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List of works by Hitoshi Shirakawa

A novel function of geranylgeraniol in regulating testosterone production.

scientific article published on 5 January 2018

Absorption and effectiveness of orally administered low molecular weight collagen hydrolysate in rats.

scientific article published in January 2010

Acidic C-tail of HMGB1 is required for its target binding to nucleosome linker DNA and transcription stimulation.

scientific article

Adenosine and adenosine-5'-monophosphate ingestion ameliorates abnormal glucose metabolism in mice fed a high-fat diet

scientific article published on 14 November 2018

Adenosine, an identified active component from the Driselase-treated fraction of rice bran, is effective at improving metabolic syndrome in stroke-prone spontaneously hypertensive rats.

scientific article published in March 2009

Administration of biotin prevents the development of insulin resistance in the skeletal muscles of Otsuka Long-Evans Tokushima fatty rats

article

Altered activity profile of a tertiary silanol analog of multi-targeting nuclear receptor modulator T0901317

scientific article published on 12 February 2016

Antihypertensive effect of biotin in stroke-prone spontaneously hypertensive rats.

scientific article published on 8 January 2008

Behavioral Analysis ofDrosophilaTransformants Expressing Human Taste Receptor Genes in the Gustatory Receptor Neurons ⬇️

scientific article published on June 1, 2012

Beneficial Effects of Vitamin K Status on Glycemic Regulation and Diabetes Mellitus: A Mini-Review

scientific article published on 18 August 2020

Cysteine Sulfoxides Enhance Steroid Hormone Production via Activation of the Protein Kinase A Pathway in Testis-Derived I-10 Tumor Cells

scientific article published on 14 October 2020

Deletion of hypoxia-inducible factor-1α in adipocytes enhances glucagon-like peptide-1 secretion and reduces adipose tissue inflammation

scientific article

Development of novel silanol-based human pregnane X receptor (PXR) agonists with improved receptor selectivity

article

Dietary Supplementation of Fermented Rice Bran Effectively Alleviates Dextran Sodium Sulfate-Induced Colitis in Mice.

scientific article published on 13 July 2017

Dietary supplementation with geranylgeraniol suppresses lipopolysaccharide-induced inflammation via inhibition of nuclear factor-κB activation in rats.

scientific article

Dietary tryptophan alleviates dextran sodium sulfate-induced colitis through aryl hydrocarbon receptor in mice

scientific article

Dietary vitamin K alleviates the reduction in testosterone production induced by lipopolysaccharide administration in rat testis

scientific article published on June 13, 2011

Difference in affinity for DNA between HMG proteins 1 and 2 determined by surface plasmon resonance measurements

scientific article published on 01 September 1997

Differences in DNA recognition and conformational change activity between boxes A and B in HMG2 protein

scientific article published on 01 January 1999

Effect of biotin ingestion on the improvement of hypertension in SHRSP

scientific article published in April 2008

Effect of biotin treatment on hepatic gene expression in streptozotocin-induced diabetic rats.

scientific article published on 7 May 2008

Effects of Japanese Torreya (Torreya nucifera) seed oil on the activities and mRNA expression of lipid metabolism-related enzymes in rats

scientific article published on 07 January 2007

Effects of Vitamin K₂ on the Expression of Genes Involved in Bile Acid Synthesis and Glucose Homeostasis in Mice with Humanized PXR

article

Existence of a transcription factor for the human HMG2 gene positively related to the level of HMG2 mRNA in the cells

scientific article published on 01 February 1995

Fermented barley extract supplementation ameliorates metabolic state in stroke-prone spontaneously hypertensive rats

scientific article published on 15 June 2015

Fermented barley extract supplementation maintained antioxidative defense suppressing lipopolysaccharide-induced inflammatory liver injury in rats

scientific article published on 07 October 2011

Fermented rice bran supplementation mitigates metabolic syndrome in stroke-prone spontaneously hypertensive rats.

scientific article

Genotyping Analysis of Bitter-Taste Receptor Genes TAS2R38 and TAS2R46 in Japanese Patients with Gastrointestinal Cancers

scientific article published on January 2017

Geranylgeraniol Suppresses the Expression of IRAK1 and TRAF6 to Inhibit NFκB Activation in Lipopolysaccharide-Induced Inflammatory Responses in Human Macrophage-Like Cells. ⬇️

scientific article

Geranylgeraniol enhances testosterone production via the cAMP/protein kinase A pathway in testis-derived I-10 tumor cells.

scientific article published on 13 January 2016

HMG box A in HMG2 protein functions as a mediator of DNA structural alteration together with box B

scientific article published in 2001

High Mobility Group Proteins 1 and 2 Can Function as DNA-Binding Regulatory Components for DNA-Dependent Protein Kinase In Vitro ⬇️

scientific article published on September 1, 1998

Identification and evaluation of anti-inflammatory compounds from Kaempferia parviflora

scientific article

Impact of fasting time on hepatic lipid metabolism in nutritional animal studies.

scientific article published on 24 June 2014

Inhibitory effects of Kaempferia parviflora extract on monocyte adhesion and cellular reactive oxygen species production in human umbilical vein endothelial cells

scientific article published on 24 December 2015

Involvement of HMGB1 and HMGB2 proteins in exogenous DNA integration reaction into the genome of HeLa S3 cells.

scientific article

Low-dose dioxins alter gene expression related to cholesterol biosynthesis, lipogenesis, and glucose metabolism through the aryl hydrocarbon receptor-mediated pathway in mouse liver.

