List of works - Helen Ball

1-L-methyltryptophan is a more effective inhibitor of vertebrate IDO2 enzymes than 1-D-methyltryptophan.

scientific article published on 23 April 2010

A novel automated test battery reveals enduring behavioural alterations and cognitive impairments in survivors of murine pneumococcal meningitis

scientific article

Amyotrophic lateral sclerosis-like superoxide dismutase 1 proteinopathy is associated with neuronal loss in Parkinson's disease brain

scientific article published on 19 May 2017

An effective, low-cost method for achieving and maintaining hypoxia during cell culture studies

scientific article published in October 2015

Assignment of the human neuropeptide Y gene to chromosome 7p15.1 by nonisotopic in situ hybridization

scientific article published on 01 March 1995

Brain endothelial cells increase the proliferation of Plasmodium falciparum through production of soluble factors

scientific article

Cerebral malaria: gamma-interferon redux

scientific article

Characterization and evolution of vertebrate indoleamine 2, 3-dioxygenases IDOs from monotremes and marsupials.

scientific article published in June 2009

Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice

scientific article

Chemokine gene expression during fatal murine cerebral malaria and protection due to CXCR3 deficiency.

scientific article published in January 2008

Cloned human neuropeptide Y receptor couples to two different second messenger systems ⬇️

scientific article published on July 1, 1992

Cyclooxygenase-2 in the pathogenesis of murine cerebral malaria.

scientific article published on 30 January 2004

Differential microRNA expression in experimental cerebral and noncerebral malaria.

scientific article

Effect of indoleamine dioxygenase-1 deficiency and kynurenine pathway inhibition on murine cerebral malaria.

scientific article

Efficient tryptophan-catabolizing activity is consistently conserved through evolution of TDO enzymes, but not IDO enzymes

scientific article published on 20 February 2015

Endothelial cells potentiate interferon-γ production in a novel tripartite culture model of human cerebral malaria.

scientific article

Evidence for reduced neurogenesis in the aging human hippocampus despite stable stem cell markers.

scientific article

Human indoleamine 2,3-dioxygenase-2 has substrate specificity and inhibition characteristics distinct from those of indoleamine 2,3-dioxygenase-1

scientific article published on 30 May 2014

IRGM3 contributes to immunopathology and is required for differentiation of antigen-specific effector CD8+ T cells in experimental cerebral malaria

scientific article

Identification of selective inhibitors of indoleamine 2,3-dioxygenase 2.

scientific article

Immunopathogenesis of cerebral malaria.

scientific article

Increased expression of indoleamine 2,3-dioxygenase in murine malaria infection is predominantly localised to the vascular endothelium.

scientific article published in November 2004

Indoleamine 2,3-dioxygenase 2 (IDO2) and the kynurenine pathway: characteristics and potential roles in health and disease

scientific article published on 09 October 2013

Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway.

scientific article published on 11 January 2008

Indoleamine 2,3-dioxygenases with very low catalytic activity are well conserved across kingdoms: IDOs of Basidiomycota.

scientific article published on 30 March 2013

Inflammasome-dependent IFN-γ drives pathogenesis in Streptococcus pneumoniae meningitis.

scientific article published on 15 October 2012

Interferon-gamma synergises with tumour necrosis factor and lymphotoxin-alpha to enhance the mRNA and protein expression of adhesion molecules in mouse brain endothelial cells.

scientific article published on January 2007

Interferon-γ-Induced Nitric Oxide Synthase-2 Contributes to Blood/Brain Barrier Dysfunction and Acute Mortality in Experimental Streptococcus pneumoniae Meningitis

scientific article published on 29 September 2015

Interleukin-18 deficiency and its long-term behavioural and cognitive impacts in a murine model of pneumococcal meningitis

scientific article

Investigation of the Tissue Distribution and Physiological Roles of Indoleamine 2,3-Dioxygenase-2.

scientific article published on 9 October 2017

Isolating vessels from the mouse brain for gene expression analysis using laser capture microdissection.

scientific article

Kynurenine is an endothelium-derived relaxing factor produced during inflammation

scientific article

Leukemia translocation protein PLZF inhibits cell growth and expression of cyclin A.

scientific article published on January 1999

Low efficiency IDO2 enzymes are conserved in lower vertebrates, whereas higher efficiency IDO1 enzymes are dispensable.

