List of works - Uwe-Karsten Hanisch

A paediatric supratentorial primitive neuroectodermal tumour associated with malignant astrocytic transformation and a clonal origin of both components

scientific article published on 27 February 2007

A presumed antagonistic LPS identifies distinct functional organization of TLR4 in mouse microglia

scientific article published on 4 May 2017

Activation of microglial cells by thrombin: past, present, and future

scientific article

Activin A increases phagocytosis of Escherichia coli K1 by primary murine microglial cells activated by toll-like receptor agonists.

scientific article published on 7 June 2018

CD11c-positive cells from brain, spleen, lung, and liver exhibit site-specific immune phenotypes and plastically adapt to new environments

scientific article published on 3 December 2014

CD14 is a key organizer of microglial responses to CNS infection and injury

scientific article published on 18 December 2015

Carcinoma cells misuse the host tissue damage response to invade the brain ⬇️

scientific article published on July 6, 2013

Coating of titanium implants with type-I collagen

scientific article published in September 2004

Coculture system with an organotypic brain slice and 3D spheroid of carcinoma cells

scientific article published on 09 October 2013

Comparative analysis of inter- and intraligamentous distribution of sensory nerve endings in ankle ligaments: a cadaver study.

scientific article

Complement receptor-3 negatively regulates the phagocytosis of degenerated myelin through tyrosine kinase Syk and cofilin

scientific article

Distinct and Nonredundant In Vivo Functions of IFNAR on Myeloid Cells Limit Autoimmunity in the Central Nervous System

Empty liposomes induce antitumoral effects associated with macrophage responses distinct from those of the TLR1/2 agonist Pam3CSK4 (BLP) ⬇️

scientific article published on August 6, 2013

Erythropoietin dampens injury-induced microglial motility

scientific article

Evaluation of bone remodeling in regard to the age of scaphoid non-unions

scientific article

Ex Vivo Intra-arterial Methylene Blue Injection in Rectal Cancer Specimens Increases the Lymph-Node Harvest, Especially After Preoperative Radiation

scientific article published on 27 August 2015

Expression of coagulation factors and their receptors in tumor tissue and coagulation factor upregulation in peripheral blood of patients with cerebral carcinoma metastases ⬇️

scientific article published on November 8, 2011

Expression of proteinase-activated receptors in mouse microglial cells

scientific article published in December 2003

FK506 protects against various immune responses and secondary degeneration following cerebral ischemia

scientific article published in December 2009

Fibronectin stimulates Escherichia coli phagocytosis by microglial cells

scientific article

Functional diversity of microglia – how heterogeneous are they to begin with? ⬇️

scientific article published on May 14, 2013

Higher mortality and impaired elimination of bacteria in aged mice after intracerebral infection with E. coli are associated with an age-related decline of microglia and macrophage functions

scientific article

Histone deacetylase inhibitors suppress immune activation in primary mouse microglia ⬇️

scientific article published on May 17, 2013

In vivo wear rate of the Birmingham Hip Resurfacing arthroplasty. A review of 10 retrieved components

scientific article published on 30 August 2008

Inflammatory chemokine release of astrocytes in vitro is reduced by all-trans retinoic acid

scientific article published on 16 June 2010

Inflammatory cytokine release of astrocytes in vitro is reduced by all-trans retinoic acid ⬇️

scientific article published on September 9, 2010

Influence of intrathecal delivery of bone marrow-derived mesenchymal stem cells on spinal inflammation and pain hypersensitivity in a rat model of peripheral nerve injury

scientific article

Influence of methylene blue on microglia-induced inflammation and motor neuron degeneration in the SOD1(G93A) model for ALS.

scientific article

Inhibition of Rho-dependent pathways by Clostridium botulinum C3 protein induces a proinflammatory profile in microglia

scientific article published in August 2008

Interferon-gamma differentially modulates the release of cytokines and chemokines in lipopolysaccharide- and pneumococcal cell wall-stimulated mouse microglia and macrophages

scientific article published in December 2002

Intraperitoneal prophylaxis with CpG oligodeoxynucleotides protects neutropenic mice against intracerebral Escherichia coli K1 infection

scientific article published on 23 January 2014

Laquinimod prevents cuprizone-induced demyelination independent of Toll-like receptor signaling

scientific article published on 17 May 2016

Lipopolysaccharide is a frequent and significant contaminant in microglia-activating factors

scientific article

Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine

scientific article

Microglia as a source and target of cytokines

scientific article

Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions

scientific article published on 18 November 2007

Microglia promote colonization of brain tissue by breast cancer cells in a Wnt-dependent way.

scientific article published in September 2010

Microglial diversity by responses and responders

scientific article published on April 2014

Microglial phenotype: is the commitment reversible?

scientific article

Neo-capsule tissue reactions in metal-on-metal hip arthroplasty

scientific article published on April 2007

Overexpression of protease-activated receptor type 1 (PAR-1) in glioblastoma multiforme WHO IV cells and blood vessels revealed by NCAM-assisted glioblastoma border labeling.

