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List of works by Pier Paolo Pandolfi

(+)α-Tocopheryl succinate inhibits the mitochondrial respiratory chain complex I and is as effective as arsenic trioxide or ATRA against acute promyelocytic leukemia in vivo.

scientific article

A CK2-dependent mechanism for degradation of the PML tumor suppressor

scientific article

A Dialog on the First 20 Years of PML Research and the Next 20 Ahead

scientific article published on 10 February 2014

A Dual Proto-Oncogenic and Tumor Suppressive Role of LRF/POKEMON In Hemopoietic Malignancies through Control of Cell Fate Decision ⬇️

scholarly article

A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

scientific article published in September 2012

A Role for PML in Innate Immunity

scientific article

A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?

scientific article

A circular twist on microRNA regulation

scientific article published on 31 October 2017

A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer

scientific article published on 2 June 2013

A co-clinical platform to accelerate cancer treatment optimization.

scientific article published on 17 November 2014

A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

scientific article

A continuum model for tumour suppression

scientific article

A genetic platform to model sarcomagenesis from primary adult mesenchymal stem cells

scientific article

A metabolic prosurvival role for PML in breast cancer.

scientific article

A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response

scientific article

A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche.

scientific article published on 4 January 2018

A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein

scientific article

A novel signaling network as a critical rheostat for the biology and maintenance of the normal stem cell and the cancer-initiating cell

scientific article published on 11 February 2009

A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis

scientific article

A unified nomenclature and amino acid numbering for human PTEN.

scientific article

AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions

scientific article published on 28 January 2019

ATM kinase enables the functional axis of YAP, PML and p53 to ameliorate loss of Werner protein-mediated oncogenic senescence.

scientific article published on 09 August 2013

ATR, PML, and CHK2 play a role in arsenic trioxide-induced apoptosis

scientific article published on 3 August 2006

Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate

scientific article published on 26 April 2009

Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events

scientific article published on August 2008

Aberrant ceRNA activity drives lung cancer.

scientific article published on 14 February 2014

Aberrant mRNA translation in cancer pathogenesis: an old concept revisited comes finally of age.

scientific article published on April 2004

Abi1 loss drives prostate tumorigenesis through activation of EMT and non-canonical WNT signaling

scientific article published on 18 September 2019

Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction

scientific article published on 15 March 2009

Acetylation of PML is involved in histone deacetylase inhibitor-mediated apoptosis

scientific article published on 11 July 2008

Acetylation-dependent regulation of Skp2 function

scientific article

Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage

scientific article

Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer

scientific article published on 13 April 2015

Acute Promyelocytic Leukemia: A Paradigm for Oncoprotein-Targeted Cure

scientific article published in November 2017

Akt phosphorylates the transcriptional repressor bmi1 to block its effects on the tumor-suppressing ink4a-arf locus

scientific article published on 23 October 2012

Alterations of tumor microenvironment by carbon monoxide impedes lung cancer growth

scientific article published on 15 March 2016

Amplification of the angiogenic signal through the activation of the TSC/mTOR/HIF axis by the KSHV vGPCR in Kaposi's sarcoma

scientific article

An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance.

scientific article published in April 2018

An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer.

scientific article published on 15 January 2018

As(2)O(3) enhances retroviral reverse transcription and counteracts Ref1 antiviral activity

scientific article

Assessing the construct validity of the Italian version of the EQ-5D: preliminary results from a cross-sectional study in North Italy

scientific article

Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation

scientific article published in March 2002

Atheroma development in apolipoprotein E-null mice is not affected by partial inactivation of PTEN

article

Atypical t(15;17)(q13;q12) in a patient with all-trans retinoic acid refractory secondary acute promyelocytic leukemia: a case report and review of the literature

scientific article

Author Correction: A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer

scientific article published on 03 September 2020

Author Correction: Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate

scientific article published on 17 August 2020

Author Correction: Intragenic antagonistic roles of protein and circRNA in tumorigenesis

scientific article published on 01 February 2020

Author Correction: Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle

scientific article published on 28 August 2020

BCR-ABL disrupts PTEN nuclear-cytoplasmic shuttling through phosphorylation-dependent activation of HAUSP.

scientific article

BCR-ABL inactivates cytosolic PTEN through Casein Kinase II mediated tail phosphorylation.

scientific article published on January 2015

BCR-mediated apoptosis associated with negative selection of immature B cells is selectively dependent on Pten

scientific article

Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice

scientific article published on 01 July 2002

Bone marrow endosteal mesenchymal progenitors depend on HIF factors for maintenance and regulation of hematopoiesis.

