List of works - Maria Zappala'

1-Aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones: novel AMPA receptor antagonists.

scientific article published in April 1997

1-Aryl-6,7-methylenedioxy-3 H -quinazolin-4-ones as anticonvulsant agents

scientific article published on 01 December 2003

2-(2,6-Dihalophenyl)-3-(pyrimidin-2-yl)-1,3-thiazolidin-4-ones as non-nucleoside HIV-1 reverse transcriptase inhibitors.

scientific article

7,8-Methylenedioxy-4H-2,3-benzodiazepin-4-ones as novel AMPA receptor antagonists

scientific article published on 01 April 1998

7-Chloro-1-(2,6-difluorophenyl)-1H,3H-thiazolo.

scientific article

Anticonvulsant activity and plasma level of 2,3-benzodiazepin-4-ones (CFMs) in genetically epilepsy-prone rats.

scientific article published in August 1999

Anticonvulsant activity of pyrrolo[1′,2′:1,2]imidazo[4,5-b]pyridines, pyrrolo[2′,1′:2,3]imidazo[4,5-c] pyridines and pyrrolo[2,1-f]purines in DBA/2 mice

scientific article published in September 1994

Azirino[1, 2-d][1, 4]benzodiazepine derivatives and related 1,4-benzodiazepines as anticonvulsant agents in DBA/2 mice

scientific article

Convulsant effects of some xanthine derivatives in genetically epilepsy-prone rats

scientific article published on 16 June 1997

Design of 1-substituted 2-arylmethyl-4,5-methylenedioxybenzene derivatives as antiseizure agents.

scientific article

Determination of 2,3-benzodiazepine derivatives in rat plasma by high-performance liquid chromatography

scientific article published on 01 June 1999

Development of Novel Amides as Noncovalent Inhibitors of Immunoproteasomes

scientific article published on 26 March 2019

Development of Novel Peptide-Based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs).

scientific article

Development of Novel Peptidomimetics Containing a Vinyl Sulfone Moiety as Proteasome Inhibitors

article

Development of novel dipeptide-like rhodesain inhibitors containing the 3-bromoisoxazoline warhead in a constrained conformation.

scientific article published on 21 September 2015

Development of novel selective peptidomimetics containing a boronic acid moiety, targeting the 20S proteasome as anticancer agents

scientific article

Development of peptidomimetic boronates as proteasome inhibitors

article

Development of peptidomimetics with a vinyl sulfone warhead as irreversible falcipain-2 inhibitors.

scientific article published on 31 January 2008

Discovery of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV-1 agents.

scientific article

Enantioselective recognition of 2,3-benzodiazepin-4-one derivatives with anticonvulsant activity on several polysaccharide chiral stationary phases

scientific article published on 24 May 2006

Enantioseparation, absolute configuration determination, and anticonvulsant activity of (±)-1-(4-aminophenyl)-7,8-methylenedioxy-1,2,3,5-tetrahydro-4H-2,3-benzodiazepin-4-one

scientific article published on 01 January 2007

Identification of a new series of amides as non-covalent proteasome inhibitors.

scientific article published on 25 January 2014

Molecular requirement for anticonvulsant activity in a series of thiazolo-1,4-benzodiazepine derivatives and comparison with classical benzodiazepines

scientific article published in July 1993

Novel 2H-isoquinolin-3-ones as antiplasmodial falcipain-2 inhibitors.

scientific article published on 12 August 2009

Novel Peptidomimetic Cysteine Protease Inhibitors as Potential Antimalarial Agents

scientific article published on 01 June 2006

Novel peptidomimetics containing a vinyl ester moiety as highly potent and selective falcipain-2 inhibitors.

scientific article published on April 2009

Optimization Strategy of Novel Peptide-Based Michael Acceptors for the Treatment of Human African Trypanosomiasis

scientific article published on 27 November 2019

Optimization of peptidomimetic boronates bearing a P3 bicyclic scaffold as proteasome inhibitors

scientific article

Peptide-based proteasome inhibitors in anticancer drug design.

