List of works - F J Dilworth

A KAP1 phosphorylation switch controls MyoD function during skeletal muscle differentiation

scientific article

A MyoD-generated feed-forward circuit temporally patterns gene expression during skeletal muscle differentiation.

scientific article

A chemical toolbox for the study of bromodomains and epigenetic signaling

scientific article published on 23 April 2019

A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes

scientific article published on 24 February 2022

Activating transcription factor 3 promotes loss of the acinar cell phenotype in response to cerulein-induced pancreatitis in mice.

scientific article published on 12 July 2017

Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus.

scientific article

Analysis of epigenetic modifications of chromatin at specific gene loci by native chromatin immunoprecipitation of nucleosomes isolated using hydroxyapatite chromatography.

scientific article published in January 2008

Chromatin-wide and transcriptome profiling integration uncovers p38α MAPK as a global regulator of skeletal muscle differentiation

scientific article

Compacting Chromatin to Ensure Muscle Satellite Cell Quiescence

scientific article published on 01 February 2016

Comparative expression profiling identifies differential roles for Myogenin and p38α MAPK signaling in myogenesis

scientific article

Constitutive heterochromatin reorganization during somatic cell reprogramming

scientific article

Contribution of several metabolites of the vitamin D analog 20-epi-22-oxa-24a,26a,27a-tri-homo-1,25-(OH)(2) vitamin D(3) (KH 1060) to the overall biological activity of KH1060 by a shared mechanism of action

scientific article

Derivation and Characterization of Immortalized Human Muscle Satellite Cell Clones from Muscular Dystrophy Patients and Healthy Individuals

scientific article published on 26 July 2020

Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages

scientific article

Differential modulation of cell cycle progression distinguishes members of the myogenic regulatory factor family of transcription factors

scientific article

Diversification of the muscle proteome through alternative splicing.

scientific article published on 6 March 2018

Dystrophic muscle environment induces changes in cell plasticity.

scientific article published on April 2014

Epigenetic regulation of satellite cell activation during muscle regeneration.

scientific article published on 19 April 2011

GSK3 temporally regulates neurogenin 2 proneural activity in the neocortex.

scientific article published in June 2012

HIRA stabilizes skeletal muscle lineage identity

scientific article published on 08 June 2021

Identification of the retinoic acid-inducible all-trans-retinoic acid 4-hydroxylase.

scientific article published in November 1996

In vitro transcription system delineates the distinct roles of the coactivators pCAF and p300 during MyoD/E47-dependent transactivation.

scholarly article

Increased biological activity of 20-epi-1,25-dihydroxyvitamin D3 is due to reduced catabolism and altered protein binding

scientific article published on 01 March 1994

Ligand-dependent activation of transcription in vitro by retinoic acid receptor alpha/retinoid X receptor alpha heterodimers that mimics transactivation by retinoids in vivo

scientific article published on March 1999

Metabolism of the vitamin D analog EB1089 by cultured human cells: redirection of hydroxylation site to distal carbons of the side-chain

scientific article published on 01 March 1997

MyoD and E-protein heterodimers switch rhabdomyosarcoma cells from an arrested myoblast phase to a differentiated state.

scientific article published on March 2009

Nuclear matrix-associated protein SMAR1 regulates alternative splicing via HDAC6-mediated deacetylation of Sam68.

scientific article published on 15 June 2015

Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription.

scientific article

Pax7 activates myogenic genes by recruitment of a histone methyltransferase complex.

scientific article

Polycomb repressive complex 1 provides a molecular explanation for repeat copy number dependency in FSHD muscular dystrophy.

scientific article

Rbfox proteins regulate tissue-specific alternative splicing of Mef2D required for muscle differentiation.

scientific article

Redirecting traffic in the nucleus

scientific article published on 01 September 2011

Reprogramming progeria fibroblasts re-establishes a normal epigenetic landscape.

scientific article

Splicing of Ezh1 gets muscle out of stressful situations

scientific article published in May 2017

Teashirt-3, a novel regulator of muscle differentiation, associates with BRG1-associated factor 57 (BAF57) to inhibit myogenin gene expression

scientific article published on 4 May 2011

The exosome-mediated autocrine and paracrine actions of plasma gelsolin in ovarian cancer chemoresistance

scientific article published on 07 November 2019

The novel transcription factor e(y)2 interacts with TAF(II)40 and potentiates transcription activation on chromatin templates

scientific article

The origin and fate of muscle satellite cells.

scientific article published on June 2012

Trichostatin A enhances vascular repair by injected human endothelial progenitors through increasing the expression of TAL1-dependent genes.

scientific article published in May 2014

Turning on myogenin in muscle: a paradigm for understanding mechanisms of tissue-specific gene expression.

