List of works - M E Murphy

1.8 Å crystal structure of the major NAD(P)H:FMN oxidoreductase of a bioluminescent bacterium, Vibrio fischeri: overall structure, cofactor and substrate-analog binding, and comparison with related flavoproteins ⬇️

scientific article published on July 10, 1998

A Bacterial Cell Shape-Determining Inhibitor.

scientific article published on 6 January 2016

A Diatom Ferritin Optimized for Iron Oxidation but Not Iron Storage.

scientific article

A Ferric-Peroxo Intermediate in the Oxidation of Heme by IsdI.

scientific article

A bacterial surface layer protein exploits multistep crystallization for rapid self-assembly

scientific article published on 17 December 2019

A copper site is required for iron transport by the periplasmic proteins P19 and FetP

scientific article published on 11 August 2020

A rearranging ligand enables allosteric control of catalytic activity in copper-containing nitrite reductase.

scientific article published on 6 March 2006

Anion-independent iron coordination by the Campylobacter jejuni ferric binding protein.

scientific article published on 21 December 2004

Catalytic roles for two water bridged residues (Asp-98 and His-255) in the active site of copper-containing nitrite reductase

scientific article

Characterization of a Dipartite Iron Uptake System from Uropathogenic Escherichia coli Strain F11 ⬇️

scientific article published on May 19, 2011

Characterization of a nucleotide-binding domain associated with neisserial iron transport.

scientific article published on May 2004

Characterization of dye-decolorizing peroxidases from Rhodococcus jostii RHA1

scientific article

Characterization of staphyloferrin A biosynthetic and transport mutants in Staphylococcus aureus

scientific article

Cofacial heme binding is linked to dimerization by a bacterial heme transport protein

scientific article published on 04 August 2006

Consequences of factor IX mutations in 26 families with haemophilia B.

scientific article

Conserved active site residues limit inhibition of a copper-containing nitrite reductase by small molecules

scientific article

Crystal structure of the soluble domain of the major anaerobically induced outer membrane protein (AniA) from pathogenic Neisseria: a new class of copper-containing nitrite reductases

scientific article

Crystallographic characterization of the passenger domain of the Bordetella autotransporter BrkA.

scientific article published on 22 May 2009

Crystallographic study of dioxygen chemistry in a copper-containing nitrite reductase from Geobacillus thermodenitrificans

scientific article published on 24 July 2018

Deciphering the Substrate Specificity of SbnA, the Enzyme Catalyzing the First Step in Staphyloferrin B Biosynthesis

scientific article

Directed evolution of copper nitrite reductase to a chromogenic reductant

scientific article

Directing the mode of nitrite binding to a copper-containing nitrite reductase from Alcaligenes faecalis S-6: Characterization of an active site isoleucine

scientific article

Discovery of an Iron-Regulated Citrate Synthase in Staphylococcus aureus

scientific article published on 01 December 2012

Effect of the methionine ligand on the reorganization energy of the type-1 copper site of nitrite reductase

scientific article

Electronic properties of the highly ruffled heme bound to the heme degrading enzyme IsdI.

scientific article

Ferritin is used for iron storage in bloom-forming marine pennate diatoms

scientific article

Haem recognition by a Staphylococcus aureus NEAT domain

scientific article

Helical shape of Helicobacter pylori requires an atypical glutamine as a zinc ligand in the carboxypeptidase Csd4

scientific article

Hemoglobin binding and catalytic heme extraction by IsdB near iron transporter domains

scientific article published on 01 April 2014

Identification of functionally important residues and structural features in a bacterial lignostilbene dioxygenase

scientific article published on 10 July 2019

Improved Manganese-Oxidizing Activity of DypB, a Peroxidase from a Lignolytic Bacterium

scientific article

Inactivation of the Heme Degrading Enzyme IsdI by an Active Site Substitution That Diminishes Heme Ruffling

scientific article

Iron Uptake Oxidoreductase (IruO) Uses a Flavin Adenine Dinucleotide Semiquinone Intermediate for Iron-Siderophore Reduction.

