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List of works by James Adjaye

3D culture of ovarian follicles: a system towards their engineering?

scientific article published in January 2015

A Cyclic AMP Analog, 8-Br-cAMP, Enhances the Induction of Pluripotency in Human Fibroblast Cells ⬇️

scientific article published on June 1, 2011

A Strand-Specific Library Preparation Protocol for RNA Sequencing ⬇️

scientific article published on January 1, 2011

A Systems Biology Approach to Deciphering the Etiology of Steatosis Employing Patient-Derived Dermal Fibroblasts and iPS Cells

scientific article

A data integration approach to mapping OCT4 gene regulatory networks operative in embryonic stem cells and embryonal carcinoma cells

scientific article published on 21 May 2010

A mitochondrial strategy for safeguarding the reprogrammed genome

scientific article published on 29 March 2014

A source for expression profiling in single preimplantation bovine embryos

scientific article

A transcriptional roadmap to the induction of pluripotency in somatic cells

scientific article published on June 2010

Activation of pluripotency-associated genes in mouse embryonic fibroblasts by non-viral transfection with in vitro-derived mRNAs encoding Oct4, Sox2, Klf4 and cMyc

scientific article published on 10 October 2011

Activation of the immune response is a key feature of aging in mice

scientific article published on December 2009

Age-Related Increase of EED Expression in Early Hematopoietic Progenitor Cells is Associated with Global Increase of the Histone Modification H3K27me3.

scientific article published on 11 May 2015

Age-related transcriptional changes in gene expression in different organs of mice support the metabolic stability theory of aging

scientific article

Age-specific hormonal decline is accompanied by transcriptional changes in human sebocytes in vitro

scientific article published on 29 June 2006

Aging of human sebocytes in vitro induced by exposure to a defined hormone environment

scientific article published in January 2006

An ES-like pluripotent state in FGF-dependent murine iPS cells

scientific article (publication date: 2010)

Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells

scientific article published on 26 October 2006

Association between in vivo bone formation and ex vivo migratory capacity of human bone marrow stromal cells

scientific article

BMP10 as a potent inducer of trophoblast differentiation in human embryonic and induced pluripotent stem cells

scientific article published on 23 September 2013

Bioinformatics in aging research: a workshop report

scientific article published in December 2010

Cancer stem cells in solid tumors: elusive or illusive?

scientific article

Characterisation of human induced pluripotent stem cell-derived hepatocyte-like cells and endodermal progenitors.

scientific article

Characterization of dermal fibroblast-derived iPSCs from a patient with high grade steatosis

scientific article published on 19 October 2016

Characterization of dermal fibroblast-derived iPSCs from a patient with low grade steatosis

scientific article published on 20 October 2016

Characterization of iPSCs derived from dermal fibroblasts from a healthy 19year old female

scientific article published on 19 October 2016

Chromatin immunoprecipitation-based analysis of gene regulatory networks operative in human embryonic stem cells

scientific article published in January 2012

Chromosomal Instability and Molecular Defects in Induced Pluripotent Stem Cells from Nijmegen Breakage Syndrome Patients

scientific article published on 17 August 2016

Combinatorial binding in human and mouse embryonic stem cells identifies conserved enhancers active in early embryonic development

scientific article

Combined sequencing of mRNA and DNA from human embryonic stem cells

scientific article

Combined ultra-low input mRNA and whole-genome sequencing of human embryonic stem cells

scientific article published on 12 November 2015

Comparative Analysis of Human Embryonic Stem Cell and Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells Reveals Current Drawbacks and Possible Strategies for Improved Differentiation ⬇️

scientific article published on January 24, 2011

Comparative molecular portraits of human unfertilized oocytes and primordial germ cells at 10 weeks of gestation ⬇️

scientific article published on January 1, 2012

Comparative performance analysis of human iPSC-derived and primary neural progenitor cells (NPC) grown as neurospheres in vitro

scientific article

Comparative proteome and transcriptome analyses of embryonic stem cells during embryoid body-based differentiation

scientific article published on November 2009

Computational analysis of genome-wide DNA methylation during the differentiation of human embryonic stem cells along the endodermal lineage

scientific article

Concise Review: Current Status and Future Directions on Research Related to Nonalcoholic Fatty Liver Disease

