List of works by Alex Sparreboom

4β-hydroxycholesterol as an endogenous CYP3A marker in cancer patients treated with taxanes

scientific article

A CYP3A4 phenotype-based dosing algorithm for individualized treatment of irinotecan

scientific article

A long-term prospective population pharmacokinetic study on imatinib plasma concentrations in GIST patients

scientific article

A pharmacogenetic predictive model for paclitaxel clearance based on the DMET platform

scientific article published on 5 August 2013

A phase II study of perifosine in androgen independent prostate cancer

scientific article published in October 2005

A phosphotyrosine switch regulates organic cation transporters ⬇️

scientific article published on 16 March 2016

ABCB1 genetic variation influences the toxicity and clinical outcome of patients with androgen-independent prostate cancer treated with docetaxel

scientific article published on July 2008

ABCG2 pharmacogenetics: ethnic differences in allele frequency and assessment of influence on irinotecan disposition

scientific article

Altered irinotecan metabolism in a patient receiving phenytoin

scientific article published in February 2002

Appropriate chemotherapy dosing for obese adult patients with cancer: American Society of Clinical Oncology clinical practice guideline

scientific article

Appropriate chemotherapy dosing in obese patients with cancer

scientific article published on 8 October 2013

Association of ABCB1 genotypes with paclitaxel-mediated peripheral neuropathy and neutropenia

scientific article

Association of Paclitaxel pharmacokinetics with the development of peripheral neuropathy in patients with advanced cancer

scientific article published in July 2005

Association of a CYP17 polymorphism with overall survival in Caucasian patients with androgen-independent prostate cancer

scientific article

Association of breast cancer resistance protein/ABCG2 phenotypes and novel promoter and intron 1 single nucleotide polymorphisms

scientific article published on 7 January 2008

Association of enzyme and transporter genotypes with the pharmacokinetics of imatinib

scientific article published on August 2006

Association of the CYP1B1*3 allele with survival in patients with prostate cancer receiving docetaxel

scientific article

BSA-based dosing and alternative approaches

scientific article published in June 2005

CCR 20th anniversary commentary: BMS-247550—microtubule stabilization as successful targeted therapy

scientific article

Can "specific" OCT1 inhibitors be used to determine OCT1 transporter activity toward imatinib?

scientific article published in June 2013

Castration-dependent pharmacokinetics of docetaxel in patients with prostate cancer

scientific article

Cellular uptake of imatinib into leukemic cells is independent of human organic cation transporter 1 (OCT1).

scientific article published on 18 December 2013

Chemically modified tetracyclines as inhibitors of matrix metalloproteinases

scientific article published in June 2004

Chemotherapy dosing in overweight and obese patients with cancer

scientific article published on 16 July 2013

Chronic imatinib mesylate exposure leads to reduced intracellular drug accumulation by induction of the ABCG2 (BCRP) and ABCB1 (MDR1) drug transport pumps

scientific article published on 9 July 2005

Cigarette smoking and irinotecan treatment: pharmacokinetic interaction and effects on neutropenia

scientific article

Cisplatin-Induced Downregulation of OCTN2 Affects Carnitine Wasting ⬇️

scientific article published on September 21, 2010

Clinical and molecular responses in lung cancer patients receiving Romidepsin

scientific article

Clinical pharmacokinetics of docetaxel : recent developments

scientific article

Clinical pharmacokinetics of irinotecan and its metabolites in relation with diarrhea

scientific article published in September 2002

Clinical pharmacokinetics of irinotecan and its metabolites: a population analysis

scientific article published in August 2002

Clinical pharmacokinetics of unbound docetaxel: role of polysorbate 80 and serum proteins

scientific article published in October 2003

Clinical studies of camptothecin and derivatives

scientific article published on January 1, 2003

Comparative in vitro properties and clinical pharmacokinetics of Paclitaxel following the administration of taxol(r) and paxene(r).

scientific article published on 10 May 2005

Comparative pharmacokinetics of unbound paclitaxel during 1- and 3-hour infusions

scientific article published in January 2002

Comparative preclinical and clinical pharmacokinetics of a cremophor-free, nanoparticle albumin-bound paclitaxel (ABI-007) and paclitaxel formulated in Cremophor (Taxol).