scientific article

Breaking the rules of cancer

scientific article published on 01 January 2006

Breast cancer--loss of PTEN predicts resistance to treatment

scientific article published on 01 November 2004

CD8 T cell-intrinsic GITR is required for T cell clonal expansion and mouse survival following severe influenza infection

scientific article published on 12 November 2010

CIP2A promotes proliferation of spermatogonial progenitor cells and spermatogenesis in mice

scientific journal article

Cancer metabolism: fatty acid oxidation in the limelight ⬇️

scientific article published on February 28, 2013

Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function

scientific article

Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells

scientific article

Carbon monoxide expedites metabolic exhaustion to inhibit tumor growth

scientific article published on 11 October 2013

Causality and Chance in the Development of Cancer

scientific article published on 01 July 2015

Causality and Chance in the Development of Cancer

scientific article published on 01 October 2015

Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

scientific article

Cellular senescence as a possible mechanism for halting progression of keloid lesions.

scientific article published on November 2011

Changing venues for tumour suppression: balancing destruction and localization by monoubiquitylation

scientific article published on 17 May 2007

Characterization and analysis of the composition and dynamics of the mammalian riboproteome.

scientific article published on 19 September 2013

Characterization of dual PTEN and p53-targeting microRNAs identifies microRNA-638/Dnm2 as a two-hit oncogenic locus.

scientific article published on 31 July 2014

Characterization, cryopreservation, and ablation of spermatogonial stem cells in adult rhesus macaques

scientific article published on 21 June 2007

Co-aggregation of FcgammaRII with FcepsilonRI on human mast cells inhibits antigen-induced secretion and involves SHIP-Grb2-Dok complexes

scientific article published on 19 May 2004

Co-inhibitory roles for glucocorticoid-induced TNF receptor in CD1d-dependent natural killer T cells

scientific article published on 01 August 2008

Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs

scientific article

Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer

scientific article published on 22 August 2012

Compound In Vivo Inactivation of Pml and p53 Uncovers a Functional Interaction in Angiosarcoma Suppression.

scientific article published on September 2012

Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis

scientific article published on 26 November 2018

Corrigendum: Loss of LDAH associated with prostate cancer and hearing loss

scientific article published on 01 May 2019

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

scientific article

Cyclin-dependent kinase antagonizes promyelocytic leukemia zinc-finger through phosphorylation

scientific article published on 4 February 2008

Cytoplasmic Nucleophosmin (NPMc+) Mutations and FMS-Like Tyrosine Kinase 3 (Flt3) Internal Tandem Duplication (ITD) Mutations Cooperate to Cause Leukemia In a Mouse Model ⬇️

scholarly article

Cytoplasmic PML function in TGF-beta signalling

scientific article

DOK2 inhibits EGFR-mutated lung adenocarcinoma

scientific article

Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis.

scientific article published on 11 April 2010

Deconstructing feedback-signaling networks to improve anticancer therapy with mTORC1 inhibitors

scientific article published on 22 December 2008

Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism.

scientific article published on 15 January 2018

Deregulated TGF-beta signaling in leukemogenesis

scientific article

Designed transcription factors as structural, functional and therapeutic probes of chromatin in vivo. Fourth in review series on chromatin dynamics

scientific article

Determining the contribution of NPM1 heterozygosity to NPM-ALK-induced lymphomagenesis

scientific article published on 27 June 2011

Development of promyelocytic zinc finger and ThPOK-expressing innate gamma delta T cells is controlled by strength of TCR signaling and Id3.

scientific article published on 28 December 2009

Development of the Proximal-Anterior Skeletal Elements in the Mouse Hindlimb Is Regulated by a Transcriptional and Signaling Network Controlled by Sall4

scientific article published on 10 March 2020

Differential expression of S6K2 dictates tissue-specific requirement for S6K1 in mediating aberrant mTORC1 signaling and tumorigenesis.

scientific article

Differential p53-independent outcomes of p19(Arf) loss in oncogenesis

scientific article

Differential requirement of mTOR in postmitotic tissues and tumorigenesis

scientific article

Disruption of PLZP in mice leads to increased T-lymphocyte proliferation, cytokine production, and altered hematopoietic stem cell homeostasis

scientific journal article

Distinct germline progenitor subsets defined through Tsc2-mTORC1 signaling

scientific article

Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL.

scientific article

Distinct nuclear body components, PML and SMRT, regulate the trans-acting function of HTLV-1 Tax oncoprotein

scientific article

Diverse genetic-driven immune landscapes dictate tumor progression through distinct mechanisms

scientific article published on 8 January 2018

Dok-1 independently attenuates Ras/mitogen-activated protein kinase and Src/c-myc pathways to inhibit platelet-derived growth factor-induced mitogenesis

scientific article published on April 2006

Dok-1 negatively regulates platelet integrin αIIbβ3 outside-in signalling and inhibits thrombosis in mice

scientific article published on 21 January 2016

Dok-1 overexpression promotes development of γδ natural killer T cells

scientific article published on 16 July 2012

Dok1 and Dok2 Proteins Regulate Cell Cycle in Hematopoietic Stem and Progenitor Cells.