scientific article published on 2 May 2017

Iron core mineralisation in prokaryotic ferritins.

scientific article published on 11 April 2010

Iron-coordinating tyrosine is a key determinant of NEAT domain heme transfer ⬇️

scientific article published on August 26, 2011

IruO is a reductase for heme degradation by IsdI and IsdG proteins in Staphylococcus aureus.

scientific article published on 26 July 2013

Mechanism of Ferrous Iron Binding and Oxidation by Ferritin from a Pennate Diatom

scientific article

Monomer-dimer control and crystal engineering in TASPs.

scientific article

Raster3D Version 2.0. A program for photorealistic molecular graphics

scientific article (publication date: November 1994)

Reconstitution of the type-1 active site of the H145G/A variants of nitrite reductase by ligand insertion

scientific article (publication date: 15 April 2003)

Redox-coupled proton transfer mechanism in nitrite reductase revealed by femtosecond crystallography.

scientific article

Role of Rhodobacter sphaeroides Photosynthetic Reaction Center Residue M214 in the Composition, Absorbance Properties, and Conformations of HA and BA Cofactors ⬇️

scientific article published on March 25, 2013

Ruffling of Metalloporphyrins Bound to IsdG and IsdI, Two Heme-degrading Enzymes in Staphylococcus aureus

scientific article

S-nitrosation of Ca(2+)-loaded and Ca(2+)-free recombinant calbindin D(28K) from human brain.

scientific article

SbnG, a citrate synthase in Staphylococcus aureus: a new fold on an old enzyme.

scientific article

Side-on copper-nitrosyl coordination by nitrite reductase.

scientific article

Site-directed mutagenesis of azurin from Pseudomonas aeruginosa enhances the formation of an electron-transfer complex with a copper-containing nitrite reductase from Alcaligenes faecalis S-6

scientific article published on 01 September 1996

Specificity of Staphyloferrin B Recognition by the SirA Receptor from Staphylococcus aureus ⬇️

scientific article published on November 5, 2010

Specificity of the synergistic anion for iron binding by ferric binding protein from Neisseria gonorrhoeae.

scientific article published in July 2004

Stable copper-nitrosyl formation by nitrite reductase in either oxidation state

scientific article

Staphylococcus aureus heme and siderophore-iron acquisition pathways

scientific article published on 25 March 2019

Steric Mechanism of Auto-Inhibitory Regulation of Specific and Non-Specific DNA Binding by the ETS Transcriptional Repressor ETV6

scientific article

Structural and Mechanistic Studies of a Stabilized Subunit Dimer Variant of Escherichia coli Bacterioferritin Identify Residues Required for Core Formation

scientific article

Structural and kinetic properties of Rhodobacter sphaeroides photosynthetic reaction centers containing exclusively Zn-coordinated bacteriochlorophyll as bacteriochlorin cofactors

scientific article

Structure and function of P19, a high-affinity iron transporter of the human pathogen Campylobacter jejuni

scientific article

Structure and site-directed mutagenesis of a flavoprotein from Escherichia coli that reduces nitrocompounds: alteration of pyridine nucleotide binding by a single amino acid substitution

scientific article

Structure determination and analysis of yeast iso-2-cytochrome c and a composite mutant protein

scientific article published on September 5, 1992

Structure-function analyses reveal key features in Staphylococcus aureus IsdB-associated unfolding of the heme-binding pocket of human hemoglobin. ⬇️

scientific article

Surface-layer protein from Caulobacter crescentus: expression, purification and X-ray crystallographic analysis.

scientific article published on 9 August 2016

Synthesis of L-2,3-diaminopropionic acid, a siderophore and antibiotic precursor

scientific article

The B-type channel is a major route for iron entry into the ferroxidase center and central cavity of bacterioferritin.

scientific article

The IsdG-family of haem oxygenases degrades haem to a novel chromophore

scientific article

The Mannoprotein Cig1 supports iron acquisition from heme and virulence in the pathogenic fungus Cryptococcus neoformans.

scientific article published on 15 January 2013

The bacterial meta-cleavage hydrolase LigY belongs to the amidohydrolase superfamily, not to the α/β-hydrolase superfamily.

