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List of works by Matthew C. Wright

A mechanism for the anti-fibrogenic effects of the pregnane X receptor (PXR) in the liver: inhibition of NF-kappaB?

scientific article published on 23 December 2007

A new fluorescence-based optical imaging method to non-invasively monitor hepatic myofibroblasts in vivo

scientific article published on 8 April 2016

A role for the pregnane X receptor in flucloxacillin-induced liver injury.

scientific article published in May 2010

AR42J-B-13 cell: an expandable progenitor to generate an unlimited supply of functional hepatocytes.

scientific article published on June 2010

Alteration of transcription factor mRNAs during the isolation and culture of rat hepatocytes suggests the activation of a proliferative mode underlies their de-differentiation

scientific article published on 01 December 1993

Antibody-targeted myofibroblast apoptosis reduces fibrosis during sustained liver injury.

scientific article published on 13 March 2008

B-13 progenitor-derived hepatocytes (B-13/H cells) model lipid dysregulation in response to drugs and chemicals.

scientific article

Cellular targeting of the apoptosis-inducing compound gliotoxin to fibrotic rat livers.

scientific article published on 12 December 2007

Changes in the gut microbiota of mice orally exposed to methylimidazolium ionic liquids

scientific article published on 12 March 2020

Control of the tissue inhibitor of metalloproteinases-1 promoter in culture-activated rat hepatic stellate cells: regulation by activator protein-1 DNA binding proteins

scientific article published on 01 March 1999

Developmental changes in the constitutive and inducible expression of cytochrome p450 3a2 ⬇️

scientific article published on October 1, 1997

Disruption of endogenous regulator homeostasis underlies the mechanism of rat CYP1A1 mRNA induction by metyrapone ⬇️

scientific article published on April 1, 1998

Effect of the adrenal 11-beta-hydroxylase inhibitor metyrapone on human hepatic cytochrome P-450 expression: induction of cytochrome P-450 3A4.

scientific article

Effect of vitamin A deficiency on the expression of low affinity glucocorticoid binding site activity and glucocorticoid-dependent induction of CYP3A2 in rat liver

scientific article published on 01 August 1997

Environmental Xenoestrogens Super-Activate a Variant Murine ER Beta in Cholangiocytes.

scientific article published on 24 December 2016

Evidence that the loss of rat liver cytochrome P450 in vitro is not solely associated with the use of collagenase, the loss of cell-cell contacts and/or the absence of an extracellular matrix ⬇️

scientific article published on January 22, 1992

Exocrine pancreas trans-differentiation to hepatocytes--a physiological response to elevated glucocorticoid in vivo

scientific journal article

Expression of CYP2S1 in human hepatic stellate cells.

scientific article published on 2 February 2007

Expression of serine/threonine protein kinase SGK1F promotes an hepatoblast state in stem cells directed to differentiate into hepatocytes

scientific article published on 26 June 2019

Extracorporeal membrane oxygenation for resuscitation of deceased cardiac donor livers for hepatocyte isolation ⬇️

scientific article published on March 28, 2013

Fibronectin-mediated hepatocyte shape change reprograms cytochrome P450 2C11 gene expression via an integrin-signaled induction of ribonuclease activity

scientific article published on 01 November 2000

Generation of a monoclonal human single chain antibody fragment to hepatic stellate cells--a potential mechanism for targeting liver anti-fibrotic therapeutics.

scientific article published on 8 April 2005

Generation of hepatocytes expressing functional cytochromes P450 from a pancreatic progenitor cell line in vitro.

scientific article published on March 2003

Glucocorticoid-dependent transdifferentiation of pancreatic progenitor cells into hepatocytes is dependent on transient suppression of WNT signalling.

scientific article

Glucocorticoid-induced pancreatic-hepatic trans-differentiation in a human cell line in vitro

scientific article published on 22 May 2018

HNF4alpha expression amplifies the glucocorticoid-induced conversion of a human pancreatic cell line to an hepatocyte-like cell

scientific article published on 26 July 2018

Hepatic effects of tartrazine (E 102) after systemic exposure are independent of oestrogen receptor interactions in the mouse

scientific article

Hepatic stellate cells regulate liver immunity to visceral leishmaniasis through P110δ-dependent induction and expansion of regulatory T cells in mice.