scientific article

Proteins in microglial activation--inputs and outputs by subsets

scientific article published on February 2013

Purinergic receptors on microglial cells: functional expression in acute brain slices and modulation of microglial activation in vitro

scientific article published in June 2003

Reduced astrocytic NF-κB activation by laquinimod protects from cuprizone-induced demyelination ⬇️

scientific article published on July 6, 2012

Resistance of the brain to Escherichia coli K1 infection depends on MyD88 signaling and the contribution of neutrophils and monocytes

scientific article published on 11 March 2013

Streptococcus pneumoniae Infection aggravates experimental autoimmune encephalomyelitis via Toll-like receptor 2.

scientific article

T cell-dependence of Lassa fever pathogenesis

scientific article

TLR4-activated microglia require IFN-γ to induce severe neuronal dysfunction and death in situ

scientific article

TRPM3 is expressed in sphingosine-responsive myelinating oligodendrocytes

scientific article published on 15 February 2010

The c-Jun N-terminal kinases in cerebral microglia: immunological functions in the brain

scientific article

The microglia-activating potential of thrombin: the protease is not involved in the induction of proinflammatory cytokines and chemokines

scientific article published on 27 September 2004

The tyrosine kinase inhibitor AG126 restores receptor signaling and blocks release functions in activated microglia (brain macrophages) by preventing a chronic rise in the intracellular calcium level

scientific article

The viral TLR3 agonist poly(I:C) stimulates phagocytosis and intracellular killing of Escherichia coli by microglial cells

scientific article

Therapeutic and adverse effects of a non-steroidal glucocorticoid receptor ligand in a mouse model of multiple sclerosis

scientific article

Thioredoxins and Methionine Sulfoxide Reductases in the Pathophysiology of Pneumococcal Meningitis

scientific article published on July 2016

Thrombin regulates CD40 expression in microglial cells

scientific article published in May 2008

Thrombin-induced regulation of CD95(Fas) expression in the N9 microglial cell line: evidence for involvement of proteinase-activated receptor(1) and extracellular signal-regulated kinase 1/2.

scientific article

Toll-like receptor activation reveals developmental reorganization and unmasks responder subsets of microglia

scientific article published on 21 August 2012

Toll-like receptor prestimulation increases phagocytosis of Escherichia coli DH5alpha and Escherichia coli K1 strains by murine microglial cells

scientific article

Toll-like receptor stimulation enhances phagocytosis and intracellular killing of nonencapsulated and encapsulated Streptococcus pneumoniae by murine microglia

scientific article published on 23 November 2009

Treatment with 5-azacitidine delay growth of glioblastoma xenografts: a potential new treatment approach for glioblastomas

scientific article published on 9 February 2018

Tyrosine kinase inhibition reduces inflammation in the acute stage of experimental pneumococcal meningitis

scientific article

Tyrphostin AG126 exerts neuroprotection in CNS inflammation by a dual mechanism.

scientific article published on 2 March 2015

Unraveling thrombin's true microglia-activating potential: markedly disparate profiles of pharmaceutical-grade and commercial-grade thrombin preparations

scientific article published in November 2005

Vitamin d deficiency reduces the immune response, phagocytosis rate, and intracellular killing rate of microglial cells

scientific article published on 31 March 2014

Zoledronic acid inhibits macrophage/microglia-assisted breast cancer cell invasion

scientific article published on September 2013

c-Jun N-terminal kinases (JNKs) mediate pro-inflammatory actions of microglia

scientific article

List of works by Uwe-Karsten Hanisch

A paediatric supratentorial primitive neuroectodermal tumour associated with malignant astrocytic transformation and a clonal origin of both components

A presumed antagonistic LPS identifies distinct functional organization of TLR4 in mouse microglia

Activation of microglial cells by thrombin: past, present, and future

Activin A increases phagocytosis of Escherichia coli K1 by primary murine microglial cells activated by toll-like receptor agonists.

CD11c-positive cells from brain, spleen, lung, and liver exhibit site-specific immune phenotypes and plastically adapt to new environments

CD14 is a key organizer of microglial responses to CNS infection and injury

Carcinoma cells misuse the host tissue damage response to invade the brain ⬇️

Coating of titanium implants with type-I collagen

Coculture system with an organotypic brain slice and 3D spheroid of carcinoma cells

Comparative analysis of inter- and intraligamentous distribution of sensory nerve endings in ankle ligaments: a cadaver study.

Complement receptor-3 negatively regulates the phagocytosis of degenerated myelin through tyrosine kinase Syk and cofilin

Distinct and Nonredundant In Vivo Functions of IFNAR on Myeloid Cells Limit Autoimmunity in the Central Nervous System

Empty liposomes induce antitumoral effects associated with macrophage responses distinct from those of the TLR1/2 agonist Pam3CSK4 (BLP) ⬇️

Erythropoietin dampens injury-induced microglial motility

Evaluation of bone remodeling in regard to the age of scaphoid non-unions

Ex Vivo Intra-arterial Methylene Blue Injection in Rectal Cancer Specimens Increases the Lymph-Node Harvest, Especially After Preoperative Radiation