scientific article published in June 2005

Contribution of ABCC4-mediated gastric transport to the absorption and efficacy of dasatinib

scientific article published on 21 June 2013

Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide

scientific article published on 22 January 2013

Contribution of tumoral and host solute carriers to clinical drug response

scientific article

Contributors

Deoxycytidine kinase modulates the impact of the ABC transporter ABCG2 on clofarabine cytotoxicity

scientific article

Determination of 2-methoxyestradiol in human plasma, using liquid chromatography/tandem mass spectrometry

scientific article

Determination of CC-5013, an analogue of thalidomide, in human plasma by liquid chromatography-mass spectrometry

scientific article published in November 2004

Determination of MS-275, a novel histone deacetylase inhibitor, in human plasma by liquid chromatography-electrospray mass spectrometry

scientific article published in May 2004

Determination of SU5416, a novel angiogenesis inhibitor, in human plasma by liquid chromatography

scientific article published in June 2004

Determination of fraction unbound docetaxel using microequilibrium dialysis

scientific article published in August 2004

Determination of irinotecan (CPT-11) and SN-38 in human whole blood and red blood cells by liquid chromatography with fluorescence detection ⬇️

scientific article published on October 5, 2003

Determination of midazolam in human plasma by liquid chromatography with mass-spectrometric detection

scientific article

Determination of the antiangiogenesis agent 2-methoxyestradiol in human plasma by liquid chromatography with ultraviolet detection

scientific article

Determination of the cyclic depsipeptide FK228, a histone deacetylase inhibitor, by liquid chromatography-mass spectrometry

scientific article

Determination of the docetaxel vehicle, polysorbate 80, in patient samples by liquid chromatography-tandem mass spectrometry

scientific article published in June 2002

Determination of the heat shock protein 90 inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin in plasma by liquid chromatography-electrospray mass spectrometry

scientific article published on 2 November 2005

Determination of topotecan in human whole blood and unwashed erythrocytes by high-performance liquid chromatography

scientific article published in January 2002

Determining the optimal dose in the development of anticancer agents

scientific article published on 25 March 2014

Development and validation of an analytical method for regorafenib and its metabolites in mouse plasma.

scientific article

Diflomotecan pharmacokinetics in relation to ABCG2 421C>A genotype

scientific article

Disposition of docosahexaenoic acid-paclitaxel, a novel taxane, in blood: in vitro and clinical pharmacokinetic studies.

scientific article

Distribution of paclitaxel in plasma and cerebrospinal fluid

scientific article published in June 2003

Does P-glycoprotein play a role in anticancer drug pharmacokinetics?

scientific article published on December 2000

Drug transporters and imatinib treatment: implications for clinical practice

scientific article

Effect of ABCG2 genotype on the oral bioavailability of topotecan

scientific article published on 11 June 2005

Effect of SLCO1B3 haplotype on testosterone transport and clinical outcome in caucasian patients with androgen-independent prostatic cancer

scientific article

Effect of common CYP3A4 and CYP3A5 variants on the pharmacokinetics of the cytochrome P450 3A phenotyping probe midazolam in cancer patients

scientific article published in October 2005

Effect of cytochrome P450 3A4 inhibition on the pharmacokinetics of docetaxel

scientific article

Effect of milk thistle (Silybum marianum) on the pharmacokinetics of irinotecan

scientific article published in November 2005

Effect of valspodar on the pharmacokinetics of unbound paclitaxel ⬇️

scientific article published on August 1, 2003

Effects of Mannose-Binding Lectin Polymorphisms on Irinotecan-Induced Febrile Neutropenia ⬇️

scientific article published on October 7, 2010

Effects of St. John's wort on irinotecan metabolism

scientific article published in August 2002

Effects of alpha1-acid glycoprotein on the clinical pharmacokinetics of 7-hydroxystaurosporine

scientific article published in October 2004

Evaluation of alternate size descriptors for dose calculation of anticancer drugs in the obese

scientific article

Evaluation of an alternate dosing strategy for cisplatin in patients with extreme body surface area values

scientific article

Evaluation of biologic end points and pharmacokinetics in patients with metastatic breast cancer after treatment with erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor

scientific article

Factors affecting the pharmacokinetic profile of MS-275, a novel histone deacetylase inhibitor, in patients with cancer

scientific article published in September 2006

Flat-fixed dosing of irinotecan: influence on pharmacokinetic and pharmacodynamic variability

scientific article

Flat-fixed dosing versus body surface area based dosing of anticancer drugs in adults: does it make a difference?