scientific article published on 20 May 2015

Mechanisms of murine cerebral malaria: Multimodal imaging of altered cerebral metabolism and protein oxidation at hemorrhage sites

scientific article published on 18 December 2015

Molecular Evolution and Characterization of Fungal Indoleamine 2,3-Dioxygenases ⬇️

scientific article published on December 18, 2010

Molecular evolution of bacterial indoleamine 2,3-dioxygenase

scientific article published on 12 June 2011

Multiple promoters regulate tissue-specific expression of the human NPY-Y1 receptor gene.

scientific article

Needle in a haystack: microdissecting the proteome of a tissue.

scientific article published on 14 July 2004

Overlapping gene structure of the human neuropeptide Y receptor subtypes Y1 and Y5 suggests coordinate transcriptional regulation

scientific article (publication date: May 1997)

Predominance of interferon-related responses in the brain during murine malaria, as identified by microarray analysis.

scientific article published on 25 February 2008

Prostaglandin E(2) inhibits calcium current in two sub-populations of acutely isolated mouse trigeminal sensory neurons.

scientific article published in March 2002

Reduced activity of the epithelial sodium channel in malaria-induced pulmonary oedema in mice.

scientific article published on 17 September 2010

Sequence-specific DNA Binding and Transcriptional Regulation by the Promyelocytic Leukemia Zinc Finger Protein ⬇️

scientific article published on September 5, 1997

Subcellular compartmentalisation of copper, iron, manganese, and zinc in the Parkinson's disease brain.

scientific article

Synergistic induction of CXCL10 by interferon-gamma and lymphotoxin-alpha in astrocytes: Possible role in cerebral malaria.

scientific article published on 11 December 2015

TIGR4 strain causes more severe disease than WU2 strain in a mouse model of Streptococcus pneumoniae meningitis: a common pathogenic role for interferon-γ.

scientific article published on 21 April 2017

The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein

scientific article

The Fe-heme structure of met-indoleamine 2,3-dioxygenase-2 determined by X-ray absorption fine structure

scientific article published on 22 May 2014

The evolution of three types of indoleamine 2,3 dioxygenases in fungi with distinct molecular and biochemical characteristics

scientific article published on 05 May 2012

The kynurenine pathway and parasitic infections that affect CNS function

scientific article published on 25 February 2016

The kynurenine pathway contributes to long-term neuropsychological changes in experimental pneumococcal meningitis.

scientific article published on 17 May 2014

The kynurenine pathway of tryptophan degradation is activated during osteoblastogenesis.

scientific article published in January 2015

The pro-inflammatory cytokine interferon-gamma is an important driver of neuropathology and behavioural sequelae in experimental pneumococcal meningitis

scientific article

The promyelocytic leukemia zinc finger (PLZF) protein binds DNA in a high molecular weight complex associated with cdc2 kinase

scientific article

Tryptophan-catabolizing enzymes - party of three

scientific article

Vascular expression, activity and function of indoleamine 2,3-dioxygenase-1 following cerebral ischaemia-reperfusion in mice

scientific article published on 27 February 2011

List of works by Helen Ball

1-L-methyltryptophan is a more effective inhibitor of vertebrate IDO2 enzymes than 1-D-methyltryptophan.

A novel automated test battery reveals enduring behavioural alterations and cognitive impairments in survivors of murine pneumococcal meningitis

Amyotrophic lateral sclerosis-like superoxide dismutase 1 proteinopathy is associated with neuronal loss in Parkinson's disease brain

An effective, low-cost method for achieving and maintaining hypoxia during cell culture studies

Assignment of the human neuropeptide Y gene to chromosome 7p15.1 by nonisotopic in situ hybridization

Brain endothelial cells increase the proliferation of Plasmodium falciparum through production of soluble factors

Cerebral malaria: gamma-interferon redux

Characterization and evolution of vertebrate indoleamine 2, 3-dioxygenases IDOs from monotremes and marsupials.

Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice

Chemokine gene expression during fatal murine cerebral malaria and protection due to CXCR3 deficiency.

Cloned human neuropeptide Y receptor couples to two different second messenger systems ⬇️

Cyclooxygenase-2 in the pathogenesis of murine cerebral malaria.

Differential microRNA expression in experimental cerebral and noncerebral malaria.

Effect of indoleamine dioxygenase-1 deficiency and kynurenine pathway inhibition on murine cerebral malaria.

Efficient tryptophan-catabolizing activity is consistently conserved through evolution of TDO enzymes, but not IDO enzymes

Endothelial cells potentiate interferon-γ production in a novel tripartite culture model of human cerebral malaria.