scientific article published on March 2014

Peptidomimetics containing a vinyl ketone warhead as falcipain-2 inhibitors

scientific article published on 03 March 2011

Relationship Between Anticonvulsant Activity and Plasma Level of Some 2,3-Benzodiazepines in Genetically Epilepsy-Prone Rats

scientific article published on 01 November 1998

Selective induction of apoptosis in multidrug resistant HL60R cells by the thiazolobenzoimidazole derivative 1-(2,6-difluorophenyl)-1H,3H-thiazolo [3,4-a] benzimidazole (TBZ)

scientific article published on 01 October 1998

Synthesis and Anticonvulsant Activity of Novel and Potent 2,3-Benzodiazepine AMPA/Kainate Receptor Antagonists

scientific article published on 01 October 1999

Synthesis and Evaluation of Pharmacological and Pharmacokinetic Properties of 11H-[1,2,4]Triazolo[4,5-c][2,3]benzodiazepin-3(2H)-ones

scientific article published on 01 December 2000

Synthesis and anti-HIV activity of 2,3-diaryl-1,3-thiazolidin-4-ones.

scientific article published on February 2003

Synthesis and anticonvulsant activity of new 2,3-benzodiazepines as AMPA receptor antagonists

scientific article published on 01 March 1999

Synthesis and anticonvulsant activity of novel and potent 1-aryl-7,8-methylenedioxy-1,2,3,5-tetrahydro-4H-2,3-benzodiazepin-4-ones

scientific article published on 01 February 2001

Synthesis and antitumor activity of 1,3-benzodioxole derivatives.

scientific article published in October 2002

Synthesis and antitumour activity of 1H,3H-thiazolo[3,4-a]benzimidazole derivatives.

scientific article

Synthesis and characterization in solid and solution of trans-dichloro-1-(2', 6'-difluorophenyl)-1H,3H-thiazolo [3,4-a]-benzimidazole(tri-n-propyl-phosphine)-palladium(II)": a palladium(II) complex of a ligand with anti-HIV properties.

scientific article published on February 1997

Synthesis and cytotoxic activity of 1,3-benzodioxole derivatives. Note II.

scientific article published on May 2003

Synthesis and in vitro antitumour activity evaluation of 1-aryl-1H,3H-thiazolo[4,3-b]quinazolines

scientific article published on 01 December 2000

Synthesis and molecular modeling studies of derivatives of a highly potent peptidomimetic vinyl ester as falcipain-2 inhibitors.

scientific article

Synthesis of 2-semicarbazonomethyl-4,5-methylenedioxyphenylacetic acids as anticonvulsant agents

scientific article published on 01 March 2005

Synthesis of Novel 3-(Alkylcarbamoyl)-2-aryl-1,2-dihydro-6,7-(methylenedioxy)-3H-quinazolin-4-ones as Anticonvulsant Agents

scientific article published on 01 March 2006

Synthesis, Chiral Resolution and Pharmacological Evaluation of a 2,3-Benzodiazepine-Derived Noncompetitive AMPA Receptor Antagonist

scientific article published on 01 March 2009

Synthesis, chiral resolution, and enantiopharmacology of a potent 2,3-benzodiazepine derivative as noncompetitive AMPA receptor antagonist.

scientific article published in January 2006

List of works by Maria Zappala'

1-Aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones: novel AMPA receptor antagonists.

1-Aryl-6,7-methylenedioxy-3 H -quinazolin-4-ones as anticonvulsant agents

2-(2,6-Dihalophenyl)-3-(pyrimidin-2-yl)-1,3-thiazolidin-4-ones as non-nucleoside HIV-1 reverse transcriptase inhibitors.

7,8-Methylenedioxy-4H-2,3-benzodiazepin-4-ones as novel AMPA receptor antagonists

7-Chloro-1-(2,6-difluorophenyl)-1H,3H-thiazolo.

Anticonvulsant activity and plasma level of 2,3-benzodiazepin-4-ones (CFMs) in genetically epilepsy-prone rats.

Anticonvulsant activity of pyrrolo[1′,2′:1,2]imidazo[4,5-b]pyridines, pyrrolo[2′,1′:2,3]imidazo[4,5-c] pyridines and pyrrolo[2,1-f]purines in DBA/2 mice

Azirino[1, 2-d][1, 4]benzodiazepine derivatives and related 1,4-benzodiazepines as anticonvulsant agents in DBA/2 mice

Convulsant effects of some xanthine derivatives in genetically epilepsy-prone rats

Design of 1-substituted 2-arylmethyl-4,5-methylenedioxybenzene derivatives as antiseizure agents.

Determination of 2,3-benzodiazepine derivatives in rat plasma by high-performance liquid chromatography

Development of Novel Amides as Noncovalent Inhibitors of Immunoproteasomes

Development of Novel Peptide-Based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs).