scientific article

The heme-sensitive regulator SbnI has a bifunctional role in staphyloferrin B production by Staphylococcus aureus

scientific article published on 13 June 2019

Two High-Resolution Crystal Structures of the Recombinant N-Lobe of Human Transferrin Reveal a Structural Change Implicated in Iron Release, ⬇️

scientific article published on June 2, 1998

Type-2 copper-containing enzymes.

scientific article published on November 2007

Unique Heme-Iron Coordination by the Hemoglobin Receptor IsdB of Staphylococcus aureus

scientific article

X-ray crystallography and mass spectroscopy reveal that the N-lobe of human transferrin expressed in Pichia pastoris is folded correctly but is glycosylated on serine-32

scientific article

List of works by M E Murphy

1.8 Å crystal structure of the major NAD(P)H:FMN oxidoreductase of a bioluminescent bacterium, Vibrio fischeri: overall structure, cofactor and substrate-analog binding, and comparison with related flavoproteins ⬇️

A Bacterial Cell Shape-Determining Inhibitor.

A Diatom Ferritin Optimized for Iron Oxidation but Not Iron Storage.

A Ferric-Peroxo Intermediate in the Oxidation of Heme by IsdI.

A bacterial surface layer protein exploits multistep crystallization for rapid self-assembly

A copper site is required for iron transport by the periplasmic proteins P19 and FetP

A rearranging ligand enables allosteric control of catalytic activity in copper-containing nitrite reductase.

Anion-independent iron coordination by the Campylobacter jejuni ferric binding protein.

Catalytic roles for two water bridged residues (Asp-98 and His-255) in the active site of copper-containing nitrite reductase

Characterization of a Dipartite Iron Uptake System from Uropathogenic Escherichia coli Strain F11 ⬇️

Characterization of a nucleotide-binding domain associated with neisserial iron transport.

Characterization of dye-decolorizing peroxidases from Rhodococcus jostii RHA1

Characterization of staphyloferrin A biosynthetic and transport mutants in Staphylococcus aureus

Cofacial heme binding is linked to dimerization by a bacterial heme transport protein

Consequences of factor IX mutations in 26 families with haemophilia B.

Conserved active site residues limit inhibition of a copper-containing nitrite reductase by small molecules

Crystal structure of the soluble domain of the major anaerobically induced outer membrane protein (AniA) from pathogenic Neisseria: a new class of copper-containing nitrite reductases

Crystallographic characterization of the passenger domain of the Bordetella autotransporter BrkA.

Crystallographic study of dioxygen chemistry in a copper-containing nitrite reductase from Geobacillus thermodenitrificans

Deciphering the Substrate Specificity of SbnA, the Enzyme Catalyzing the First Step in Staphyloferrin B Biosynthesis

Directed evolution of copper nitrite reductase to a chromogenic reductant

Directing the mode of nitrite binding to a copper-containing nitrite reductase from Alcaligenes faecalis S-6: Characterization of an active site isoleucine

Discovery of an Iron-Regulated Citrate Synthase in Staphylococcus aureus

Effect of the methionine ligand on the reorganization energy of the type-1 copper site of nitrite reductase

Electronic properties of the highly ruffled heme bound to the heme degrading enzyme IsdI.

Ferritin is used for iron storage in bloom-forming marine pennate diatoms

Haem recognition by a Staphylococcus aureus NEAT domain

Helical shape of Helicobacter pylori requires an atypical glutamine as a zinc ligand in the carboxypeptidase Csd4

Hemoglobin binding and catalytic heme extraction by IsdB near iron transporter domains

Identification of functionally important residues and structural features in a bacterial lignostilbene dioxygenase

Improved Manganese-Oxidizing Activity of DypB, a Peroxidase from a Lignolytic Bacterium

Inactivation of the Heme Degrading Enzyme IsdI by an Active Site Substitution That Diminishes Heme Ruffling

Iron Uptake Oxidoreductase (IruO) Uses a Flavin Adenine Dinucleotide Semiquinone Intermediate for Iron-Siderophore Reduction.