Expression of coagulation factors and their receptors in tumor tissue and coagulation factor upregulation in peripheral blood of patients with cerebral carcinoma metastases ⬇️

Expression of proteinase-activated receptors in mouse microglial cells

FK506 protects against various immune responses and secondary degeneration following cerebral ischemia

Fibronectin stimulates Escherichia coli phagocytosis by microglial cells

Functional diversity of microglia – how heterogeneous are they to begin with? ⬇️

Higher mortality and impaired elimination of bacteria in aged mice after intracerebral infection with E. coli are associated with an age-related decline of microglia and macrophage functions

Histone deacetylase inhibitors suppress immune activation in primary mouse microglia ⬇️

In vivo wear rate of the Birmingham Hip Resurfacing arthroplasty. A review of 10 retrieved components

Inflammatory chemokine release of astrocytes in vitro is reduced by all-trans retinoic acid

Inflammatory cytokine release of astrocytes in vitro is reduced by all-trans retinoic acid ⬇️

Influence of intrathecal delivery of bone marrow-derived mesenchymal stem cells on spinal inflammation and pain hypersensitivity in a rat model of peripheral nerve injury

Influence of methylene blue on microglia-induced inflammation and motor neuron degeneration in the SOD1(G93A) model for ALS.

Inhibition of Rho-dependent pathways by Clostridium botulinum C3 protein induces a proinflammatory profile in microglia

Interferon-gamma differentially modulates the release of cytokines and chemokines in lipopolysaccharide- and pneumococcal cell wall-stimulated mouse microglia and macrophages

Intraperitoneal prophylaxis with CpG oligodeoxynucleotides protects neutropenic mice against intracerebral Escherichia coli K1 infection

Laquinimod prevents cuprizone-induced demyelination independent of Toll-like receptor signaling

Lipopolysaccharide is a frequent and significant contaminant in microglia-activating factors

Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine

Microglia as a source and target of cytokines

Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions

Microglia promote colonization of brain tissue by breast cancer cells in a Wnt-dependent way.

Microglial diversity by responses and responders

Microglial phenotype: is the commitment reversible?

Neo-capsule tissue reactions in metal-on-metal hip arthroplasty

Overexpression of protease-activated receptor type 1 (PAR-1) in glioblastoma multiforme WHO IV cells and blood vessels revealed by NCAM-assisted glioblastoma border labeling.

Proteins in microglial activation--inputs and outputs by subsets

Purinergic receptors on microglial cells: functional expression in acute brain slices and modulation of microglial activation in vitro

Reduced astrocytic NF-κB activation by laquinimod protects from cuprizone-induced demyelination ⬇️

Resistance of the brain to Escherichia coli K1 infection depends on MyD88 signaling and the contribution of neutrophils and monocytes

Streptococcus pneumoniae Infection aggravates experimental autoimmune encephalomyelitis via Toll-like receptor 2.

T cell-dependence of Lassa fever pathogenesis

TLR4-activated microglia require IFN-γ to induce severe neuronal dysfunction and death in situ

TRPM3 is expressed in sphingosine-responsive myelinating oligodendrocytes

The c-Jun N-terminal kinases in cerebral microglia: immunological functions in the brain

The microglia-activating potential of thrombin: the protease is not involved in the induction of proinflammatory cytokines and chemokines

The tyrosine kinase inhibitor AG126 restores receptor signaling and blocks release functions in activated microglia (brain macrophages) by preventing a chronic rise in the intracellular calcium level

The viral TLR3 agonist poly(I:C) stimulates phagocytosis and intracellular killing of Escherichia coli by microglial cells

Therapeutic and adverse effects of a non-steroidal glucocorticoid receptor ligand in a mouse model of multiple sclerosis

Thioredoxins and Methionine Sulfoxide Reductases in the Pathophysiology of Pneumococcal Meningitis

Thrombin regulates CD40 expression in microglial cells

Thrombin-induced regulation of CD95(Fas) expression in the N9 microglial cell line: evidence for involvement of proteinase-activated receptor(1) and extracellular signal-regulated kinase 1/2.

Toll-like receptor activation reveals developmental reorganization and unmasks responder subsets of microglia

Toll-like receptor prestimulation increases phagocytosis of Escherichia coli DH5alpha and Escherichia coli K1 strains by murine microglial cells

Toll-like receptor stimulation enhances phagocytosis and intracellular killing of nonencapsulated and encapsulated Streptococcus pneumoniae by murine microglia

Treatment with 5-azacitidine delay growth of glioblastoma xenografts: a potential new treatment approach for glioblastomas

Tyrosine kinase inhibition reduces inflammation in the acute stage of experimental pneumococcal meningitis

Tyrphostin AG126 exerts neuroprotection in CNS inflammation by a dual mechanism.

Unraveling thrombin's true microglia-activating potential: markedly disparate profiles of pharmaceutical-grade and commercial-grade thrombin preparations

Vitamin d deficiency reduces the immune response, phagocytosis rate, and intracellular killing rate of microglial cells

Zoledronic acid inhibits macrophage/microglia-assisted breast cancer cell invasion

c-Jun N-terminal kinases (JNKs) mediate pro-inflammatory actions of microglia