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List of works by Nan Hatch

ARQ 087 inhibits FGFR signaling and rescues aberrant cell proliferation and differentiation in experimental models of craniosynostoses and chondrodysplasias caused by activating mutations in FGFR1, FGFR2 and FGFR3.

scientific article published on 18 August 2017

Bone mineralization-dependent craniosynostosis and craniofacial shape abnormalities in the mouse model of infantile hypophosphatasia.

scientific article

Cranial Neural Crest Cells and Their Role in the Pathogenesis of Craniofacial Anomalies and Coronal Craniosynostosis

scientific article published on 09 September 2020

Craniosynostosis-associated Fgfr2(C342Y) mutant bone marrow stromal cells exhibit cell autonomous abnormalities in osteoblast differentiation and bone formation.

scientific article

Dental and craniofacial defects in the Crtap-/- mouse model of osteogenesis imperfecta type VII

scientific article published on 05 March 2020

Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) Protein Regulates Osteoblast Differentiation ⬇️

scientific article published on September 19, 2011

Enzyme replacement for craniofacial skeletal defects and craniosynostosis in murine hypophosphatasia.

scientific article published on 8 May 2015

FGF2 promotes Msx2 stimulated PC-1 expression via Frs2/MAPK signaling.

scientific article published on December 2010

FGF2 stimulation of the pyrophosphate-generating enzyme, PC-1, in pre-osteoblast cells is mediated by RUNX2.

scientific article published on April 2009

Further Analysis of the Crouzon Mouse: Effects of the FGFR2C342Y Mutation Are Cranial Bone–Dependent ⬇️

scientific article published on January 29, 2013

Glial fibrillary acidic protein transcriptional regulation is independent of a TFIID-binding downstream initiator sequence.

scientific article published on December 1994

Identification and functional characterization of ERK/MAPK phosphorylation sites in the Runx2 transcription factor.

scientific article published on 30 September 2009

Impact of pharmacologic inhibition of tooth movement on periodontal and tooth root tissues during orthodontic force application

scientific article published on 25 October 2019

Improvement of the skeletal and dental hypophosphatasia phenotype in Alpl-/- mice by administration of soluble (non-targeted) chimeric alkaline phosphatase.

scientific article

Inhibition of osteoblast mineralization by phosphorylated phage-derived apatite-specific peptide

scientific article published on 15 September 2015

Intracellular retention, degradation, and signaling of glycosylation-deficient FGFR2 and craniosynostosis syndrome-associated FGFR2C278F

scientific article

Locally limited inhibition of bone resorption and orthodontic relapse by recombinant osteoprotegerin protein.

scientific article published on April 2015

Periodontal Defects in the A116T Knock-in Murine Model of Odontohypophosphatasia.

scientific article published on 25 February 2015

Postnatal Craniofacial Skeletal Development of Female C57BL/6NCrl Mice

scientific article published on 14 September 2017

Potential role of PC-1 expression and pyrophosphate elaboration in the molecular etiology of the FGFR-associated craniosynostosis syndromes.

scientific article published on May 2007

The effects of tissue-non-specific alkaline phosphatase gene therapy on craniosynostosis and craniofacial morphology in the FGFR2C342Y/+ mouse model of Crouzon craniosynostosis.

scientific article

The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin

scientific article

Tissue Nonspecific Alkaline Phosphatase (TNAP) Regulates Cranial Base Growth and Synchondrosis Maturation

scientific article published on 21 March 2017

Tissue nonspecific alkaline phosphatase promotes calvarial progenitor cell cycle progression and cytokinesis via Erk1,2

scientific article published on 17 October 2018

Tissue-nonspecific alkaline phosphatase deficiency causes abnormal craniofacial bone development in the Alpl(-/-) mouse model of infantile hypophosphatasia

scientific article

Viral delivery of tissue nonspecific alkaline phosphatase diminishes craniosynostosis in one of two FGFR2C342Y/+ mouse models of Crouzon syndrome

scientific article published on 29 May 2020

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