scientific article published on 4 July 2016

Conserved molecular portraits of bovine and human blastocysts as a consequence of the transition from maternal to embryonic control of gene expression

scientific article published on 26 June 2007

Control of early fate decisions in human ES cells by distinct states of TGFbeta pathway activity

scientific article published in December 2008

Cross-species hybridisation of human and bovine orthologous genes on high density cDNA microarrays

scientific article

Episomal plasmid-based generation of induced pluripotent stem cells from fetal femur-derived human mesenchymal stromal cells

scientific article published on 28 December 2015

Episomal-based generation of an iPS cell line from human fetal foreskin fibroblasts

scientific article published on 17 December 2015

Erratum: Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer's disease donor as a model for investigating AD-associated gene regulatory networks

scientific article

FGF Inhibition Directs BMP4-Mediated Differentiation of Human Embryonic Stem Cells to Syncytiotrophoblast ⬇️

scientific article published on August 6, 2012

Fibroblast growth factor 2 modulates transforming growth factor beta signaling in mouse embryonic fibroblasts and human ESCs (hESCs) to support hESC self-renewal

scientific article published on 12 October 2006

Footprint-free human fetal foreskin derived iPSCs: A tool for modeling hepatogenesis associated gene regulatory networks

scientific article published on 24 July 2017

Functional comparison of chronological and in vitro aging: differential role of the cytoskeleton and mitochondria in mesenchymal stromal cells

scientific article

Functional genomics of human pre-implantation development

scientific article published on June 2007

Gatekeeper of pluripotency: a common Oct4 transcriptional network operates in mouse eggs and embryonic stem cells

scientific article

Generation and characterization of two iPSC lines from human epicardium-derived cells

scientific article

Generation of amplified RNAs and cDNA libraries from single mammalian cells

scientific article

Generation of an iPS cell line from bone marrow derived mesenchymal stromal cells from an elderly patient

scientific article published on 09 October 2015

Generation of iPSC line epiHUVEC from human umbilical vein endothelial cells

scientific article published on 14 October 2015

Generation of iPSC lines from a Nijmegen Breakage Syndrome patient

scientific article published on 23 October 2015

Generation of iPSC lines from primary human amniotic fluid cells

scientific article published on 11 November 2015

Generation of iPSC lines from primary human chorionic villi cells

scientific article published on 23 October 2015

HIF1α modulates cell fate reprogramming through early glycolytic shift and upregulation of PDK1-3 and PKM2.

scientific article published in February 2014

Human Stromal (Mesenchymal) Stem Cells from Bone Marrow, Adipose Tissue and Skin Exhibit Differences in Molecular Phenotype and Differentiation Potential ⬇️

scientific article published on February 1, 2013

Human embryonic stem cells and embryonal carcinoma cells have overlapping and distinct metabolic signatures

scientific article

Human iPSC-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological mtDNA Disorders

scientific article published on 25 January 2017

Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature

Human induced pluripotent stem cells harbor homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining human embryonic stem cell-like metabolic reprogramming

scientific article published on September 2011

Human induced pluripotent stem cells—from mechanisms to clinical applications ⬇️

scientific article published on May 30, 2012

Human mesenchymal factors induce rat hippocampal- and human neural stem cell dependent oligodendrogenesis

scientific article

Human pluripotent stem cell derived HLC transcriptome data enables molecular dissection of hepatogenesis

scientific article published on 13 March 2018

Human skin stem cells and the ageing process

scientific article published on 09 September 2008

Identification of 2-[4-[(4-Methoxyphenyl)methoxy]-phenyl]acetonitrile and Derivatives as Potent Oct3/4 Inducers

scientific article published on 7 May 2015

Identification of biomarkers of human skin ageing in both genders. Wnt signalling - a label of skin ageing?

scientific article

In silico identification of a core regulatory network of OCT4 in human embryonic stem cells using an integrated approach

scientific article published on 15 July 2009

Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer's disease donor as a model for investigating AD-associated gene regulatory networks

scientific article

Lymphoblast-derived integration-free iPSC line AD-TREM2-3 from a 74 year-old Alzheimer's disease patient expressing the TREM2 p.R47H variant.