scientific article published on 18 April 2016

Dok1 and Dok2 proteins regulate natural killer cell development and function

scientific article

Dok1 and SHIP act as negative regulators of v-Abl-induced pre-B cell transformation, proliferation and Ras/Erk activation.

scientific article

Dosage and tumour suppression

scientific article published in June 2012

Downstream of kinase, p62(dok), is a mediator of Fc gamma IIB inhibition of Fc epsilon RI signaling

scientific article published in May 2002

Downstream of tyrosine kinases-1 and Src homology 2-containing inositol 5'-phosphatase are required for regulation of CD4+CD25+ T cell development

scientific article published on 01 April 2006

Dual DNA and protein tagging of open chromatin unveils dynamics of epigenomic landscapes in leukemia

scientific article published on 01 March 2021

Dual Pten/Tp53 suppression promotes sarcoma progression by activating Notch signaling

scientific article published on June 2013

Dyskeratosis congenita and cancer in mice deficient in ribosomal RNA modification

scientific article

E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis

scientific article published on 11 June 2012

EGFRvIII expression and PTEN loss synergistically induce chromosomal instability and glial tumors

scientific article published on 23 September 2008

ETS rearrangements and prostate cancer initiation

scientific article published on February 2009

Effect of angiogenesis inhibition by Id loss and the contribution of bone-marrow-derived endothelial cells in spontaneous murine tumors

scientific article published in October 2003

Effective utilization and appropriate selection of genetically engineered mouse models for translational integration of mouse and human trials

scientific article published on November 2013

Effects of promyelocytic leukemia protein on virus-host balance

scientific article

Endosome and INPP4B.

scientific article published on 18 December 2015

Enhancing Chemotherapy Efficacy in Pten -Deficient Prostate Tumors by Activating the Senescence-Associated Antitumor Immunity

scientific article published on 25 September 2014

Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program

scientific article published on 19 August 2019

Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation

scientific journal article

Erratum: Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

scientific article published in Nature

Essential role for nuclear PTEN in maintaining chromosomal integrity

scientific journal article

Essential role of Plzf in maintenance of spermatogonial stem cells

scientific journal article

Essential role of the p110beta subunit of phosphoinositide 3-OH kinase in male fertility.

scientific article

Establishment of a humanized APL model via the transplantation of PML-RARA-transduced human common myeloid progenitors into immunodeficient mice

scientific article

Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling

scientific article

Faithfull modeling of PTEN loss driven diseases in the mouse

scientific article published on January 2010

Found in translation of mTOR signaling.

scientific article published on 29 May 2012

From pseudo-ceRNAs to circ-ceRNAs: a tale of cross-talk and competition ⬇️

scientific article published on May 1, 2013

Functional antagonism between Sall4 and Plzf defines germline progenitors

scientific article

Functional connection between Rad51 and PML in homology-directed repair

scientific article

G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L

scientific article published on 30 March 2015

GITR activation induces an opposite effect on alloreactive CD4(+) and CD8(+) T cells in graft-versus-host disease

scientific article

Gata3 antagonizes cancer progression in Pten-deficient prostates

scientific article published on 20 February 2013

Generation of functional hepatocytes from mouse germ line cell-derived pluripotent stem cells in vitro.

scientific article published on August 2010

Generation of functional multipotent adult stem cells from GPR125+ germline progenitors

scientific article

Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression

scientific article

Germline NPM1 mutations lead to altered rRNA 2'-O-methylation and cause dyskeratosis congenita

scientific article published on 30 September 2019

Giving blood: a new role for CD40 in tumorigenesis

scientific article published on 16 October 2006

Gli3 and Plzf cooperate in proximal limb patterning at early stages of limb development

scientific article published in July 2005

Glucocorticoid-induced tumor necrosis factor receptor is a p21Cip1/WAF1 transcriptional target conferring resistance of keratinocytes to UV light-induced apoptosis

scientific article published on 9 September 2005

HIF factors cooperate with PML-RARα to promote acute promyelocytic leukemia progression and relapse

scientific article

Haplo-insufficiency: a driving force in cancer

scientific article published on 29 October 2010

High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia

scientific article published on 20 May 2009

Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies ⬇️

article by Marina Botto et al published May 1998 in Nature Genetics

Identification of DOK genes as lung tumor suppressors

scientific article

Identification of PTEN at the ER and MAMs and its regulation of Ca(2+) signaling and apoptosis in a protein phosphatase-dependent manner

scientific article published on 28 June 2013

Identification of S664 TSC2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mTOR activation in tuberous sclerosis and human cancer

scientific article published in August 2007

Identification of a tumour suppressor network opposing nuclear Akt function

scientific article

Identification of competing endogenous RNAs of the tumor suppressor gene PTEN: A probabilistic approach

scientific article published on 10 August 2017

Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation

scientific article

In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes

scientific article published on 16 April 2015

In vivo analysis of the role of aberrant histone deacetylase recruitment and RAR alpha blockade in the pathogenesis of acute promyelocytic leukemia.