Evidence for reduced neurogenesis in the aging human hippocampus despite stable stem cell markers.

Human indoleamine 2,3-dioxygenase-2 has substrate specificity and inhibition characteristics distinct from those of indoleamine 2,3-dioxygenase-1

IRGM3 contributes to immunopathology and is required for differentiation of antigen-specific effector CD8+ T cells in experimental cerebral malaria

Identification of selective inhibitors of indoleamine 2,3-dioxygenase 2.

Immunopathogenesis of cerebral malaria.

Increased expression of indoleamine 2,3-dioxygenase in murine malaria infection is predominantly localised to the vascular endothelium.

Indoleamine 2,3-dioxygenase 2 (IDO2) and the kynurenine pathway: characteristics and potential roles in health and disease

Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway.

Indoleamine 2,3-dioxygenases with very low catalytic activity are well conserved across kingdoms: IDOs of Basidiomycota.

Inflammasome-dependent IFN-γ drives pathogenesis in Streptococcus pneumoniae meningitis.

Interferon-gamma synergises with tumour necrosis factor and lymphotoxin-alpha to enhance the mRNA and protein expression of adhesion molecules in mouse brain endothelial cells.

Interferon-γ-Induced Nitric Oxide Synthase-2 Contributes to Blood/Brain Barrier Dysfunction and Acute Mortality in Experimental Streptococcus pneumoniae Meningitis

Interleukin-18 deficiency and its long-term behavioural and cognitive impacts in a murine model of pneumococcal meningitis

Investigation of the Tissue Distribution and Physiological Roles of Indoleamine 2,3-Dioxygenase-2.

Isolating vessels from the mouse brain for gene expression analysis using laser capture microdissection.

Kynurenine is an endothelium-derived relaxing factor produced during inflammation

Leukemia translocation protein PLZF inhibits cell growth and expression of cyclin A.

Low efficiency IDO2 enzymes are conserved in lower vertebrates, whereas higher efficiency IDO1 enzymes are dispensable.

Mechanisms of murine cerebral malaria: Multimodal imaging of altered cerebral metabolism and protein oxidation at hemorrhage sites

Molecular Evolution and Characterization of Fungal Indoleamine 2,3-Dioxygenases ⬇️

Molecular evolution of bacterial indoleamine 2,3-dioxygenase

Multiple promoters regulate tissue-specific expression of the human NPY-Y1 receptor gene.

Needle in a haystack: microdissecting the proteome of a tissue.

Overlapping gene structure of the human neuropeptide Y receptor subtypes Y1 and Y5 suggests coordinate transcriptional regulation

Predominance of interferon-related responses in the brain during murine malaria, as identified by microarray analysis.

Prostaglandin E(2) inhibits calcium current in two sub-populations of acutely isolated mouse trigeminal sensory neurons.

Reduced activity of the epithelial sodium channel in malaria-induced pulmonary oedema in mice.

Sequence-specific DNA Binding and Transcriptional Regulation by the Promyelocytic Leukemia Zinc Finger Protein ⬇️

Subcellular compartmentalisation of copper, iron, manganese, and zinc in the Parkinson's disease brain.

Synergistic induction of CXCL10 by interferon-gamma and lymphotoxin-alpha in astrocytes: Possible role in cerebral malaria.

TIGR4 strain causes more severe disease than WU2 strain in a mouse model of Streptococcus pneumoniae meningitis: a common pathogenic role for interferon-γ.

The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein

The Fe-heme structure of met-indoleamine 2,3-dioxygenase-2 determined by X-ray absorption fine structure

The evolution of three types of indoleamine 2,3 dioxygenases in fungi with distinct molecular and biochemical characteristics

The kynurenine pathway and parasitic infections that affect CNS function

The kynurenine pathway contributes to long-term neuropsychological changes in experimental pneumococcal meningitis.

The kynurenine pathway of tryptophan degradation is activated during osteoblastogenesis.

The pro-inflammatory cytokine interferon-gamma is an important driver of neuropathology and behavioural sequelae in experimental pneumococcal meningitis

The promyelocytic leukemia zinc finger (PLZF) protein binds DNA in a high molecular weight complex associated with cdc2 kinase

Tryptophan-catabolizing enzymes - party of three

Vascular expression, activity and function of indoleamine 2,3-dioxygenase-1 following cerebral ischaemia-reperfusion in mice