scientific article

Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects

scientific article

Hepatic uptake transporters and docetaxel disposition in mice-letter

scientific article published on 11 June 2014

Herbal remedies in the United States: potential adverse interactions with anticancer agents

scientific article published on June 2004

Human OCT2 variant c.808G>T confers protection effect against cisplatin-induced ototoxicity

scientific article

Human immunodeficiency virus protease inhibitors interact with ATP binding cassette transporter 4/multidrug resistance protein 4: a basis for unanticipated enhanced cytotoxicity

scientific article published on 17 June 2013

Identification of OATP1B3 as a high-affinity hepatocellular transporter of paclitaxel

scientific article

Impact of ABCB1 allelic variants on QTc interval prolongation

scientific article

Impact of Membrane Drug Transporters on Resistance to Small-Molecule Tyrosine Kinase Inhibitors

scientific article published on 19 September 2016

Impact of body-size measures on irinotecan clearance: alternative dosing recommendations

scientific article published in January 2002

Indirect determination of the irinotecan metabolite 7-ethyl-10-O-glucuronyl-camptothecin in human samples

scientific article

Induction of CYP3A4 by Vinblastine: Role of the Nuclear Receptor NR1I2 ⬇️

scientific article published on October 19, 2010

Influence of CYP3A4 inhibition on the steady-state pharmacokinetics of imatinib

scientific article

Influence of Cremophor El on the bioavailability of intraperitoneal paclitaxel

scientific article published in April 2002

Influence of Oct1/Oct2-deficiency on cisplatin-induced changes in urinary N-acetyl-beta-D-glucosaminidase

scientific article

Influence of drug formulation on OATP1B-mediated transport of paclitaxel

scientific article published on 22 April 2014

Influence of garlic (Allium sativum) on the pharmacokinetics of docetaxel

scientific article

Influence of genetic variants in UGT1A1 and UGT1A9 on the in vivo glucuronidation of SN-38.

scientific article

Influence of polymorphic OATP1B-type carriers on the disposition of docetaxel

scientific article

Influence of the dual ABCB1 and ABCG2 inhibitor tariquidar on the disposition of oral imatinib in mice

scientific article published on 10 July 2009

Inhibition of OCTN2-mediated transport of carnitine by etoposide

scientific article

Inhibition of imatinib transport by uremic toxins during renal failure

scientific article published in September 2008

Inter-patient variability in docetaxel pharmacokinetics: A review

scientific article published on 07 May 2015

Interaction of Cisplatin with the human organic cation transporter 2.

scientific article published in June 2008

Interaction of imatinib with human organic ion carriers

scientific article

Interaction of the multikinase inhibitors sorafenib and sunitinib with solute carriers and ATP-binding cassette transporters

scientific article published on 22 September 2009

Interspecies differences in plasma protein binding of MS-275, a novel histone deacetylase inhibitor

scientific article published on 19 July 2005

Irinotecan pathway genotype analysis to predict pharmacokinetics

scientific journal article

Kinase Inhibitors: The Reality Behind the Success

scientific article published on 10 August 2017

Lack of ABC transporter autoinduction in mice following long-term exposure to imatinib

scientific article

Lifestyle habits as a contributor to anti-cancer treatment failure

scientific article

Limited cerebrospinal fluid penetration of docetaxel

scientific article

Liquid chromatographic assays for DE-310, a novel camptothecin analog, and two major enzymatic products in human matrices

scientific article published in January 2004

Liquid-chromatographic determination of erlotinib (OSI-774), an epidermal growth factor receptor tyrosine kinase inhibitor

scientific article published in October 2003

Lysosomal Sequestration Determines Intracellular Imatinib Levels

scientific article

Mechanism-based models for topotecan-induced neutropenia

scientific article published in December 2004

Mechanisms of resistance to anticancer drugs: the role of the polymorphic ABC transporters ABCB1 and ABCG2.