scientific article

In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma

scientific article

Inactivation of PBX3 and HOXA9 by down-regulating H3K79 methylation represses NPM1-mutated leukemic cell survival

scientific article published on 30 July 2018

Inhibition of HECT E3 ligases as potential therapy for COVID-19

scientific article

Initiation of mRNA translation in oncogenesis: the role of eIF4E.

scientific article published on 21 November 2004

Inositol pentakisphosphate promotes apoptosis through the PI 3-K/Akt pathway

scientific article (publication date: 4 March 2004)

Integrated transcriptional and competitive endogenous RNA networks are cross-regulated in permissive molecular environments

scientific article published on 27 March 2013

Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis

scientific article published on 16 August 2019

Intragenic antagonistic roles of protein and circRNA in tumorigenesis

scientific article published on 17 June 2019

Intravital imaging reveals p53-dependent cancer cell death induced by phototherapy via calcium signaling

scientific article

Keloid disease can be inhibited by antagonizing excessive mTOR signaling with a novel dual TORC1/2 inhibitor

scientific article published on 11 September 2012

LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control

scientific article published on 03 February 2020

LRF is an essential downstream target of GATA1 in erythroid development and regulates BIM-dependent apoptosis

scientific article published on October 2009

LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair

scientific article

Leukemia with distinct phenotypes in transgenic mice expressing PML/RAR alpha, PLZF/RAR alpha or NPM/RAR alpha

scientific article

Loss of LDAH associated with prostate cancer and hearing loss

scientific article published on 01 December 2018

Loss of PML cooperates with mutant p53 to drive more aggressive cancers in a gender-dependent manner

scientific article published on 08 May 2013

Loss of Wave1 gene defines a subtype of lethal prostate cancer

scientific article published in May 2015

Loss of the tumor suppressor PML in human cancers of multiple histologic origins

scientific article

MCM7 and its hosted miR-25, 93 and 106b cluster elicit YAP/TAZ oncogenic activity in lung cancer.

scientific article published on 17 October 2016

MUC1 Expression Is Essential For Establishment Of Acute Myeloid Leukemia In Vivo ⬇️

scholarly article

MUC1 is a potential target for the treatment of acute myeloid leukemia stem cells

scientific article published on 18 July 2013

MUC1-mediated induction of myeloid-derived suppressor cells in patients with acute myeloid leukemia

scientific article

Maternally transmitted severe glucose 6-phosphate dehydrogenase deficiency is an embryonic lethal

scientific article

Metastasis-associated MCL1 and P16 copy number alterations dictate resistance to vemurafenib in a BRAFV600E patient-derived papillary thyroid carcinoma preclinical model.

scientific article published on 30 November 2015

MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling.

scientific article published on 03 July 2013

MicroRNAs in the pathogenesis of myelodysplastic syndromes and myeloid leukaemia

scientific article published on July 2014

Mitochondria associated membranes (MAMs) as critical hubs for apoptosis

scientific article published on May 2011

Modeling Cancer-Associated Mutations of PTEN in Mice

scientific article published on 01 January 2016

Modelling haematopoietic malignancies in the mouse and therapeutical implications

scientific article

Molecular genetics of acute lymphoblastic leukemia

scientific article published on 01 January 2009

Morgana acts as a proto-oncogene through inhibition of a ROCK-PTEN pathway

scientific article published on 6 August 2014

Morgana acts as an oncosuppressor in chronic myeloid leukemia.

scientific article published on 12 February 2015

Morgana/chp-1, a ROCK inhibitor involved in centrosome duplication and tumorigenesis

scientific article

Mouse hospital and co-clinical trial project--from bench to bedside.

