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List of works by David O. Morgan

A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration.

scientific article

A late mitotic regulatory network controlling cyclin destruction in Saccharomyces cerevisiae.

scientific article published on October 1998

A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase

scientific article (publication date: 26 August 1994)

A novel destruction sequence targets the meiotic regulator Spo13 for anaphase-promoting complex-dependent degradation in anaphase I.

scientific article

Activation of human cyclin-dependent kinases in vitro ⬇️

scientific article published on May 1, 1992

Activation of the APC/C ubiquitin ligase by enhanced E2 efficiency

scientific article

An E2 accessory domain increases affinity for the anaphase-promoting complex and ensures E2 competition.

scientific article

An architectural map of the anaphase-promoting complex

scientific article

Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism.

scientific article

Assembly of SARS-CoV-2 ribonucleosomes by truncated N* variant of the nucleocapsid protein

preprint article published on 17 August 2023

Assembly of SARS-CoV-2 ribonucleosomes by truncated N∗ variant of the nucleocapsid protein

scientific article published in December 2023

Building a Regulatory Network with Short Linear Sequence Motifs: Lessons from the Degrons of the Anaphase-Promoting Complex.

scientific article

Cak1 is required for Kin28 phosphorylation and activation in vivo.

scientific article

Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase ⬇️

scientific article published on October 12, 2011

Catalysis of lysine 48-specific ubiquitin chain assembly by residues in E2 and ubiquitin.

scientific article

Cdc14 activates cdc15 to promote mitotic exit in budding yeast.

scientific article published on May 2000

Cdc37 promotes the stability of protein kinases Cdc28 and Cak1.

scientific article

Cdk and APC activities limit the spindle-stabilizing function of Fin1 to anaphase

scientific article

Cdk1-dependent destruction of Eco1 prevents cohesion establishment after S phase

scientific article

Cdk1-dependent phosphorylation of Iqg1 governs actomyosin ring assembly prior to cytokinesis.

scientific article published on 10 January 2014

Cell Size Determines the Strength of the Spindle Assembly Checkpoint during Embryonic Development.

scientific article

Cell cycle control by a complex of the cyclin HCS26 (PCL1) and the kinase PHO85.

scientific article

Cell cycle control in normal and neoplastic cells

scientific article published on February 1, 1992

Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15 ⬇️

scientific article published on November 1, 1992

Cell division: Mitotic regulation comes into focus.

scientific article published on 10 August 2016

Co-activator independent differences in how the metaphase and anaphase APC/C recognise the same substrate.

scientific article published on 12 September 2014

Cohesin cleavage by separase is enhanced by a substrate motif distinct from the cleavage site

scientific article published on 15 November 2019

Control of eukaryotic cell cycle progression by phosphorylation of cyclin-dependent kinases.

scientific article published in May 1998

Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25C

scientific journal article

Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates.

scholarly article

Crystal structure of cyclin-dependent kinase 2

scientific article (publication date: 17 June 1993)

Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates.

scientific article

Cyclin-dependent kinases: a family portrait.

scientific article

Cyclin-specific control of ribosomal DNA segregation

scientific article published on 30 June 2008

Dynamics of Cdk1 Substrate Specificity during the Cell Cycle ⬇️

scientific article published on June 10, 2011

Effects of covalently linked insulin dimers on receptor kinase activity and receptor down regulation ⬇️

scientific article published on May 21, 1984

Enzymology of the anaphase-promoting complex.

scientific article published on January 2005

Evolution of Ime2 phosphorylation sites on Cdk1 substrates provides a mechanism to limit the effects of the phosphatase Cdc14 in meiosis

scientific article published in March 2007

Exploiting Chemical Libraries, Structure, and Genomics in the Search for Kinase Inhibitors ⬇️

scientific article published on July 24, 1998

Finishing mitosis, one step at a time.

scientific article published on November 2007

Firing of Replication Origins Frees Dbf4-Cdc7 to Target Eco1 for Destruction.

scientific article

Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle

scientific article (publication date: 18 September 1992)

Functionally distinct isoforms of Cik1 are differentially regulated by APC/C-mediated proteolysis.

scientific article published on March 2009

Identification of yeast IQGAP (Iqg1p) as an anaphase-promoting-complex substrate and its role in actomyosin-ring-independent cytokinesis.

scientific article

Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC.

scientific article

Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit.