scientific article

Maternal Oct-4 is a potential key regulator of the developmental competence of mouse oocytes

scientific article

Matrix metalloproteinases of epithelial origin in facial sebum of patients with acne and their regulation by isotretinoin

scientific article published in October 2005

Mesenchymal stem cell conditioning promotes rat oligodendroglial cell maturation

scientific article

Meta-analysis reveals up-regulation of cholesterol processes in non-alcoholic and down-regulation in alcoholic fatty liver disease

scientific article published on March 2017

Metabolic restructuring and cell fate conversion

scientific article

Mitochondrial function in pluripotent stem cells and cellular reprogramming

scientific article

Mitochondrial-associated cell death mechanisms are reset to an embryonic-like state in aged donor-derived iPS cells harboring chromosomal aberrations

scientific article

Modeling Nonalcoholic Fatty Liver Disease with Human Pluripotent Stem Cell-Derived Immature Hepatocyte-Like Cells Reveals Activation of PLIN2 and Confirms Regulatory Functions of Peroxisome Proliferator-Activated Receptor Alpha

scientific article published on 16 June 2016

Modulation of mitochondrial biogenesis and bioenergetic metabolism upon in vitro and in vivo differentiation of human ES and iPS cells ⬇️

scientific article published on January 1, 2010

Molecular Phenotyping of Telomerized Human Bone Marrow Skeletal Stem Cells Reveals a Genetic Program of Enhanced Proliferation and Maintenance of Differentiation Responses

article

Molecular approaches to the study of gene expression during human preimplantation development

scientific article published in January 2000

Molecular characterization of cultured adult human liver progenitor cells

scientific article published on October 2010

Molecular insights into reprogramming-initiation events mediated by the OSKM gene regulatory network

scientific article

Mouse embryonic stem cells irradiated with γ-rays differentiate into cardiomyocytes but with altered contractile properties

scientific article published on 20 June 2013

Multi-omic profiles of human non-alcoholic fatty liver disease tissue highlight heterogenic phenotypes

scientific article

Network-Like Impact of MicroRNAs on Neuronal Lineage Differentiation of Unrestricted Somatic Stem Cells from Human Cord Blood ⬇️

scientific article published on March 8, 2011

New insights into human primordial germ cells and early embryonic development from single-cell analysis

scientific article published on 18 June 2017

Nijmegen Breakage Syndrome fibroblasts and iPSCs: cellular models for uncovering disease-associated signaling pathways and establishing a screening platform for anti-oxidants

scientific article published on 8 August 2017

OCT4 and the acquisition of oocyte developmental competence during folliculogenesis

scientific article published on January 2012

Oct-4 regulates the expression of Stella and Foxj2 at the Nanog locus: implications for the developmental competence of mouse oocytes

scientific article published on 28 May 2009

Preparation of Mouse Embryonic Fibroblast Cells Suitable for Culturing Human Embryonic and Induced Pluripotent Stem Cells ⬇️

scientific article published on June 21, 2012

Primary differentiation in the human blastocyst: comparative molecular portraits of inner cell mass and trophectoderm cells

scientific article

Qualitative modeling identifies IL-11 as a novel regulator in maintaining self-renewal in human pluripotent stem cells

scientific article published on 28 October 2013

Quantitative real-time PCR-based analysis of gene expression

scientific article published in January 2011

Role of Oct-4 during acquisition of developmental competence in mouse oocyte

scientific article published on January 2009

Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal

scientific article

Skin and brain age together: The role of hormones in the ageing process

scientific article published on 16 August 2010

The LARGE principle of cellular reprogramming: lost, acquired and retained gene expression in foreskin and amniotic fluid-derived human iPS cells

scientific article

The cytotoxic and immunogenic hurdles associated with non-viral mRNA-mediated reprogramming of human fibroblasts

scientific article published on 28 February 2012

The molecular basis of genistein-induced mitotic arrest and exit of self-renewal in embryonal carcinoma and primary cancer cell lines

scientific article

The proteasome complex and the maintenance of pluripotency: sustain the fate by mopping up?

scientific article

The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells

scientific article published in April 2010

Transcriptome based identification of mouse cumulus cell markers that predict the developmental competence of their enclosed antral oocytes

scientific article

Valproic acid confers functional pluripotency to human amniotic fluid stem cells in a transgene-free approach

scientific article

Whole-genome approaches for large-scale gene identification and expression analysis in mammalian preimplantation embryos

scientific article

miR-27 negatively regulates pluripotency-associated genes in human embryonal carcinoma cells

scientific article

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