scientific article published on 21 April 2015

Mouse modeling in oncologic preclinical and translational research

scientific article published on September 2006

Mutational analysis of the DOK2 haploinsufficient tumor suppressor gene in chronic myelomonocytic leukemia (CMML)

article

Mutations of the PML tumor suppressor gene in acute promyelocytic leukemia

scientific article published on 20 November 2003

Myeloid leukemia with promyelocytic features in transgenic mice expressing hCG-NuMA-RARalpha

scientific article published in January 2004

NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN

scientific article

NGF-promoted axon growth and target innervation requires GITRL-GITR signaling

scientific article

NPM mutations in acute myelogenous leukemia

scientific article published on 01 January 2005

NPM-MLF1 synergizes with Npm haploinsufficiency to enhance myeloid progenitor activity

scientific article published on 23 December 2011

NPMc+ cooperates with Flt3/ITD mutations to cause acute leukemia recapitulating human disease

scientific article published on 29 October 2013

Nanoformulation of Olaparib Amplifies PARP Inhibition and Sensitizes PTEN/TP53-Deficient Prostate Cancer to Radiation

scientific article published on 12 May 2017

Noncoding RNAs and Cancer

scientific article published on 01 March 2013

Npm1 is a haploinsufficient suppressor of myeloid and lymphoid malignancies in the mouse

scientific article published on 22 January 2008

Nuclear Akt2 opposes limbal keratinocyte stem cell self-renewal by repressing a FOXO-mTORC1 signaling pathway.

scientific article published on March 2014

Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner

scientific article

Nuclear and cytoplasmic shuttling of TRADD induces apoptosis via different mechanisms

scientific article

Nucleophosmin and cancer

scientific article published on July 2006

Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome

scientific article

Of model pets and cancer models: an introduction to mouse models of cancer

scientific article published on 01 January 2014

Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations

scientific article published on 30 March 2016

Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations

scientific article

Optimized RNA-targeting CRISPR/Cas13d technology outperforms shRNA in identifying functional circRNAs

scientific article published on 21 January 2021

Ornithine Decarboxylase Is Sufficient for Prostate Tumorigenesis via Androgen Receptor Signaling

scientific article published on 19 October 2016

PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2.

scientific article published on September 2016

PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo

scientific article

PML Controls PTEN Localization and Function in APL through a Novel Deubiquitination Pathway ⬇️

scholarly article

PML activates transcription by protecting HIPK2 and p300 from SCFFbx3-mediated degradation

scientific article published on 22 September 2008

PML at Mitochondria-Associated Membranes Is Critical for the Repression of Autophagy and Cancer Development

scientific article published on 18 August 2016

PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR

scientific article

PML interacts with Myc, and Myc target gene expression is altered in PML-null fibroblasts

scientific journal article

PML is a direct p53 target that modulates p53 effector functions

scientific journal article

PML regulates apoptosis at endoplasmic reticulum by modulating calcium release

scientific journal article

PML regulates p53 stability by sequestering Mdm2 to the nucleolus

scientific article

PML targeting eradicates quiescent leukaemia-initiating cells

scientific article

PML, YAP, and p73 are components of a proapoptotic autoregulatory feedback loop.

scientific article

PML-retinoic acid receptor alpha inhibits PML IV enhancement of PU.1-induced C/EBPepsilon expression in myeloid differentiation

scientific article

PML/RARa inhibits PTEN expression in hematopoietic cells by competing with PU.1 transcriptional activity.

scientific article published on 10 September 2016

POKEMON Is a Proto-Oncogene Which Plays a Key Role in Lymphomagenesis. ⬇️

scholarly article

PTEN Level in Tumor Suppression: How Much Is Too Little? ⬇️

scientific article published on January 25, 2011

PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage

scientific article published on 19 June 2019

PTEN Mouse Models of Cancer Initiation and Progression

scientific article published on 03 February 2020

PTEN and TNF-alpha regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-kappaB-dependent pathway

scientific article published in October 2002

PTEN and p53: who will get the upper hand?

scientific article published on 01 February 2003

PTEN ceRNA networks in human cancer.

scientific article

PTEN in neural precursor cells: regulation of migration, apoptosis, and proliferation

scientific article

PTEN induces apoptosis and cavitation via HIF-2-dependent Bnip3 upregulation during epithelial lumen formation

scientific article

PTEN is a negative regulator of NK cell cytolytic function.

scientific article

PTEN mediates Notch-dependent stalk cell arrest in angiogenesis

scientific article

PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression

scientific article published in Nature Communications

PTENP1 is a ceRNA for PTEN: it's CRISPR clear

scientific article published on 09 June 2020

Persistent Immune Stimulation Exacerbates Genetically Driven Myeloproliferative Disorders via Stromal Remodeling.

scientific article published on 23 May 2017

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

scientific article (publication date: 22 April 2005)

Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB

scientific article

Physical and functional link of the leukemia-associated factors AML1 and PML.

scientific article published on 26 August 2004

Pills of PTEN? In and out for tumor suppression.

scientific article published on 6 August 2013

Plzf Regulates Germline Progenitor Self-Renewal by Opposing mTORC1 ⬇️

scientific article published on August 6, 2010

Plzf mediates transcriptional repression of HoxD gene expression through chromatin remodeling

scientific article (publication date: October 2002)

Plzf regulates limb and axial skeletal patterning

scientific journal article

Pml represses tumour progression through inhibition of mTOR.