scientific article

Medicinal cannabis does not influence the clinical pharmacokinetics of irinotecan and docetaxel

scientific article

Medicinal cannabis in oncology practice: still a bridge too far?

scientific article

Modeling mechanisms of in vivo variability in methotrexate accumulation and folate pathway inhibition in acute lymphoblastic leukemia cells

scientific article

Modulation of OATP1B-type transporter function alters cellular uptake and disposition of platinum chemotherapeutics

scientific article published on 11 June 2013

Modulation of cytochrome P450 activity: implications for cancer therapy

scientific article

Modulation of irinotecan metabolism by ketoconazole

scientific article published in July 2002

Multikinase Inhibitors Induce Cutaneous Toxicity through OAT6-Mediated Uptake and MAP3K7-Driven Cell Death

scientific article

New directions in cancer research 2003: technological advances in biology, drug resistance, and molecular pharmacology

scientific article published in December 2003

O(6)-methylguanine-DNA methyltransferase (MGMT) as a determinant of resistance to camptothecin derivatives

scientific article published in January 2002

OCTN1 Is a High-Affinity Carrier of Nucleoside Analogues

scientific article published on 16 February 2017

Oral bioavailability of a novel paclitaxel formulation (Genetaxyl) administered with cyclosporin A in cancer patients

scientific article published on March 2008

Organic anion transporting polypeptide 1B transporters modulate hydroxyurea pharmacokinetics

scientific article published on 28 August 2013

Oxaliplatin-induced neurotoxicity is dependent on the organic cation transporter OCT2

scientific article published on 17 June 2013

Paclitaxel chemotherapy: from empiricism to a mechanism-based formulation strategy

scientific article

Paclitaxel pharmacokinetics and response to chemotherapy in patients with advanced cancer treated with a weekly regimen

scientific article

Paclitaxel pharmacokinetics, threshold models, and dosing strategies.

scientific article published in July 2003

Peripheral neuropathy induced by paclitaxel: recent insights and future perspectives

scientific article published on April 2006

Peripheral neuropathy: a persisting challenge in paclitaxel-based regimes

scientific article

PharmGKB summary: Macrolide antibiotic pathway, pharmacokinetics/pharmacodynamics

scientific article published on 31 January 2017

Pharmacogenetic profiling across the irinotecan pathway in Asian patients with cancer

scientific article published in April 2005

Pharmacogenetics and regulation of human cytochrome P450 1B1: implications in hormone-mediated tumor metabolism and a novel target for therapeutic intervention

scientific article

Pharmacogenetics of estrogen metabolism and transport in relation to cancer

scientific article published on December 2003

Pharmacogenetics of irinotecan disposition and toxicity: a review

scientific article published on August 2010

Pharmacogenetics of irinotecan metabolism and transport: an update

scientific article

Pharmacogenetics of the organic anion transporting polypeptide 1A2

scientific article published on March 2009

Pharmacogenetics of tipifarnib (R115777) transport and metabolism in cancer patients

scientific article

Pharmacogenomic importance of ABCG2.

scientific article published on August 2008

Pharmacokinetics, pharmacodynamics, and pharmacogenetics of hydroxyurea treatment for children with sickle cell anemia

scientific article published on 29 August 2011

Pharmacological effects of formulation vehicles : implications for cancer chemotherapy

scientific article published in January 2003

Pharmacology of topoisomerase I inhibitors irinotecan (CPT-11) and topotecan

scientific article published in June 2002

Phase 1 and pharmacologic study of MS-275, a histone deacetylase inhibitor, in adults with refractory and relapsed acute leukemias

scientific article published on April 2007

Phase I and pharmacokinetic study of DE-310 in patients with advanced solid tumors.