Iron core mineralisation in prokaryotic ferritins.

Iron-coordinating tyrosine is a key determinant of NEAT domain heme transfer ⬇️

IruO is a reductase for heme degradation by IsdI and IsdG proteins in Staphylococcus aureus.

Mechanism of Ferrous Iron Binding and Oxidation by Ferritin from a Pennate Diatom

Monomer-dimer control and crystal engineering in TASPs.

Raster3D Version 2.0. A program for photorealistic molecular graphics

Reconstitution of the type-1 active site of the H145G/A variants of nitrite reductase by ligand insertion

Redox-coupled proton transfer mechanism in nitrite reductase revealed by femtosecond crystallography.

Role of Rhodobacter sphaeroides Photosynthetic Reaction Center Residue M214 in the Composition, Absorbance Properties, and Conformations of HA and BA Cofactors ⬇️

Ruffling of Metalloporphyrins Bound to IsdG and IsdI, Two Heme-degrading Enzymes in Staphylococcus aureus

S-nitrosation of Ca(2+)-loaded and Ca(2+)-free recombinant calbindin D(28K) from human brain.

SbnG, a citrate synthase in Staphylococcus aureus: a new fold on an old enzyme.

Side-on copper-nitrosyl coordination by nitrite reductase.

Site-directed mutagenesis of azurin from Pseudomonas aeruginosa enhances the formation of an electron-transfer complex with a copper-containing nitrite reductase from Alcaligenes faecalis S-6

Specificity of Staphyloferrin B Recognition by the SirA Receptor from Staphylococcus aureus ⬇️

Specificity of the synergistic anion for iron binding by ferric binding protein from Neisseria gonorrhoeae.

Stable copper-nitrosyl formation by nitrite reductase in either oxidation state

Staphylococcus aureus heme and siderophore-iron acquisition pathways

Steric Mechanism of Auto-Inhibitory Regulation of Specific and Non-Specific DNA Binding by the ETS Transcriptional Repressor ETV6

Structural and Mechanistic Studies of a Stabilized Subunit Dimer Variant of Escherichia coli Bacterioferritin Identify Residues Required for Core Formation

Structural and kinetic properties of Rhodobacter sphaeroides photosynthetic reaction centers containing exclusively Zn-coordinated bacteriochlorophyll as bacteriochlorin cofactors

Structure and function of P19, a high-affinity iron transporter of the human pathogen Campylobacter jejuni

Structure and site-directed mutagenesis of a flavoprotein from Escherichia coli that reduces nitrocompounds: alteration of pyridine nucleotide binding by a single amino acid substitution

Structure determination and analysis of yeast iso-2-cytochrome c and a composite mutant protein

Structure-function analyses reveal key features in Staphylococcus aureus IsdB-associated unfolding of the heme-binding pocket of human hemoglobin. ⬇️

Surface-layer protein from Caulobacter crescentus: expression, purification and X-ray crystallographic analysis.

Synthesis of L-2,3-diaminopropionic acid, a siderophore and antibiotic precursor

The B-type channel is a major route for iron entry into the ferroxidase center and central cavity of bacterioferritin.

The IsdG-family of haem oxygenases degrades haem to a novel chromophore

The Mannoprotein Cig1 supports iron acquisition from heme and virulence in the pathogenic fungus Cryptococcus neoformans.

The bacterial meta-cleavage hydrolase LigY belongs to the amidohydrolase superfamily, not to the α/β-hydrolase superfamily.

The heme-sensitive regulator SbnI has a bifunctional role in staphyloferrin B production by Staphylococcus aureus

Two High-Resolution Crystal Structures of the Recombinant N-Lobe of Human Transferrin Reveal a Structural Change Implicated in Iron Release, ⬇️

Type-2 copper-containing enzymes.

Unique Heme-Iron Coordination by the Hemoglobin Receptor IsdB of Staphylococcus aureus

X-ray crystallography and mass spectroscopy reveal that the N-lobe of human transferrin expressed in Pichia pastoris is folded correctly but is glycosylated on serine-32