scientific article published on 8 March 2011

Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1.

scientific article published on 2 March 2009

Posttranscriptional Regulation of PTEN by Competing Endogenous RNAs

scientific article published on 01 January 2016

Preclinical and Coclinical Studies in Prostate Cancer

scientific article published on 16 October 2017

Pro-senescence therapy for cancer treatment

scientific article published on 24 June 2011

Promyelocytic leukemia activates Chk2 by mediating Chk2 autophosphorylation

scientific article published on 11 July 2006

Promyelocytic leukemia protein 4 induces apoptosis by inhibition of survivin expression

scientific article published on 3 November 2003

Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation

scientific article

Promyelocytic leukemia protein mediates interferon-based anti-herpes simplex virus 1 effects

scientific article

Promyelocytic leukemia protein sensitizes tumor necrosis factor alpha-induced apoptosis by inhibiting the NF-kappaB survival pathway

scientific article published on 22 January 2003

Promyelocytic leukemia zinc finger protein activates GATA4 transcription and mediates cardiac hypertrophic signaling from angiotensin II receptor 2.

scientific article

Promyelocytic leukemia zinc finger protein regulates interferon-mediated innate immunity

scientific article published on 11 June 2009

Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance

scientific article

Pseudogenes as competitive endogenous RNAs: target prediction and validation

scientific article published on 01 January 2014

Pseudogenes in Human Cancer

scientific article

Pten dose dictates cancer progression in the prostate

scientific article

RARalpha-PLZF overcomes PLZF-mediated repression of CRABPI, contributing to retinoid resistance in t(11;17) acute promyelocytic leukemia

scholarly article

Rabies virus P and small P products interact directly with PML and reorganize PML nuclear bodies.

scientific article

Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway

scientific article published on 01 May 2019

Reciprocal products of chromosomal translocations in human cancer pathogenesis: key players or innocent bystanders?

scientific article

Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF.

scientific article published on May 2007

Regulation of NF-κB by PML and PML-RARα.

scientific article published on 20 March 2017

Regulation of the p73 protein stability and degradation

scientific article

Repression of kit expression by Plzf in germ cells

scientific article

Role of BRAFV600E in the first preclinical model of multifocal infiltrating myopericytoma development and microenvironment

scientific article

Role of Dok-1 and Dok-2 in leukemia suppression

scientific article

Role of GITR in activation response of T lymphocytes.

scientific article

Role of LRF/Pokemon in lineage fate decisions

scientific article published on 8 February 2013

Role of PML and the PML-nuclear body in the control of programmed cell death

scientific article (publication date: 8 December 2003)

Role of aberrant PI3K pathway activation in gallbladder tumorigenesis

scientific article published on February 2014

Role of nucleophosmin in embryonic development and tumorigenesis

scientific journal article

Role of the proto-oncogene Pokemon in cellular transformation and ARF repression

scientific article

SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization

scientific article

SPAR, a lncRNA encoded mTORC1 inhibitor.

scientific article published on 20 March 2017

SPOP Promotes Nanog Destruction to Suppress Stem Cell Traits and Prostate Cancer Progression.

scientific article published on 27 December 2018

SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression.

scientific article published on 2 September 2015

SUMO modification of Huntingtin and Huntington's disease pathology

scientific article

SUMO-1 protease-1 regulates gene transcription through PML

scientific journal article

Shape-shifting and tumor suppression by PLZF

scientific article published on May 2010

Signaling control of mRNA translation in cancer pathogenesis

scientific article published on April 2004

Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity

scientific article

Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle

scientific article published on 15 July 2020

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

scientific article

SnapShot: PTEN signaling pathways

scientific article published in May 2008

Somatic human ZBTB7A zinc finger mutations promote cancer progression

scientific article published on 12 October 2015

Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation

scientific article published in June 2005

Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain

scientific journal article

Stage-specific functions of leukemia/lymphoma-related factor (LRF) in the transcriptional control of osteoclast development

scientific article published on 30 January 2012

Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma.

scientific article published on April 2016

Stromal cell-derived factor-1alpha/CXCL12-induced chemotaxis of T cells involves activation of the RasGAP-associated docking protein p62Dok-1.

scientific article published on 2 September 2004

Subtle variations in Pten dose determine cancer susceptibility

scientific article

Suppression of T-cell lymphomagenesis in mice requires PTEN phosphatase activity.

scientific article published on 4 December 2014

Synergy against PML-RARa: targeting transcription, proteolysis, differentiation, and self-renewal in acute promyelocytic leukemia.