scientific article

Phase I and pharmacokinetic study of MS-275, a histone deacetylase inhibitor, in patients with advanced and refractory solid tumors or lymphoma

scientific article published on 25 April 2005

Phase I and pharmacokinetic study of brostallicin (PNU-166196), a new DNA minor-groove binder, administered intravenously every 3 weeks to adult patients with metastatic cancer

scientific article published in August 2003

Phase I and pharmacokinetic study of oral irinotecan given once daily for 5 days every 3 weeks in combination with capecitabine in patients with solid tumors

scientific article

Phase I and pharmacokinetic study of the polyamine synthesis inhibitor SAM486A in combination with 5-fluorouracil/leucovorin in metastatic colorectal cancer

scientific article

Phase I and pharmacologic study of liposomal lurtotecan, NX 211: urinary excretion predicts hematologic toxicity

scientific article published in March 2002

Phase I and pharmacologic study of oral ZD9331, a novel nonpolyglutamated thymidylate synthase inhibitor, in adult patients with solid tumors

scientific article published in April 2002

Phase I clinical trial of oral 2-methoxyestradiol, an antiangiogenic and apoptotic agent, in patients with solid tumors

scientific article published on 22 January 2006

Phase I pharmacokinetic, food effect, and pharmacogenetic study of oral irinotecan given as semisolid matrix capsules in patients with solid tumors

scientific article

Phase I trial of the cyclin-dependent kinase inhibitor flavopiridol in combination with docetaxel in patients with metastatic breast cancer

scientific article

Polymorphic transporters and platinum pharmacodynamics

scientific article published on 18 September 2012

Population pharmacokinetics of cisplatin in adult cancer patients

scientific article

Preclinical evaluation of alternative pharmaceutical delivery vehicles for paclitaxel

scientific article published in August 2002

Prediction of irinotecan pharmacokinetics by use of cytochrome P450 3A4 phenotyping probes

scientific article published in November 2004

Prophylaxis of irinotecan-induced diarrhea with neomycin and potential role for UGT1A1*28 genotype screening: a double-blind, randomized, placebo-controlled study

scientific article

Proximal tubular secretion of creatinine by organic cation transporter OCT2 in cancer patients

scientific article published on 5 January 2012

Quantitative and Mechanistic Understanding of AZD1775 Penetration across Human Blood-Brain Barrier in Glioblastoma Patients Using an IVIVE-PBPK Modeling Approach

scientific article

Randomized cross-over evaluation of body-surface area-based dosing versus flat-fixed dosing of paclitaxel

scientific article published in January 2003

Randomized crossover pharmacokinetic study of solvent-based paclitaxel and nab-paclitaxel

scientific article published on July 2008

Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition

scientific article published on 6 December 2011

Rational development of histone deacetylase inhibitors as anticancer agents: a review

scientific article

Red blood cells: a neglected compartment in topotecan pharmacokinetic analysis

scientific article published in March 2003

Relationship of systemic exposure to unbound docetaxel and neutropenia.

scientific article published on January 2005

Repeated administrations of interleukin (IL)-12 are associated with persistently elevated plasma levels of IL-10 and declining IFN-gamma, tumor necrosis factor-alpha, IL-6, and IL-8 responses.

scientific article

Review of UCN-01 development: a lesson in the importance of clinical pharmacology

scientific article

Role of body surface area in dosing of investigational anticancer agents in adults, 1991-2001.

scientific article

Role of the liver-specific transporters OATP1B1 and OATP1B3 in governing drug elimination

scientific article published on October 2005

Shortening infusion time for high-dose methotrexate alters antileukemic effects: a randomized prospective clinical trial

scientific article

Simultaneous analysis of docetaxel and the formulation vehicle polysorbate 80 in human plasma by liquid chromatography/tandem mass spectrometry

scientific article published in January 2004

Structural identification and biological activity of 7-methyl-10,11-ethylenedioxy-20(S)-camptothecin, a photodegradant of lurtotecan

scientific article published in March 2002

Subcutaneous injection of interleukin 12 induces systemic inflammatory responses in humans: implications for the use of IL-12 as vaccine adjuvant

scientific article

Taxane-mediated antiangiogenesis in vitro: influence of formulation vehicles and binding proteins

scientific article published in February 2004

The role of drug-metabolising enzymes in clinical responses to chemotherapy

scientific article published on February 2006

Toward individualized treatment: prediction of anticancer drug disposition and toxicity with pharmacogenetics

scientific article published on February 2007

Transcellular movement of hydroxyurea is mediated by specific solute carrier transporters

scientific article published on 21 January 2011

Uptake carriers and oncology drug safety

scientific article published on 30 December 2013

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