scientific article published on December 1993

Inhibitor scaffolds as new allele specific kinase substrates

scientific article published in October 2002

Mechanisms of ubiquitin transfer by the anaphase-promoting complex.

scientific article published on January 2009

Modulation of the mitotic regulatory network by APC-dependent destruction of the Cdh1 inhibitor Acm1.

scientific article

Multiple mechanisms determine the order of APC/C substrate degradation in mitosis

scientific article

Multisite phosphorylation by Cdk1 initiates delayed negative feedback to control mitotic transcription

scientific article published on 10 January 2022

Nuclear Localization of Cyclin B1 Controls Mitotic Entry After DNA Damage ⬇️

scientific article published on May 18, 1998

Oscillation sensation

scientific article published in Nature

Oxytocin action: lack of correlation between receptor number and tissue responsiveness

scientific article published on 01 January 1980

Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and after DNA damage.

scientific article

Phosphate-binding pocket on cyclin B governs CDK substrate phosphorylation and mitotic timing

scientific article published on 29 February 2024

Phosphoregulation of Phase Separation by the SARS-CoV-2 N Protein Suggests a Biophysical Basis for its Dual Functions

scientific article published on 20 November 2020

Phosphorylation modulates liquid-liquid phase separation of the SARS-CoV-2 N protein

scientific article published on 29 June 2020

Polyanions provide selective control of APC/C interactions with the activator subunit

scientific article published on 20 December 2019

Positive feedback sharpens the anaphase switch

scientific article

Protein-linked Ubiquitin Chain Structure Restricts Activity of Deubiquitinating Enzymes ⬇️

scientific article published on November 9, 2011

Quantitative framework for ordered degradation of APC/C substrates.

scientific article

Ran-independent nuclear import of cyclin B1-Cdc2 by importin beta

scientific journal article

Reconstitution of the SARS-CoV-2 ribonucleosome provides insights into genomic RNA packaging and regulation by phosphorylation

scientific article published in November 2022

Reconstitution of the SARS-CoV-2 ribonucleosome provides insights into genomic RNA packaging and regulation by phosphorylation

scientific article published on 24 May 2022

Separase Biosensor Reveals that Cohesin Cleavage Timing Depends on Phosphatase PP2ACdc55 Regulation ⬇️

scientific article published on July 17, 2012

Sequential E2s drive polyubiquitin chain assembly on APC targets

scientific article published in July 2007

Sequential primed kinases create a damage-responsive phosphodegron on Eco1 ⬇️

scientific article published on January 13, 2013

Sgo1 recruits PP2A to chromosomes to ensure sister chromatid bi-orientation during mitosis.

scientific article

Single-molecule analysis of specificity and multivalency in binding of short linear substrate motifs to the APC/C

scientific article published on 17 January 2022

SnapShot: Cell-cycle regulators II.

scientific article published in November 2008

SnapShot: cell-cycle regulators I.

scientific article

Staurosporine-Derived Inhibitors Broaden the Scope of Analog-Sensitive Kinase Technology

scientific article

Structural basis for selective inhibition of Src family kinases by PP1

scientific article published on 01 September 1999

Structural basis of human separase regulation by securin and CDK1-cyclin B1

scientific article published in August 2021

Suppression of c-Src Activity by C-Terminal Src Kinase Involves the c-Src SH2 and SH3 Domains: Analysis with Saccharomyces cerevisiae ⬇️

scientific article published on September 1, 1993

Targets of the cyclin-dependent kinase Cdk1

scientific article (publication date: 23 October 2003)

The APC subunit Doc1 promotes recognition of the substrate destruction box.

scientific article published in January 2005

The APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation.

scientific article

The D Box Meets Its Match ⬇️

scientific article published on June 6, 2013

The Doc1 subunit is a processivity factor for the anaphase-promoting complex.

scientific article

The HIV transactivator TAT binds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase II

scientific article

The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae ⬇️

scientific article published on April 23, 1998

The anaphase-promoting complex promotes actomyosin-ring disassembly during cytokinesis in yeast.

scientific article

The hidden rhythms of the dividing cell.

scientific article published in April 2010

The pseudosubstrate inhibitor Acm1 inhibits the anaphase-promoting complex/cyclosome by combining high-affinity activator binding with disruption of Doc1/Apc10 function

scientific article published on 27 September 2019

The role of self-association in Fin1 function on the mitotic spindle

scientific article

Ubiquitination of Cdc20 by the APC occurs through an intramolecular mechanism

scientific article

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