scientific article published on December 2013

Systemic elevation of PTEN induces a tumor-suppressive metabolic state

scientific article published on 6 March 2012

TCR-inducible PLZF transcription factor required for innate phenotype of a subset of gammadelta T cells with restricted TCR diversity

scientific article

TSPYL2 is an essential component of the REST/NRSF transcriptional complex for TGFβ signaling activation

scientific article

TSPYL5 suppresses p53 levels and function by physical interaction with USP7

scientific article

Taking apart a cancer protein

scientific article published in Nature

Target competition: transcription factors enter the limelight

scientific article

Targeting Leukemia Initiating Cells by MUC1-C Subunit Inhibition ⬇️

scholarly article

Targeting aberrant transcriptional repression in acute myeloid leukemia.

scientific article published on June 2003

Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells.

scientific article

Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN loss and tumorigenesis.

scientific article published in November 2011

Tenets of PTEN tumor suppression

scientific article published on May 2008

Tetravalent SARS-CoV-2 Neutralizing Antibodies Show Enhanced Potency and Resistance to Escape Mutations

scientific article published on 21 December 2020

The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas

article

The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function

scientific article published on 7 February 2017

The APL paradigm and the "co-clinical trial" project

scientific article published on July 2011

The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation

scientific journal article

The BRAF Pseudogene Is a Proto-Oncogenic Competitive Endogenous RNA ⬇️

scholarly article

The BRAF pseudogene functions as a competitive endogenous RNA and induces lymphoma in vivo.

scientific article

The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions

scientific article

The Csk-Associated Adaptor PAG Inhibits Effector T Cell Activation in Cooperation with Phosphatase PTPN22 and Dok Adaptors

scientific article

The ETS protein MEF plays a critical role in perforin gene expression and the development of natural killer and NK-T cells

scientific journal article

The Epitranscriptome of Noncoding RNAs in Cancer.

scientific article published on 20 March 2017

The Interplay Between the Genetic and Immune Landscapes of AML: Mechanisms and Implications for Risk Stratification and Therapy

scientific article published on 07 November 2019

The Lilliputians and the Giant: An Emerging Oncogenic microRNA Network that Suppresses the PTEN Tumor Suppressor In Vivo

scientific article

The Mechanisms of PML-Nuclear Body Formation

scientific article published on 07 December 2006

The Mouse Hospital and Its Integration in Ultra-Precision Approaches to Cancer Care

The PTEN Tumor Suppressor Forms Homodimers in Solution.

scientific article

The PTEN⁻PI3K Axis in Cancer

scientific article published on 17 April 2019

The RNA binding protein ESRP1 fine-tunes the expression of pluripotency-related factors in mouse embryonic stem cells

scientific article

The RNA-binding protein ESRP1 promotes human colorectal cancer progression

scientific article published on 28 December 2016

The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice

scientific article published on 01 December 2005

The TLX1 oncogene drives aneuploidy in T cell transformation

scientific article

The Tug1 lncRNA locus is essential for male fertility

scientific article published on 07 September 2020

The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model

scientific article

The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice

scientific article

The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network

scientific article

The effect of deleting p110delta on the phenotype and function of PTEN-deficient B cells

scientific article published on 01 January 2008

The functions and regulation of the PTEN tumour suppressor ⬇️

scientific article (publication date: 4 April 2012)

The functions and regulation of the PTEN tumour suppressor: new modes and prospects

scientific article published on 01 September 2018

The mTOR Targets 4E-BP1/2 Restrain Tumor Growth and Promote Hypoxia Tolerance in PTEN-driven Prostate Cancer

scientific article published on 16 February 2018

The mechanisms of PML-nuclear body formation

scientific article

The mitochondrial Italian Human Proteome Project initiative (mt-HPP).

scientific article published on 28 May 2013

The multilayered complexity of ceRNA crosstalk and competition

scientific article

The nuclear bodies inside out: PML conquers the cytoplasm

scientific article published on 16 April 2011

The nucleolus: at the stem of immortality

scientific article published in January 2003

The oncogenic microRNA miR-22 targets the TET2 tumor suppressor to promote hematopoietic stem cell self-renewal and transformation

scientific article

The p85 isoform of the kinase S6K1 functions as a secreted oncoprotein to facilitate cell migration and tumor growth.

scientific article

The pleiotropic role of non-coding genes in development and cancer.

scientific article published on 16 November 2016

The promyelocytic leukaemia protein tumour suppressor functions as a transcriptional regulator of p63.

scientific article published in October 2005

The promyelocytic leukemia protein PML regulates c-Jun function in response to DNA damage

scientific article

The promyelocytic leukemia protein functions as a negative regulator of IFN-gamma signaling

scholarly article

The promyelocytic leukemia protein is upregulated in conditions of obesity and liver steatosis

scientific article published on 11 April 2015

The promyelocytic leukemia protein protects p53 from Mdm2-mediated inhibition and degradation

scientific article

The proto-oncogene LRF is under post-transcriptional control of MiR-20a: implications for senescence

scientific article

The role of PML in the control of apoptotic cell fate: a new key player at ER–mitochondria sites ⬇️

scientific article published on 08 April 2011

The role of PML in tumor suppression

scientific article (publication date: 25 January 2002)