scientific article published on 28 June 2012

UTX demethylase activity is required for satellite cell-mediated muscle regeneration

scientific article published on 21 March 2016

UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia

scientific article published on March 2016

UTX mediates demethylation of H3K27me3 at muscle-specific genes during myogenesis

scientific journal article

cDNA Cloning of Human Retinoic Acid-metabolizing Enzyme (hP450RAI) Identifies a Novel Family of Cytochromes P450 (CYP26) ⬇️

scientific article published on July 25, 1997

List of works by F J Dilworth

A KAP1 phosphorylation switch controls MyoD function during skeletal muscle differentiation

A MyoD-generated feed-forward circuit temporally patterns gene expression during skeletal muscle differentiation.

A chemical toolbox for the study of bromodomains and epigenetic signaling

A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes

Activating transcription factor 3 promotes loss of the acinar cell phenotype in response to cerulein-induced pancreatitis in mice.

Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus.

Analysis of epigenetic modifications of chromatin at specific gene loci by native chromatin immunoprecipitation of nucleosomes isolated using hydroxyapatite chromatography.

Chromatin-wide and transcriptome profiling integration uncovers p38α MAPK as a global regulator of skeletal muscle differentiation

Compacting Chromatin to Ensure Muscle Satellite Cell Quiescence

Comparative expression profiling identifies differential roles for Myogenin and p38α MAPK signaling in myogenesis

Constitutive heterochromatin reorganization during somatic cell reprogramming

Contribution of several metabolites of the vitamin D analog 20-epi-22-oxa-24a,26a,27a-tri-homo-1,25-(OH)(2) vitamin D(3) (KH 1060) to the overall biological activity of KH1060 by a shared mechanism of action

Derivation and Characterization of Immortalized Human Muscle Satellite Cell Clones from Muscular Dystrophy Patients and Healthy Individuals

Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages

Differential modulation of cell cycle progression distinguishes members of the myogenic regulatory factor family of transcription factors

Diversification of the muscle proteome through alternative splicing.

Dystrophic muscle environment induces changes in cell plasticity.

Epigenetic regulation of satellite cell activation during muscle regeneration.

GSK3 temporally regulates neurogenin 2 proneural activity in the neocortex.

HIRA stabilizes skeletal muscle lineage identity

Identification of the retinoic acid-inducible all-trans-retinoic acid 4-hydroxylase.

In vitro transcription system delineates the distinct roles of the coactivators pCAF and p300 during MyoD/E47-dependent transactivation.

Increased biological activity of 20-epi-1,25-dihydroxyvitamin D3 is due to reduced catabolism and altered protein binding

Ligand-dependent activation of transcription in vitro by retinoic acid receptor alpha/retinoid X receptor alpha heterodimers that mimics transactivation by retinoids in vivo

Metabolism of the vitamin D analog EB1089 by cultured human cells: redirection of hydroxylation site to distal carbons of the side-chain

MyoD and E-protein heterodimers switch rhabdomyosarcoma cells from an arrested myoblast phase to a differentiated state.

Nuclear matrix-associated protein SMAR1 regulates alternative splicing via HDAC6-mediated deacetylation of Sam68.

Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription.

Pax7 activates myogenic genes by recruitment of a histone methyltransferase complex.

Polycomb repressive complex 1 provides a molecular explanation for repeat copy number dependency in FSHD muscular dystrophy.

Rbfox proteins regulate tissue-specific alternative splicing of Mef2D required for muscle differentiation.

Redirecting traffic in the nucleus

Reprogramming progeria fibroblasts re-establishes a normal epigenetic landscape.

Splicing of Ezh1 gets muscle out of stressful situations

Teashirt-3, a novel regulator of muscle differentiation, associates with BRG1-associated factor 57 (BAF57) to inhibit myogenin gene expression

The exosome-mediated autocrine and paracrine actions of plasma gelsolin in ovarian cancer chemoresistance

The novel transcription factor e(y)2 interacts with TAF(II)40 and potentiates transcription activation on chromatin templates

The origin and fate of muscle satellite cells.

Trichostatin A enhances vascular repair by injected human endothelial progenitors through increasing the expression of TAL1-dependent genes.

Turning on myogenin in muscle: a paradigm for understanding mechanisms of tissue-specific gene expression.

UTX demethylase activity is required for satellite cell-mediated muscle regeneration

UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia

UTX mediates demethylation of H3K27me3 at muscle-specific genes during myogenesis

cDNA Cloning of Human Retinoic Acid-metabolizing Enzyme (hP450RAI) Identifies a Novel Family of Cytochromes P450 (CYP26) ⬇️