬇️

Casein kinase 2 and the cell response to growth factors

Casein kinase II and the tumor suppressor protein P53 associate in a molecular complex that is negatively regulated upon P53 phosphorylation ⬇️

Characterization of a cyclic AMP-independent protein kinase in the bovine adrenal cortex ⬇️

Characterization of an endogenous substrate of protein kinases in the bovine adrenal cortex

Characterization of steroid-binding macromolecules in small biological samples by a rapid minigel filtration method

Characterization of two different cytoplasmic protein tyrosine kinases from human breast cancer ⬇️

Chemical features of the protein kinase CK2 polyamine binding site.

Combined inhibition of PI3K and Src kinases demonstrates synergistic therapeutic efficacy in clear-cell renal carcinoma

Crystallization and preliminary x-ray diffraction analysis of the regulatory subunit of human protein kinase CK2

Cyclic AMP-dependent and -independent protein kinases in the adrenal cortex

Cysteine oxidation in the mitogenic S100B protein leads to changes in phosphorylation by catalytic CKII-alpha subunit.

DNA topoisomerase II and casein kinase II associate in a molecular complex that is catalytically active.

Demonstration of high affinity binding of estradiol in adrenal cortex tissue

Disruption of CK2beta in embryonic neural stem cells compromises proliferation and oligodendrogenesis in the mouse telencephalon

Disruption of the regulatory beta subunit of protein kinase CK2 in mice leads to a cell-autonomous defect and early embryonic lethality

Dissecting subdomains involved in multiple functions of the CK2beta subunit

Dynamic localization/association of protein kinase CK2 subunits in living cells: a role in its cellular regulation?

Engrailed homeoprotein secretion is a regulated process.

Expanding the chemical diversity of CK2 inhibitors.

Functional analysis of protein kinase CK2 of the human malaria parasite Plasmodium falciparum

Glucocorticoid binding in the chicken liver cytosol. Characterization of five macromolecular binding components

Growth factors and pericellular components as a local signalling relay in the action of systemic hormones

High affinity binding of dexamethasone to chicken plasma proteins: Some characteristics of chicken corticosteroid binding globulin ⬇️

In Search of Small Molecule Inhibitors Targeting the Flexible CK2 Subunit Interface

In vitro and in vivo assays of protein kinase CK2 activity.

Joining the cell survival squad: an emerging role for protein kinase CK2.

Live-cell fluorescence imaging reveals the dynamics of protein kinase CK2 individual subunits.

Mitotic phosphorylation of DNA topoisomerase II alpha by protein kinase CK2 creates the MPM-2 phosphoepitope on Ser-1469

Modulation of the molecular organization and activity of casein kinase 2 by naturally occurring polyamines.

Modulatory role of the anti-apoptotic protein kinase CK2 in the sub-cellular localization of Fas associated death domain protein (FADD).

Monoclonal anti-epidermal growth factor receptor antibodies which are inhibitors of epidermal growth factor binding and antagonists of epidermal growth factor binding and antagonists of epidermal growth factor-stimulated tyrosine protein kinase acti ⬇️

NF-κB-Mediated Modulation of Inducible Nitric Oxide Synthase Activity Controls Induction of the Epstein-Barr Virus Productive Cycle by Transforming Growth Factor Beta 1 ⬇️

New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights

New protein kinase CK2 inhibitors: jumping out of the catalytic box.

Nuclear localization of protein kinase CK2 catalytic subunit (CK2alpha) is associated with poor prognostic factors in human prostate cancer

Oligomeric casein kinase II isoforms are expressed in bovine tissues and adrenocortical cells in culture

Phosphorylation by CK2 and MAPK enhances calnexin association with ribosomes.

Phosphorylation of the C subunit (p66) of human DNA polymerase delta.

Polyamine-mediated protein phosphorylations: a possible target for intracellular polyamine action.

Protein kinase CK2 and cell polarity.

Protein kinase CK2 controls T-cell polarization through dendritic cell activation in response to contact sensitizers.

Protein kinase CK2 in breast cancer: the CK2β regulatory subunit takes center stage in epithelial plasticity

Protein kinase CK2 in health and disease: Cellular functions of protein kinase CK2: a dynamic affair.

Protein kinase CK2 phosphorylation of EB2 regulates its function in the production of Epstein-Barr virus infectious viral particles.

Protein kinase CK2 regulates CDC25B phosphatase activity

Protein kinase CK2α subunit over-expression correlates with metastatic risk in breast carcinomas: quantitative immunohistochemistry in tissue microarrays

Protein kinases curb cell death.

Quaternary structure of casein kinase 2. Characterization of multiple oligomeric states and relation with its catalytic activity.

Regulation of epithelial to mesenchymal transition: CK2β on stage.

Relationship between the MAP kinase activity and the dual effect of EGF on A431 cell proliferation.

Salicylaldehyde derivatives as new protein kinase CK2 inhibitors.

Searching interaction partners of protein kinase CK2beta subunit by two-hybrid screening.

Selective inhibition of a cyclic nucleotide-independent protein kinase (G-type casein kinase) by naturally occurring glycosaminoglycans

Stem Cell-Like Properties of CK2β-down Regulated Mammary Cells.

Strength and specificity of the CMBA screening platform for bioactive molecules discovery

Structure-based discovery of small molecules targeting different surfaces of protein-kinase CK2.

Structure-function analysis of the beta regulatory subunit of protein kinase CK2 by targeting embryonic stem cell.

TRIM17 and TRIM28 antagonistically regulate the ubiquitination and anti-apoptotic activity of BCL2A1

The antiapoptotic protein ICBP90 is a target for protein kinase 2.

The binding of the alpha subunit of protein kinase CK2 and RAP74 subunit of TFIIF to protein-coding genes in living cells is DRB sensitive.

The tight association of protein kinase CK2 with plasma membranes is mediated by a specific domain of its regulatory β-subunit ⬇️

The tyrosine-kinase inhibitor sunitinib targets vascular endothelial (VE)-cadherin: a marker of response to antitumoural treatment in metastatic renal cell carcinoma

Unbalanced expression of CK2 kinase subunits is sufficient to drive epithelial-to-mesenchymal transition by Snail1 induction.

Visualization and molecular analysis of nuclear import of protein kinase CK2 subunits in living cells.

[Protein kinase CK2 and cancer: further clues are accumulating]

[Protein kinase CK2: an enzyme that likes to be different]

[Therapeutic agents targetting protein-protein interactions: myth or reality?]

p53-dependent inhibition of mammalian cell survival by a genetically selected peptide aptamer that targets the regulatory subunit of protein kinase CK2.