The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor suppressor in acute myeloid leukemia

scientific article published on 24 June 2002

The topoisomerase I-binding RING protein, topors, is associated with promyelocytic leukemia nuclear bodies

scientific article (publication date: 15 July 2002)

The transcription factor Pokemon: a new key player in cancer pathogenesis

scientific article

The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

scientific article published on 18 April 2004

The tumor suppressor PML specifically accumulates at RPA/Rad51-containing DNA damage repair foci but is nonessential for DNA damage-induced fibroblast senescence

scientific article

Therapeutic inhibition of USP7-PTEN network in chronic lymphocytic leukemia: a strategy to overcome TP53 mutated/deleted clones

scientific article

Tolerability, pharmacodynamics, and pharmacokinetics studies of depsipeptide (romidepsin) in patients with acute myelogenous leukemia or advanced myelodysplastic syndromes

scientific article

Translation-dependent mechanisms lead to PML upregulation and mediate oncogenic K-RAS-induced cellular senescence

scientific article

Treatment with 5-azacytidine accelerates acute promyelocytic leukemia leukemogenesis in a transgenic mouse model.

scientific article

Tsc2-Rheb signaling regulates EphA-mediated axon guidance

scientific article

Tumor microenvironment revisited

scientific article published on 14 April 2014

Twenty-first annual Pezcoller Symposium: Unconventional Therapeutic Targets in Cancer

scientific article published on 22 December 2009

Two Different Therapeutic Approaches for SARS-CoV-2 in hiPSCs-Derived Lung Organoids

scientific article published on 05 April 2022

Ubiquitin-dependent degradation of p73 is inhibited by PML.

scientific article

Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors.

scientific article published on 8 March 2011

Ubiquitination regulates PTEN nuclear import and tumor suppression

scientific article

Up-regulation of translation eukaryotic initiation factor 4E in nucleophosmin 1 haploinsufficient cells results in changes in CCAAT enhancer-binding protein α activity: implications in myelodysplastic syndrome and acute myeloid leukemia.

scientific article

Utility of LRF/Pokemon and NOTCH1 protein expression in the distinction between nodular lymphocyte-predominant Hodgkin lymphoma and classical Hodgkin lymphoma

scientific article published on 10 December 2013

Virus against virus: a potential treatment for 2019-nCov (SARS-CoV-2) and other RNA viruses

scientific article published on 18 February 2020

Vulnerabilities in mIDH2 AML confer sensitivity to APL-like targeted combination therapy

scientific article published on 25 April 2019

Vulnerabilities of PTEN-TP53-deficient prostate cancers to compound PARP-PI3K inhibition.

scientific article

WWP1 Gain-of-Function Inactivation of PTEN in Cancer Predisposition

scientific article published on 01 May 2020

WWP1 germline variants are associated with normocephalic autism spectrum disorder

scientific article published on 23 July 2020

ZBTB7A Suppresses Melanoma Metastasis by Transcriptionally Repressing MCAM.

scientific article

ZBTB7A governs estrogen receptor alpha expression in breast cancer

scientific article published on 01 August 2018

Zbtb7a suppresses prostate cancer through repression of a Sox9-dependent pathway for cellular senescence bypass and tumor invasion

scientific article

beta-tting on p63 as a metastatic suppressor

scientific article published in April 2009

c-Abl phosphorylates Dok1 to promote filopodia during cell spreading

scientific journal article

ceRNA cross-talk in cancer: when ce-bling rivalries go awry.

scientific article published on 26 September 2013

ceRNAs and ceRNA Networks in Normal and Malignant Hematopoiesis and Their Therapeutic Implications ⬇️

scholarly article

eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression

scientific article

mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma

scientific article published on April 2005

mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide

scientific journal article

miR-22 in tumorigenesis

scientific article

miR-96-5p targets PTEN expression affecting radio-chemosensitivity of HNSCC cells

scientific article published on 29 March 2019

p18 Ink4c and Pten constrain a positive regulatory loop between cell growth and cell cycle control

scientific article

p27 deficiency desensitizes Rb-/- cells to signals that trigger apoptosis during pituitary tumor development

scientific article

p53 De-ubiquitination: at the edge between life and death

scientific article published on 01 June 2002

p53 at the endoplasmic reticulum regulates apoptosis in a Ca2+-dependent manner

scientific article

“Snorkeling” for missing players in cancer ⬇️

scientific article published on July 2, 2012

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