scientific article

Lupeol supplementation improves blood pressure and lipid metabolism parameters in stroke-prone spontaneously hypertensive rats

scientific article published on 07 January 2012

Menaquinone-4 Amplified Glucose-Stimulated Insulin Secretion in Isolated Mouse Pancreatic Islets and INS-1 Rat Insulinoma Cells

scientific article published on 23 April 2019

Menaquinone-4 Suppresses Lipopolysaccharide-Induced Inflammation in MG6 Mouse Microglia-Derived Cells by Inhibiting the NF-κB Signaling Pathway. ⬇️

scientific article published on 10 May 2019

Metabolic characteristics and oxidative damage to skeletal muscle in broiler chickens exposed to chronic heat stress.

scientific article published on 28 December 2009

Non-histone Chromosomal Proteins HMG1 and 2 Enhance Ligation Reaction of DNA Double-Strand Breaks ⬇️

scientific article published on May 8, 1998

Novel effect of adenosine 5'-monophosphate on ameliorating hypertension and the metabolism of lipids and glucose in stroke-prone spontaneously hypertensive rats.

scientific article

Novel effects of a single administration of ferulic acid on the regulation of blood pressure and the hepatic lipid metabolic profile in stroke-prone spontaneously hypertensive rats.

scientific article

Nuclear accumulation of HMG2 protein is mediated by basic regions interspaced with a long DNA-binding sequence, and retention within the nucleus requires the acidic carboxyl terminus

scientific article published on 01 May 1997

Occurrence, properties, and applications of feruloyl esterases.

scientific article published on 31 July 2009

Orally administered zinc increases food intake via vagal stimulation in rats.

scientific article published on 21 January 2009

Orexigenic action of oral zinc: metabolomic analysis in the rat hypothalamus

scientific article published on 21 September 2018

Physiological effects and tissue distribution from large doses of tocotrienol in rats

scientific article published on 07 September 2012

Prevalence and characterization of perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCA) directed against HMG1 and HMG2 in ulcerative colitis (UC)

scientific article published on 01 February 1998

Properties of Zip4 accumulation during zinc deficiency and its usefulness to evaluate zinc status: a study of the effects of zinc deficiency during lactation.

scientific article published on 23 December 2015

Rat-derived feeder cells immortalized by expression of mutant CDK4, cyclin D, and telomerase can support stem cell growth

scientific article published on 01 March 2019

Reduction of blood pressure by soybean saponins, renin inhibitors from soybean, in spontaneously hypertensive rats

scientific article published on 07 November 2010

Regulation of blood pressure and glucose metabolism induced by L-tryptophan in stroke-prone spontaneously hypertensive rats ⬇️

scientific article published on June 28, 2011

Repression of cell cycle progression by antisense HMG2 RNA.

scientific article published on May 1995

Rice Bran Supplementation Ameliorates Gut Dysbiosis and Muscle Atrophy in Ovariectomized Mice Fed with a High-Fat Diet

scientific article published in 2023

Serotonin Improves High Fat Diet Induced Obesity in Mice

scientific article published on 14 January 2016

Stimulation of DNA-dependent protein kinase activity by high mobility group proteins 1 and 2

scientific article published on 01 July 1994

Stimulation of transcription accompanying relaxation of chromatin structure in cells overexpressing high mobility group 1 protein.

scientific article published on April 1995

Stimulation of transcription in cultured cells by high mobility group protein 1: essential role of the acidic carboxyl-terminal region

scientific article published on 01 December 1994

Supplementation with Fermented Rice Bran Attenuates Muscle Atrophy in a Diabetic Rat Model

scientific article published on 12 August 2020

Systematic synthesis and anti-inflammatory activity of ω-carboxylated menaquinone derivatives--Investigations on identified and putative vitamin K₂ metabolites

scientific article published on 04 April 2015

Targeting of high mobility group-14/-17 proteins in chromatin is independent of DNA sequence

scientific article published on 01 December 2000

Temperature Dependence in the Terahertz Spectrum of Nicotinamide: Anharmonicity and Hydrogen-Bonded Network

scientific article published on 20 March 2017

The Driselase-treated fraction of rice bran is a more effective dietary factor to improve hypertension, glucose and lipid metabolism in stroke-prone spontaneously hypertensive rats compared to ferulic acid.

scientific article published in January 2007

The aryl hydrocarbon receptor and glucocorticoid receptor interact to activate human metallothionein 2A.

scientific article published on 28 August 2013

The nucleosomal binding protein NSBP1 is highly expressed in the placenta and modulates the expression of differentiation markers in placental Rcho-1 cells.

scientific article

The stabilized structural array of two HMG1/2-boxes endowed by a linker sequence between them is requisite for the effective binding of HMG1 with DNA

scientific article published on 01 February 1999

Tocotrienol inhibits secretion of angiogenic factors from human colorectal adenocarcinoma cells by suppressing hypoxia-inducible factor-1alpha.

scientific article published on November 2008

Vitamin K deficiency reduces testosterone production in the testis through down-regulation of the Cyp11a a cholesterol side chain cleavage enzyme in rats

scientific journal article

Vitamin K suppresses lipopolysaccharide-induced inflammation in the rat.

scientific article published on April 2006

Vitamin K suppresses the lipopolysaccharide-induced expression of inflammatory cytokines in cultured macrophage-like cells via the inhibition of the activation of nuclear factor κB through the repression of IKKα/β phosphorylation.

scientific article

Yamabushitake mushroom (Hericium erinaceus) improved lipid metabolism in mice fed a high-fat diet.

scientific article published on 7 July 2010

[Clarification of the Mechanism Involved in Orexigenic Action by Oral Zinc Ingestion]

scientific article published on 01 January 2018

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