scientific article published on 20 August 2015

Identification of a truncated ratp28-related protein expressed in kidney.

scientific article

Identification of a xenobiotic as a potential environmental trigger in primary biliary cholangitis

scientific article published on 11 July 2018

Induction of rat hepatic glucocorticoid-inducible cytochrome P450 3A by metyrapone

scientific article published on 01 February 1994

Induction of the cytochrome P450 3A subfamily in rat liver correlates with the binding of inducers to a microsomal protein

scientific article published on 01 June 1994

Inhibition of CXCR4-CXCL12 chemotaxis in melanoma by AMD11070.

scientific article published on 28 March 2013

Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis.

scientific article published in January 2005

Liver fibrosis

scientific article published on 01 April 2008

Low affinity glucocorticoid binding site ligands as potential anti-fibrogenics.

scientific article published on 11 May 2009

Mechanism of action of the antifibrogenic compound gliotoxin in rat liver cells.

scientific article published in July 2004

Methapyrilene hepatotoxicity is associated with oxidative stress, mitochondrial disfunction and is prevented by the Ca2+ channel blocker verapamil

scientific article published on 01 September 1998

Oral administration of amphotericin B nanoparticles: antifungal activity, bioavailability and toxicity in rats.

scientific article published on November 2017

Pancreatic B-13 Cell Trans-Differentiation to Hepatocytes Is Dependent on Epigenetic-Regulated Changes in Gene Expression

scientific article

Pancreatic progenitor-derived hepatocytes are viable and functional in a 3D high density bioreactor culture system

article

Persistent activation of nuclear factor-kappaB in cultured rat hepatic stellate cells involves the induction of potentially novel Rel-like factors and prolonged changes in the expression of IkappaB family proteins.

scientific article

Pregnane X receptor activators inhibit human hepatic stellate cell transdifferentiation in vitro.

scientific article published on July 2006

Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms.

scientific article published on May 2005

Progenitor-derived hepatocyte-like (B-13/H) cells metabolise 1'-hydroxyestragole to a genotoxic species via a SULT2B1-dependent mechanism.

scientific article published on 28 December 2015

Quiescent hepatic stellate cells functionally contribute to the hepatic innate immune response via TLR3.

scientific article published on 8 January 2014

Resistance of precision-cut liver slices to the toxic effects of menadione.

scientific article

Serine/threonine protein kinase SGK1 in glucocorticoid-dependent transdifferentiation of pancreatic acinar cells to hepatocytes.

scientific article

Stealth Amphotericin B nanoparticles for oral drug delivery: In vitro optimization

scientific article

Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced β-catenin/Tcf-Lef dependent transcription

scientific article

Sustained Isoprostane E2 Elevation, Inflammation and Fibrosis after Acute Ischaemia-Reperfusion Injury Are Reduced by Pregnane X Receptor Activation

scientific article

Targeting liver myofibroblasts: a novel approach in anti-fibrogenic therapy.

scientific article published on 3 September 2008

Tartrazine and sunset yellow are xenoestrogens in a new screening assay to identify modulators of human oestrogen receptor transcriptional activity.

scientific article published on 3 May 2012

Temperature-sensitive mRNA degradation is an early event in hepatocyte de-differentiation ⬇️

scientific article published on December 15, 1997

The cytochrome P450 3A4 inducer metyrapone is an activator of the human pregnane X receptor

scientific article published on 01 August 1999

The impact of pregnane X receptor activation on liver fibrosis

scientific article published on 01 December 2006

The ionic liquid 1-octyl-3-methylimidazolium (M8OI) is an activator of the human estrogen receptor alpha

scientific article published on 04 August 2018

Therapeutic monitoring of amphotericin B in Saudi ICU patients using UPLC MS/MS assay

scientific article

Upstream tissue inhibitor of metalloproteinases-1 (TIMP-1) element-1, a novel and essential regulatory DNA motif in the human TIMP-1 gene promoter, directly interacts with a 30-kDa nuclear protein.

scientific article

Utility of B-13 progenitor-derived hepatocytes in hepatotoxicity and genotoxicity studies

scientific article

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