Development of Novel Peptidomimetics Containing a Vinyl Sulfone Moiety as Proteasome Inhibitors

Development of novel dipeptide-like rhodesain inhibitors containing the 3-bromoisoxazoline warhead in a constrained conformation.

Development of novel selective peptidomimetics containing a boronic acid moiety, targeting the 20S proteasome as anticancer agents

Development of peptidomimetic boronates as proteasome inhibitors

Development of peptidomimetics with a vinyl sulfone warhead as irreversible falcipain-2 inhibitors.

Discovery of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV-1 agents.

Enantioselective recognition of 2,3-benzodiazepin-4-one derivatives with anticonvulsant activity on several polysaccharide chiral stationary phases

Enantioseparation, absolute configuration determination, and anticonvulsant activity of (±)-1-(4-aminophenyl)-7,8-methylenedioxy-1,2,3,5-tetrahydro-4H-2,3-benzodiazepin-4-one

Identification of a new series of amides as non-covalent proteasome inhibitors.

Molecular requirement for anticonvulsant activity in a series of thiazolo-1,4-benzodiazepine derivatives and comparison with classical benzodiazepines

Novel 2H-isoquinolin-3-ones as antiplasmodial falcipain-2 inhibitors.

Novel Peptidomimetic Cysteine Protease Inhibitors as Potential Antimalarial Agents

Novel peptidomimetics containing a vinyl ester moiety as highly potent and selective falcipain-2 inhibitors.

Optimization Strategy of Novel Peptide-Based Michael Acceptors for the Treatment of Human African Trypanosomiasis

Optimization of peptidomimetic boronates bearing a P3 bicyclic scaffold as proteasome inhibitors

Peptide-based proteasome inhibitors in anticancer drug design.

Peptidomimetics containing a vinyl ketone warhead as falcipain-2 inhibitors

Relationship Between Anticonvulsant Activity and Plasma Level of Some 2,3-Benzodiazepines in Genetically Epilepsy-Prone Rats

Selective induction of apoptosis in multidrug resistant HL60R cells by the thiazolobenzoimidazole derivative 1-(2,6-difluorophenyl)-1H,3H-thiazolo [3,4-a] benzimidazole (TBZ)

Synthesis and Anticonvulsant Activity of Novel and Potent 2,3-Benzodiazepine AMPA/Kainate Receptor Antagonists

Synthesis and Evaluation of Pharmacological and Pharmacokinetic Properties of 11H-[1,2,4]Triazolo[4,5-c][2,3]benzodiazepin-3(2H)-ones

Synthesis and anti-HIV activity of 2,3-diaryl-1,3-thiazolidin-4-ones.

Synthesis and anticonvulsant activity of new 2,3-benzodiazepines as AMPA receptor antagonists

Synthesis and anticonvulsant activity of novel and potent 1-aryl-7,8-methylenedioxy-1,2,3,5-tetrahydro-4H-2,3-benzodiazepin-4-ones

Synthesis and antitumor activity of 1,3-benzodioxole derivatives.

Synthesis and antitumour activity of 1H,3H-thiazolo[3,4-a]benzimidazole derivatives.

Synthesis and characterization in solid and solution of trans-dichloro-1-(2', 6'-difluorophenyl)-1H,3H-thiazolo [3,4-a]-benzimidazole(tri-n-propyl-phosphine)-palladium(II)": a palladium(II) complex of a ligand with anti-HIV properties.

Synthesis and cytotoxic activity of 1,3-benzodioxole derivatives. Note II.

Synthesis and in vitro antitumour activity evaluation of 1-aryl-1H,3H-thiazolo[4,3-b]quinazolines

Synthesis and molecular modeling studies of derivatives of a highly potent peptidomimetic vinyl ester as falcipain-2 inhibitors.

Synthesis of 2-semicarbazonomethyl-4,5-methylenedioxyphenylacetic acids as anticonvulsant agents

Synthesis of Novel 3-(Alkylcarbamoyl)-2-aryl-1,2-dihydro-6,7-(methylenedioxy)-3H-quinazolin-4-ones as Anticonvulsant Agents

Synthesis, Chiral Resolution and Pharmacological Evaluation of a 2,3-Benzodiazepine-Derived Noncompetitive AMPA Receptor Antagonist

Synthesis, chiral resolution, and enantiopharmacology of a potent 2,3-benzodiazepine derivative as noncompetitive AMPA receptor antagonist.